{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:10:18Z","timestamp":1791389418332,"version":"4.3.3"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2314-B-650-004"],"award-info":[{"award-number":["107-2314-B-650-004"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004738","name":"E-Da Hospital","doi-asserted-by":"publisher","award":["EDPJ106101"],"award-info":[{"award-number":["EDPJ106101"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004738","name":"E-Da Hospital","doi-asserted-by":"publisher","award":["NCKUEDA10717"],"award-info":[{"award-number":["NCKUEDA10717"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jtcvs.2019.10.151","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T11:48:28Z","timestamp":1573732108000},"page":"e337-e347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Transplantation of viable mitochondria attenuates neurologic injury after spinal cord ischemia"],"prefix":"10.1016","volume":"161","author":[{"given":"Shih-Yuan","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Neng","family":"Roan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Shun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Hsuan","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Fuh","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2019.10.151_bib1","doi-asserted-by":"crossref","first-page":"3s","DOI":"10.1016\/j.jvs.2010.06.137","article-title":"Outcomes in open repair of the thoracic and thoracoabdominal aorta","volume":"52","author":"Acher","year":"2010","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib2","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.jvs.2015.01.044","article-title":"Risk factors for spinal cord ischemia after endovascular repair of thoracoabdominal aortic aneurysms","volume":"61","author":"Bisdas","year":"2015","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ejvs.2014.11.018","article-title":"Ten-year experience with endovascular repair of thoracoabdominal aortic aneurysms: results from 166 consecutive patients","volume":"49","author":"Verhoeven","year":"2015","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jtcvs.2017.03.020","article-title":"Open repair of chronic thoracic and thoracoabdominal aortic dissection using deep hypothermia and circulatory arrest","volume":"154","author":"Corvera","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib5","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1089\/neu.2006.0242","article-title":"Temporal characterization of mitochondrial bioenergetics after spinal cord injury","volume":"24","author":"Sullivan","year":"2007","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib6","doi-asserted-by":"crossref","first-page":"924","DOI":"10.14336\/AD.2017.1126","article-title":"Mitochondria in ischemic stroke: new insight and implications","volume":"9","author":"Liu","year":"2018","journal-title":"Aging Dis"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/ars.2012.4580","article-title":"Oxidative damage in clinical ischemia\/reperfusion injury: a reappraisal","volume":"19","author":"de Vries","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1124\/jpet.117.244806","article-title":"Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target","volume":"363","author":"Scholpa","year":"2017","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib9","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jtcvs.2017.02.018","article-title":"Autologous mitochondrial transplantation for dysfunction after ischemia-reperfusion injury","volume":"154","author":"Emani","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jtcvs.2017.03.074","article-title":"Mitochondrial transplantation: another miracle of molecular medicine?","volume":"154","author":"Kumar","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mito.2017.03.004","article-title":"Mitochondrial transplantation: from animal models to clinical use in humans","volume":"34","author":"McCully","year":"2017","journal-title":"Mitochondrion"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1213\/ANE.0000000000001704","article-title":"Isoflurane impairs motor\u00a0function\u00a0recovery by increasing neuroapoptosis and degeneration during\u00a0spinal ischemia-reperfusion injury in rats","volume":"124","author":"Fang","year":"2017","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/BRS.0b013e31823b0440","article-title":"Delayed granulocyte colony-stimulating factor treatment promotes functional recovery in rats with severe contusive spinal cord injury","volume":"37","author":"Lee","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor\u00a0rating\u00a0scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib15","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1089\/neu.2017.5605","article-title":"Effects of mitochondrial transplantation on bioenergetics, cellular incorporation, and functional recovery after spinal cord injury","volume":"35","author":"Gollihue","year":"2018","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jhep.2016.03.021","article-title":"A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in\u00a0vivo","volume":"65","author":"Luli","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s12035-018-0994-z","article-title":"Ursodeoxycholic acid inhibits inflammatory responses and promotes functional recovery after spinal cord injury in rats","volume":"56","author":"Ko","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tice.2018.11.007","article-title":"Reactivity of microglia and astrocytes after an excitotoxic injury induced by kainic acid in the rat spinal cord","volume":"56","author":"Zanuzzi","year":"2019","journal-title":"Tissue Cell"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","article-title":"Diverse roles of mitochondria in ischemic stroke","volume":"16","author":"Yang","year":"2018","journal-title":"Redox Biol"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib20","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1161\/01.STR.0000077255.15597.69","article-title":"Different expression patterns of Bcl-2, Bcl-xl, and Bax proteins after sublethal forebrain ischemia in C57Black\/Crj6 mouse striatum","volume":"34","author":"Wu","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3892\/ijmm.2015.2260","article-title":"Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice","volume":"36","author":"Zhao","year":"2015","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib22","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/jnr.20400","article-title":"Exogenous Bcl-xL fusion protein spares neurons after spinal cord injury","volume":"79","author":"Nesic-Taylor","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib23","doi-asserted-by":"crossref","first-page":"16012","DOI":"10.1038\/cddiscovery.2016.12","article-title":"Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes","volume":"2","author":"de Castro","year":"2016","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib24","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1089\/ars.2009.2485","article-title":"Role of the unfolded protein response regulator GRP78\/BiP in development, cancer, and neurological disorders","volume":"11","author":"Wang","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jb\/mvr143","article-title":"CHOP is a multifunctional transcription factor in the ER stress response","volume":"151","author":"Nishitoh","year":"2012","journal-title":"J Biochem"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/dneu.22625","article-title":"Chromatolysis: do injured axons regenerate poorly when ribonucleases attack rough endoplasmic reticulum, ribosomes and RNA?","volume":"78","author":"Moon","year":"2018","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib27","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/1673-5374.226382","article-title":"Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma","volume":"13","author":"Gollihue","year":"2018","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib28","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10616-019-00302-9","article-title":"Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases","volume":"71","author":"Roushandeh","year":"2019","journal-title":"Cytotechnology"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib29","first-page":"e51682","article-title":"Rapid isolation and purification of mitochondria for transplantation by tissue dissociation and differential filtration","author":"Preble","year":"2014","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jtcvs.2019.10.151_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mito.2018.03.002","article-title":"Alloreactivity and allorecognition of syngeneic and allogeneic mitochondria","volume":"46","author":"Ramirez-Barbieri","year":"2019","journal-title":"Mitochondrion"}],"updated-by":[{"DOI":"10.1016\/j.jtcvs.2021.07.031","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000}}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522319327758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522319327758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:31:29Z","timestamp":1777422689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522319327758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0022522319327758"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2019.10.151","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transplantation of viable mitochondria attenuates neurologic injury after spinal cord ischemia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2019.10.151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}