{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:20:18Z","timestamp":1777504818756,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jtct.2024.12.004","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T02:51:18Z","timestamp":1734144678000},"page":"97.e1-97.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Retrospective Analysis of Fresh versus Cryopreserved Allogenic Bone Marrow Transplant within a Pediatric Population: A Change in Practice Due to the COVID-19 Pandemic"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6729-3317","authenticated-orcid":false,"given":"Rhea","family":"Hans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0525-4768","authenticated-orcid":false,"given":"Charlotte","family":"Schwalbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-1134","authenticated-orcid":false,"given":"Roberta H.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5243-860X","authenticated-orcid":false,"given":"Holly","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Salzberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Sinno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-4397","authenticated-orcid":false,"given":"Kristen","family":"Beebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Giralt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Stahlecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Crosby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jefferson","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6724-2213","authenticated-orcid":false,"given":"Lucia","family":"Mirea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9652-1617","authenticated-orcid":false,"given":"Kevin","family":"Land","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-5642","authenticated-orcid":false,"given":"Alexander","family":"Ngwube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jtct.2024.12.004_bib0001","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jtct.2021.03.015","article-title":"The effect of donor graft cryopreservation on allogeneic hematopoietic cell transplantation outcomes: a center for international blood and marrow transplant research analysis. Implications during the COVID-19 Pandemic","volume":"27","author":"Hsu","year":"2021","journal-title":"Transplant Cell Ther"},{"issue":"3","key":"10.1016\/j.jtct.2024.12.004_bib0002","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s12185-022-03493-8","article-title":"Cryopreserved versus fresh peripheral blood allogeneic stem cell transplantation outcomes in patients receiving post-transplant cyclophosphamide for graft-versus-host prophylaxis during the COVID-19 pandemic: a single center experience","volume":"117","author":"Guo","year":"2023","journal-title":"Int J Hematol"},{"issue":"4","key":"10.1016\/j.jtct.2024.12.004_bib0003","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1182\/blood-2013-02-453175","article-title":"Umbilical cord blood transplantation: the first 25 years and beyond","volume":"122","author":"Ballen","year":"2013","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jtct.2024.12.004_bib0004","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000326623","article-title":"Cryopreservation of human stem cells for clinical application: a review","volume":"38","author":"Hunt","year":"2011","journal-title":"Transfus Med Hemother"},{"issue":"8","key":"10.1016\/j.jtct.2024.12.004_bib0005","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.transproceed.2023.03.070","article-title":"Cryopreservation of allogeneic hematopoietic cell products during COVID-19 pandemic: graft characterization and engraftment outcomes","volume":"55","author":"Keyzner","year":"2023","journal-title":"Transplant Proc"},{"issue":"3","key":"10.1016\/j.jtct.2024.12.004_bib0006","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000496068","article-title":"Cryopreservation of hematopoietic stem cells: emerging assays, cryoprotectant agents, and technology to improve outcomes","volume":"46","author":"Hornberger","year":"2019","journal-title":"Transfus Med Hemother"},{"issue":"7","key":"10.1016\/j.jtct.2024.12.004_bib0007","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jcyt.2020.12.001","article-title":"Coronavirus disease 2019 pandemic and allogeneic hematopoietic stem cell transplantation: a single center reappraisal","volume":"23","author":"Valentini","year":"2021","journal-title":"Cytotherapy"},{"issue":"3","key":"10.1016\/j.jtct.2024.12.004_bib0008","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1182\/bloodadvances.2020003883","article-title":"COVID-19 and hematopoietic stem cell transplantation and immune effector cell therapy: a US cancer center experience","volume":"5","author":"Maurer","year":"2021","journal-title":"Blood Adv"},{"issue":"10","key":"10.1016\/j.jtct.2024.12.004_bib0009","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1038\/s41409-021-01367-x","article-title":"Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?","volume":"56","author":"Fernandez-Sojo","year":"2021","journal-title":"Bone Marrow Transplant"},{"issue":"23","key":"10.1016\/j.jtct.2024.12.004_bib0010","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1182\/bloodadvances.2021005139","article-title":"Impact of cryopreservation and transit times of allogeneic grafts on hematopoietic and immune reconstitution","volume":"5","author":"Maurer","year":"2021","journal-title":"Blood Adv"},{"issue":"12","key":"10.1016\/j.jtct.2024.12.004_bib0011","doi-asserted-by":"crossref","first-page":"1022.e1","DOI":"10.1016\/j.jtct.2021.09.012","article-title":"Good