{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:36:08Z","timestamp":1790868968716,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jtct.2024.08.009","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T19:47:36Z","timestamp":1723837656000},"page":"16.e1-16.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surrogates of Endothelial Injury Predict Survival After Post-transplant Cyclophosphamide"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-0489","authenticated-orcid":false,"given":"Anmol","family":"Baranwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly J.","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7394-5185","authenticated-orcid":false,"given":"Mohamed A.","family":"Kharfan-Dabaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Foran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-4248","authenticated-orcid":false,"given":"Hemant","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-4620","authenticated-orcid":false,"given":"Vivek","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiha","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Z.","family":"Sproat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-8696","authenticated-orcid":false,"given":"Saurabh","family":"Chhabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Khera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-2424","authenticated-orcid":false,"given":"Urshila","family":"Durani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Hefazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Mangaonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-336X","authenticated-orcid":false,"given":"Mithun V.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Litzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-8404","authenticated-orcid":false,"given":"Hassan B.","family":"Alkhateeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jtct.2024.08.009_bib0001","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbmt.2008.03.005","article-title":"HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide","volume":"14","author":"Luznik","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"10.1016\/j.jtct.2024.08.009_bib0002","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bbmt.2009.11.011","article-title":"Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome","volume":"16","author":"Kasamon","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"issue":"25","key":"10.1016\/j.jtct.2024.08.009_bib0003","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1056\/NEJMoa2215943","article-title":"Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis","volume":"388","author":"Bola\u00f1os-Meade","year":"2023","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.jtct.2024.08.009_bib0004","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1182\/blood-2005-05-2004","article-title":"Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT","volume":"106","author":"Sorror","year":"2005","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jtct.2024.08.009_bib0005","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1182\/blood-2012-03-414573","article-title":"Validation of the hematopoietic cell transplantation-specific comorbidity index: a prospective, multicenter GITMO study","volume":"120","author":"Raimondi","year":"2012","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jtct.2024.08.009_bib0006","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/s41409-021-01390-y","article-title":"Endothelial cell dysfunction: a key determinant for the outcome of allogeneic stem cell transplantation","volume":"56","author":"Luft","year":"2021","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"10.1016\/j.jtct.2024.08.009_bib0007","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3324\/haematol.2019.238790","article-title":"Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel","volume":"106","author":"Sihe","year":"2020","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.jtct.2024.08.009_bib0008","doi-asserted-by":"crossref","first-page":"187.e1","DOI":"10.1016\/j.jtct.2023.11.016","article-title":"Easix score correlates with endothelial dysfunction biomarkers and predicts risk of acute graft-versus-host disease after allogeneic transplantation","volume":"30","author":"Pedraza","year":"2024","journal-title":"Transplant Cell Ther"},{"issue":"5","key":"10.1016\/j.jtct.2024.08.009_bib0009","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbmt.2020.01.028","article-title":"Endothelial activation and stress index (EASIX) at admission predicts fluid overload in recipients of allogeneic stem cell transplantation","volume":"26","author":"Varma","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2024.08.009_bib0010","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41409-019-0703-1","article-title":"EASIX and mortality after allogeneic stem cell transplantation","volume":"55","author":"Luft","year":"2020","journal-title":"Bone Marrow Transplant"},{"issue":"12","key":"10.1016\/j.jtct.2024.08.009_bib0011","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1038\/s41409-022-01829-w","article-title":"High EASIX score is an independent predictor of non-relapse mortality in patients with CMML undergoing allogeneic stem cell transplant","volume":"57","author":"Baranwal","year":"2022","journal-title":"Bone Marrow