{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:27:36Z","timestamp":1790515656453,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":1466,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.jtcvs.2011.10.097","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T06:33:50Z","timestamp":1329201230000},"page":"256-262.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["miRNA-141 is a novel regulator of BMP-2\u2013mediated calcification in aortic stenosis"],"prefix":"10.1016","volume":"144","author":[{"given":"Bobby","family":"Yanagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fina","family":"Lovren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praphulla C.","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil P.","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subodh","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2011.10.097_bib1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.CIR.0000027905.26586.E8","article-title":"Clinical and pathophysiological implications of a bicuspid aortic valve","volume":"106","author":"Fedak","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib2","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.CIR.103.11.1522","article-title":"Bone formation and inflammation in cardiac valves","volume":"103","author":"Mohler","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib3","first-page":"560","article-title":"Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis","volume":"13","author":"Kaden","year":"2004","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1101\/gad.10.13.1580","article-title":"Bone morphogenetic proteins: multifunctional regulators of vertebrate development","volume":"10","author":"Hogan","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib5","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1161\/01.CIR.92.8.2163","article-title":"Osteopontin is expressed in human aortic valvular lesions","volume":"92","author":"O\u2019Brien","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib6","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI119265","article-title":"Increased cellular expression of matrix proteins that regulate mineralization is associated with calcification of native human and porcine xenograft bioprosthetic heart valves","volume":"99","author":"Srivatsa","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib7","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation: molecular clones and activities","volume":"242","author":"Wozney","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib8","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.jtcvs.2009.06.024","article-title":"Bone morphogenic protein 2 induces RunX2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1\/2","volume":"138","author":"Yang","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib9","doi-asserted-by":"crossref","first-page":"34387","DOI":"10.1074\/jbc.M211386200","article-title":"BMP-2-induced RunX2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression","volume":"278","author":"Lee","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib10","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1172\/JCI116901","article-title":"Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta","volume":"92","author":"Ikeda","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib12","doi-asserted-by":"crossref","first-page":"19272","DOI":"10.1074\/jbc.M109.014001","article-title":"MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5","volume":"284","author":"Itoh","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/heart.83.1.81","article-title":"Clinical significance of the bicuspid aortic valve","volume":"83","author":"Ward","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.carpath.2007.02.008","article-title":"Cardiac valve interstitial cells secrete fibronectin and form fibrillar adhesions in response to injury","volume":"16","author":"Fayet","year":"2007","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib15","first-page":"254","article-title":"Identification and characterization of calcifying valve cells from human and canine aortic valves","volume":"8","author":"Mohler","year":"1999","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jacc.2008.09.052","article-title":"Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2","volume":"53","author":"Yang","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib17","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.yjmcc.2009.08.008","article-title":"Notch1 represses osteogenic pathways in aortic valve cells","volume":"47","author":"Nigam","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature03940","article-title":"Mutations in NOTCH1 cause aortic valve disease","volume":"437","author":"Garg","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib19","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s10620-009-1008-9","article-title":"MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells","volume":"55","author":"Hu","year":"2010","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib20","doi-asserted-by":"crossref","first-page":"14910","DOI":"10.1074\/jbc.C800074200","article-title":"The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2","volume":"283","author":"Korpal","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/01.RES.0000136520.07995.aa","article-title":"Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease","volume":"95","author":"Walker","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib22","first-page":"459","article-title":"Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves","volume":"19","author":"Nigam","year":"2010","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib23","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.bbamcr.2010.06.013","article-title":"MicroRNAs: synthesis, mechanism, function, and recent clinical trials","volume":"1803","author":"Wahid","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib24","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jtcvs.2011.03.002","article-title":"Increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis","volume":"142","author":"Moreno","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2011.10.097_bib25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/hrt.2010.215046","article-title":"Do statins improve outcomes and delay the progression of non-rheumatic calcific aortic stenosis?","volume":"97","author":"Parolari","year":"2011","journal-title":"Heart"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522312000815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522312000815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:51:30Z","timestamp":1758387090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522312000815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0022522312000815"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2011.10.097","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miRNA-141 is a novel regulator of BMP-2\u2013mediated calcification in aortic stenosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2011.10.097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}