{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:09:27Z","timestamp":1789578567631,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jtct.2024.05.014","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T02:41:34Z","timestamp":1716000094000},"page":"812.e1-812.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Total Body Irradiation on Hematopoietic Cell Transplantation Outcomes in Pediatric Acute Myeloid Leukemia with Prior Central Nervous System Involvement"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8296-6412","authenticated-orcid":false,"given":"Takuto","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Lake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-3612","authenticated-orcid":false,"given":"Franziska","family":"Wachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Alvarez","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Dandoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4187-8456","authenticated-orcid":false,"given":"Amy K.","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.jtct.2024.05.014_bib0001","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1056\/NEJM197504172921605","article-title":"Bone-marrow transplantation","volume":"292","author":"Thomas","year":"1975","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jtct.2024.05.014_bib0002","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbmt.2011.10.004","article-title":"The national marrow donor program's symposium on hematopoietic cell transplantation in 2020: a health care resource and infrastructure assessment","volume":"18","author":"Majhail","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jtct.2024.05.014_bib0003","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3390\/curroncol28010089","article-title":"Total body irradiation for hematopoietic stem cell transplantation: what can we agree on?","volume":"28","author":"Sabloff","year":"2021","journal-title":"Curr Oncol"},{"issue":"3","key":"10.1016\/j.jtct.2024.05.014_bib0004","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ijrobp.2018.04.071","article-title":"Total body irradiation: guidelines from the international lymphoma radiation oncology group (ILROG)","volume":"101","author":"Wong","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.jtct.2024.05.014_bib0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1200\/JCO.20.02529","article-title":"Total body irradiation or chemotherapy conditioning in childhood all: a multinational, randomized, noninferiority phase III study","volume":"39","author":"Peters","year":"2021","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.jtct.2024.05.014_bib0006","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1200\/JCO.22.00767","article-title":"Busulfan plus cyclophosphamide versus total body irradiation plus cyclophosphamide for adults acute b lymphoblastic leukemia: an open-label, multicenter, phase III trial","volume":"41","author":"Zhang","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jtct.2024.05.014_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.774348","article-title":"Total body irradiation in haematopoietic stem cell transplantation for paediatric acute lymphoblastic leukaemia: review of the literature and future directions","volume":"9","author":"Hoeben","year":"2021","journal-title":"Front Pediatr"},{"issue":"4","key":"10.1016\/j.jtct.2024.05.014_bib0008","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.clml.2023.01.004","article-title":"Total body irradiation versus chemotherapy conditioning in pediatric acute lymphoblastic leukemia patients undergoing hematopoietic stem cell transplant: a systematic review and meta-analysis","volume":"23","author":"Rehman","year":"2023","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"7","key":"10.1016\/j.jtct.2024.05.014_bib0009","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.3324\/haematol.2020.249458","article-title":"Comparison of total body irradiation versus non-total body irradiation containing regimens for de novo acute myeloid leukemia in children","volume":"106","author":"Dandoy","year":"2021","journal-title":"Haematologica"},{"issue":"12","key":"10.1016\/j.jtct.2024.05.014_bib0010","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.bbmt.2014.09.001","article-title":"Outcome of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with central nervous system involvement","volume":"20","author":"Aoki","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"issue":"8","key":"10.1016\/j.jtct.2024.05.014_bib0011","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/bmt.2015.82","article-title":"Allogeneic hematopoietic cell transplant for AML: no impact of pre-transplant extramedullary disease on outcome","volume":"50","author":"Goyal","year":"2015","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jtct.2024.05.014_bib0012","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijrobp.2010.01.062","article-title":"Impact of cranial irradiation added to intrathecal conditioning in hematopoietic cell transplantation in adult acute myeloid leukemia with central nervous system involvement","volume":"80","author":"Mayadev","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.jtct.2024.05.014_bib0013","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12253-016-0162-6","article-title":"Central nervous system involvement at the time of allogeneic hematopoietic stem cell transplantation is associated with a poor outcome in patients with acute myeloid leukemia","volume":"23","author":"Ikegawa","year":"2017","journal-title":"Pathol Oncol Res"},{"issue":"8","key":"10.1016\/j.jtct.2024.05.014_bib0014","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1182\/blood-2014-10-609032","article-title":"Composite