{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:59:19Z","timestamp":1781215159185,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016966","name":"Bethune Charitable Foundation","doi-asserted-by":"publisher","award":["2020-Z-07"],"award-info":[{"award-number":["2020-Z-07"]}],"id":[{"id":"10.13039\/100016966","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z221100007422008"],"award-info":[{"award-number":["Z221100007422008"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation and Cellular Therapy"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jtct.2026.01.037","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:49:27Z","timestamp":1770565767000},"page":"713.e1-713.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Desensitization Therapy Using Sirolimus and Anti-CD20 Monoclonal Antibody Based Regimen In Haploidentical Transplant Recipients Positive for Donor-Specific Anti-HLA Antibodies"],"prefix":"10.1016","volume":"32","author":[{"given":"Ning","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Su","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.jtct.2026.01.037_bib0001","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1182\/blood-2009-10-249219","article-title":"The impact of anti-HLA antibodies on unrelated cord blood transplantations","volume":"116","author":"Takanashi","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jtct.2026.01.037_bib0002","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13045-015-0182-9","article-title":"Donor-specific anti-human leukocyte antigen antibodies were associated with primary graft failure after unmanipulated haploidentical blood and marrow transplantation: a prospective study with randomly assigned training and validation sets","volume":"8","author":"Chang","year":"2015","journal-title":"J Hematol Oncol"},{"issue":"8","key":"10.1016\/j.jtct.2026.01.037_bib0003","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.bbmt.2015.05.001","article-title":"Complement-binding donor-specific anti-HLA antibodies and risk of primary graft failure in hematopoietic stem cell transplantation","volume":"21","author":"Ciurea","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"8","key":"10.1016\/j.jtct.2026.01.037_bib0004","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1182\/blood-2005-05-2146","article-title":"Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched\/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation","volume":"107","author":"Lu","year":"2006","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.jtct.2026.01.037_bib0005","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bbmt.2019.02.020","article-title":"Donor-specific anti-HLA antibodies in haploidentical stem cell transplantation with post-transplantation cyclophosphamide: risk of graft failure, poor graft function, and impact on outcomes","volume":"25","author":"Bramanti","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"issue":"5","key":"10.1016\/j.jtct.2026.01.037_bib0006","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41409-017-0062-8","article-title":"The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation","volume":"53","author":"Ciurea","year":"2018","journal-title":"Bone Marrow Transplantation"},{"issue":"13","key":"10.1016\/j.jtct.2026.01.037_bib0007","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1182\/blood-2009-09-244525","article-title":"The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure","volume":"115","author":"Spellman","year":"2010","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.jtct.2026.01.037_bib0008","first-page":"1233","article-title":"Targeting T(FH) cells is a novel approach for donor-specific antibody desensitization of allograft candidates: an in vitro and in vivo study","volume":"109","author":"Ma","year":"2024","journal-title":"Haematologica"},{"issue":"8 Suppl 2","key":"10.1016\/j.jtct.2026.01.037_bib0009","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/TP.0000000000003270","article-title":"Monitoring of donor-specific anti-HLA antibodies and management of immunosuppression in kidney transplant recipients: an evidence-based expert paper","volume":"104","author":"Crespo","year":"2020","journal-title":"Transplantation"},{"issue":"7","key":"10.1016\/j.jtct.2026.01.037_bib0010","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/s41409-020-0928-z","article-title":"Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody","volume":"55","author":"Chang","year":"2020","journal-title":"Bone Marrow Transplant"},{"issue":"10","key":"10.1016\/j.jtct.2026.01.037_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtct.2022.07.019","article-title":"Untreated donor-specific HLA antibodies are associated with graft failure and poor survival after haploidentical transplantation with post-transplantation cyclophosphamide in pediatric patients with nonmalignant disorders","volume":"28","author":"Lima","year":"2022","journal-title":"Transplant Cell Ther"},{"issue":"6","key":"10.1016\/j.jtct.2026.01.037_bib0012","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/bmt.2014.331","article-title":"Donor HLA-specific Abs: to BMT or not to BMT?","volume":"50","author":"Leffell","year":"2015","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"10.1016\/j.jtct.2026.01.037_bib0013","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/bjh.19046","article-title":"Double filtration plasmapheresis combined with rituximab for donor-specific antibody desensitization in haploidentical haematopoietic stem cell transplantation","volume":"203","author":"Liu","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jtct.2026.01.037_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110299","article-title":"High-dose immunoglobulin intervention as an effective and simple strategy for donor specific anti-HLA antibody desensitization in haploidentical transplant","volume":"120","author":"Zhu","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"10.1016\/j.jtct.2026.01.037_bib0015","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jtct.2023.05.005","article-title":"Treatment with the combination of rituximab and intravenous \u03b3 globulin is effective in promoting engraftment