{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:50:35Z","timestamp":1789044635449,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":1070,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.jtcvs.2013.02.003","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T03:17:34Z","timestamp":1363403854000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"title":["High lactate levels are predictors of major complications after cardiac surgery"],"prefix":"10.1016","volume":"146","clinical-trial-number":[{"clinical-trial-number":"nct01021631","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Ludhmila A.","family":"Hajjar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano P.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia T.","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo A.","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena R.B.G.","family":"Galas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2013.02.003_bib1","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1378\/chest.123.5.1361","article-title":"Frequency, risk factors, and outcome of hyperlactatemia after cardiac surgery","volume":"123","author":"Maillet","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/cc9017","article-title":"Hyperlactatemia in critical illness and cardiac surgery","volume":"14","author":"O'Connor","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-5223(00)70231-5","article-title":"Changes in whole blood lactate levels during cardiopulmonary bypass for surgery for congenital cardiac disease: an early indicator of morbidity and mortality","volume":"119","author":"Munoz","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jtcvs.2005.04.029","article-title":"Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months","volume":"130","author":"Cheung","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib5","first-page":"315","article-title":"Lactate and shock state: the metabolic view","volume":"12","author":"Levy","year":"2006","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib6","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1590\/S1807-59322011001200007","article-title":"Lactate and base deficit are predictors of mortality in critically ill patients with cancer","volume":"66","author":"Hajjar","year":"2011","journal-title":"Clinics"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/jama.1988.03410050082034","article-title":"\u201cLactate washout\u201d following circulatory arrest","volume":"260","author":"Leavy","year":"1988","journal-title":"JAMA"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib8","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1001\/jama.2010.1446","article-title":"Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial","volume":"304","author":"Hajjar","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ccell.2005.07.005","article-title":"Low cardiac output syndrome: identification and management","volume":"17","author":"Mass\u00e9","year":"2005","journal-title":"Crit Care Nurs Clin North Am"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib10","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.jtcvs.2009.07.007","article-title":"A comparison of the RIFLE and Acute Kidney Injury Network classifications for cardiac surgery\u2013associated acute kidney injury: a prospective cohort study","volume":"138","author":"Haase","year":"2009","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European Consensus Conference on ARDS\u2014definitions, mechanisms, relevant outcomes, and clinical-trial coordination","volume":"149","author":"Bernard","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0022-5223(00)70132-2","article-title":"Oxygen consumption after cardiopulmonary bypass surgery in children: determinants and implications","volume":"119","author":"Li","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0022-5223(99)70143-1","article-title":"Myocardial substrate uptake and oxidation during and after routine cardiac surgery","volume":"118","author":"Pietersen","year":"1999","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/cc2841","article-title":"Increased blood lacate levels: an important warning signal in surgical practice","volume":"8","author":"Bakker","year":"2004","journal-title":"Crit Care"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0002-9610(01)00755-3","article-title":"Prolonged lactate clearance is associated with increased mortality in the surgical intensive care unit","volume":"182","author":"McNelis","year":"2001","journal-title":"Am J Surg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib16","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/00000539-200005000-00010","article-title":"A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients","volume":"90","author":"Polonen","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib17","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/cc7918","article-title":"Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill","volume":"13","author":"Khosravani","year":"2009","journal-title":"Crit Care"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib18","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/cc8888","article-title":"Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study","volume":"14","author":"Nichol","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1186\/cc3818","article-title":"Lactate as a marker of energy failure in critically ill patients: hypothesis","volume":"9","author":"Valenza","year":"2005","journal-title":"Crit Care"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00003246-199701000-00011","article-title":"Type B lactic acidosis following cardiopulmonary bypass","volume":"25","author":"Raper","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib21","first-page":"483","article-title":"Lactate metabolism and regional lactate exchange after cardiac surgery","volume":"4","author":"Takala","year":"1996","journal-title":"New Horiz"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib22","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1152\/jappl.1987.62.5.1845","article-title":"Effects of adrenergic agonists and antagonists on muscle O-2 uptake and lactate metabolism","volume":"62","author":"Stainsby","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/cc1518","article-title":"Bench-to-bedside review: lactate and the kidney","volume":"6","author":"Bellomo","year":"2002","journal-title":"Crit Care"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/bmj.38156.767118.7C","article-title":"Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery","volume":"329","author":"McKendry","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.athoracsur.2007.02.099","article-title":"Perioperative blood transfusion and blood conservation in cardiac surgery: The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Clinical Practice Guideline","volume":"83","author":"Ferraris","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib26","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S1010-7940(99)00106-2","article-title":"Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients","volume":"15","author":"Roques","year":"1999","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib27","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7326\/0003-4819-128-3-199802010-00005","article-title":"Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization","volume":"128","author":"Mangano","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtcvs.2013.02.003_bib28","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/jama.290.6.773","article-title":"Predictors of readmission for complications of coronary artery bypass graft surgery","volume":"290","author":"Hannan","year":"2003","journal-title":"JAMA"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522313001530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522313001530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:52:21Z","timestamp":1758387141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522313001530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0022522313001530"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2013.02.003","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High lactate levels are predictors of major complications after cardiac surgery","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2013.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}