{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:28:57Z","timestamp":1793500137424,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jtct.2025.07.019","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T22:32:43Z","timestamp":1754778763000},"page":"900.e1-900.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Haploidentical-Hematopoietic Stem Cell Transplantation Using Modified Post-Transplantation Cyclophosphamide and Eltrombopag Combined With Immunosuppression for the Treatment of Severe Aplastic Anemia"],"prefix":"10.1016","volume":"31","author":[{"given":"Andie","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fankai","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-9638","authenticated-orcid":false,"given":"Donghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangsheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jtct.2025.07.019_bib0001","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/bjh.19236","article-title":"Guidelines for the diagnosis and management of adult aplastic anaemia: a British Society for Haematology Guideline","volume":"204","author":"Kulasekararaj","year":"2024","journal-title":"Br J Haematol"},{"issue":"6","key":"10.1016\/j.jtct.2025.07.019_bib0002","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/bjh.17403","article-title":"Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries","volume":"194","author":"Scheinberg","year":"2021","journal-title":"Br J Haematol."},{"key":"10.1016\/j.jtct.2025.07.019_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1384640","article-title":"Comparison of upfront haploidentical hematopoietic stem cell transplantation and salvage haploidentical hematopoietic stem cell transplantation after immunosuppressive therapy in children with acquired severe aplastic anemia - a multicenter study","volume":"15","author":"Luo","year":"2024","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.jtct.2025.07.019_bib0004","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41409-024-02377-1","article-title":"First-line treatment of severe aplastic anemia: immunosuppressive therapy plus eltrombopag versus haploidentical hematopoietic stem cell transplantation, a multicenter prospective study","volume":"59","author":"Liu","year":"2024","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jtct.2025.07.019_bib0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa2109965","article-title":"Eltrombopag added to immunosuppression in severe aplastic anemia","volume":"386","author":"Peffault de Latour","year":"2022","journal-title":"N Engl J Med"},{"issue":"23","key":"10.1016\/j.jtct.2025.07.019_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315192","article-title":"Anti-thymocyte globulin (ATG)-free nonmyeloablative haploidentical PBSCT plus post-transplantation cyclophosphamide is a safe and efficient treatment approach for pediatric acquired aplastic anemia","volume":"23","author":"Chen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtct.2025.07.019_bib0007","article-title":"Comparison of hematopoietic stem cell transplantation outcomes using matched sibling donors, haploidentical donors, and immunosuppressive therapy for patients with acquired aplastic anemia","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jtct.2025.07.019_bib0008","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13045-021-01159-2","article-title":"The consensus from the Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update","volume":"14","author":"Zhang","year":"2021","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jtct.2025.07.019_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2022.101035","article-title":"Haploidentical transplants with a G-CSF\/ATG-based protocol: experience from China","volume":"62","author":"Xu","year":"2023","journal-title":"Blood Rev"},{"key":"10.1016\/j.jtct.2025.07.019_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.796349","article-title":"Post-transplantation cyclophosphamide uniquely restrains alloreactive CD4(+) T-cell proliferation and differentiation after murine MHC-haploidentical hematopoietic cell transplantation","volume":"13","author":"Hadjis","year":"2022","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.jtct.2025.07.019_bib0011","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/bjh.18483","volume":"200","author":"Zhang","year":"2023","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.jtct.2025.07.019_bib0012","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13045-024-01612-y","article-title":"Increased Epstein\u2012Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation","volume":"17","author":"Kong","year":"2024","journal-title":"J Hematol Oncol"},{"issue":"9","key":"10.1016\/j.jtct.2025.07.019_bib0013","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.scib.2022.01.024","article-title":"Long-term follow-up of haploidentical transplantation in relapsed\/refractory severe aplastic anemia: a multicenter prospective study","volume":"67","author":"Xu","year":"2022","journal-title":"Sci Bull (Beijing)"},{"issue":"9","key":"10.1016\/j.jtct.2025.07.019_bib0014","doi-asserted-by":"crossref","first-page":"586.e581","DOI":"10.1016\/j.jtct.2022.05.027","article-title":"Frontline therapy options for adults with newly diagnosed severe aplastic anemia: intensive immunosuppressive therapy plus eltrombopag or matched sibling donor hematopoietic stem cell transplantation?","volume":"28","author":"Huang","year":"2022","journal-title":"Transplant Cell Ther"},{"issue":"11","key":"10.1016\/j.jtct.2025.07.019_bib0015","first-page":"890","article-title":"[Efficacy and safety of eltrombopag in aplastic anemia: A multi-center survey in China]","volume":"41","author":"Yang","year":"2020","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"issue":"5","key":"10.1016\/j.jtct.2025.07.019_bib0016","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jtct.2024.02.023","article-title":"Recombinant human thrombopoietin promotes platelet engraftment in severe aplastic anemia patients following treatment