{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:21:23Z","timestamp":1786972883303,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jtct.2025.01.881","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:33:00Z","timestamp":1736987580000},"page":"178.e1-178.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Obesity on GVHD in Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies"],"prefix":"10.1016","volume":"31","author":[{"given":"Valentina","family":"Ardila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1997-3799","authenticated-orcid":false,"given":"Claudio","family":"Brunstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Kalaycio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-3261","authenticated-orcid":false,"given":"Ronald","family":"Sobecks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1252-6539","authenticated-orcid":false,"given":"Betty K.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtct.2025.01.881_bib0001","unstructured":"Defining adult overweight & obesity centers for disease control and prevention 2022 [updated 6\/3\/2022; cited 20241\/6\/2024]. Available from: https:\/\/www.cdc.gov\/obesity\/basics\/adult-defining.html."},{"issue":"1","key":"10.1016\/j.jtct.2025.01.881_bib0002","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N Engl J Med"},{"issue":"288","key":"10.1016\/j.jtct.2025.01.881_bib0003","first-page":"1","article-title":"Prevalence of obesity among adults and youth: United States, 2015-2016","author":"Hales","year":"2017","journal-title":"NCHS Data Brief"},{"issue":"25","key":"10.1016\/j.jtct.2025.01.881_bib0004","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1056\/NEJMsa1909301","article-title":"Projected U.S. state-level prevalence of adult obesity and severe obesity","volume":"381","author":"Ward","year":"2019","journal-title":"N Engl J Med"},{"issue":"25 Suppl 2","key":"10.1016\/j.jtct.2025.01.881_bib0005","first-page":"S102","article-title":"2013 AHA\/ACC\/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and The Obesity Society","volume":"129","author":"Jensen","year":"2014","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.jtct.2025.01.881_bib0006","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"Calle","year":"2003","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.jtct.2025.01.881_bib0007","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/bmt.2014.178","article-title":"Impact of pretransplant body mass index on the clinical outcome after allogeneic hematopoietic SCT","volume":"49","author":"Fuji","year":"2014","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"10.1016\/j.jtct.2025.01.881_bib0008","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41409-023-02154-6","article-title":"The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party","volume":"59","author":"Gj\u00e6rde","year":"2024","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"10.1016\/j.jtct.2025.01.881_bib0009","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jjco\/hyaa053","article-title":"Obesity is correlated with poor outcome after allogeneic hematopoietic stem cell transplantation in patients with acute leukemia","volume":"50","author":"Yu","year":"2020","journal-title":"Jpn J Clin Oncol"},{"issue":"3","key":"10.1016\/j.jtct.2025.01.881_bib0010","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/bmt.2014.280","article-title":"Baseline body mass index among children and adults undergoing allogeneic hematopoietic cell transplantation: clinical characteristics and outcomes","volume":"50","author":"Gleimer","year":"2015","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2025.01.881_bib0011","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.bbmt.2018.10.006","article-title":"Impact of body mass index on outcomes of hematopoietic stem cell transplantation in adults","volume":"25","author":"Doney","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2025.01.881_bib0012","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0002-9343(96)00450-0","article-title":"Impact of obesity on allogeneic stem cell transplant patients: a matched case-controlled study","volume":"102","author":"Fleming","year":"1997","journal-title":"Am J Med"},{"issue":"10","key":"10.1016\/j.jtct.2025.01.881_bib0013","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.bbmt.2010.04.009","article-title":"Obesity does not preclude safe and effective myeloablative hematopoietic cell transplantation (HCT) for acute myelogenous leukemia (AML) in adults","volume":"16","author":"Navarro","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jtct.2025.01.881_bib0014","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.bbmt.2018.08.031","article-title":"Impact of obesity on clinical outcomes of elderly patients undergoing allogeneic hematopoietic cell transplantation for myeloid malignancies","volume":"25","author":"Voshtina","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jtct.2025.01.881_bib0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1399-0012.2011.01445.x","article-title":"The relationship between body mass index and outcomes in leukemic patients undergoing allogeneic hematopoietic stem cell