{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:14:07Z","timestamp":1791886447490,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021510","name":"Department of Haematology, Christian Medical College, Vellore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jtct.2024.11.009","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T04:15:22Z","timestamp":1732594522000},"page":"73.e1-73.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["CD7 CART Therapy Bridging Allo-HSCT Remarkably Improves Long-Term DFS in Refractory\/Relapsed T-ALL\/LBL"],"prefix":"10.1016","volume":"31","author":[{"given":"Zhihui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0936-7063","authenticated-orcid":false,"given":"Keyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiaopei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-2799","authenticated-orcid":false,"given":"Yanzhi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtct.2024.11.009_bib0001","doi-asserted-by":"crossref","unstructured":"Dores GM, Devesa SS, Curtis RE, Linet MS, Morton LM. Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007. Blood. 2012;119(1):34-43.","DOI":"10.1182\/blood-2011-04-347872"},{"key":"10.1016\/j.jtct.2024.11.009_bib0002","doi-asserted-by":"crossref","unstructured":"Goggins WB, Lo FF. Racial and ethnic disparities in survival of US children with acute lymphoblastic leukemia: evidence from the SEER database 1988-2008. Cancer Causes Control. 2012;23(5):737-43.","DOI":"10.1007\/s10552-012-9943-8"},{"key":"10.1016\/j.jtct.2024.11.009_bib0003","doi-asserted-by":"crossref","unstructured":"Stock W, Luger SM, Advani AS, et al. A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403. Blood. 2019;133(14):1548-59.","DOI":"10.1182\/blood-2018-10-881961"},{"key":"10.1016\/j.jtct.2024.11.009_bib0004","doi-asserted-by":"crossref","unstructured":"Schmitz N, Lenz G, Stelljes M. Allogeneic hematopoietic stem cell transplantation for T-cell lymphomas. Blood. 2018;132(3):245-53.","DOI":"10.1182\/blood-2018-01-791335"},{"key":"10.1016\/j.jtct.2024.11.009_bib0005","doi-asserted-by":"crossref","unstructured":"Huang YH, Wan CL, Dai HP, Xue SL. Targeted therapy and immunotherapy for T cell acute lymphoblastic leukemia\/lymphoma. Ann Hematol. 2023;102(8):2001-13.","DOI":"10.1007\/s00277-023-05286-3"},{"issue":"30","key":"10.1016\/j.jtct.2024.11.009_bib0006","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1200\/JCO.21.00389","article-title":"Donor-derived CD7 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia: first-in-human, phase I trial","volume":"39","author":"Pan","year":"2021","journal-title":"J clinical oncol: offi j Am Soc Clinical Oncol"},{"issue":"3","key":"10.1016\/j.jtct.2024.11.009_bib0007","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jtct.2022.11.013","article-title":"Donor CD7 chimeric antigen receptor T cell bridging to allogeneic hematopoietic stem cell transplantation for T cell hematologic malignancy","volume":"29","author":"Li","year":"2023","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2024.11.009_bib0008","doi-asserted-by":"crossref","unstructured":"Pan J, Tan Y, Deng B, Tong C, Hua L, Ling Z, et al. Frequent occurrence of CD19-negative relapse after CD19 CAR T and consolidation therapy in 14 TP53-mutated r\/r B-ALL children. Leukemia. 2020;34(12):3382-7.","DOI":"10.1038\/s41375-020-0831-z"},{"key":"10.1016\/j.jtct.2024.11.009_bib0009","doi-asserted-by":"crossref","unstructured":"Pan J, Zuo S, Deng B, et al. Sequential CD19-22 CAR T therapy induces sustained remission in children with r\/r B-ALL. Blood. 2020;135(5):387-91.","DOI":"10.1182\/blood.2019003293"},{"key":"10.1016\/j.jtct.2024.11.009_bib0010","doi-asserted-by":"crossref","unstructured":"Stenson PD, Mort M, Ball EV, et al. The Human Gene Mutation Database (HGMD(R)): optimizing its use in a clinical diagnostic or research setting. Hum Genet. 