engraftment but quality and donor concerns for cryopreserved hemopoietic progenitor cell products collected during the COVID-19 pandemic","volume":"27","author":"Purtill","year":"2021","journal-title":"Transplant Cell Ther"},{"issue":"4","key":"10.1016\/j.jtct.2024.12.004_bib0012","doi-asserted-by":"crossref","first-page":"215.e1","DOI":"10.1016\/j.jtct.2022.01.010","article-title":"Real-world experience of cryopreserved allogeneic hematopoietic grafts during the COVID-19 Pandemic: a single-center report","volume":"28","author":"Bankova","year":"2022","journal-title":"Transplant Cell Ther"},{"issue":"14","key":"10.1016\/j.jtct.2024.12.004_bib0013","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.3390\/jcm11144114","article-title":"Impact of cryopreservation of peripheral blood stem cells (PBSC) in transplantation from matched unrelated donor (MUD)","volume":"11","author":"Facchin","year":"2022","journal-title":"J Clin Med"},{"issue":"8","key":"10.1016\/j.jtct.2024.12.004_bib0014","doi-asserted-by":"crossref","first-page":"664.e1","DOI":"10.1016\/j.jtct.2021.04.022","article-title":"Cryopreservation of unrelated hematopoietic stem cells from a blood and marrow donor bank during the COVID-19 pandemic: a nationwide survey by the japan marrow donor program","volume":"27","author":"Kanda","year":"2021","journal-title":"Transplant Cell Ther"},{"issue":"5","key":"10.1016\/j.jtct.2024.12.004_bib0015","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1182\/blood-2012-12-469668","article-title":"Peripheral blood stem cells versus bone marrow in pediatric unrelated donor stem cell transplantation","volume":"121","author":"Meisel","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtct.2024.12.004_bib0016","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tmrv.2018.11.003","article-title":"Peripheral blood or bone marrow stem cells? Practical considerations in hematopoietic stem cell transplantation","volume":"33","author":"Amouzegar","year":"2019","journal-title":"Transfus Med Rev"},{"issue":"12","key":"10.1016\/j.jtct.2024.12.004_bib0017","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/j.bbmt.2018.08.010","article-title":"Bone marrow versus peripheral blood from unrelated donors for children and adolescents with acute leukemia","volume":"24","author":"Keesler","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"issue":"12","key":"10.1016\/j.jtct.2024.12.004_bib0018","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","article-title":"Defining the intensity of conditioning regimens: working definitions","volume":"15","author":"Bacigalupo","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"issue":"8","key":"10.1016\/j.jtct.2024.12.004_bib0019","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jtct.2021.04.007","volume":"27","author":"Kharfan-Dabaja","year":"2021","journal-title":"Transplant Cell Ther"},{"issue":"1","key":"10.1016\/j.jtct.2024.12.004_bib0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbmt.2015.09.001","article-title":"International, multicenter standardization of acute graft-versus-host disease clinical data collection: a report from the mount Sinai acute GVHD international consortium","volume":"22","author":"Harris","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"issue":"11","key":"10.1016\/j.jtct.2024.12.004_bib0021","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/s41409-018-0204-7","article-title":"EBMT-NIH-CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment","volume":"53","author":"Schoemans","year":"2018","journal-title":"Bone Marrow Transplant"},{"issue":"12","key":"10.1016\/j.jtct.2024.12.004_bib0022","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report","volume":"11","author":"Filipovich","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2024.12.004_bib0023","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"10.1016\/j.jtct.2024.12.004_bib0024","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/bmt.2012.118","article-title":"Cryopreservation of allogeneic PBSC from related and unrelated donors is associated with delayed platelet engraftment but has no impact on survival","volume":"48","author":"Medd","year":"2013","journal-title":"Bone Marrow Transplant"},{"issue":"7","key":"10.1016\/j.jtct.2024.12.004_bib0025","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.bbmt.2020.04.001","article-title":"Graft cryopreservation does not impact overall survival after allogeneic hematopoietic cell transplantation using post-transplantation cyclophosphamide for graft-versus-host disease prophylaxis","volume":"26","author":"Hamadani","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"10.1016\/j.jtct.2024.12.004_bib0026","doi-asserted-by":"crossref","first-page":"102742","DOI":"10.1016\/j.transci.2020.102742","article-title":"Comparison of allogenic stem cell transplantations performed with frozen or fresh stem cell products with regard to GVHD and mortality","volume":"59","author":"Dagdas","year":"2020","journal-title":"Transfus Apher Sci"},{"issue":"19","key":"10.1016\/j.jtct.2024.12.004_bib0027","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1182\/bloodadvances.2023009786","article-title":"Clinical impact of cryopreservation of allogeneic hematopoietic cell grafts during the onset of the COVID-19 pandemic","volume":"7","author":"Devine","year":"2023","journal-title":"Blood Adv"},{"issue":"11","key":"10.1016\/j.jtct.2024.12.004_bib0028","doi-asserted-by":"crossref","first-page":"700.e1","DOI":"10.1016\/j.jtct.2023.08.025","article-title":"Cryopreservation