{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:43:14Z","timestamp":1771530194849,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":3474,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.jtcvs.2006.07.036","type":"journal-article","created":{"date-parts":[[2006,12,31]],"date-time":"2006-12-31T07:04:46Z","timestamp":1167548686000},"page":"155-161","source":"Crossref","is-referenced-by-count":43,"title":["Matrix metalloproteinase and tissue inhibitor expression in atherosclerotic and nonatherosclerotic thoracic aortic aneurysms"],"prefix":"10.25013","volume":"133","author":[{"given":"Joseph D.","family":"Schmoker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"McPartland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika K.","family":"Fellinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Boyum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Trombley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank P.","family":"Ittleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Christopher","family":"Terrien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2006.07.036_bib1","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0741-5214(94)70169-5","article-title":"Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall","volume":"20","author":"Newman","year":"1994","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/01.ATV.15.8.1145","article-title":"Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm","volume":"15","author":"Freestone","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib3","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1161\/01.CIR.96.7.2115","article-title":"Inflammation, metalloproteinases, and increased proteolysis: an emerging paradigm in aortic aneurysm","volume":"96","author":"Shah","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/res.90.3.251","article-title":"Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly","volume":"90","author":"Galis","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s100169900144","article-title":"Expression of matrix metalloproteinases and TIMPs in human abdominal aortic aneurysms","volume":"12","author":"Elmore","year":"1998","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib6","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1053\/hupa.2001.27107","article-title":"Smooth muscle cells of the media in the dilatative pathology of ascending thoracic aorta: morphology immunoreactivity for osteopontin, matrix metalloproteinases, and their inhibitors","volume":"32","author":"Lesauskaite","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jtcvs.2003.11.049","article-title":"Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves","volume":"127","author":"Boyum","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib8","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.athoracsur.2004.05.088","article-title":"Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections","volume":"78","author":"Koullias","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jss.2004.06.007","article-title":"Matrix metalloproteinase in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves","volume":"123","author":"LeMaire","year":"2005","journal-title":"J Surg Res"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib10","first-page":"II331","article-title":"Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan\u2019s syndrome","volume":"98","author":"Segura","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0022-5223(02)73576-9","article-title":"Altered patterns of gene expression distinguishing ascending aortic aneurysm from abdominal aortic aneurysms: complementary DNA expression profiling in the molecular characterization of aortic disease","volume":"126","author":"Absi","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib12","doi-asserted-by":"crossref","first-page":"II268","DOI":"10.1161\/01.CIR.0000138384.68947.20","article-title":"Effects of deletion of the tissue inhibitor of matrix metalloproteinase-1 gene on the progression of murine thoracic aortic aneurysms","volume":"110","author":"Ikonomidis","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/01.RES.0000016501.56641.83","article-title":"Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) gene","volume":"90","author":"Silence","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib14","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/01.HYP.0000014506.13322.66","article-title":"Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging","volume":"39","author":"Wang","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib15","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/01.HYP.0000073843.56046.45","article-title":"Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates","volume":"41","author":"Wang","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.amjhyper.2004.11.011","article-title":"Aging is associated with increased matrix metalloproteinase-2 activity in the human aorta","volume":"18","author":"McNulty","year":"2005","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib17","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1097\/01.hjh.0000176787.04753.ee","article-title":"Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade","volume":"23","author":"Spiers","year":"2005","journal-title":"J Hypertension"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/01.ATV.0000151373.33830.41","article-title":"Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness","volume":"25","author":"Yasmin","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib19","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0022-5223(03)00398-2","article-title":"Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation","volume":"126","author":"Fedak","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib20","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1067\/mva.2003.163","article-title":"A nonintrinsic regional basis for increased infrarenal aortic MMP-9 expression and activity","volume":"37","author":"Ailawadi","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jvs.2005.10.013","article-title":"A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: a role for matrix metalloproteinase 9 and 2","volume":"43","author":"Sinha","year":"2006","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0002-8703(94)90488-X","article-title":"Transesophageal echocardiographic assessment of the effects of age, gender, and hypertension on thoracic aortic wall size, thickness, and stiffness","volume":"128","author":"Pearson","year":"1994","journal-title":"Am Heart J"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib23","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jvs.2005.07.010","article-title":"Age-related increase in wall stress of the human abdominal aorta: an in vivo study","volume":"42","author":"Astrand","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.HYP.33.1.116","article-title":"Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats","volume":"33","author":"Li","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib25","doi-asserted-by":"crossref","first-page":"13453","DOI":"10.1074\/jbc.270.22.13453","article-title":"Tissue inhibitor of metalloproteinase-2 stimulates fibroblast proliferation via a cAMP-dependent mechanism","volume":"270","author":"Corcoran","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib26","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1161\/01.CIR.99.16.2138","article-title":"Mechanisms underlying aortic dilation in congenital aortic valve malformation","volume":"99","author":"Bonderman","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib27","doi-asserted-by":"crossref","first-page":"II329","DOI":"10.1161\/01.cir.0000087660.82721.15","article-title":"Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in Marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm","volume":"108","author":"Nataatmadja","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1161\/01.RES.88.1.37","article-title":"Phenotypic alteration of vascular smooth muscle cells precedes elastolysis in a mouse model of Marfan Syndrome","volume":"88","author":"Bunton","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2006.07.036_bib29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.atherosclerosis.2004.07.013","article-title":"Application of real-time RT-PCR to quantifying gene expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human abdominal aortic aneurysms","volume":"177","author":"Higashikata","year":"2004","journal-title":"Atherosclerosis"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522306015108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522306015108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T08:00:23Z","timestamp":1556006423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522306015108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0022522306015108"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2006.07.036","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}