{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:24:00Z","timestamp":1789341840983,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":731,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jtcvs.2015.05.034","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T02:10:04Z","timestamp":1431655804000},"page":"696-704","source":"Crossref","is-referenced-by-count":56,"title":["Computational fluid dynamic study of hemodynamic effects on aortic root blood flow of systematically varied left ventricular assist device graft anastomosis design"],"prefix":"10.1016","volume":"150","author":[{"given":"Andrew","family":"Callington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Mohite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun Kumar","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2015.05.034_bib1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pcad.2011.04.001","article-title":"Surgical treatment of advanced heart failure: alternatives to heart transplantation and mechanical circulatory assist devices","volume":"54","author":"George","year":"2011","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib3","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.healun.2010.05.001","article-title":"New prioritization of heart transplant candidates on mechanical circulatory support in an era of severe donor shortage","volume":"29","author":"Komoda","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.healun.2011.12.001","article-title":"The Fourth INTERMACS Annual Report: 4,000 implants and counting","volume":"31","author":"Kirklin","year":"2012","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib5","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.jacc.2009.12.052","article-title":"Continuous flow left ventricular assist device improves functional capacity and quality of life of advanced heart failure patients","volume":"55","author":"Rogers","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib6","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.athoracsur.2014.05.030","article-title":"De novo aortic regurgitation after continuous-flow left ventricular assist device implantation","volume":"98","author":"Patil","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/01.mat.0000201961.97981.e9","article-title":"Effect of left ventricular assist device outflow conduit anastomosis location on flow patterns in the native aorta","volume":"52","author":"May-Newman","year":"2006","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib8","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/MAT.0b013e31826d6232","article-title":"Influence of LVAD cannula outflow tract location on hemodynamics in the ascending aorta: a patient-specific computational fluid dynamics approach","volume":"58","author":"Karmonik","year":"2012","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib9","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jtcvs.2013.09.069","article-title":"Computational fluid dynamics in patients with continuous-flow left ventricular assist device support show hemodynamic alterations in the ascending aorta","volume":"147","author":"Karmonik","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/aor.12132","article-title":"Comparison of hemodynamics in the ascending aorta between pulsatile and continuous flow left ventricular assist devices using computational fluid dynamics based on computed tomography images","volume":"38","author":"Karmonik","year":"2014","journal-title":"Artif Organs"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/MAT.0b013e3182578b6a","article-title":"Effect of LVAD outlet graft anastomosis angle on the aortic valve, wall, and flow","volume":"58","author":"Inci","year":"2012","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/ejcts\/ezt095","article-title":"Effect of cannula position in the thoracic aorta with continuous left ventricular support: four-dimensional flow-sensitive magnetic resonance imaging in an in\u00a0vitro model","volume":"44","author":"Benk","year":"2013","journal-title":"Eur J Cardio-Thorac Surg"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1080\/10255842.2011.629616","article-title":"Computational fluid dynamics analysis of surgical adjustment of left ventricular assist device implantation to minimise stroke risk","volume":"16","author":"Osorio","year":"2013","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib14","first-page":"263","article-title":"Echocardiographic evaluation of the Jarvik 2000 Axial-Flow LVAD","volume":"32","author":"Stainback","year":"2005","journal-title":"Tex Heart Inst J"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib15","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1161\/CIRCULATIONAHA.111.040238","article-title":"Imaging for ventricular function and myocardial recovery on nonpulsatile ventricular assist devices","volume":"125","author":"Estep","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib16","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1073\/pnas.83.7.2114","article-title":"Turbulent fluid shear stress induces vascular endothelial cell turnover in\u00a0vitro","volume":"83","author":"Davies","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0021-9150(94)90207-0","article-title":"Fluid wall shear stress measurements in a model of the human abdominal aorta: oscillatory behavior and relationship to atherosclerosis","volume":"110","author":"Moore","year":"1994","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib18","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1161\/01.RES.35.4.608","article-title":"Measured turbulence and its effect on thrombus formation","volume":"35","author":"Stein","year":"1974","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/mrm.21861","article-title":"Phase-contrast magnetic resonance imaging measurements in intracranial aneurysms in\u00a0vivo of flow patterns, velocity fields, and wall shear stress: comparison with computational fluid dynamics","volume":"61","author":"Boussel","year":"2009","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/jmri.23610","article-title":"Assessment of the accuracy of MRI wall shear stress estimation using numerical simulations","volume":"36","author":"Petersson","year":"2012","journal-title":"J Magn Reson Imaging"},{"issue":"23 Suppl 1","key":"10.1016\/j.jtcvs.2015.05.034_bib21","first-page":"III27","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib22","doi-asserted-by":"crossref","first-page":"C1109","DOI":"10.1152\/ajpcell.00369.2011","article-title":"Endothelial cells express a unique transcriptional profile under very high wall shear stress known to induce expansive arterial remodeling","volume":"302","author":"Dolan","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib23","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1016\/j.athoracsur.2005.08.072","article-title":"Native aortic valve insufficiency in patients with left ventricular assist devices","volume":"81","author":"Bryant","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/CIRCHEARTFAILURE.109.917765","article-title":"The development of aortic insufficiency in left ventricular assist device-supported patients","volume":"3","author":"Cowger","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1067\/mtc.2001.114770","article-title":"Insufficiency of the native aortic valve and left ventricular assist system inflow valve after support with an implantable left ventricular assist system: signs, symptoms, and concerns","volume":"122","author":"Samuels","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2015.05.034_bib26","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/ehjci\/jes273","article-title":"Wall shear stress and flow patterns in the ascending aorta in patients with bicuspid aortic valves differ significantly from tricuspid aortic valves: a prospective study","volume":"14","author":"Meierhofer","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"Suppl 1","key":"10.1016\/j.jtcvs.2015.05.034_bib27","doi-asserted-by":"crossref","first-page":"P161","DOI":"10.1186\/1532-429X-16-S1-P161","article-title":"Thoracic aortic wall shear stress atlases in patients with bicuspid aortic valves","volume":"16","author":"Ooij","year":"2014","journal-title":"J Cardiovasc Magn Reson"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522315007254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522315007254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T15:54:48Z","timestamp":1537631688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522315007254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0022522315007254"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2015.05.034","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}