{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:44:26Z","timestamp":1791917066194,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jtcvsonline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jtcvs.2017.05.065","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T19:31:00Z","timestamp":1495740660000},"page":"1756-1762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Elevated oxidative stress in the aortic media of patients with bicuspid aortic valve"],"prefix":"10.1016","volume":"154","author":[{"given":"Marie","family":"Billaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Phillippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary P.","family":"Kotlarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley W.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudette M.","family":"St Croix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadiezhda","family":"Cantu-Med\u00e9llin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Gleason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2017.05.065_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0002-9149(70)90761-7","article-title":"The congenitally bicuspid aortic valve. A study of 85 autopsy cases","volume":"26","author":"Roberts","year":"1970","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/heart.83.1.81","article-title":"Clinical significance of the bicuspid aortic valve","volume":"83","author":"Ward","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0008-6363(03)00523-6","article-title":"Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin II type 1 receptor blocker","volume":"59","author":"Ejiri","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ijcard.2010.04.077","article-title":"Evidence for oxidative stress in plasma of patients with Marfan syndrome","volume":"145","author":"Fiorillo","year":"2010","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.atherosclerosis.2008.03.029","article-title":"Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model","volume":"202","author":"Xiong","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib6","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1161\/CIRCULATIONAHA.108.770776","article-title":"Basal and oxidative stress-induced expression of metallothionein is decreased in ascending aortic aneurysms of bicuspid aortic valve patients","volume":"119","author":"Phillippi","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib7","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jtcvs.2007.01.039","article-title":"A classification system for the bicuspid aortic valve from 304 surgical specimens","volume":"133","author":"Sievers","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.athoracsur.2016.10.039","article-title":"Bicuspid aortic valve morphotype correlates with regional antioxidant gene expression profiles in the proximal ascending aorta","volume":"140","author":"Phillippi","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib9","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.jtcvs.2014.04.007","article-title":"Toward individualized management of the ascending aorta in bicuspid aortic valve surgery: the role of valve phenotype in 1362 patients","volume":"148","author":"Sievers","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/nprot.2007.473","article-title":"Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine","volume":"3","author":"Zielonka","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nprot.2009.197","article-title":"Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue","volume":"5","author":"Weydert","year":"2010","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib12","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1161\/RES.0000000000000110","article-title":"Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement From the American Heart Association","volume":"119","author":"Griendling","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib13","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1080\/01621459.1987.10478551","article-title":"Fine-tuning some resistant rules for outlier labeling","volume":"82","author":"Hoaglin","year":"1987","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib14","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jss.2013.06.007","article-title":"Molecular mechanisms of thoracic aortic dissection","volume":"184","author":"Wu","year":"2013","journal-title":"J Surg Res"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib15","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1053\/j.semtcvs.2005.06.001","article-title":"Heritable disorders predisposing to aortic dissection","volume":"17","author":"Gleason","year":"2005","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jacc.2009.08.084","article-title":"Thoracic aortic aneurysm clinically pertinent controversies and uncertainties","volume":"55","author":"Elefteriades","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib17","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1161\/CIRCULATIONAHA.106.630400","article-title":"Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002","volume":"114","author":"Olsson","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib18","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jama.2011.1286","article-title":"Incidence of aortic complications in patients with bicuspid aortic valves","volume":"306","author":"Michelena","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4065\/74.1.14","article-title":"Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2,715 additional cases","volume":"74","author":"Sabet","year":"1999","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib20","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.107.740878","article-title":"Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community","volume":"117","author":"Michelena","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1001\/jama.300.11.1317","article-title":"Outcomes in adults with bicuspid aortic valves","volume":"300","author":"Tzemos","year":"2008","journal-title":"JAMA"},{"issue":"19 suppl 3","key":"10.1016\/j.jtcvs.2017.05.065_bib22","first-page":"III35","article-title":"Bicuspid aortic valves are associated with aortic dilatation out of proportion to coexistent valvular lesions","volume":"102","author":"Keane","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib23","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.jtcvs.2016.02.019","article-title":"Extracellular matrix fiber microarchitecture is region-specific in bicuspid aortic valve-associated ascending aortic aneurysms","volume":"151","author":"Tsamis","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib24","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.jtcvs.2013.04.028","article-title":"Mechanism of aortic medial matrix remodeling is distinct in patients with bicuspid aortic valve","volume":"147","author":"Phillippi","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib25","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1016\/j.jbiomech.2013.09.003","article-title":"Fiber