transplantation","volume":"26","author":"Hadjibabaie","year":"2012","journal-title":"Clin Transplant"},{"issue":"11","key":"10.1016\/j.jtct.2025.01.881_bib0016","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00277-010-1001-6","article-title":"Allogeneic transplant outcomes are not affected by body mass index (BMI) in patients with haematological malignancies","volume":"89","author":"Nikolousis","year":"2010","journal-title":"Ann Hematol"},{"issue":"22","key":"10.1016\/j.jtct.2025.01.881_bib0017","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMra1609337","article-title":"Acute graft-versus-host disease - biologic process, prevention, and therapy","volume":"377","author":"Zeiser","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jtct.2025.01.881_bib0018","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1182\/hematology.2021000301","article-title":"Updates in chronic graft-versus-host disease","volume":"2021","author":"Hamilton","year":"2021","journal-title":"Hematol Am Soc Hematol Educ Prog"},{"issue":"3","key":"10.1016\/j.jtct.2025.01.881_bib0019","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1056\/NEJMoa2033122","article-title":"Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease","volume":"385","author":"Zeiser","year":"2021","journal-title":"N Engl J Med"},{"issue":"571","key":"10.1016\/j.jtct.2025.01.881_bib0020","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay7713","article-title":"Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation","volume":"12","author":"Khuat","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtct.2025.01.881_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.752484","article-title":"Mechanisms by which obesity promotes acute graft-versus-host disease in mice","volume":"12","author":"Khuat","year":"2021","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.jtct.2025.01.881_bib0022","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1182\/blood-2010-10-316109","article-title":"Association between serum high-molecular-weight adiponectin level and the severity of chronic graft-versus-host disease in allogeneic stem cell transplantation recipients","volume":"117","author":"Nakasone","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtct.2025.01.881_bib0023","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbmt.2008.10.029","article-title":"Possible association between obesity and post-transplantation complications including infectious diseases and acute graft-versus-host disease","volume":"15","author":"Fuji","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3,Supplement","key":"10.1016\/j.jtct.2025.01.881_bib0024","doi-asserted-by":"crossref","first-page":"S321","DOI":"10.1016\/j.bbmt.2018.12.519","article-title":"High body mass index (BMI) is associated with lower survival and increased chronic gvhd after allogeneic hematopoietic stem cell transplantation","volume":"25","author":"Asslan","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"issue":"26","key":"10.1016\/j.jtct.2025.01.881_bib0025","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1182\/blood-2009-12-258442","article-title":"The best endpoint for acute GVHD treatment trials","volume":"115","author":"MacMillan","year":"2010","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jtct.2025.01.881_bib0026","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.bbmt.2015.02.025","article-title":"Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report","volume":"21","author":"Lee","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"10.1016\/j.jtct.2025.01.881_bib0027","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","article-title":"Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors","volume":"18","author":"Glucksberg","year":"1974","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.jtct.2025.01.881_bib0028","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. the 2014 diagnosis and staging working group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.01.881_bib0029","doi-asserted-by":"crossref","first-page":"e8317","DOI":"10.7717\/peerj.8317","article-title":"Alteration of the gut microbiota associated with childhood obesity by 16S rRNA gene sequencing","volume":"8","author":"Chen","year":"2020","journal-title":"PeerJ"},{"issue":"9","key":"10.1016\/j.jtct.2025.01.881_bib0030","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41430-020-0607-6","article-title":"Profile of the gut microbiota of adults with obesity: a systematic review","volume":"74","author":"Crovesy","year":"2020","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"10.1016\/j.jtct.2025.01.881_bib0031","doi-asserted-by":"crossref","DOI":"10.3390\/nu14010012","article-title":"Gut microbiome composition in obese and non-obese persons: a systematic review and meta-analysis","volume":"14","author":"Pinart","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.jtct.2025.01.881_bib0032","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrc.2018.10","article-title":"Gut microbiota injury in allogeneic haematopoietic stem cell transplantation","volume":"18","author":"Shono","year":"2018","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"10.1016\/j.jtct.2025.01.881_bib0033","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1172\/JCI125797","article-title":"The