{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:28:53Z","timestamp":1793500133190,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01HL157414-01"],"award-info":[{"award-number":["R01HL157414-01"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"School of Medicine, Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jtct.2025.08.013","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T08:14:34Z","timestamp":1755245674000},"page":"922.e1-922.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bronchiectasis in Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-2623","authenticated-orcid":false,"given":"David J.","family":"Epstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0809-5548","authenticated-orcid":false,"given":"Nidia","family":"Rodriguez-Ormaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-3961","authenticated-orcid":false,"given":"Husham","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-722X","authenticated-orcid":false,"given":"Yu Kuang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5511-1750","authenticated-orcid":false,"given":"Haiwei Henry","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9625-168X","authenticated-orcid":false,"given":"Carlos Hernandez","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Huda","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajaypal","family":"Sahota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9281-4864","authenticated-orcid":false,"given":"Ekroop S.","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zayan Maliha","family":"Musa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-1562","authenticated-orcid":false,"given":"Carson Tyler","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-5459","authenticated-orcid":false,"given":"Paulami","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7822-6865","authenticated-orcid":false,"given":"Grady Harrison","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-6504","authenticated-orcid":false,"given":"Joe L.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtct.2025.08.013_bib0001","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbmt.2014.10.021","article-title":"Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research","volume":"21","author":"Arai","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0002","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0003","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1016\/j.bbmt.2009.11.002","article-title":"Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease","volume":"16","author":"Chien","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0004","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bbmt.2015.10.018","article-title":"Late acute and chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation","volume":"22","author":"Arora","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1164\/rccm.201809-1635OC","article-title":"First-onset herpesviral infection and lung injury in allogeneic hematopoietic cell transplantation","volume":"200","author":"Zhou","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2025.08.013_bib0006","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1513\/AnnalsATS.201604-262OC","article-title":"Lung function trajectory in bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplant","volume":"13","author":"Cheng","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jtct.2025.08.013_bib0007","doi-asserted-by":"crossref","first-page":"264.e1","DOI":"10.1016\/j.jtct.2022.01.021","article-title":"Prospective phase II trial of montelukast to treat bronchiolitis obliterans syndrome after hematopoietic cell transplantation and investigation into bronchiolitis obliterans syndrome pathogenesis","volume":"28","author":"Williams","year":"2022","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2025.08.013_bib0008","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bbmt.2019.10.025","article-title":"Azithromycin use and increased cancer risk among patients with bronchiolitis obliterans after hematopoietic cell transplantation","volume":"26","author":"Cheng","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0009","doi-asserted-by":"crossref","first-page":"616.e1","DOI":"10.1016\/j.jtct.2021.03.024","article-title":"Home spirometry telemonitoring for early detection of bronchiolitis obliterans syndrome in patients with chronic graft-versus-host disease","volume":"27","author":"Turner","year":"2021","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2025.08.013_bib0010","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41409-022-01716-4","article-title":"The safety and tolerability of pirfenidone for bronchiolitis obliterans syndrome after hematopoietic cell transplant (STOP-BOS) trial","volume":"57","author":"Matthaiou","year":"2022","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0011","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/jama.2017.9938","article-title":"Effect of azithromycin on airflow decline-free survival after allogeneic hematopoietic stem cell transplant: the ALLOZITHRO Randomized Clinical Trial","volume":"318","author":"Bergeron","year":"2017","journal-title":"Jama"},{"key":"10.1016\/j.jtct.2025.08.013_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106608","article-title":"Relationship between FEV1 decline and mortality in patients with bronchiolitis obliterans syndrome\u2014a systematic literature review","volume":"188","author":"Kemp","year":"2021","journal-title":"Respir Med"},{"key":"10.1016\/j.jtct.2025.08.013_bib0013","doi-asserted-by":"crossref","unstructured":"Berger I, Bondeelle L, Archer G, et al. Bronchiectasis in patients with bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation: a distinct phenotype? B63. From Airways to Alveoli: Mechanistic and Clinical Studies. American Thoracic Society International Conference Abstracts. American Journal of Respiratory and Critical Care Medicine 2022;205:A3294.https:\/\/www.atsjournals.org\/doi\/abs\/10.1164\/ajrccm-conference.2022.205.1_MeetingAbstracts.A3294. visited on 01\/29\/2025.","DOI":"10.1164\/ajrccm-conference.2022.205.1_MeetingAbstracts.A3294"},{"key":"10.1016\/j.jtct.2025.08.013_bib0014","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jtct.2025.08.013_bib0015","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.bbmt.2015.02.006","article-title":"Predictive value of bronchiolitis obliterans syndrome stage 0p in chronic graft-versus-host disease of the lung","volume":"21","author":"Abedin","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0016","doi-asserted-by":"crossref","first-page":"204.e1","DOI":"10.1016\/j.jtct.2022.12.001","article-title":"Risk factors for bronchiolitis obliterans syndrome after initial detection of pulmonary impairment after hematopoietic cell transplantation","volume":"29","author":"Alkhunaizi","year":"2023","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2025.08.013_bib0017","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jtct.2021.06.001","article-title":"National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2020 highly morbid forms report","volume":"27","author":"Wolff","year":"2021","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.jtct.2025.08.013_bib0018","unstructured":"The longitudinal impact of respiratory viruses on bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation (the RV-BOS Study). Clinical trial registration. Submitted: 2022-01-20. 