end point of graft-versus-host disease-free, relapse-free survival after allogeneic hematopoietic cell transplantation","volume":"125","author":"Holtan","year":"2015","journal-title":"Blood"},{"issue":"446","key":"10.1016\/j.jtct.2024.05.014_bib0015","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"issue":"12","key":"10.1016\/j.jtct.2024.05.014_bib0023","doi-asserted-by":"crossref","first-page":"e26612","DOI":"10.1002\/pbc.26612","article-title":"Central nervous system disease in pediatric acute myeloid leukemia: a report from the Children\u2019s Oncology Group","volume":"64","author":"Johnston","year":"2017","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"10.1016\/j.jtct.2024.05.014_bib0024","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/pbc.22511","article-title":"The presence of central nervous system disease at diagnosis in pediatric acute myeloid leukemia does not affect survival: a Children's Oncology Group study","volume":"55","author":"Johnston","year":"2010","journal-title":"Pediatr Blood Cancer"},{"issue":"7","key":"10.1016\/j.jtct.2024.05.014_bib0017","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1182\/bloodadvances.2018025908","article-title":"The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia","volume":"3","author":"Keating","year":"2019","journal-title":"Blood Adv"},{"issue":"12","key":"10.1016\/j.jtct.2024.05.014_bib0025","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.bbmt.2011.05.018","article-title":"Platelet recovery before allogeneic stem cell transplantation predicts posttransplantation outcomes in patients with acute myelogenous leukemia and myelodysplastic syndrome","volume":"17","author":"Alatrash","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"issue":"10","key":"10.1016\/j.jtct.2024.05.014_bib0026","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1182\/bloodadvances.2022009253","article-title":"T-cell replete cord transplants give superior outcomes in high-risk and relapsed\/refractory pediatric myeloid malignancy","volume":"7","author":"Horgan","year":"2023","journal-title":"Blood Adv"},{"issue":"10","key":"10.1016\/j.jtct.2024.05.014_bib0027","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1056\/NEJMoa1602074","article-title":"Cord-blood transplantation in patients with minimal residual disease","volume":"375","author":"Milano","year":"2016","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.jtct.2024.05.014_bib0028","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3324\/haematol.2011.042960","article-title":"Central nervous system involvement at first relapse in patients with acute myeloid leukemia","volume":"96","author":"Mart\u00ednez-Cuadr\u00f3n","year":"2011","journal-title":"Haematologica"},{"issue":"22","key":"10.1016\/j.jtct.2024.05.014_fur1","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMra1609337","article-title":"Acute graft-versus-host disease\u2014biologic process, prevention, and therapy","volume":"377","author":"Zeiser","year":"2017","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jtct.2024.05.014_fur2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/bmt.2014.293","article-title":"Impact of conditioning intensity and TBI on acute GVHD after hematopoietic cell transplantation","volume":"50","author":"Nakasone","year":"2015","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jtct.2024.05.014_fur3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2011-06-364265","article-title":"Risk factors for acute GVHD and survival after hematopoietic cell transplantation","volume":"119","author":"Jagasia","year":"2012","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.jtct.2024.05.014_fur4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.bbmt.2017.04.017","article-title":"Survival and late effects after allogeneic hematopoietic cell transplantation for hematologic malignancy at less than three years of age","volume":"23","author":"Vrooman","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"issue":"21","key":"10.1016\/j.jtct.2024.05.014_fur5","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1200\/JCO.2017.76.3268","article-title":"Endocrine late effects in childhood cancer survivors","volume":"36","author":"Chemaitilly","year":"2018","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.jtct.2024.05.014_fur6","first-page":"502.e501","article-title":"Comparison of pulmonary toxicity after total body irradiation- and busulfan-based myeloablative conditioning for allogeneic hematopoietic stem cell transplantation in pediatric patients","volume":"28","author":"Liu","year":"2022","journal-title":"Transpl Cell Ther"}],"updated-by":[{"DOI":"10.1016\/j.jtct.2026.03.003","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000}},{"DOI":"10.1016\/j.jtct.2026.03.003","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000}}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266663672400410X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266663672400410X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T02:17:07Z","timestamp":1754014627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266663672400410X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S266663672400410X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2024.05.014","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Total Body Irradiation on Hematopoietic Cell Transplantation Outcomes in Pediatric Acute Myeloid Leukemia with Prior Central Nervous System Involvement","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2024.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}