gut microbiota and graft-versus-host disease","volume":"129","author":"Fredricks","year":"2019","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.jtct.2025.01.881_bib0034","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1056\/NEJMoa1900623","article-title":"Microbiota as predictor of mortality in allogeneic hematopoietic-cell transplantation","volume":"382","author":"Peled","year":"2020","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jtct.2025.01.881_bib0035","doi-asserted-by":"crossref","first-page":"e6799","DOI":"10.1002\/cam4.6799","article-title":"Gut microbiota, microbiota-derived metabolites, and graft-versus-host disease","volume":"13","author":"Yue","year":"2024","journal-title":"Cancer Med"},{"key":"10.1016\/j.jtct.2025.01.881_bib0036","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2147\/CCID.S447412","article-title":"Facial physiological characteristics and skin microbiomes changes are associated with body mass index (BMI)","volume":"17","author":"Ma","year":"2024","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1016\/j.jtct.2025.01.881_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.humic.2019.100063","article-title":"Beyond the gut: Skin microbiome compositional changes are associated with BMI","volume":"13","author":"Brandwein","year":"2019","journal-title":"Human Microbiome J"},{"issue":"1","key":"10.1016\/j.jtct.2025.01.881_bib0038","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3613","article-title":"Alteration in the skin microbiome in cutaneous graft versus host disease","volume":"101","author":"Gu","year":"2021","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"10.1016\/j.jtct.2025.01.881_bib0039","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1016\/S2352-3026(18)30221-7","volume":"6","author":"Bola\u00f1os-Meade","year":"2019","journal-title":"Lancet Haematol"},{"issue":"25","key":"10.1016\/j.jtct.2025.01.881_bib0040","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1056\/NEJMoa2215943","article-title":"Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis","volume":"388","author":"Bola\u00f1os-Meade","year":"2023","journal-title":"N Engl J Med"},{"issue":"18","key":"10.1016\/j.jtct.2025.01.881_bib0041","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1200\/JCO.21.00471","article-title":"Appropriate systemic therapy dosing for obese adult patients with cancer: ASCO guideline update","volume":"39","author":"Griggs","year":"2021","journal-title":"J Clin Oncol"},{"issue":"63 Suppl 2","key":"10.1016\/j.jtct.2025.01.881_bib0042","first-page":"S85","article-title":"Effect of obesity on the pharmacokinetics and pharmacodynamics of anticancer agents","author":"Zamboni","year":"2023","journal-title":"J Clin Pharmacol"},{"issue":"8","key":"10.1016\/j.jtct.2025.01.881_bib0043","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.bbmt.2018.02.016","article-title":"Evolution of body composition following autologous and allogeneic hematopoietic cell transplantation: incidence of sarcopenia and association with clinical outcomes","volume":"24","author":"DeFilipp","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"issue":"12","key":"10.1016\/j.jtct.2025.01.881_bib0044","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/sj.bmt.1704996","article-title":"Longitudinal follow-up of body composition in hematopoietic stem cell transplant patients","volume":"35","author":"Kyle","year":"2005","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"10.1016\/j.jtct.2025.01.881_bib0045","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/jnci\/djy231","article-title":"Impact of sarcopenia on adverse outcomes after allogeneic hematopoietic cell transplantation","volume":"111","author":"Armenian","year":"2019","journal-title":"J Natl Cancer Inst"},{"issue":"15 Suppl","key":"10.1016\/j.jtct.2025.01.881_bib0046","first-page":"S288","article-title":"A review of current guidelines for the treatment of obesity","volume":"28","author":"Cornier","year":"2022","journal-title":"Am J Manag Care"},{"issue":"7","key":"10.1016\/j.jtct.2025.01.881_bib0047","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.21305","article-title":"Glucagon-like peptide 1 receptor agonists and 13 obesity-associated cancers in patients with type 2 diabetes","volume":"7","author":"Wang","year":"2024","journal-title":"JAMA Netw Open"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636725009108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636725009108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T21:49:04Z","timestamp":1741124944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636725009108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2666636725009108"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2025.01.881","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Obesity on GVHD in Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2025.01.881","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of The American Society for Transplantation and Cellular Therapy.","name":"copyright","label":"Copyright"}]}}