{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:07:45Z","timestamp":1771376865764,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,30]],"date-time":"2027-01-30T00:00:00Z","timestamp":1801267200000},"content-version":"am","delay-in-days":363,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jtct.2025.11.006","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T17:35:31Z","timestamp":1762968931000},"page":"203.e1-203.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Inflammatory Bowel Disease on Clinical Outcomes of Hematopoietic Cell Transplantation for Inborn Errors of Immunity"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-0958","authenticated-orcid":false,"given":"Ryu","family":"Yanagisawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-4559","authenticated-orcid":false,"given":"Satoshi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-1535","authenticated-orcid":false,"given":"Yoji","family":"Sasahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-4136","authenticated-orcid":false,"given":"Michiko","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Ishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-1187","authenticated-orcid":false,"given":"Hirotoshi","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maho","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8342-4578","authenticated-orcid":false,"given":"Saori","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0476-4978","authenticated-orcid":false,"given":"Katsuyoshi","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-6497","authenticated-orcid":false,"given":"Masakatsu","family":"Yanagimachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiichiro","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Takita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3866-3582","authenticated-orcid":false,"given":"Shoji","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5276-9667","authenticated-orcid":false,"given":"Atsushi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moeko","family":"Hino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-3781","authenticated-orcid":false,"given":"Kimikazu","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Tabuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimikazu","family":"Yakushijin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-2011","authenticated-orcid":false,"given":"Katsutsugu","family":"Umeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jtct.2025.11.006_bib0001","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1182\/blood-2005-05-2004","article-title":"Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT","volume":"106","author":"Sorror","year":"2005","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jtct.2025.11.006_bib0002","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1182\/blood-2014-01-550566","article-title":"Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality","volume":"124","author":"Sorror","year":"2014","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.jtct.2025.11.006_bib0003","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1038\/s41409-021-01458-9","article-title":"Influence of pretransplant inflammatory bowel disease on the outcome of allogeneic hematopoietic stem cell transplantation: a matched-pair analysis study from the Transplant Complications Working Party (TCWP) of the EBMT","volume":"56","author":"Peric","year":"2021","journal-title":"Bone Marrow Transplant"},{"issue":"9","key":"10.1016\/j.jtct.2025.11.006_bib0004","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.bbmt.2016.05.022","article-title":"Influence of previous inflammatory bowel disease on the outcome of allogeneic hematopoietic stem cell transplantation: a matched-pair analysis","volume":"22","author":"Rabian","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"10.1016\/j.jtct.2025.11.006_bib0005","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41409-023-02147-5","article-title":"Artificial intelligence methods to estimate overall mortality and non-relapse mortality following allogeneic HCT in the modern era: an EBMT-TCWP study","volume":"59","author":"Mussetti","year":"2024","journal-title":"Bone Marrow Transplant"},{"issue":"11","key":"10.1016\/j.jtct.2025.11.006_bib0006","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.bbmt.2017.07.028","article-title":"Prognostic scoring systems in allogeneic hematopoietic stem cell transplantation: where do we stand?","volume":"23","author":"Potdar","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2025.11.006_bib0007","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1182\/bloodadvances.2023011752","article-title":"Longitudinal clinical data improve survival prediction after hematopoietic cell transplantation using machine learning","volume":"8","author":"Zhou","year":"2024","journal-title":"Blood Adv"},{"key":"10.1016\/j.jtct.2025.11.006_bib0008","article-title":"Primary immunodeficiencies associated with early-onset inflammatory bowel disease in Southeast and East Asia","volume":"12","author":"Sasahara","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jtct.2025.11.006_bib0009","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/imr.12726","article-title":"Early-onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms","volume":"287","author":"Pazmandi","year":"2019","journal-title":"Immunol Rev"},{"issue":"3","key":"10.1016\/j.jtct.2025.11.006_bib0010","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10875-024-01669-x","article-title":"Cord blood transplantation for very early-onset inflammatory bowel disease caused by interleukin-10 receptor deficiency","volume":"44","author":"Wang","year":"2024","journal-title":"J Clin Immunol"},{"issue":"1","key":"10.1016\/j.jtct.2025.11.006_bib0011","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10875-016-0348-4","article-title":"Hematopoietic stem cell transplantation for XIAP deficiency in Japan","volume":"37","author":"Ono","year":"2017","journal-title":"J Clin Immunol"},{"issue":"4","key":"10.1016\/j.jtct.2025.11.006_bib0012","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1016\/j.cgh.2021.03.021","article-title":"A systematic review of monogenic inflammatory bowel disease","volume":"20","author":"Nambu","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.jtct.2025.11.006_bib0013","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10875-019-00659-8","article-title":"Chronic granulomatous disease-associated IBD resolves and does not adversely impact survival following allogeneic HCT","volume":"39","author":"Marsh","year":"2019","journal-title":"J Clin Immunol"},{"issue":"10","key":"10.1016\/j.jtct.2025.11.006_bib0014","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1016\/j.jaip.2021.05.045","article-title":"Hematopoietic cell transplantation rescues inflammatory bowel disease and dysbiosis of gut microbiota in XIAP