{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:24:34Z","timestamp":1793741074672,"version":"4.6.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["438201081"],"award-info":[{"award-number":["438201081"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008131","name":"Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01EO2107"],"award-info":[{"award-number":["01EO2107"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jtct.2024.09.011","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T22:47:36Z","timestamp":1726613256000},"page":"1195.e1-1195.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Antibiotic Prophylaxis During Allogeneic Stem Cell transplantation\u2014A Comprehensive Single Center Retrospective Analysis"],"prefix":"10.1016","volume":"30","author":[{"given":"Charlotte K.F.","family":"Neuerburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-1088","authenticated-orcid":false,"given":"Friederike","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Therese","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Rehnelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjio","family":"Par\u010dina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brossart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-523X","authenticated-orcid":false,"given":"Tobias A.W.","family":"Holderried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtct.2024.09.011_bib0001","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1002\/sctm.20-0481","article-title":"Optimizing allogeneic grafts in hematopoietic stem cell transplantation","volume":"10","author":"Xu","year":"2021","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jtct.2024.09.011_bib0002","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1080\/17474086.2020.1831382","article-title":"Reducing infectious complications after allogeneic stem cell transplant","volume":"13","author":"Bacigalupo","year":"2020","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.jtct.2024.09.011_bib0003","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.bbmt.2015.12.024","article-title":"Improved treatment-related mortality and overall survival of patients with Grade IV acute GVHD in the modern years","volume":"22","author":"El-Jawahri","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0004","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7326\/M19-2936","article-title":"Survival, nonrelapse mortality, and relapse-related mortality after allogeneic hematopoietic cell transplantation: comparing 2003\u20132007 versus 2013\u20132017 cohorts","volume":"172","author":"McDonald","year":"2020","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtct.2024.09.011_bib0005","doi-asserted-by":"crossref","unstructured":"E H Lucy, M H Nina, A T Randy. Rethinking antimicrobial prophylaxis in the transplant patient in the world of emerging resistant organisms\u2014where are we today? Curr Hematol Malig Rep 13:59\u201367. doi: 10.1007\/s11899-018-0435-0","DOI":"10.1007\/s11899-018-0435-0"},{"key":"10.1016\/j.jtct.2024.09.011_bib0006","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1182\/bloodadvances.2017005108","article-title":"Empiric antibiotic use in allogeneic hematopoietic cell transplantation: should we avoid anaerobe coverage?","volume":"1","author":"Shono","year":"2017","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtct.2024.09.011_bib0007","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1086\/322604","article-title":"Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patients","volume":"33","author":"Collin","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jtct.2024.09.011_bib0008","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bmt.1705677","article-title":"Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients","volume":"39","author":"Oliveira","year":"2007","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2024.09.011_bib0009","doi-asserted-by":"crossref","first-page":"168.e1","DOI":"10.1016\/j.jtct.2021.12.012","article-title":"Omitting ciprofloxacin prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation and its impact on clinical outcomes and microbiome structure","volume":"28","author":"Haneen","year":"2022","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2024.09.011_bib0010","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1002\/cam4.2395","article-title":"Efficacy of antibiotic prophylaxis in patients with cancer and hematopoietic stem cell transplantation recipients: a systematic review of randomized trials","volume":"8","author":"Egan","year":"2019","journal-title":"Cancer Med"},{"key":"10.1016\/j.jtct.2024.09.011_bib0011","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.bbmt.2019.04.013","article-title":"Levofloxacin versus cefpodoxime for antibacterial prophylaxis in allogeneic stem cell transplantation","volume":"25","author":"Doan","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0012","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41409-023-01916-6","article-title":"Infection prevention practices among EBMT hematopoietic cell transplant centers: the EBMT Infectious Disease Working Party survey","volume":"58","author":"Yeshurun","year":"2023","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0013","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/bmt.2016.66","article-title":"Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation","volume":"51","author":"Weber","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0014","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/bmt.2016.206","article-title":"Antibiotic-mediated