{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:47:23Z","timestamp":1784242043123,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81400196"],"award-info":[{"award-number":["81400196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Liaoning Province","award":["L2011140"],"award-info":[{"award-number":["L2011140"]}]},{"name":"Department of Liaoning Province","award":["L2013297"],"award-info":[{"award-number":["L2013297"]}]},{"name":"Department of Liaoning Province","award":["L2013316"],"award-info":[{"award-number":["L2013316"]}]},{"name":"Specialized Research Fund","award":["20132104110004"],"award-info":[{"award-number":["20132104110004"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jtcvsonline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jtcvs.2016.02.071","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T16:31:42Z","timestamp":1457800302000},"page":"570-582","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model"],"prefix":"10.1016","volume":"152","author":[{"given":"Guang-Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Xiang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Li-Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2016.02.071_bib1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jtcvs.2010.12.013","article-title":"Intramyocardial bone marrow stem cell transplantation during coronary artery\u00a0bypass surgery: a meta-analysis","volume":"142","author":"Donndorf","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2013.282909","article-title":"Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial","volume":"311","author":"Heldman","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1634\/stemcells.2007-0098","article-title":"Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis","volume":"26","author":"Chen","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/hc0102.101442","article-title":"Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart","volume":"105","author":"Toma","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib5","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jtcvs.2007.07.071","article-title":"Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis","volume":"135","author":"Hu","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib6","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0022-5223(03)00693-7","article-title":"MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu\/Zn superoxide dismutase after transient ischemia in rabbits","volume":"126","author":"Takahashi","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jtcvs.2006.10.032","article-title":"Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction","volume":"133","author":"Suzuki","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib8","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1161\/CIRCULATIONAHA.105.555623","article-title":"Correction\u00a0of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure","volume":"112","author":"Yano","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib9","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.jtcvs.2007.01.068","article-title":"Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts","volume":"133","author":"Kotani","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neuroscience.2012.08.001","article-title":"Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model","volume":"223","author":"Shen","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib11","doi-asserted-by":"crossref","first-page":"e90667","DOI":"10.1371\/journal.pone.0090667","article-title":"Preconditioning of mesenchymal stem cells by sevoflurane to improve their therapeutic potential","volume":"9","author":"Sun","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jacc.2011.05.013","article-title":"Endogenous cardiac stem cell activation by insulin-like growth factor-1\/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart","volume":"58","author":"Ellison","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib13","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jtcvs.2007.10.024","article-title":"Cardiac stem cells in the real world","volume":"135","author":"Pouly","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejphar.2010.02.038","article-title":"Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt\/ERK-eNOS-mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice","volume":"634","author":"Qi","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib15","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1582-4934.2010.01070.x","article-title":"Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia","volume":"15","author":"Zhang","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib16","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1248\/bpb.32.1335","article-title":"Berberine protects mesenchymal stem cells against hypoxia-induced apoptosis in\u00a0vitro","volume":"32","author":"Zhang","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib17","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3727\/096368912X657251","article-title":"Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice","volume":"22","author":"Wei","year":"2013","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib18","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s10495-006-9037-8","article-title":"Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways","volume":"11","author":"Sun","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10495-007-0160-y","article-title":"Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2, c-IAPs, and caspase-3 in mouse embryonic stem cells","volume":"13","author":"Kim","year":"2008","journal-title":"Apoptosis"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib20","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1179\/1743132813Y.0000000252","article-title":"In\u00a0vivo optical imaging correlates with improvement of cerebral ischemia treated by intravenous bone marrow stromal cells (BMSCs) and edaravone","volume":"35","author":"Tian","year":"2013","journal-title":"Neurol Res"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/CIRCRESAHA.110.222703","article-title":"Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation","volume":"107","author":"Hatzistergos","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib22","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/01.RES.0000118601.37875.AC","article-title":"Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in\u00a0vitro and in\u00a0vivo arteriogenesis through paracrine mechanisms","volume":"94","author":"Kinnaird","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1096\/fj.05-5211com","article-title":"Evidence\u00a0supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement","volume":"20","author":"Gnecchi","year":"2006","journal-title":"FASEB"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jtcvs.2009.03.010","article-title":"Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1alpha mediates estrogen receptor-alpha-induced mesenchymal stem cell vascular endothelial growth factor production","volume":"138","author":"Wang","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.yexcr.2011.11.009","article-title":"Transmyocardial drilling revascularization combined with heparinized bFGF-incorporating stent activates resident cardiac stem cells via SDF-1\/CXCR4 axis","volume":"318","author":"Zhang","year":"2012","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib26","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jtcvs.2015.06.076","article-title":"Transcoronary infusion of cardiac progenitor cells in hypoplastic left heart syndrome: three-year follow-up of the Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single-Ventricle Physiology (TICAP) trial","volume":"150","author":"Tarui","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cellsig.2005.04.002","article-title":"Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression","volume":"18","author":"Iiyama","year":"2006","journal-title":"Cell Signal"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/expphysiol.1997.sp004024","article-title":"Oxidative stress: oxidants and antioxidants","volume":"82","author":"Sies","year":"1997","journal-title":"Exp Physiol"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib29","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jtcvs.2014.11.011","article-title":"Erythropoietin activates the phosporylated cAMP [adenosine 3\u20325\u2032 cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury","volume":"149","author":"Mares","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib30","doi-asserted-by":"crossref","first-page":"e85808","DOI":"10.1371\/journal.pone.0085808","article-title":"Angiopoietin-like 4 confers resistance to hypoxia\/serum deprivation-induced apoptosis through PI3K\/Akt and ERK1\/2 signaling pathways in mesenchymal stem cells","volume":"9","author":"Hou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib32","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1002\/jnr.21412","article-title":"MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling","volume":"85","author":"Niyaz","year":"2007","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11010-009-0037-1","article-title":"Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells","volume":"327","author":"Liu","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib34","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1248\/bpb.29.713","article-title":"Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats","volume":"29","author":"Wen","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jtcvs.2016.02.071_bib35","doi-asserted-by":"crossref","first-page":"e54125","DOI":"10.1371\/journal.pone.0054125","article-title":"ATP mediates NADPH oxidase\/ROS generation and COX-2\/PGE2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation","volume":"8","author":"Cheng","year":"2013","journal-title":"PloS One"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002252231600430X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002252231600430X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T06:12:17Z","timestamp":1617603137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002252231600430X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S002252231600430X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2016.02.071","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2016.02.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}