{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:53:43Z","timestamp":1782507223889,"version":"3.54.5"},"reference-count":9,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jtcvs.2019.12.057","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T01:47:31Z","timestamp":1578361651000},"page":"e499-e500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Commentary: Nitric oxide: An important contributor to neuroprotection during pediatric cardiac surgery"],"prefix":"10.1016","volume":"161","author":[{"given":"Nobuyuki","family":"Ishibashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Jonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2019.12.057_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tins.2012.11.007","article-title":"Microglia: actively surveying and shaping neuronal circuit structure and function","volume":"36","author":"Wake","year":"2013","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jtcvs.2019.12.057_bib2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.athoracsur.2015.04.017","article-title":"Prolonged white matter inflammation after cardiopulmonary bypass and circulatory arrest in a juvenile porcine model","volume":"100","author":"Korotcova","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2019.12.057_bib3","doi-asserted-by":"crossref","first-page":"e485","DOI":"10.1016\/j.jtcvs.2019.12.075","article-title":"Inhaled nitric oxide reduces injury and microglia activation in porcine hippocampus after deep hypothermic circulatory arrest","volume":"161","author":"Kajimoto","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2019.12.057_bib4","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1007\/s00134-016-4420-6","article-title":"Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial","volume":"42","author":"James","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jtcvs.2019.12.057_bib5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jtcvs.2012.09.100","article-title":"Nitric oxide delivery during cardiopulmonary bypass reduces postoperative morbidity in children\u2014a randomized trial","volume":"146","author":"Checchia","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2019.12.057_bib6","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0022-5223(96)70054-5","article-title":"Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester","volume":"112","author":"Hiramatsu","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2019.12.057_bib7","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/CIRCRESAHA.116.309048","article-title":"Neurodevelopmental abnormalities and congenital heart disease: insights into altered brain maturation","volume":"120","author":"Morton","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2019.12.057_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2019.06.102","article-title":"Prenatal hypoxemia alters microglial morphology in fetal sheep","author":"Lawrence","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2019.12.057_bib9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.tins.2018.12.003","article-title":"Cortical dysmaturation in congenital heart disease","volume":"42","author":"Leonetti","year":"2019","journal-title":"Trends Neurosci"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522320300325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522320300325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T17:13:30Z","timestamp":1758388410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522320300325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0022522320300325"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2019.12.057","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Commentary: Nitric oxide: An important contributor to neuroprotection during pediatric cardiac surgery","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2019.12.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2019.12.075","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}