modification of the intestinal microbiome in allogeneic hematopoietic stem cell transplantation","volume":"52","author":"Whangbo","year":"2017","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0015","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/jnci\/52.2.401","article-title":"Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora","volume":"52","author":"van Bekkum","year":"1974","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jtct.2024.09.011_bib0016","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2307\/3573066","article-title":"Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras","volume":"45","author":"Jones","year":"1971","journal-title":"Radiat Res"},{"key":"10.1016\/j.jtct.2024.09.011_bib0017","doi-asserted-by":"crossref","first-page":"339ra71","DOI":"10.1126\/scitranslmed.aaf2311","article-title":"Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice","volume":"8","author":"Shono","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtct.2024.09.011_bib0018","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/j.bbmt.2020.07.011","article-title":"Anaerobic antibiotics and the risk of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation","volume":"26","author":"Tanaka","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0019","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1080\/03007995.2018.1551193","article-title":"Mortality, length of stay and costs associated with acute graft-versus-host disease during hospitalization for allogeneic hematopoietic stem cell transplantation","volume":"35","author":"Yu","year":"2019","journal-title":"Curr M\u00e9d Res Opin"},{"key":"10.1016\/j.jtct.2024.09.011_bib0020","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1038\/s41409-021-01274-1","article-title":"Acute graft-versus-host disease is the foremost cause of late nonrelapse mortality","volume":"56","author":"Ramdial","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0021","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/jac\/dkr508","article-title":"Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics","volume":"67","author":"Hensgens","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jtct.2024.09.011_bib0022","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/jac\/dkt129","article-title":"Community-associated Clostridium difficile infection and antibiotics: a meta-analysis","volume":"68","author":"Deshpande","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jtct.2024.09.011_bib0023","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.chom.2022.04.013","article-title":"Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria","volume":"30","author":"Drummond","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jtct.2024.09.011_bib0024","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s11046-017-0146-4","article-title":"Factors influencing non-albicans candidemia: a Case\u2013Case\u2013Control Study","volume":"182","author":"Kofteridis","year":"2017","journal-title":"Mycopathologia"},{"key":"10.1016\/j.jtct.2024.09.011_bib0025","doi-asserted-by":"crossref","first-page":"167.e1","DOI":"10.1016\/j.jtct.2021.11.017","article-title":"Teusink-Cross A Safety and efficacy of prophylactic levofloxacin in pediatric and adult hematopoietic stem cell transplantation patients","volume":"28","author":"Gardner","year":"2022","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2024.09.011_bib0026","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1080\/14740338.2022.2147924","article-title":"Fluoroquinolones: old drugs, putative new toxicities","volume":"21","author":"Bove","year":"2022","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.jtct.2024.09.011_bib0027","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/sim.5984","article-title":"The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments","volume":"33","author":"Austin","year":"2014","journal-title":"Stat Med"},{"key":"10.1016\/j.jtct.2024.09.011_bib0028","series-title":"Multistate models and their connection to competing risks. Competing Risks and Multistate Models with R. Use R!","first-page":"169","author":"Beyersmann","year":"2012"},{"key":"10.1016\/j.jtct.2024.09.011_bib0029","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1186\/s12889-015-2408-8","article-title":"Causal inference in multi-state models\u2013sickness absence and work for 1145 participants after work rehabilitation","volume":"15","author":"Gran","year":"2015","journal-title":"BMC Public Heal"},{"key":"10.1016\/j.jtct.2024.09.011_bib0030","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/acn3.51515","article-title":"Evolution of disability in spinocerebellar ataxias type 1, 2, 3, and 6","volume":"9","author":"Jacobi","year":"2022","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.jtct.2024.09.011_bib0031","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10742-022-00280-0","article-title":"A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents","volume":"23","author":"Markoulidakis","year":"2023","journal-title":"Heal Serv Outcomes Res Methodol"},{"key":"10.1016\/j.jtct.2024.09.011_bib0032","doi-asserted-by":"crossref","unstructured":"Katie M A, Shuli L, D. H Bradley, et al. Ciprofloxacin