{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:43:19Z","timestamp":1790527399494,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jtcvsonline.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jtcvs.2017.08.123","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T08:46:46Z","timestamp":1505378806000},"page":"461-469.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Machine-learning phenotypic classification of bicuspid aortopathy"],"prefix":"10.1016","volume":"155","author":[{"given":"Charles M.","family":"Wojnarski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Roselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay J.","family":"Idrees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa A.","family":"Carnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick H.","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ehrlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene H.","family":"Blackstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars G.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce W.","family":"Lytle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2017.08.123_bib1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/01.CIR.0000155623.48408.C5","article-title":"Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation","volume":"111","author":"Roberts","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/heart.83.1.81","article-title":"Clinical significance of the bicuspid aortic valve","volume":"83","author":"Ward","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib3","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMra1207059","article-title":"Aortic dilatation in patients with bicuspid aortic valve","volume":"370","author":"Verma","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib4","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1136\/hrt.2007.132092","article-title":"The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape","volume":"94","author":"Schaefer","year":"2008","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/ejcts\/ezr168","article-title":"Corrigendum to Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery","volume":"41","author":"Jackson","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib6","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jtcvs.2008.01.022","article-title":"The aortopathy of bicuspid aortic valve disease has distinctive patterns and usually involves the transverse aortic arch","volume":"135","author":"Fazel","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ejcts.2011.01.001","article-title":"Is aortopathy in bicuspid aortic valve disease a congenital defect or a result of abnormal hemodynamics? A critical reappraisal of a one-sided argument","volume":"39","author":"Girdauskas","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib8","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/ejcts\/ezr216","article-title":"Multiple aortopathy phenotypes with bicuspid aortic valve: the importance of terminology and definition criteria","volume":"41","author":"Della Corte","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib10","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1161\/CIR.0b013e3181d47d48","volume":"121","author":"Hiratzka","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib11","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jtcvs.2007.01.039","article-title":"A classification system for the bicuspid aortic valve from 304 surgical specimens","volume":"133","author":"Sievers","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1532-429X-10-56","article-title":"Normal values for aortic diameters in children and adolescents: assessment in\u00a0vivo by contrast-enhanced CMR-angiography","volume":"10","author":"Kaiser","year":"2008","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib13","series-title":"Finding Groups in Data: an Introduction to Cluster Analysis","author":"Kaufman","year":"2005"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Machine Learn"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib15","unstructured":"Ishwaran H, Kogalur UB. Random forests for survival, regression, and classification (RF-SRC), R package version 1.6.0, Available at: http:\/\/cran.r-project.org\/web\/packages\/randomForestSRC\/index.html. Accessed February 27, 2015."},{"key":"10.1016\/j.jtcvs.2017.08.123_bib16","unstructured":"Ehrlinger J. ggRandomForests: visually exploring Random Forests. R package version 1.1.4. Available at: http:\/\/cran.r-project.org\/package=ggRandomForests. Accessed February 27, 2015."},{"key":"10.1016\/j.jtcvs.2017.08.123_bib17","series-title":"Classification and Regression Trees","author":"Breiman","year":"1984"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib18","unstructured":"Maechler M, Rousseeuw PJ, Struyf A, Hubert M, Hornik K. 2013. Cluster: cluster analysis basics and extensions. R package version 1.14.4."},{"key":"10.1016\/j.jtcvs.2017.08.123_bib19","series-title":"R: a language and environment for statistical computing. Version 3.3.1","year":"2016"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib20","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1214\/08-AOAS169","article-title":"Random survival forests","volume":"2","author":"Ishwaran","year":"2008","journal-title":"Ann Appl Stat"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/jmri.24376","article-title":"Association between leaflet fusion pattern and thoracic aorta morphology in patients with bicuspid aortic valve","volume":"40","author":"Merritt","year":"2014","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/CIRCIMAGING.112.973370","article-title":"Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta","volume":"5","author":"Barker","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1148\/radiol.09091437","article-title":"Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns","volume":"255","author":"Hope","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/hrt.82.1.19","article-title":"Aortic root dilatation in young men with normally functioning bicuspid aortic valves","volume":"82","author":"Nistri","year":"1999","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib25","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/ejcts\/ezs137","article-title":"Risk of late aortic events after an isolated aortic valve replacement for bicuspid aortic valve stenosis with concomitant ascending aortic dilation","volume":"42","author":"Girdauskas","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib26","first-page":"1","article-title":"Survival and reoperation risk following bicuspid aortic valve-sparing root replacement","volume":"18","author":"Sareyyupoglu","year":"2009","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib27","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.amjcard.2006.04.043","article-title":"Comparison of feasibility and accuracy of transthoracic echocardiography versus computed tomography in patients with known ascending aortic aneurysm","volume":"98","author":"Tamborini","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jtcvs.2012.05.035","article-title":"Bicuspid aortic valve configuration and aortopathy pattern might represent different pathophysiologic substrates","volume":"144","author":"Kari","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib29","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.athoracsur.2013.11.036","article-title":"Long-term durability of bicuspid aortic valve repair","volume":"97","author":"Svensson","year":"2014","journal-title":"Ann Thorac Surg"},{"issue":"3 Suppl","key":"10.1016\/j.jtcvs.2017.08.123_bib30","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.jtcvs.2012.11.043","article-title":"Tirone David valve-sparing aortic root replacement and cusp repair for bicuspid aortic valve disease","volume":"145","author":"Kari","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib31","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.athoracsur.2007.03.057","article-title":"Long-term survival after the Bentall procedure in 206 patients with bicuspid aortic valve","volume":"84","author":"Etz","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jtcvs.2010.08.086","article-title":"Should the proximal arch be routinely replaced in patients with bicuspid aortic valve disease and ascending aortic aneurysm?","volume":"142","author":"Park","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2 Suppl","key":"10.1016\/j.jtcvs.2017.08.123_bib33","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.jtcvs.2014.11.029","article-title":"Distal aortic interventions after repair of ascending dissection: the argument for a more aggressive approach","volume":"149","author":"Roselli","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/01.sla.0000140756.30517.1b","article-title":"Staged repair of extensive aortic aneurysms: long-term experience with the elephant trunk technique","volume":"240","author":"Safi","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0022-5223(19)33737-7","article-title":"Deep hypothermia with circulatory arrest. Determinants of stroke and early mortality in 656 patients","volume":"106","author":"Svensson","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2017.08.123_bib36","series-title":"Principles of Statistics","author":"Bulmer","year":"1979"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522317318986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522317318986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T18:56:39Z","timestamp":1750877799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522317318986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0022522317318986"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2017.08.123","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine-learning phenotypic classification of bicuspid aortopathy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2017.08.123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}