{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:18:32Z","timestamp":1792466312393,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jtcvsonline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jtcvs.2016.10.060","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T12:01:41Z","timestamp":1478952101000},"page":"656-664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"title":["Liver health in adults with Fontan circulation: A multicenter cross-sectional study"],"prefix":"10.1016","volume":"153","author":[{"given":"Fred M.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kogon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Earing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil A.","family":"Aboulhosn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Broberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anitha S.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Harmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha I.","family":"Sainani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Odze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie E.","family":"Johncilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinweike","family":"Ukomadu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberlee","family":"Gauvreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Valente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Landzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2016.10.060_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/thx.26.3.240","article-title":"Surgical repair of tricuspid atresia","volume":"26","author":"Fontan","year":"1971","journal-title":"Thorax"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib2","doi-asserted-by":"crossref","first-page":"I157","DOI":"10.1161\/CIRCULATIONAHA.106.676445","article-title":"The Fontan procedure: contemporary techniques have improved long-term outcomes","volume":"116","author":"d'Udekem","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/CIRCULATIONAHA.107.738559","article-title":"Long-term survival, modes of death, and predictors of mortality in patients with Fontan surgery","volume":"117","author":"Khairy","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1747-0803.2011.00504.x","article-title":"Liver disease in the patient with Fontan circulation","volume":"6","author":"Wu","year":"2011","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib5","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1056\/NEJMc1214222","article-title":"Hepatocellular carcinoma after the Fontan procedure","volume":"368","author":"Asrani","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib6","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.jtcvs.2004.10.005","article-title":"Progression of liver pathology in patients undergoing the Fontan procedure: chronic passive congestion, cardiac cirrhosis, hepatic adenoma, and hepatocellular carcinoma","volume":"129","author":"Ghaferi","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jtcvs.2012.09.005","article-title":"Identifying predictors of hepatic disease in patients after the Fontan operation: a postmortem analysis","volume":"146","author":"Johnson","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib8","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.jtcvs.2011.08.038","article-title":"Hepatic pathology may develop before the Fontan operation in children with functional single ventricle: an autopsy study","volume":"143","author":"Schwartz","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00246-012-0402-9","article-title":"Portal and sinusoidal fibrosis are common on liver biopsy after Fontan surgery","volume":"34","author":"Schwartz","year":"2013","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/hrt.2006.094516","article-title":"Hepatic changes in the failing Fontan circulation","volume":"93","author":"Kiesewetter","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib11","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0022-5223(19)33989-3","article-title":"Specific sequelae after Fontan operation at mid- and long-term follow-up. Arrhythmia, liver dysfunction, and coagulation disorders","volume":"106","author":"Cromme-Dijkhuis","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/hrt.78.2.154","article-title":"Sequelae after modified Fontan operation: postoperative haemodynamic data and organ function","volume":"78","author":"Kaulitz","year":"1997","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/hrt.82.1.40","article-title":"Abnormalities in liver function and coagulation profile following the Fontan procedure","volume":"82","author":"van Nieuwenhuizen","year":"1999","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1017\/S1047951108002795","article-title":"Nomenclature for congenital and paediatric cardiac disease: historical perspectives and The International Pediatric and Congenital Cardiac Code","volume":"18","author":"Franklin","year":"2008","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib15","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/hep.1840200104","article-title":"Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group","volume":"20","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/heartjnl-2012-303347","article-title":"MELD-XI score and cardiac mortality or transplantation in patients after Fontan surgery","volume":"99","author":"Assenza","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib18","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1016\/j.ijcard.2013.06.008","article-title":"Features of portal hypertension are associated with major adverse events in Fontan patients: the VAST study","volume":"168","author":"Elder","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1747-0803.2011.00500.x","article-title":"Exercise testing identifies patients at increased risk for morbidity and mortality following Fontan surgery","volume":"6","author":"Fernandes","year":"2011","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/CIRCHEARTFAILURE.109.872556","article-title":"Clinical predictors of hepatic fibrosis in chronic advanced heart failure","volume":"3","author":"Gelow","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pathophys.2004.07.003","article-title":"Mechanical stretch induces matrix metalloproteinase 1 production in human hepatic stellate cells","volume":"11","author":"Goto","year":"2004","journal-title":"Pathophysiology"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib22","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1136\/hrt.2010.201772","article-title":"Late hepatic complications after Fontan operation;\u00a0non-invasive markers of hepatic fibrosis and risk factors","volume":"96","author":"Baek","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijcard.2010.05.047","article-title":"Arterialised hepatic nodules in the Fontan circulation: hepatico-cardiac interactions","volume":"151","author":"Bryant","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.athoracsur.2008.03.077","article-title":"Liver and cardiac function in the long term after Fontan operation","volume":"86","author":"Camposilvan","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/hrt.2003.026419","article-title":"Coagulation profile and liver function in 102 patients after total cavopulmonary connection at mid term follow up","volume":"91","author":"Chaloupecky","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib26","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jtcvs.2007.09.039","article-title":"Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers","volume":"135","author":"Friedrich-Rust","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1747-0803.2012.00632.x","article-title":"Noninvasive assessment of liver fibrosis in adult patients following the Fontan procedure","volume":"7","author":"Ginde","year":"2012","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib28","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00005176-200303000-00009","article-title":"Hepatic dysfunction following the Fontan procedure","volume":"36","author":"Narkewicz","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/hep.26631","article-title":"Increased hepatic stiffness as consequence of high hepatic afterload in the Fontan circulation: a vascular Doppler and elastography study","volume":"59","author":"Kutty","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s00247-012-2531-y","article-title":"Hepatic pathology after Fontan palliation: spectrum of imaging findings","volume":"43","author":"Wallihan","year":"2013","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jpeds.2012.12.071","article-title":"Magnetic resonance imaging identifies unsuspected liver abnormalities in patients after the Fontan procedure","volume":"163","author":"Bulut","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib32","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/chd.12159","article-title":"Transient elastography may identify Fontan patients with unfavorable hemodynamics and advanced hepatic fibrosis","volume":"9","author":"Wu","year":"2014","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib33","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jtcvs.2015.09.079","article-title":"Hepatic stiffness in the bidirectional cavopulmonary circulation: The Liver Adult-Pediatric-Congenital-Heart-Disease Dysfunction Study group","volume":"151","author":"Kutty","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib34","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1440-1746.2004.03312.x","article-title":"Non-alcoholic steatohepatitis in type 2 diabetes mellitus","volume":"19","author":"Gupte","year":"2004","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib35","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/gut.2005.084475","article-title":"An appraisal of the histopathological assessment of liver fibrosis","volume":"55","author":"Standish","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib36","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.healun.2015.01.993","article-title":"Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes","volume":"34","author":"Wu","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib37","series-title":"STS congenital heart surgery executive summary, all patients, Jan 2012-Dec 2015","year":"2016"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jtcvs.2015.10.009","article-title":"Taking care all along the way","volume":"151","author":"Haller","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib39","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.jtcvs.2015.08.107","article-title":"Hypoplastic left heart syndrome: how to improve late survival and quality of life","volume":"150","author":"Jaquiss","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2016.10.060_bib40","series-title":"SEER Survival Monograph: Cancer Survival Among Adults: U.S. SEER Program, 1988-2001, Patient and Tumor Characteristics","author":"Ries","year":"2007"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522316314581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522316314581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T04:14:42Z","timestamp":1601180082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522316314581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0022522316314581"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2016.10.060","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liver health in adults with Fontan circulation: A multicenter cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2016.10.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}