deficiency","volume":"9","author":"Ono","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.jtct.2025.11.006_bib0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10875-021-01103-6","article-title":"Reduced-intensity\/reduced-toxicity conditioning approaches are tolerated in XIAP deficiency but patients fare poorly with acute GVHD","volume":"42","author":"Arnold","year":"2022","journal-title":"J Clin Immunol"},{"issue":"1","key":"10.1016\/j.jtct.2025.11.006_bib0016","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10875-024-01770-1","article-title":"Successful haematopoietic stem cell transplantation for LRBA deficiency with fludarabine, treosulfan, and thiotepa-based conditioning","volume":"45","author":"Shadur","year":"2024","journal-title":"J Clin Immunol"},{"issue":"5","key":"10.1016\/j.jtct.2025.11.006_bib0017","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/bjh.18497","article-title":"Treatment of inborn errors of immunity patients with inflammatory bowel disease phenotype by allogeneic stem cell transplantation","volume":"200","author":"Moser","year":"2023","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.jtct.2025.11.006_bib0018","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12185-015-1894-x","article-title":"Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data)","volume":"103","author":"Atsuta","year":"2016","journal-title":"Int J Hematol"},{"issue":"3","key":"10.1016\/j.jtct.2025.11.006_bib0019","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1532\/IJH97.06239","article-title":"Unification of hematopoietic stem cell transplantation registries in Japan and establishment of the TRUMP system","volume":"86","author":"Atsuta","year":"2007","journal-title":"Int J Hematol"},{"issue":"7","key":"10.1016\/j.jtct.2025.11.006_bib0020","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s10875-022-01289-3","article-title":"Human inborn errors of immunity: 2022 update on the classification from the International Union of Immunological Societies Expert Committee","volume":"42","author":"Tangye","year":"2022","journal-title":"J Clin Immunol"},{"issue":"12","key":"10.1016\/j.jtct.2025.11.006_bib0021","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","article-title":"Defining the intensity of conditioning regimens: working definitions","volume":"15","author":"Bacigalupo","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2025.11.006_bib0022","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbmt.2008.12.497","article-title":"Reduced-intensity conditioning regimen workshop: defining the dose spectrum. Report of a workshop convened by the Center for International Blood and Marrow Transplant Research","volume":"15","author":"Giralt","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"issue":"6","key":"10.1016\/j.jtct.2025.11.006_bib0023","first-page":"825","article-title":"1994 consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka","year":"1995","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"10.1016\/j.jtct.2025.11.006_bib0024","first-page":"250","article-title":"Chronic graft-versus-host disease and other late complications of bone marrow transplantation","volume":"28","author":"Sullivan","year":"1991","journal-title":"Semin Hematol"},{"issue":"3","key":"10.1016\/j.jtct.2025.11.006_bib0025","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"10.1016\/j.jtct.2025.11.006_bib0026","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s10875-021-01112-5","article-title":"Hematopoietic cell transplantation for severe combined immunodeficiency patients: a Japanese Retrospective Study","volume":"41","author":"Miyamoto","year":"2021","journal-title":"J Clin Immunol"},{"issue":"3","key":"10.1016\/j.jtct.2025.11.006_bib0027","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s10875-021-01199-w","article-title":"Hematopoietic cell transplantation for inborn errors of immunity other than severe combined immunodeficiency in Japan: retrospective analysis for 1985-2016","volume":"42","author":"Miyamoto","year":"2022","journal-title":"J Clin Immunol"},{"issue":"9674","key":"10.1016\/j.jtct.2025.11.006_bib0028","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","article-title":"Graft-versus-host disease","volume":"373","author":"Ferrara","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jtct.2025.11.006_bib0029","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/mi.2015.40","article-title":"Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease","volume":"8","author":"Nalle","year":"2015","journal-title":"Mucosal Immunol"},{"issue":"12","key":"10.1016\/j.jtct.2025.11.006_bib0030","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrgastro.2017.126","article-title":"Acute graft-versus-host disease of the gut: considerations for the gastroenterologist","volume":"14","author":"Naymagon","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"21","key":"10.1016\/j.jtct.2025.11.006_bib0031","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1182\/bloodadvances.2021004959","article-title":"Genetic variants associated with inflammatory bowel disease and gut graft-versus-host disease","volume":"5","author":"Martin","year":"2021","journal-title":"Blood Adv"},{"issue":"4","key":"10.1016\/j.jtct.2025.11.006_bib0032","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1182\/blood-2015-07-659672","article-title":"Alemtuzumab levels impact acute GVHD, mixed chimerism, and lymphocyte recovery following alemtuzumab, fludarabine, and melphalan RIC HCT","volume":"127","author":"Marsh","year":"2016","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jtct.2025.11.006_bib0033","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1016\/S2352-3026(15)00045-9","article-title":"Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis","volume":"2","author":"Admiraal","year":"2015","journal-title":"Lancet Haematol"},{"issue":"5","key":"10.1016\/j.jtct.2025.11.006_bib0034","doi-asserted-by":"crossref","first-page":"546.e1","DOI":"10.1016\/j.jtct.2024.03.006","article-title":"Gut immunomodulation with vedolizumab prior to allogeneic hematopoietic stem cell transplantation in pediatric patients with inflammatory bowel disease","volume":"30","author":"Chopra","year":"2024","journal-title":"Transplant Cell Ther"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636725015581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636725015581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:23:45Z","timestamp":1771374225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636725015581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2666636725015581"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2025.11.006","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Inflammatory Bowel Disease on Clinical Outcomes of Hematopoietic Cell Transplantation for Inborn Errors of Immunity","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2025.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Transplantation and Cellular Therapy. Published by Elsevier, Inc.","name":"copyright","label":"Copyright"}]}}