{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:59:24Z","timestamp":1790870364117,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":2623,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005348","name":"American Association for Thoracic Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.jtcvs.2008.12.029","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T04:24:49Z","timestamp":1240201489000},"page":"1241-1248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Enhanced fibrinolysis protects against lung ischemia\u2013reperfusion injury"],"prefix":"10.1016","volume":"137","author":[{"given":"Christine L.","family":"Lau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunge","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving L.","family":"Kron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zequan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E.","family":"Laubach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorav","family":"Ailawadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Pinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2008.12.029_bib1","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.jtcvs.2005.01.022","article-title":"Primary graft dysfunction and other selected complications of lung transplantation: a single-center experience of 983 patients","volume":"129","author":"Meyers","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib2","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1378\/chest.124.4.1232","article-title":"Clinical risk factors for primary graft failure following lung transplantation","volume":"124","author":"Christie","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1164\/rccm.200608-1079OC","article-title":"Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome","volume":"175","author":"Daud","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib4","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0003-4975(01)03606-2","article-title":"Ischemia\u2013reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome","volume":"73","author":"Fiser","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib5","doi-asserted-by":"crossref","first-page":"L307","DOI":"10.1152\/ajplung.00157.2006","article-title":"Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury","volume":"291","author":"Ware","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4 Suppl","key":"10.1016\/j.jtcvs.2008.12.029_bib6","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.1097\/01.CCM.0000057846.21303.AB","article-title":"Coagulation, fibrinolysis, and fibrin deposition in acute lung injury","volume":"31","author":"Idell","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1172\/JCI307","article-title":"Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition","volume":"102","author":"Pinsky","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib8","doi-asserted-by":"crossref","first-page":"L1018","DOI":"10.1152\/ajplung.00086.2006","article-title":"Alveolar macrophage activation is a key initiation signal for acute lung ischemia\u2013reperfusion injury","volume":"291","author":"Zhao","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib9","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1074\/jbc.M210975200","article-title":"Activation of pro-gelatinase B by endometase\/matrilysin-2 promotes invasion of human prostate cancer cells","volume":"278","author":"Zhao","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib10","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1158\/0008-5472.CAN-03-1932","article-title":"Endometase\/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion","volume":"64","author":"Zhao","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0022-1759(01)00419-7","article-title":"Development and optimization of cytokine ELISAs using commercial antibody pairs","volume":"255","author":"Nemzek","year":"2001","journal-title":"J Immunol Meth"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/path.1939","article-title":"Differential expression of HOX genes in neoplastic and non-neoplastic human astrocytes","volume":"209","author":"Abdel-Fattah","year":"2006","journal-title":"J Pathol"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib13","doi-asserted-by":"crossref","first-page":"21468","DOI":"10.1074\/jbc.M002682200","article-title":"Potentiation of endogenous fibrinolysis and rescue from lung ischemia\/reperfusion injury in interleukin (IL)-10-reconstituted IL-10 null mice","volume":"275","author":"Okada","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.athoracsur.2005.09.047","article-title":"Crosstalk between thrombosis and inflammation in lung reperfusion injury","volume":"81","author":"Farivar","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1164\/rccm.200606-827OC","article-title":"Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction","volume":"175","author":"Christie","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1164\/ajrccm\/140.2.287","article-title":"Fibrinolysis in critically ill patients","volume":"140","author":"Moalli","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/01.HYP.34.2.285","article-title":"Comparative effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on plasma fibrinolytic balance in humans","volume":"34","author":"Brown","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.jtcvs.2008.12.029_bib18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/01.CIR.96.2.442","article-title":"Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators","volume":"96","author":"Vaughan","year":"1997","journal-title":"Circulation"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522309000178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522309000178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:45:42Z","timestamp":1758386742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522309000178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022522309000178"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2008.12.029","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced fibrinolysis protects against lung ischemia\u2013reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2008.12.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}