2024. URL:https:\/\/clinicaltrials.gov\/study\/NCT05250037. (visited on 01\/29\/2025)."},{"key":"10.1016\/j.jtct.2025.08.013_bib0019","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S2213-2600(21)00277-0","article-title":"Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations","volume":"10","author":"Aliberti","year":"2022","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jtct.2025.08.013_bib0020","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1056\/NEJMra2309906","article-title":"Unexplained or refractory chronic cough in adults","volume":"392","author":"Irwin","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtct.2025.08.013_bib0021","unstructured":"Global Lung Function Initiative. Global Lung Function Initiative Online Calculator. 2024. URL: https:\/\/gli-calculator.ersnet.org\/index.html. (visited on 01\/29\/2025)."},{"key":"10.1016\/j.jtct.2025.08.013_bib0022","unstructured":"Center for Open Science. OSFHOME. URL: https:\/\/osf.io\/x8a59\/?view_only=033190a6949c4b5783e5ba52414c3f55. (visited on 01\/29\/2025)."},{"key":"10.1016\/j.jtct.2025.08.013_bib0023","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index. An international derivation and validation study","volume":"189","author":"Chalmers","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2025.08.013_bib0024","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1164\/rccm.201410-1818OC","article-title":"Budesonide\/formoterol for bronchiolitis obliterans after hematopoietic stem cell transplantation","volume":"191","author":"Bergeron","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2025.08.013_bib0025","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.bbmt.2015.10.009","article-title":"Fluticasone, azithromycin, and montelukast treatment for new-onset bronchiolitis obliterans syndrome after hematopoietic cell transplantation","volume":"22","author":"Williams","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0026","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1111\/ajt.15814","article-title":"Multicenter evaluation of parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation","volume":"20","author":"Cheng","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jtct.2025.08.013_bib0027","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.1182\/bloodadvances.2022008095","article-title":"Clinical response to belumosudil in bronchiolitis obliterans syndrome: a combined analysis from 2 prospective trials","volume":"6","author":"DeFilipp","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtct.2025.08.013_bib0028","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1086\/587669","article-title":"Infections in 252 patients with common variable immunodeficiency","volume":"46","author":"Oksenhendler","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jtct.2025.08.013_bib0029","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1432-2277.2011.01388.x","article-title":"The lack of memory B cells including T cell independent IgM+ IgD+ memory B cells in chronic graft-versus host disease is associated with susceptibility to infection","volume":"25","author":"Hilgendorf","year":"2012","journal-title":"Transpl Int"},{"key":"10.1016\/j.jtct.2025.08.013_bib0030","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1046\/j.1365-2141.2001.03135.x","article-title":"Prolonged immune deficiency following allogeneic stem cell transplantation: risk factors and complications in adult patients","volume":"115","author":"Maury","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtct.2025.08.013_bib0031","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1097\/TP.0000000000004726","article-title":"Prognostic value of chest CT findings at BOS diagnosis in lung transplant recipients","volume":"107","author":"Van Herck","year":"2023","journal-title":"Transplantation"},{"key":"10.1016\/j.jtct.2025.08.013_bib0032","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1164\/rccm.200301-053SO","article-title":"Bronchiolar disorders","volume":"168","author":"Ryu","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtct.2025.08.013_bib0033","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1513\/AnnalsATS.201506-333OC","article-title":"A comprehensive analysis of the impact of Pseudomonas aeruginosa colonization on prognosis in adult bronchiectasis","volume":"12","author":"Finch","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jtct.2025.08.013_bib0034","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.chest.2023.06.015","article-title":"Microbiological cure at treatment completion is associated with longer survival in patients with Mycobacterium avium complex pulmonary disease","volume":"164","author":"Kim","year":"2023","journal-title":"Chest"},{"key":"10.1016\/j.jtct.2025.08.013_bib0035","doi-asserted-by":"crossref","first-page":"e610","DOI":"10.1093\/cid\/ciaa1381","article-title":"Mortality and prognostic factors of nontuberculous mycobacterial infection in Korea: a population-based comparative study","volume":"72","author":"Lee","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jtct.2025.08.013_bib0036","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.chest.2016.10.055","article-title":"Adult patients with bronchiectasis: a first look at the US bronchiectasis research registry","volume":"151","author":"Aksamit","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.jtct.2025.08.013_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccm.2021.12.001","article-title":"Bronchiectasis from 2012 to 2022","volume":"43","author":"Chalmers","year":"2022","journal-title":"Clin Chest Med"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636725013788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636725013788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:29:58Z","timestamp":1793496598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636725013788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2666636725013788"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2025.08.013","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bronchiectasis in Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2025.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}