{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:59:17Z","timestamp":1790179157902,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jtcvs.2018.11.022","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T11:49:28Z","timestamp":1542368968000},"page":"730-740.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Increased mortality, morbidities, and costs after heart transplantation in heterotaxy syndrome and other complex situs arrangements"],"prefix":"10.1016","volume":"157","author":[{"given":"Son Q.","family":"Duong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Godown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Soslow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary","family":"Thurm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Sainathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor O.","family":"Morell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Feingold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2018.11.022_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.carpath.2016.01.003","article-title":"Manifestations of bodily isomerism","volume":"25","author":"Loomba","year":"2016","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1017\/S1047951115001389","article-title":"CHD associated with syndromic diagnoses: peri-operative risk factors and early outcomes","volume":"26","author":"Landis","year":"2016","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/2150135110396908","article-title":"Surgical management of the neonate with heterotaxy and long-term outcomes of heterotaxy","volume":"2","author":"Jonas","year":"2011","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jtcvs.2008.12.011","article-title":"Heart transplantation in situs inversus totalis","volume":"139","author":"Deuse","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib5","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0002-9149(02)02325-1","article-title":"Usefulness of cardiac transplantation in children with visceral heterotaxy (asplenic and polysplenic syndromes and single right-sided spleen with levocardia) and comparison of results with cardiac transplantation in children with dilated cardiomyopathy","volume":"89","author":"Larsen","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ahj.2017.08.014","article-title":"A unique linkage of administrative and clinical registry databases to expand analytic possibilities in pediatric heart transplantation research","volume":"194","author":"Godown","year":"2017","journal-title":"Am Heart J"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib9","unstructured":"MapIT Automated In-house Stand-alone Mapping Tool. Posted March 2014. Rockville, MD: Agency for Healthcare Research and Quality. Available at: https:\/\/www.qualityindicators.ahrq.gov\/resources\/toolkits.aspx."},{"key":"10.1016\/j.jtcvs.2018.11.022_bib10","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/sim.4780120803","article-title":"Kaplan-Meier, marginal or conditional probability curves in summarizing competing risks failure time data?","volume":"12","author":"Pepe","year":"1993","journal-title":"Stat Med"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2008030287","article-title":"New equations to estimate GFR in children with CKD","volume":"20","author":"Schwartz","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib12","unstructured":"Nichols A. VINCENTY: Stata module to calculate distances on the Earth's surface. Statistical Software Components. 2017; S456815."},{"key":"10.1016\/j.jtcvs.2018.11.022_bib13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib14","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.athoracsur.2010.10.083","article-title":"Lessons learned from 119 consecutive cardiac transplants for pediatric and congenital heart disease","volume":"91","author":"Jacobs","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib15","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.athoracsur.2006.05.039","article-title":"Heterotaxy syndrome with functional single ventricle: does prenatal diagnosis improve survival?","volume":"82","author":"Cohen","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib16","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.healun.2017.07.018","article-title":"The Registry of the International Society for Heart and Lung Transplantation: twentieth pediatric heart transplantation report-2017; focus theme: allograft ischemic time","volume":"36","author":"Rossano","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.healun.2010.08.031","article-title":"Rejection with hemodynamic compromise in the current era of pediatric heart transplantation: a multi-institutional study","volume":"30","author":"Everitt","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1053-2498(00)00228-X","article-title":"Death after rejection with severe hemodynamic compromise in pediatric heart transplant recipients: a multi-institutional study","volume":"20","author":"Pahl","year":"2001","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib19","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jacc.2015.05.063","article-title":"Improved detection of cardiac allograft vasculopathy: a multi-institutional analysis of functional parameters in pediatric heart transplant recipients","volume":"66","author":"Kindel","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(06)67933-6","article-title":"Lymphoproliferative disorders after paediatric heart transplantation: a multi-institutional study","volume":"367","author":"Webber","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/0974-2069.140834","article-title":"Non-cardiac issues in patients with heterotaxy syndrome","volume":"7","author":"Kothari","year":"2014","journal-title":"Ann Pediatr Cardiol"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/uog.14871","article-title":"Extracardiac anomalies in prenatally diagnosed heterotaxy