micro-architecture in the longitudinal-radial and circumferential-radial planes of ascending thoracic aortic aneurysm media","volume":"46","author":"Tsamis","year":"2013","journal-title":"J Biomech"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib26","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.athoracsur.2013.07.001","article-title":"Differential tensile strength and collagen composition in ascending aortic aneurysms by aortic valve phenotype","volume":"96","author":"Pichamuthu","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib27","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jtcvs.2011.07.058","article-title":"Effect of aneurysm on the mechanical dissection properties of the human ascending thoracic aorta","volume":"143","author":"Pasta","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib28","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.athoracsur.2010.07.069","article-title":"Altered oxidative stress responses and increased type I collagen expression in bicuspid aortic valve patients","volume":"90","author":"Phillippi","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib29","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1073\/pnas.96.7.3819","article-title":"Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1","volume":"96","author":"Pereira","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.vph.2009.10.005","article-title":"Vasomotor dysfunction in the thoracic aorta of Marfan syndrome is associated with accumulation of oxidative stress","volume":"52","author":"Yang","year":"2010","journal-title":"Vasc Pharmacol"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib31","first-page":"L301","article-title":"Functional consequences of the collagen\/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-\/-, and iNOS-\/- mice","volume":"299","author":"Steed","year":"2010","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib32","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2119\/molmed.2011.00286","article-title":"Unraveling divergent gene expression profiles in bicuspid and tricuspid aortic valve patients with thoracic aortic dilatation: the ASAP study","volume":"17","author":"Folkersen","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib33","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.4081\/ejh.2014.2383","article-title":"Analysis of extracellular superoxide dismutase and Akt in ascending aortic aneurysm with tricuspid or bicuspid aortic valve","volume":"58","author":"Arcucci","year":"2014","journal-title":"Eur J Histochem"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib34","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/cvr\/cvt205","article-title":"Oxidative stress modulates vascular smooth muscle cell phenotype via CTGF in thoracic aortic aneurysm","volume":"100","author":"Branchetti","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/BJ20071063","article-title":"Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells","volume":"410","author":"Hill","year":"2008","journal-title":"Biochem J"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0021-9150(03)00196-5","article-title":"Cytotoxic effects of the lipid peroxidation product 2,4-decadienal in vascular smooth muscle cells","volume":"169","author":"Cabre","year":"2003","journal-title":"Atherosclerosis"},{"issue":"suppl","key":"10.1016\/j.jtcvs.2017.05.065_bib37","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/S0021-9150(97)00305-5","article-title":"Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis","volume":"137","author":"Holvoet","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib38","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.ATV.21.5.844","article-title":"Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease","volume":"21","author":"Holvoet","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000357835","article-title":"Autoantibodies to oxidized low-density lipoprotein in patients with aortic regurgitation: association with aortic diameter size","volume":"128","author":"Shimoni","year":"2014","journal-title":"Cardiology"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib40","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbalip.2006.06.001","article-title":"The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells","volume":"1761","author":"Fruhwirth","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib41","first-page":"39","article-title":"Oxidative stress in human abdominal aortic aneurysmal and occlusive disease","volume":"59","author":"Ejiri","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib42","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.athoracsur.2016.04.001","article-title":"Regional disruptions in endothelial nitric oxide pathway associated with bicuspid aortic valve","volume":"102","author":"Kotlarczyk","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib43","doi-asserted-by":"crossref","first-page":"165957","DOI":"10.1155\/2012\/165957","article-title":"Locally different endothelial nitric oxide synthase protein levels in ascending aortic aneurysms of bicuspid and tricuspid aortic valve","volume":"2012","author":"Mohamed","year":"2012","journal-title":"Cardiol Res Pract"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib44","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/icvts\/ivr114","article-title":"Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications","volume":"14","author":"Pisano","year":"2012","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib45","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.1167\/iovs.15-16810","article-title":"In\u00a0vivo imaging of retinal oxidative stress using a reactive oxygen species-activated fluorescent probe","volume":"56","author":"Prunty","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib46","doi-asserted-by":"crossref","first-page":"19311","DOI":"10.1038\/srep19311","article-title":"Role of carbonyl modifications on aging-associated protein aggregation","volume":"6","author":"Tanase","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtcvs.2017.05.065_bib47","first-page":"12.42.1-11","article-title":"In\u00a0vivo immuno-spin trapping: imaging the footprints of oxidative Stress","volume":"74","author":"Khoo","year":"2015","journal-title":"Curr Protoc Cytom"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522317311182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522317311182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T23:23:21Z","timestamp":1572650601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522317311182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0022522317311182"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2017.05.065","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated oxidative stress in the aortic media of patients with bicuspid aortic valve","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2017.05.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}