2020;139(10):1197-207.","DOI":"10.1007\/s00439-020-02199-3"},{"key":"10.1016\/j.jtct.2024.11.009_bib0011","doi-asserted-by":"crossref","unstructured":"Kalia SS, Adelman K, Bale SJ, et al. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics. Genet Med. 2017;19(2):249-55.","DOI":"10.1038\/gim.2017.17"},{"key":"10.1016\/j.jtct.2024.11.009_bib0012","doi-asserted-by":"crossref","unstructured":"Hoy SM, Lyseng-Williamson KA. Intravenous busulfan: in the conditioning treatment of pediatric patients prior to hematopoietic stem cell transplantation. Pediatric Drugs. 2007;9:271-8.","DOI":"10.2165\/00148581-200709040-00008"},{"key":"10.1016\/j.jtct.2024.11.009_bib0013","doi-asserted-by":"crossref","unstructured":"Glucksberg H, Storb R, Fefer A, et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. 1974;18(4):295-304.","DOI":"10.1097\/00007890-197410000-00001"},{"key":"10.1016\/j.jtct.2024.11.009_bib0014","unstructured":"Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant. 1995;15(6):825-8."},{"key":"10.1016\/j.jtct.2024.11.009_bib0015","doi-asserted-by":"crossref","unstructured":"Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant. 2005;11(12):945-56.","DOI":"10.1016\/j.bbmt.2005.10.001"},{"key":"10.1016\/j.jtct.2024.11.009_bib0016","doi-asserted-by":"crossref","unstructured":"Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis. 2002;34(8):1094-7.","DOI":"10.1086\/339329"},{"key":"10.1016\/j.jtct.2024.11.009_bib0017","doi-asserted-by":"crossref","unstructured":"Bordon V, Padalko E, Benoit Y, Dhooge C, Laureys G. Incidence, kinetics, and risk factors of Epstein-Barr virus viremia in pediatric patients after allogeneic stem cell transplantation. Pediatr Transplant. 2012;16(2):144-50.","DOI":"10.1111\/j.1399-3046.2011.01634.x"},{"key":"10.1016\/j.jtct.2024.11.009_bib0018","doi-asserted-by":"crossref","unstructured":"McGuirk J, Divine C, Moon SH, Chandak A, Zhang Z, Papanicolaou GA. Economic and clinical burden of virus-associated hemorrhagic cystitis in patients following allogeneic hematopoietic stem cell transplantation in the United States. Transplant Cell Ther. 2021;27(6):505 e1- e9.","DOI":"10.1016\/j.jtct.2021.02.021"},{"key":"10.1016\/j.jtct.2024.11.009_bib0019","doi-asserted-by":"crossref","unstructured":"Brown PA, Shah B, Advani A, et al. Acute lymphoblastic leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Comprehensive Cancer Network. 2021;19(9):1079-109.","DOI":"10.6004\/jnccn.2021.0042"},{"key":"10.1016\/j.jtct.2024.11.009_bib0020","doi-asserted-by":"crossref","unstructured":"Forman SJ, Rowe JM. The myth of the second remission of acute leukemia in the adult. Blood. 2013;121(7):1077-82.","DOI":"10.1182\/blood-2012-08-234492"},{"key":"10.1016\/j.jtct.2024.11.009_bib0021","doi-asserted-by":"crossref","unstructured":"Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015;373(16):1541-52.","DOI":"10.1056\/NEJMra1400972"},{"key":"10.1016\/j.jtct.2024.11.009_bib0022","doi-asserted-by":"crossref","unstructured":"Cordo V, van der Zwet JCG, Cante-Barrett K, Pieters R, Meijerink JPP. T-cell acute lymphoblastic leukemia: a roadmap to targeted therapies. Blood Cancer Discov. 2021;2(1):19-31.","DOI":"10.1158\/2643-3230.BCD-20-0093"},{"key":"10.1016\/j.jtct.2024.11.009_bib0023","doi-asserted-by":"crossref","unstructured":"Liew E, Atenafu EG, Schimmer AD, et al. Outcomes of adult patients with relapsed acute lymphoblastic leukemia following frontline treatment with a pediatric regimen. Leukemia research. 