of growth factor-mobilized peripheral blood stem cells does not compromise major outcomes after allogeneic hematopoietic cell transplantation: a single-center experience","volume":"29","author":"Connelly-Smith","year":"2023","journal-title":"Transplant Cell Ther"},{"issue":"10","key":"10.1016\/j.jtct.2024.12.004_bib0029","doi-asserted-by":"crossref","first-page":"677.e1","DOI":"10.1016\/j.jtct.2022.06.022","article-title":"Effect of cryopreservation in unrelated bone marrow and peripheral blood stem cell transplantation in the era of the COVID-19 pandemic: an update from the japan marrow donor program","volume":"28","author":"Kanda","year":"2022","journal-title":"Transplant Cell Ther"},{"issue":"6","key":"10.1016\/j.jtct.2024.12.004_bib0030","doi-asserted-by":"crossref","first-page":"103821","DOI":"10.1016\/j.transci.2023.103821","article-title":"The effect of cryopreservation on engraftment kinetics in fully matched allogeneic stem cell transplantation: Real-life data and literature review","volume":"62","author":"Ersal","year":"2023","journal-title":"Transfus Apher Sci"},{"issue":"1","key":"10.1016\/j.jtct.2024.12.004_bib0031","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/ejh.13714","article-title":"Anti-thymocyte globulin and post-transplant cyclophosphamide predisposes to inferior outcome when using cryopreserved stem cell grafts","volume":"108","author":"Novitzky-Basso","year":"2022","journal-title":"Eur J Haematol"},{"issue":"7","key":"10.1016\/j.jtct.2024.12.004_bib0032","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/j.bbmt.2020.04.027","article-title":"Hematopoietic Cell Transplantation with Cryopreserved Grafts for Severe Aplastic Anemia","volume":"26","author":"Eapen","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"10.1016\/j.jtct.2024.12.004_bib0033","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/bmt.2008.93","article-title":"Transportation and cryopreservation may impair haematopoietic stem cell function and engraftment of allogeneic PBSCs, but not BM","volume":"42","author":"Lioznov","year":"2008","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"10.1016\/j.jtct.2024.12.004_bib0034","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/sj.bmt.1705462","article-title":"Has allogeneic stem cell cryopreservation been given the \u2018cold shoulder\u2019? An analysis of the pros and cons of using frozen versus fresh stem cell products in allogeneic stem cell transplantation","volume":"38","author":"Frey","year":"2006","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"10.1016\/j.jtct.2024.12.004_bib0035","first-page":"125","article-title":"Comparison of engraftment and acute GVHD in patients undergoing cryopreserved or fresh allogeneic BMT","volume":"11","author":"Eckardt","year":"1993","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"10.1016\/j.jtct.2024.12.004_bib0036","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/ejh.12140","article-title":"To freeze or not to freeze peripheral blood stem cells prior to allogeneic transplantation from matched related donors","volume":"91","author":"Parody","year":"2013","journal-title":"Eur J Haematol"},{"issue":"3","key":"10.1016\/j.jtct.2024.12.004_bib0037","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000497289","article-title":"Technical considerations in the freezing, low-temperature storage and thawing of stem cells for cellular therapies","volume":"46","author":"Hunt","year":"2019","journal-title":"Transfus Med Hemother"},{"issue":"6","key":"10.1016\/j.jtct.2024.12.004_bib0038","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3390\/cells13060552","article-title":"Pros and cons of cryopreserving allogeneic stem cell products","volume":"13","author":"Valentini","year":"2024","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.jtct.2024.12.004_bib0039","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.3390\/life13091794","article-title":"Fresh umbilical cord Blood-A source of multipotent stem cells, collection, banking, cryopreservation, and ethical concerns","volume":"13","author":"Devi","year":"2023","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.jtct.2024.12.004_bib0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.tracli.2022.08.141","article-title":"Patients experienced serious adverse reactions within one hour of hematopoietic stem-cell infusion","volume":"30","author":"Meric","year":"2023","journal-title":"Transfus Clin Biol"},{"issue":"6","key":"10.1016\/j.jtct.2024.12.004_bib0041","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1111\/trf.14072","article-title":"Adverse events of cryopreserved hematopoietic stem cell infusions in adults: a single-center observational study","volume":"57","author":"Otrock","year":"2017","journal-title":"Transfusion"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636724008054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636724008054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:03:48Z","timestamp":1769915028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636724008054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2666636724008054"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2024.12.004","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Retrospective Analysis of Fresh versus Cryopreserved Allogenic Bone Marrow Transplant within a Pediatric Population: A Change in Practice Due to the COVID-19 Pandemic","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2024.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}