syndrome","volume":"47","author":"Gottschalk","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib23","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1016\/j.transproceed.2008.07.115","article-title":"Cardiac transplantation in situs inversus: two cases reports","volume":"40","author":"Chang","year":"2008","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib24","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.healun.2006.12.002","article-title":"Challenging venous reconstruction and heart transplantation in a patient with viscero-atrial situs inversus and complex congenital heart disease with Fontan circulation","volume":"26","author":"Beiras-Fernandez","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0003-4975(95)00168-K","article-title":"Orthotopic heart transplantation in situs inversus","volume":"60","author":"Rubay","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib26","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0003-4975(94)01063-3","article-title":"Novel approach for orthotopic heart transplantation in visceroatrial situs inversus","volume":"60","author":"Michler","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib27","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.healun.2011.05.001","article-title":"Association of graft ischemic time with survival after heart transplant among children in the United States","volume":"30","author":"Ford","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib28","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s00246-010-9764-z","article-title":"Heterotaxy syndrome: defining contemporary disease trends","volume":"31","author":"Prendiville","year":"2010","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jtcvs.2010.07.082","article-title":"Increased postoperative and respiratory complications in patients with congenital heart disease associated with heterotaxy","volume":"141","author":"Swisher","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib30","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/CIRCULATIONAHA.111.079780","article-title":"High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy","volume":"125","author":"Nakhleh","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3934\/molsci.2013.1.27","article-title":"The roles of primary cilia in polycystic kidney disease","volume":"1","author":"Kathem","year":"2014","journal-title":"AIMS Mol Sci"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib32","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1053\/j.ajkd.2006.08.002","article-title":"Risks and outcomes of acute kidney injury requiring dialysis after cardiac transplantation","volume":"48","author":"Boyle","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib33","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1399-6576.2007.01379.x","article-title":"Risk factors for acute renal failure requiring dialysis after surgery for congenital heart disease in children","volume":"51","author":"Pedersen","year":"2007","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib34","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0003-4975(03)01026-9","article-title":"Peritoneal dialysis after surgery for congenital heart disease in infants and young children","volume":"76","author":"Chan","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ahj.2018.04.006","article-title":"Mechanical circulatory support costs in children bridged to heart transplantation - analysis of a linked database","volume":"201","author":"Godown","year":"2018","journal-title":"Am Heart J"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/petr.13095","article-title":"Charges and resource utilization for pediatric heart transplantation across a positive virtual and\/or cytotoxicity crossmatch","volume":"22","author":"West","year":"2018","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib37","doi-asserted-by":"crossref","first-page":"e006917","DOI":"10.1161\/CIRCIMAGING.117.006917","article-title":"Disharmonious patterns of heterotaxy and isomerism: how often are the classic patterns breached?","volume":"11","author":"Yim","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib38","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/adc.59.3.242","article-title":"Consanguinity and complex cardiac anomalies with situs ambiguus","volume":"59","author":"Gatrad","year":"1984","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4070\/kcj.2011.41.5.227","article-title":"Heterotaxy syndrome","volume":"41","author":"Kim","year":"2011","journal-title":"Korean Circ J"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jtcvs.2007.12.032","article-title":"Outcome of 200 patients after an extracardiac Fontan procedure","volume":"136","author":"Kim","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib41","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1002\/ajmg.a.36695","article-title":"Laterality defects in the national birth defects prevention study (1998-2007): birth prevalence and descriptive epidemiology","volume":"164A","author":"Lin","year":"2014","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jtcvs.2018.11.022_bib42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/petr.12038","article-title":"Ten yr of pediatric heart transplantation: a report from the Pediatric Heart Transplant Study","volume":"17","author":"Dipchand","year":"2013","journal-title":"Pediatr Transplant"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522318329702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522318329702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T16:59:09Z","timestamp":1758387549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522318329702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0022522318329702"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2018.11.022","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased mortality, morbidities, and costs after heart transplantation in heterotaxy syndrome and other complex situs arrangements","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2018.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}