in donor-specific antibody positive patients receiving myeloablative conditioning haploidentical stem cell transplantation","volume":"29","author":"Shen","year":"2023","journal-title":"Transplant Cell Ther"},{"issue":"10","key":"10.1016\/j.jtct.2026.01.037_bib0016","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1681\/ASN.2020030320","article-title":"Coordinated circulating t follicular helper and activated b cell responses underlie the onset of antibody-mediated rejection in kidney transplantation","volume":"31","author":"Louis","year":"2020","journal-title":"J Am Soc Nephrol: JASN"},{"issue":"2","key":"10.1016\/j.jtct.2026.01.037_bib0017","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/bmt.2013.154","article-title":"Combination of a haploidentical SCT with an unrelated cord blood unit: a single-arm prospective study","volume":"49","author":"Chen","year":"2014","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jtct.2026.01.037_bib0018","doi-asserted-by":"crossref","DOI":"10.1111\/tan.15300","article-title":"The impact of donor-specific anti-HLA antibody levels on primary poor graft function and graft rejection in rituximab desensitized haploidentical stem cell transplantation","volume":"103","author":"Liu","year":"2024","journal-title":"Hla"},{"issue":"9","key":"10.1016\/j.jtct.2026.01.037_bib0019","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1182\/blood-2005-04-1531","article-title":"CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy","volume":"106","author":"Li","year":"2005","journal-title":"Blood"},{"issue":"24","key":"10.1016\/j.jtct.2026.01.037_bib0020","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1200\/JCO.2015.65.3642","article-title":"Phase II multicenter, randomized, double-blind controlled study of efficacy and safety of umbilical cord-derived mesenchymal stromal cells in the prophylaxis of chronic graft-versus-host disease after HLA-haploidentical stem-cell transplantation","volume":"34","author":"Gao","year":"2016","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.jtct.2026.01.037_bib0021","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1182\/bloodadvances.2018029454","article-title":"Prophylactic oral NAC reduced poor hematopoietic reconstitution by improving endothelial cells after haploidentical transplantation","volume":"3","author":"Kong","year":"2019","journal-title":"Blood advances"},{"key":"10.1016\/j.jtct.2026.01.037_bib0022","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1043836","article-title":"Donor-specific anti-human leukocyte antigen antibodies predict prolonged isolated thrombocytopenia and inferior outcomes of haploidentical hematopoietic stem cell transplantation","author":"Zhao","year":"2017","journal-title":"J Immunol Res"},{"issue":"4","key":"10.1016\/j.jtct.2026.01.037_bib0023","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/tan.14704","article-title":"Prevalence and risk factors of antibodies to HLA according to different cut-off values of mean fluorescence intensity in haploidentical allograft candidates: a prospective study of 3805 subjects","volume":"100","author":"Ma","year":"2022","journal-title":"Hla"},{"issue":"12","key":"10.1016\/j.jtct.2026.01.037_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.29993","article-title":"Outcomes of patients who underwent treatment for anti-HLA donor-specific antibodies before receiving a haploidentical hematopoietic cell transplant","volume":"69","author":"Lipsitt","year":"2022","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jtct.2026.01.037_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.109941","article-title":"Bruton's tyrosine kinase ablation inhibits B cell responses and antibody production for the prevention of chronic rejection in cardiac transplantation","volume":"261","author":"Han","year":"2024","journal-title":"Clin Immunol"},{"issue":"3","key":"10.1016\/j.jtct.2026.01.037_bib0026","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1016\/S2352-3026(24)00372-7","article-title":"Haploidentical peripheral blood stem cells combined with bone marrow or unrelated cord blood as grafts for haematological malignancies: an open-label, multicentre, randomised, phase 3 trial","volume":"12","author":"Yu","year":"2025","journal-title":"The Lancet. Haematology"},{"issue":"1","key":"10.1016\/j.jtct.2026.01.037_bib0027","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41392-024-01820-5","article-title":"Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia: a multicenter, randomized, open-label, phase 3 trial","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transd Targeted Ther"},{"issue":"22","key":"10.1016\/j.jtct.2026.01.037_bib0028","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1182\/blood-2011-06-362111","article-title":"Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation","volume":"118","author":"Ciurea","year":"2011","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.jtct.2026.01.037_bib0029","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1182\/blood-2011-05-355263","article-title":"Donor-specific anti-HLA antibodies predict outcome in double umbilical cord blood transplantation","volume":"118","author":"Cutler","year":"2011","journal-title":"Blood"}],"container-title":["Transplantation and Cellular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636726000837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666636726000837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:16:10Z","timestamp":1781212570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666636726000837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2666636726000837"],"URL":"https:\/\/doi.org\/10.1016\/j.jtct.2026.01.037","relation":{},"ISSN":["2666-6367"],"issn-type":[{"value":"2666-6367","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Desensitization Therapy Using Sirolimus and Anti-CD20 Monoclonal Antibody Based Regimen In Haploidentical Transplant Recipients Positive for Donor-Specific Anti-HLA Antibodies","name":"articletitle","label":"Article Title"},{"value":"Transplantation and Cellular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtct.2026.01.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}