Transplant"},{"issue":"12","key":"10.1016\/j.jtct.2024.08.009_bib0012","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1182\/bloodadvances.2019032268","article-title":"External validation and comparison of multiple prognostic scores in allogeneic hematopoietic stem cell transplantation","volume":"3","author":"Shouval","year":"2019","journal-title":"Blood Adv"},{"issue":"9","key":"10.1016\/j.jtct.2024.08.009_bib0013","doi-asserted-by":"crossref","first-page":"e414","DOI":"10.1016\/S2352-3026(17)30108-4","article-title":"EASIX in patients with acute graft-versus-host disease: a retrospective cohort analysis","volume":"4","author":"Luft","year":"2017","journal-title":"Lancet Haematol"},{"issue":"4","key":"10.1016\/j.jtct.2024.08.009_bib0014","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41409-023-02184-0","article-title":"EASIX and CPSS Cytogenetics score-based composite risk model for patients with CMML undergoing allogeneic transplant","volume":"59","author":"Baranwal","year":"2024","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"10.1016\/j.jtct.2024.08.009_bib0015","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/HYPERTENSIONAHA.114.03575","article-title":"Endothelial dysfunction and hypertension","volume":"64","author":"Brandes","year":"2014","journal-title":"Hypertension"},{"issue":"suppl_2","key":"10.1016\/j.jtct.2024.08.009_bib0016","doi-asserted-by":"crossref","first-page":"S285","DOI":"10.2337\/dc11-s239","article-title":"Endothelial dysfunction in diabetes","volume":"34","author":"Avogaro","year":"2011","journal-title":"Diabetes Care"},{"issue":"24","key":"10.1016\/j.jtct.2024.08.009_bib0017","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1182\/bloodadvances.2021004846","article-title":"Cardiac toxicity after matched allogeneic hematopoietic cell transplant in the posttransplant cyclophosphamide era","volume":"5","author":"Yeh","year":"2021","journal-title":"Blood Adv"},{"issue":"1","key":"10.1016\/j.jtct.2024.08.009_bib0018","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0022-3565(25)38491-0","article-title":"Cyclophosphamide-induced lung toxicity: mechanism of endothelial cell injury","volume":"268","author":"Kachel","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.jtct.2024.08.009_bib0019","doi-asserted-by":"crossref","first-page":"e30897","DOI":"10.1371\/journal.pone.0030897","article-title":"Busulphan-cyclophosphamide cause endothelial injury, remodeling of resistance arteries and enhanced expression of endothelial nitric oxide synthase","volume":"7","author":"Al-Hashmi","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jtct.2024.08.009_bib0020","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1139\/cjpp-2014-0204","article-title":"Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPAR\u03b3 and abrogation of oxidative stress and inflammation","volume":"92","author":"Mahmoud","year":"2014","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jtct.2024.08.009_bib0021","doi-asserted-by":"crossref","DOI":"10.1177\/09603271221111440","article-title":"Simvastatin cardioprotection in cyclophosphamide-induced toxicity via the modulation of inflammasome\/caspase1\/interleukin1\u03b2 pathway","volume":"41","author":"Refaie","year":"2022","journal-title":"Hum Exp Toxicol"},{"issue":"13","key":"10.1016\/j.jtct.2024.08.009_bib0022","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/0006-2952(79)90222-3","article-title":"Cyclophosphamide cystitis\u2014identification of acrolein as the causative agent","volume":"28","author":"Cox","year":"1979","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"10.1016\/j.jtct.2024.08.009_bib0023","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000934","article-title":"Acrolein exposure is associated with increased cardiovascular disease risk","volume":"3","author":"DeJarnett","year":"2014","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.jtct.2024.08.009_bib0024","doi-asserted-by":"crossref","first-page":"F299","DOI":"10.1152\/ajprenal.00297.2013","article-title":"Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation","volume":"306","author":"Hughes","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"10.1016\/j.jtct.2024.08.009_bib0025","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","article-title":"Defining the intensity of conditioning regimens: working definitions","volume":"15","author":"Bacigalupo","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"10.1016\/j.jtct.2024.08.009_bib0026","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","article-title":"Clinical manifestations of graft-versus-host disease in human recipients of marrow from hl-a-matched sibling donors","volume":"18","author":"Glucksberg","year":"1974","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.jtct.2024.08.009_bib0027","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and Staging Working Group Report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2024.08.009_bib0028","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1214\/aos\/1176350951","article-title":"A class of K-sample tests for comparing the cumulative incidence of a competing risk","volume":"16","author":"Gray","year":"1988","journal-title":"Ann Stat"},{"issue":"446","key":"10.1016\/j.jtct.2024.08.009_bib0029","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"issue":"282","key":"10.1016\/j.jtct.2024.08.009_bib0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"issue":"1","key":"10.1016\/j.jtct.2024.08.009_bib0031","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1200\/JCO.1991.9.1.191","article-title":"Median