with haploid hematopoietic stem cell transplantation using modified post-transplantation cyclophosphamide","volume":"30","author":"Fu","year":"2024","journal-title":"Transplant Cell Ther"},{"issue":"6","key":"10.1016\/j.jtct.2025.07.019_bib0017","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/s41409-024-02251-0","article-title":"Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: a report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT","volume":"59","author":"Sureda","year":"2024","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"10.1016\/j.jtct.2025.07.019_bib0018","first-page":"599","article-title":"Hematopoietic cell transplantation, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology","volume":"18","author":"Sureda","year":"2024","journal-title":"J Natl Compr Canc Netw"},{"issue":"6","key":"10.1016\/j.jtct.2025.07.019_bib0019","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.jtho.2020.11.030","article-title":"Using propensity score matching to balance the baseline characteristics","volume":"16","author":"Liang","year":"2021","journal-title":"J Thorac Oncol"},{"issue":"1","key":"10.1016\/j.jtct.2025.07.019_bib0020","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/S2352-3026(23)00305-8","article-title":"Indication and management of allogeneic haematopoietic stem-cell transplantation in myelofibrosis: updated recommendations by the EBMT\/ELN International Working Group","volume":"11","author":"Kr\u00f6ger","year":"2024","journal-title":"Lancet Haematol"},{"issue":"1","key":"10.1016\/j.jtct.2025.07.019_bib0021","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1182\/blood.2021012130","article-title":"Long-term outcomes in patients with severe aplastic anemia treated with immunosuppression and eltrombopag: a phase 2 study","volume":"139","author":"Patel","year":"2022","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jtct.2025.07.019_bib0022","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13045-017-0398-y","article-title":"Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant","volume":"10","author":"Xu","year":"2017","journal-title":"J Hematol Oncol"},{"issue":"1","key":"10.1016\/j.jtct.2025.07.019_bib0023","first-page":"781","article-title":"Similar outcomes between HLA-haploid and matched sibling donor hematopoietic stem cell transplantation: a multicenter, retrospective study and severe aplastic anemia transplant-specific prognostic scoring system","volume":"104","author":"Gao","year":"2025","journal-title":"Ann Hematol"},{"issue":"6","key":"10.1016\/j.jtct.2025.07.019_bib0024","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s11427-019-9585-x","article-title":"Haploidentical hematopoietic cell transplantation for severe acquired aplastic anemia: a case-control study of post-transplant cyclophosphamide included regimen vs. anti-thymocyte globulin & colony-stimulating factor-based regimen","volume":"63","author":"Xu","year":"2020","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.jtct.2025.07.019_bib0025","article-title":"Development and validation of early death risk score model for emergency status prediction in very severe aplastic anemia","volume":"14","author":"Liu","year":"2023","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.jtct.2025.07.019_bib0026","doi-asserted-by":"crossref","first-page":"e660","DOI":"10.1016\/S2352-3026(22)00206-X","article-title":"Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial","volume":"9","author":"DeZern","year":"2022","journal-title":"Lancet Haematol"},{"issue":"11","key":"10.1016\/j.jtct.2025.07.019_bib0027","doi-asserted-by":"crossref","first-page":"1099.e1","DOI":"10.1016\/j.jtct.2024.08.016","article-title":"Efficacy of a modified post-transplant cyclophosphamide regimen for unrelated donor hematopoietic stem cell transplantation in patients with severe aplastic anemia: a prospective study","volume":"30","author":"Chen","year":"2024","journal-title":"Transplant Cell Ther"},{"issue":"1","key":"10.1016\/j.jtct.2025.07.019_bib0028","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41408-024-01021-x","article-title":"Unrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia","volume":"14","author":"Wu","year":"2024","journal-title":"Blood Cancer J"},{"issue":"9","key":"10.1016\/j.jtct.2025.07.019_bib0029","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1038\/s41375-022-01636-8","article-title":"Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia","volume":"36","author":"Groarke","year":"2022","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.jtct.2025.07.019_bib0030","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.7150\/ijms.94012","article-title":"Haploidentical hematopoietic stem cell transplantation as a first-line treatment for paediatric severe aplastic anemia: a single-center research","volume":"21","author":"Yuan","year":"2024","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.jtct.2025.07.019_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.912917","article-title":"Comparison of haploidentical hematopoietic stem cell transplant with or without unrelated cord blood infusion in severe aplastic anemia: outcomes of a multicenter study","volume":"13","author":"Lei","year":"2022","journal-title":"Front Immunol"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636725013314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636725013314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:30:23Z","timestamp":1793496623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636725013314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2666636725013314"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2025.07.019","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Haploidentical-Hematopoietic Stem Cell Transplantation Using Modified Post-Transplantation Cyclophosphamide and Eltrombopag Combined With Immunosuppression for the Treatment of Severe Aplastic Anemia","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2025.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}