{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:26:27Z","timestamp":1781670387557,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1T32HL098049"],"award-info":[{"award-number":["1T32HL098049"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jtcvs.2020.04.164","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:41:28Z","timestamp":1589560888000},"page":"1556-1563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Use of patient-specific computational models for optimization of aortic insufficiency after implantation of left ventricular assist device"],"prefix":"10.1016","volume":"162","author":[{"given":"Patpilai","family":"Kasinpila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Shad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison L.","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Joseph","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hiesinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2020.04.164_bib1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.healun.2017.07.005","article-title":"Eighth annual INTERMACS report: special focus on framing the impact of adverse events","volume":"36","author":"Kirklin","year":"2017","journal-title":"J Hear Lung Transplant"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/CIRCHEARTFAILURE.109.917765","article-title":"The development of aortic insufficiency in LVAD supported patients","volume":"3","author":"Cowger","year":"2015","journal-title":"Circ Hear Fail"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib3","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jchf.2018.07.012","article-title":"Aortic insufficiency during contemporary left ventricular assist device support: analysis of the INTERMACS registry","volume":"6","author":"Truby","year":"2018","journal-title":"JACC Hear Fail"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib4","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jtcvs.2013.09.069","article-title":"Computational fluid dynamics in patients with continuous-flow left ventricular assist device support show hemodynamic alterations in the ascending aorta","volume":"147","author":"Karmonik","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.healun.2018.07.002","article-title":"Aortic regurgitation in patients with a left ventricular assist device: a contemporary review","volume":"37","author":"Bouabdallaoui","year":"2018","journal-title":"J Hear Lung Transplant"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/01.mat.0000201961.97981.e9","article-title":"Effect of left ventricular assist device outflow conduit anastomosis location on flow patterns in the native aorta","volume":"52","author":"May-Newman","year":"2006","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jtcvs.2015.05.034","article-title":"Computational fluid dynamic study of hemodynamic effects on aortic root blood flow of systematically varied left ventricular assist device graft anastomosis design","volume":"150","author":"Callington","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10439-016-1762-8","article-title":"SimVascular: an open source pipeline for cardiovascular simulation","volume":"45","author":"Updegrove","year":"2017","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2008","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/MAT.0000000000000042","article-title":"De novo aortic insufficiency during long-term support on a left ventricular assist device: a systematic review and meta-analysis","volume":"60","author":"Deo","year":"2014","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib11","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.athoracsur.2017.01.114","article-title":"De novo aortic regurgitation after continuous-flow left ventricular assist device implantation","volume":"104","author":"Gasparovic","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/icvts\/ivt263","article-title":"Analysis of aortic valve commissural fusion after support with continuous-flow left ventricular assist device","volume":"17","author":"Martina","year":"2013","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11897-013-0172-6","article-title":"Management of aortic insufficiency in the continuous flow left ventricular assist device population","volume":"11","author":"Holtz","year":"2014","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib14","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.healun.2018.07.012","article-title":"Aortic root thrombosis in patients supported with continuous-flow left ventricular assist devices","volume":"37","author":"Fried","year":"2018","journal-title":"J Hear Lung Transplant"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1161\/01.RES.35.4.608","article-title":"Measured turbulence and its effect on thrombus formation","volume":"35","author":"Stein","year":"1974","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.jtcvs.2020.04.164_bib16","doi-asserted-by":"crossref","first-page":"e88304","DOI":"10.1371\/journal.pone.0088304","article-title":"Wall shear stress effects on endothelial-endothelial and endothelial-smooth muscle cell interactions in tissue engineered models of the vascular wall","volume":"9","author":"Shav","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib17","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nm.1955","article-title":"A shear gradient\u2013dependent platelet aggregation mechanism drives thrombus formation","volume":"15","author":"Nesbitt","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib18","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1016\/j.jbiomech.2010.04.020","article-title":"Device thrombogenicity emulator (DTE) \u00c0 Design optimization methodology for cardiovascular devices: a study in two bileaflet MHV designs","volume":"43","author":"Xenos","year":"2010","journal-title":"J Biomech"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib19","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.healun.2014.11.008","article-title":"Concomitant aortic valve procedures in patients undergoing implantation of continuous-flow left ventricular assist devices: an INTERMACS database analysis","volume":"34","author":"Robertson","year":"2015","journal-title":"J Hear Lung Transplant"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/MAT.0000000000000443","article-title":"LVAD Outflow Graft Angle and Thrombosis Risk","volume":"63","author":"Aliseda","year":"2017","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1525-1594.1998.06137.x","article-title":"Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall","volume":"22","author":"Nishimura","year":"1998","journal-title":"Artif Organs"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0003-4975(02)04087-0","article-title":"Smooth muscle cell hypertrophy of renal cortex arteries with chronic continuous flow left ventricular assist","volume":"75","author":"Kihara","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2020.04.164_bib23","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s10439-009-9760-8","article-title":"On coupling a lumped parameter heart model and a three-dimensional finite element aorta model","volume":"37","author":"Kim","year":"2009","journal-title":"Ann Biomed Eng"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522320311739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522320311739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T17:14:43Z","timestamp":1758388483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522320311739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0022522320311739"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2020.04.164","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of patient-specific computational models for optimization of aortic insufficiency after implantation of left ventricular assist device","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2020.04.164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}