prophylaxis is associated with a lower incidence of gram-negative bacteremia in patients undergoing allogeneic hematopoietic cell transplantation. (2020) 55:2319\u20132321. doi: 10.1038\/s41409-020-0923-4","DOI":"10.1038\/s41409-020-0923-4"},{"key":"10.1016\/j.jtct.2024.09.011_bib0033","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1182\/blood-2020-142357","article-title":"Omitting fluoroquinolones antibiotic prophylaxis in allogeneic hematopoietic stem cell transplantation does not increase gram-negative bacteremia rate or transplant-related mortality","volume":"136","author":"Henig","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2024.09.011_bib0034","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/16078454.2021.1872957","article-title":"Impact of pre-transplant use of antibiotics on the graft-versus-host disease in adult patients with hematological malignancies","volume":"26","author":"Lee","year":"2021","journal-title":"Hematology"},{"key":"10.1016\/j.jtct.2024.09.011_bib0035","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.bbmt.2019.06.001","article-title":"Alteration of the intestinal microbiota by broad-spectrum antibiotic use correlates with the occurrence of intestinal graft-versus-host disease","volume":"25","author":"Lee","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0036","first-page":"e1258506","article-title":"The influence of gut-decontamination prophylactic antibiotics on acute graft-versus-host disease and survival following allogeneic hematopoietic stem cell transplantation","volume":"6","author":"Bertrand","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.jtct.2024.09.011_bib0037","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3390\/antibiotics11091269","article-title":"Impact of discontinuing levofloxacin prophylaxis on bloodstream infections in neutropenic hematopoietic stem cell transplantation patients","volume":"11","author":"Guimar\u00e3es","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.jtct.2024.09.011_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.874117","article-title":"Results of an innovative program for surveillance, prophylaxis, and treatment of infectious complications following allogeneic stem cell transplantation in hematological malignancies (BATMO Protocol)","volume":"12","author":"Malagola","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.jtct.2024.09.011_bib0039","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/1078155217735153","article-title":"Impact of fluoroquinolone prophylaxis on infectious-related outcomes after hematopoietic cell transplantation","volume":"25","author":"Amber","year":"2019","journal-title":"J Oncol Pharm Pract"},{"key":"10.1016\/j.jtct.2024.09.011_bib0040","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bbmt.2017.02.004","article-title":"Antibiotic-induced depletion of anti-inflammatory Clostridia is associated with the development of graft-versus-host disease in pediatric stem cell transplantation patients","volume":"23","author":"Simms-Waldrip","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0041","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1016\/j.bbmt.2018.06.031","article-title":"Impact of the use and type of antibiotics on acute graft-versus-host disease","volume":"24","author":"Nishi","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0042","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bbmt.2014.01.030","article-title":"Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease","volume":"20","author":"Holler","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0043","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbmt.2017.02.006","article-title":"Microbiota disruption induced by early use of broad-spectrum antibiotics is an independent risk factor of outcome after allogeneic stem cell transplantation","volume":"23","author":"Weber","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2024.09.011_bib0044","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1258506","article-title":"The influence of gut-decontamination prophylactic antibiotics on acute graft-versus-host disease and survival following allogeneic hematopoietic stem cell transplantation","volume":"6","author":"Routy","year":"2017","journal-title":"OncoImmunology"},{"key":"10.1016\/j.jtct.2024.09.011_bib0045","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.bbmt.2018.03.018","article-title":"De-escalation and discontinuation of empirical antibiotic treatment in a cohort of allogeneic hematopoietic stem cell transplantation recipients during the pre-engraftment period","volume":"24","author":"Gustinetti","year":"2018","journal-title":"Biol Blood Marrow Tr"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266663672400664X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266663672400664X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:25:40Z","timestamp":1733185540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266663672400664X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S266663672400664X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2024.09.011","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotic Prophylaxis During Allogeneic Stem Cell transplantation\u2014A Comprehensive Single Center Retrospective Analysis","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2024.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}