follow-up in clinical trials","volume":"9","author":"Shuster","year":"1991","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jtct.2024.08.009_bib0032","series-title":"Applied Survival Analysis Using R","author":"Moore","year":"2016"},{"issue":"4","key":"10.1016\/j.jtct.2024.08.009_bib0033","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbmt.2018.12.758","article-title":"ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells","volume":"25","author":"Lee","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.08.009_bib0034","series-title":"R: A Language and Environment for Statistical Computing","year":"2022"},{"issue":"4","key":"10.1016\/j.jtct.2024.08.009_bib0035","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1182\/blood-2012-03-418202","article-title":"A disease risk index for patients undergoing allogeneic stem cell transplantation","volume":"120","author":"Armand","year":"2012","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.jtct.2024.08.009_bib0036","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1182\/blood-2014-01-552984","article-title":"Validation and refinement of the disease risk index for allogeneic stem cell transplantation","volume":"123","author":"Armand","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.jtct.2024.08.009_bib0037","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1182\/bloodadvances.2023010960","article-title":"Genetic features and outcomes of allogeneic transplantation in patients with WT1-mutated myeloid neoplasms","volume":"8","author":"Baranwal","year":"2024","journal-title":"Blood Adv"},{"issue":"6","key":"10.1016\/j.jtct.2024.08.009_bib0038","doi-asserted-by":"crossref","first-page":"377.e1","DOI":"10.1016\/j.jtct.2023.03.028","article-title":"Impact of donor age in haploidentical-post-transplantation cyclophosphamide versus matched unrelated donor post-transplantation cyclophosphamide hematopoietic stem cell transplantation in patients with acute myeloid leukemia","volume":"29","author":"Mehta","year":"2023","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2024.08.009_bib0039","article-title":"Endothelial dysfunction in hypertension: current concepts and clinical implications","volume":"8","author":"Gallo","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"3","key":"10.1016\/j.jtct.2024.08.009_bib0040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/jama.1994.03510270072043","article-title":"Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction","volume":"271","author":"Beal","year":"1994","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.jtct.2024.08.009_bib0041","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1097\/00003246-199510000-00007","article-title":"Multiple organ dysfunction score","volume":"23","author":"Marshall","year":"1995","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.jtct.2024.08.009_bib0042","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5339\/qmj.2020.22","article-title":"Multiple organ dysfunction syndrome: contemporary insights on the clinicopathological spectrum","volume":"2020","author":"Asim","year":"2020","journal-title":"Qatar Med J"},{"key":"10.1016\/j.jtct.2024.08.009_bib0043","article-title":"The multiple organ dysfunction syndrome","author":"Marshall","year":"2001","journal-title":"Surgical Treatment: Evidence-Based and Problem-Oriented"},{"issue":"1","key":"10.1016\/j.jtct.2024.08.009_bib0044","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/s13054-015-1163-7","article-title":"Fluid overload and acute kidney injury: cause or consequence?","volume":"19","author":"Ostermann","year":"2015","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.jtct.2024.08.009_bib0045","doi-asserted-by":"crossref","first-page":"360.e1","DOI":"10.1016\/j.jtct.2023.02.002","article-title":"Comparison of pretransplantation prediction models for nonrelapse mortality in patients with myelofibrosis undergoing allogeneic stem cell transplantation","volume":"29","author":"Acosta-Medina","year":"2023","journal-title":"Transplant Cell Ther"},{"issue":"3","key":"10.1016\/j.jtct.2024.08.009_bib0046","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41409-022-01874-5","article-title":"EASIX predicts non-relapse mortality after haploidentical transplantation with post-transplant cyclophosphamide","volume":"58","author":"Mariotti","year":"2023","journal-title":"Bone Marrow Transplant"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266663672400589X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266663672400589X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T03:40:14Z","timestamp":1767238814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266663672400589X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S266663672400589X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2024.08.009","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surrogates of Endothelial Injury Predict Survival After Post-transplant Cyclophosphamide","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2024.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc. on behalf of The American Society for Transplantation and Cellular Therapy.","name":"copyright","label":"Copyright"}]}}