{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:04:29Z","timestamp":1780351469897,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":2531,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.jtcvs.2009.02.027","type":"journal-article","created":{"date-parts":[[2009,4,11]],"date-time":"2009-04-11T04:11:39Z","timestamp":1239423099000},"page":"374-381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease"],"prefix":"10.1016","volume":"138","clinical-trial-number":[{"clinical-trial-number":"nct00006183","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Janet S.","family":"Soul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wypij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Bellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Visconti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adr\u00e9 J.","family":"du Plessis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry D.","family":"Kussman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Scoppettuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Pigula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Jonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane W.","family":"Newburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2009.02.027_bib1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM199503023320901","article-title":"Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass","volume":"332","author":"Bellinger","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/088307389601100112","article-title":"Outcome after open-heart surgery in infants and children","volume":"11","author":"Miller","year":"1996","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/01.CIR.100.5.526","article-title":"Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass","volume":"100","author":"Bellinger","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00004703-200306000-00007","article-title":"Visual-spatial skills in children after open-heart surgery","volume":"24","author":"Bellinger","year":"2003","journal-title":"J Dev Behav Pediatr"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib5","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0022-5223(03)00711-6","article-title":"Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston Circulatory Arrest Trial","volume":"126","author":"Bellinger","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jtcvs.2003.06.001","article-title":"Arterial switch with full-flow cardiopulmonary bypass and limited circulatory arrest: neurodevelopmental outcome","volume":"127","author":"Karl","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/01.hco.0000153451.68212.68","article-title":"Central nervous system outcomes in children with complex congenital heart disease","volume":"20","author":"Wernovsky","year":"2005","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jpeds.2005.08.036","article-title":"Long-term neuromotor outcome at school entry of infants with congenital heart defects requiring open-heart surgery","volume":"148","author":"Majnemer","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib9","doi-asserted-by":"crossref","first-page":"S2381","DOI":"10.1016\/j.athoracsur.2006.02.074","article-title":"Factors influencing neurologic outcome after neonatal cardiopulmonary bypass: what we can and cannot control","volume":"81","author":"Hsia","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00401-005-1077-6","article-title":"Hypoxic-ischemic brain injury in infants with congenital heart disease dying after cardiac surgery","volume":"110","author":"Kinney","year":"2005","journal-title":"Acta Neuropathol (Berl)"},{"issue":"12 Suppl. 1","key":"10.1016\/j.jtcvs.2009.02.027_bib11","first-page":"I109","article-title":"An MRI study of neurological injury before and after congenital heart surgery","volume":"106","author":"Mahle","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib12","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jtcvs.2003.09.053","article-title":"Periventricular leukomalacia is common after neonatal cardiac surgery","volume":"127","author":"Galli","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/CIRCULATIONAHA.105.566752","article-title":"Balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries","volume":"113","author":"McQuillen","year":"2006","journal-title":"Circulation"},{"issue":"2 Suppl","key":"10.1016\/j.jtcvs.2009.02.027_bib14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/01.STR.0000247941.41234.90","article-title":"Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects","volume":"38","author":"McQuillen","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0022-5223(97)70013-8","article-title":"Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants","volume":"114","author":"du Plessis","year":"1997","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib16","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.jtcvs.2003.04.003","article-title":"The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: results of a randomized trial in infants","volume":"126","author":"Jonas","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0022-3476(03)00183-5","article-title":"Length of stay after infant heart surgery is related to cognitive outcome at age 8 years","volume":"143","author":"Newburger","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib18","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/S0022-5223(03)00940-1","article-title":"The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial","volume":"126","author":"Wypij","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1542\/peds.2007-1282","article-title":"Neurodevelopmental outcomes after staged palliation for hypoplastic left heart syndrome","volume":"121","author":"Tabbutt","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jtcvs.2007.01.051","article-title":"Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery","volume":"135","author":"Newburger","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2214\/ajr.171.1.9648769","article-title":"Line scan diffusion imaging: characterization in healthy subjects and stroke patients","volume":"171","author":"Maier","year":"1998","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00234-003-0946-8","article-title":"Incidental intracranial hemorrhage after uncomplicated birth: MRI before and after neonatal heart surgery","volume":"45","author":"Tavani","year":"2003","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib23","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1542\/peds.85.6.991","article-title":"Acquired neuropathologic lesions associated with the hypoplastic left heart syndrome","volume":"85","author":"Glauser","year":"1990","journal-title":"Pediatrics"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jpeds.2007.12.019","article-title":"Developmental and functional outcomes at school entry in children with congenital heart defects","volume":"153","author":"Majnemer","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib25","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1056\/NEJMoa067393","article-title":"Abnormal brain development in newborns with congenital heart disease","volume":"357","author":"Miller","year":"2007","journal-title":"N Engl J Med"},{"issue":"1 Pt 1","key":"10.1016\/j.jtcvs.2009.02.027_bib26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1148\/radiology.166.1.3336675","article-title":"Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T","volume":"166","author":"Barkovich","year":"1988","journal-title":"Radiology"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib27","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/ana.20772","article-title":"Pyramidal tract maturation after brain injury in newborns with heart disease","volume":"59","author":"Partridge","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jtcvs.2009.02.027_bib28","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/mrm.20198","article-title":"Susceptibility weighted imaging (SWI)","volume":"52","author":"Haacke","year":"2004","journal-title":"Magn Reson Med"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522309003316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522309003316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:46:00Z","timestamp":1758386760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522309003316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0022522309003316"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2009.02.027","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2009.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}