2012;36(12):1517-20.","DOI":"10.1016\/j.leukres.2012.08.019"},{"key":"10.1016\/j.jtct.2024.11.009_bib0024","doi-asserted-by":"crossref","unstructured":"Samra B, Alotaibi AS, Short NJ, et al. Outcome of adults with relapsed\/refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. Am J Hematol. 2020;95(9):E245-E7.","DOI":"10.1002\/ajh.25896"},{"key":"10.1016\/j.jtct.2024.11.009_bib0025","doi-asserted-by":"crossref","first-page":"1048296","DOI":"10.3389\/fonc.2022.1048296","article-title":"CAR-T therapy followed by allogeneic hematopoietic stem cell transplantation for refractory\/relapsed acute B lymphocytic leukemia: Long-term follow-up results","volume":"12","author":"Li","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.jtct.2024.11.009_bib0026","doi-asserted-by":"crossref","unstructured":"Chen H, Qin Y, Yang J, et al. Dismal outcome of relapsed or primary refractory adult T-cell lymphoblastic lymphoma: a retrospective study from China. Asia Pac J Clin Oncol. 2022;18(2):e87-e95.","DOI":"10.1111\/ajco.13562"},{"key":"10.1016\/j.jtct.2024.11.009_bib0027","doi-asserted-by":"crossref","unstructured":"van Heijst JW, Ceberio I, Lipuma LB, et al. Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nat Med. 2013;19(3):372-7.","DOI":"10.1038\/nm.3100"},{"key":"10.1016\/j.jtct.2024.11.009_bib0028","doi-asserted-by":"crossref","unstructured":"Soares MV, Azevedo RI, Ferreira IA, et al. Naive and stem cell memory T cell subset recovery reveals opposing reconstitution patterns in CD4 and CD8 T cells in chronic graft vs. host disease. Front Immunol. 2019;10:334.","DOI":"10.3389\/fimmu.2019.00334"},{"key":"10.1016\/j.jtct.2024.11.009_bib0029","doi-asserted-by":"crossref","unstructured":"Leick M, Gittelman RM, Yusko E, et al. T cell clonal dynamics determined by high-resolution TCR-beta sequencing in recipients after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2020;26(9):1567-74.","DOI":"10.1016\/j.bbmt.2020.04.026"},{"key":"10.1016\/j.jtct.2024.11.009_bib0030","doi-asserted-by":"crossref","unstructured":"Niu J, Chen Z, Gao J, et al. Total body irradiation-based conditioning regimen improved the survival of adult patients with T-cell lymphoblastic lymphoma after allogeneic peripheral blood stem cell transplantation. Cell Transplant. 2022;31:9636897221108890.","DOI":"10.1177\/09636897221108890"},{"key":"10.1016\/j.jtct.2024.11.009_bib0031","doi-asserted-by":"crossref","unstructured":"Hamilton BK, Rybicki L, Abounader D, et al. Allogeneic hematopoietic cell transplantation for adult T cell acute lymphoblastic leukemia. Biol Blood Marrow Transplant. 2017;23(7):1117-21.","DOI":"10.1016\/j.bbmt.2017.04.003"},{"issue":"11","key":"10.1016\/j.jtct.2024.11.009_bib0032","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3390\/biomedicines9111621","article-title":"T-cell acute lymphoblastic leukemia-current concepts in molecular biology and management","volume":"9","author":"Shiraz","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jtct.2024.11.009_bib0033","doi-asserted-by":"crossref","unstructured":"Girardi T, Vicente C, Cools J, De Keersmaecker K. The genetics and molecular biology of T-ALL. Blood. 2017;129(9):1113-23.","DOI":"10.1182\/blood-2016-10-706465"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636724007802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636724007802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:02:54Z","timestamp":1769914974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636724007802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2666636724007802"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2024.11.009","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD7 CART Therapy Bridging Allo-HSCT Remarkably Improves Long-Term DFS in Refractory\/Relapsed T-ALL\/LBL","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2024.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}