{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:14:03Z","timestamp":1784243643539,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006370","name":"Small Business Innovation Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2T32AR007592-21"],"award-info":[{"award-number":["2T32AR007592-21"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jtcvs.2020.06.154","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T16:32:18Z","timestamp":1598977938000},"page":"975-986.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Exosomes isolated from human cardiosphere\u2013derived cells attenuate pressure overload\u2013induced right ventricular dysfunction"],"prefix":"10.1016","volume":"162","author":[{"given":"Gregory J.","family":"Bittle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Pietris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Parchment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Parsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiel","family":"Peck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher B.","family":"Deatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Rodriguez-Borlado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Marb\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunjay","family":"Kaushal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2020.06.154_bib1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0022-5223(02)73575-7","article-title":"Right ventricle-pulmonary artery shunt in first-stage palliation of hypoplastic left heart syndrome","volume":"126","author":"Sano","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/CIRCULATIONAHA.109.881904","article-title":"Mortality in the first 5 years in infants with functional single ventricle born in Texas, 1996-2003","volume":"121","author":"Fixler","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jpeds.2008.03.009","article-title":"Decreasing number of deaths of infants with hypoplastic left heart syndrome","volume":"153","author":"Gordon","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jpeds.2008.05.059","article-title":"Prevalence of congenital heart defects in metropolitan Atlanta, 1998-2005","volume":"153","author":"Reller","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib5","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/CIRCULATIONAHA.107.741579","article-title":"Two-year survival and mental and psychomotor outcomes after the Norwood procedure: an analysis of the modified Blalock-Taussig shunt and right ventricle-to-pulmonary artery shunt surgical eras","volume":"118","author":"Atallah","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib6","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0002-9149(00)01131-0","article-title":"Two-dimensional echocardiographic assessment of right ventricular function in hypoplastic left heart syndrome","volume":"86","author":"Altmann","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1080\/14779072.2017.1379898","article-title":"Stem cell therapy for the systemic right ventricle","volume":"15","author":"Si","year":"2017","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.healun.2011.12.013","article-title":"Early survival after heart transplant in young infants is lowest after failed single-ventricle palliation: a multi-institutional study","volume":"31","author":"Everitt","year":"2012","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib9","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.116.304671","article-title":"Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial","volume":"116","author":"Ishigami","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib10","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jtcvs.2015.06.076","article-title":"Transcoronary infusion of cardiac progenitor cells in hypoplastic left heart syndrome: three-year follow-up of the transcoronary infusion of cardiac progenitor cells in patients with single-ventricle physiology (TICAP) trial","volume":"150","author":"Tarui","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib11","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/CIRCRESAHA.116.310253","article-title":"Intracoronary cardiac progenitor cells in single ventricle physiology: the PERSEUS randomized phase 2 trial","volume":"120","author":"Ishigami","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib12","doi-asserted-by":"crossref","first-page":"916837","DOI":"10.1155\/2013\/916837","article-title":"Human cardiospheres as a source of multipotent stem and progenitor cells","volume":"2013","author":"Barile","year":"2013","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.yjmcc.2010.08.005","article-title":"Paracrine mechanisms of stem cell reparative and regenerative actions in the heart","volume":"50","author":"Mirotsou","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib14","doi-asserted-by":"crossref","first-page":"H2308","DOI":"10.1152\/ajpheart.00565.2008","article-title":"VEGF is critical for stem-cell mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function","volume":"295","author":"Markel","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2011.11.029","article-title":"Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells","volume":"59","author":"Li","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib16","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/CIRCRESAHA.116.309782","article-title":"A deep proteome analysis identifies the complete secretome as the functional unit of human cardiac progenitor cells","volume":"120","author":"Sharma","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib17","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.athoracsur.2017.04.058","article-title":"Cardiac progenitor cells enhance neonatal right ventricular function after pulmonary artery banding","volume":"104","author":"Wehman","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib18","doi-asserted-by":"crossref","first-page":"H1816","DOI":"10.1152\/ajpheart.00955.2015","article-title":"Mesenchymal stem cells preserve neonatal right ventricular function in a porcine model of pressure overload","volume":"310","author":"Wehman","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ahj.2017.06.009","article-title":"Study design and rationale for ELPIS: a phase I\/IIb randomized pilot study of allogeneic human mesenchymal stem cell injection in patients with hypoplastic left heart syndrome","volume":"192","author":"Kaushal","year":"2017","journal-title":"Am Heart J"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jacc.2013.08.724","article-title":"Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial","volume":"63","author":"Malliaras","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/emmm.201201737","article-title":"Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart","volume":"5","author":"Malliaras","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib22","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1084\/jem.20070166","article-title":"Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart","volume":"204","author":"Cho","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nm0405-367","article-title":"Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells","volume":"11","author":"Gnecchi","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1096\/fj.05-5211com","article-title":"Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement","volume":"20","author":"Gnecchi","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib25","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","article-title":"Paracrine mechanisms in adult stem cell signaling and therapy","volume":"103","author":"Gnecchi","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/CIRCULATIONAHA.109.871905","article-title":"Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction","volume":"121","author":"Tang","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/CIRCULATIONAHA.111.042598","article-title":"Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells","volume":"125","author":"Malliaras","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib28","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvu167","article-title":"Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction","volume":"103","author":"Barile","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib29","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.stemcr.2014.04.006","article-title":"Exosomes as critical agents of cardiac regeneration triggered by cell therapy","volume":"2","author":"Ibrahim","year":"2014","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib30","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2013.01.015","article-title":"Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia\/reperfusion injury","volume":"431","author":"Chen","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jtcvs.2020.06.154_bib32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1126\/science.1114519","article-title":"MicroRNA expression in zebrafish embryonic development","volume":"309","author":"Wienholds","year":"2005","journal-title":"Science"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522320324855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522320324855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T17:13:11Z","timestamp":1758388391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522320324855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0022522320324855"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2020.06.154","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomes isolated from human cardiosphere\u2013derived cells attenuate pressure overload\u2013induced right ventricular dysfunction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2020.06.154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}