{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:20:01Z","timestamp":1792552801532,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":732,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jtcvs.2021.02.099","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T20:39:57Z","timestamp":1617914397000},"page":"427-436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Perioperative outcomes of pulmonary resection after neoadjuvant pembrolizumab in patients with non\u2013small cell lung cancer"],"prefix":"10.1016","volume":"163","author":[{"given":"Betty C.","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Wigle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"David H.","family":"Harpole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A.","family":"Klapper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal E.","family":"Ready","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"D'Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2021.02.099_bib1","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib2","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.6004\/jnccn.2019.0059","article-title":"NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 1.2020","volume":"17","author":"Ettinger","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib3","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.jtcvs.2019.08.138","article-title":"The immunotherapeutic landscape in non-small cell lung cancer and its surgical horizons","volume":"159","author":"Rhodin","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jtcvs.2018.11.124","article-title":"Initial results of pulmonary resection after neoadjuvant nivolumab in patients with resectable non-small cell lung cancer","volume":"158","author":"Bott","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib5","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.athoracsur.2017.09.030","article-title":"Surgical outcomes after neoadjuvant chemotherapy and ipilimumab for non-small cell lung cancer","volume":"105","author":"Sepesi","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib6","doi-asserted-by":"crossref","first-page":"S241","DOI":"10.1016\/j.jtho.2019.08.481","article-title":"Surgical outcomes following neoadjuvant nivolumab or nivolumab plus ipilimumab in non-small cell lung cancer - NEOSTAR Study","volume":"14","author":"Sepesi","year":"2019","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib7","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S1470-2045(20)30140-6","article-title":"Neoadjuvant atezolizumab and chemotherapy in patients with resectable non-small-cell lung cancer: an open-label, multicentre, single-arm, phase 2 trial","volume":"21","author":"Shu","year":"2020","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jtho.2016.09.122","article-title":"Timing of surgery after neoadjuvant chemoradiation in locally advanced non-small cell lung cancer","volume":"12","author":"Gao","year":"2017","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib9","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.athoracsur.2019.09.076","article-title":"Optimal surgical timing after neoadjuvant therapy for stage IIIa non-small cell lung cancer","volume":"109","author":"Rice","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib10","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00050-2017","article-title":"Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients","volume":"50","author":"Delaunay","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib11","doi-asserted-by":"crossref","first-page":"e001282","DOI":"10.1136\/jitc-2020-001282","article-title":"Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer","volume":"8","author":"Reuss","year":"2020","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ctrv.2017.07.002","article-title":"Atypical responses in patients with advanced melanoma, lung cancer, renal-cell carcinoma and other solid tumors treated with anti-PD-1 drugs: a systematic review","volume":"59","author":"Queriolo","year":"2017","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/01.sla.0000234892.79056.63","article-title":"Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients","volume":"244","author":"Onaitis","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jtcvs.2014.08.074","article-title":"Intraoperative conversion from video-assisted thoracoscopic surgery lobectomy to open thoracotomy: a study of causes and implications","volume":"149","author":"Puri","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"Suppl 3","key":"10.1016\/j.jtcvs.2021.02.099_bib15","first-page":"S267","article-title":"Feasibility of complete video-assisted thoracoscopic surgery following neoadjuvant therapy for locally advanced non-small cell lung cancer","volume":"5","author":"Huang","year":"2013","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib16","doi-asserted-by":"crossref","first-page":"S406","DOI":"10.21037\/jtd.2016.04.56","article-title":"Minimally invasive (robotic assisted thoracic surgery and video-assisted thoracic surgery) lobectomy for the treatment of locally advanced non-small cell lung cancer","volume":"8","author":"Park","year":"2016","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.athoracsur.2010.03.100","article-title":"Risk factors for atrial fibrillation after lung cancer surgery: analysis of the Society of Thoracic Surgeons general thoracic surgery database","volume":"90","author":"Onaitis","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib18","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jtcvs.2009.08.026","article-title":"Thoracoscopic lobectomy is associated with lower morbidity than open lobectomy: a propensity-matched analysis from the STS database","volume":"139","author":"Paul","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib19","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S1470-2045(16)00173-X","article-title":"Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial","volume":"17","author":"Bendixen","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S1052-3359(25)00373-4","article-title":"Postoperative atelectasis","volume":"8","author":"Massard","year":"1998","journal-title":"Chest Surg Clin N Am"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib21","doi-asserted-by":"crossref","first-page":"S369","DOI":"10.1016\/j.jtho.2018.08.346","article-title":"Neoadjuvant atezolizumab in resectable non-small cell lung cancer (NSCLC): updated results from a multicenter study (LCMC3)","volume":"13","author":"Rusch","year":"2018","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.annonc.2019.10.008","article-title":"Adverse event profile for immunotherapy agents compared with chemotherapy in solid organ tumors: a systematic review and meta-analysis of randomized clinical trials","volume":"31","author":"Magee","year":"2020","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fonc.2018.00005","article-title":"Before or after: evolving neoadjuvant approaches to locally advanced non-small cell lung cancer","volume":"8","author":"Lewis","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib24","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1200\/JOP.2017.025288","article-title":"Representation of minorities and women in oncology clinical trials: review of the past 14 years","volume":"14","author":"Duma","year":"2018","journal-title":"J Oncol Pract"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib25","first-page":"djx077","article-title":"Proportion of study volunteers by race and ethnicity in clinical research studies, 2012","volume":"109","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(04)17670-8","article-title":"External validity of randomised controlled trials: \"to whom do the results of this trial apply?\"","volume":"365","author":"Rothwell","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib27","doi-asserted-by":"crossref","first-page":"S2006","DOI":"10.1016\/j.jtho.2017.09.945","article-title":"PD-L1 expression analysis in African American (AA) and Hispanic lung cancer patients at a minority-based academic cancer center","volume":"12","author":"Shum","year":"2017","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib28","doi-asserted-by":"crossref","first-page":"e18073","DOI":"10.1200\/JCO.2017.35.15_suppl.e18073","article-title":"PD-L1 expression profile and immunotherapy (IO) experience in African American (AA) and Hispanic (H) lung cancer (LC) patients: Addressing disparities at a minority-based academic cancer center","volume":"35","author":"Shum","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jtcvs.2021.02.099_bib29","first-page":"2235","article-title":"Racial disparities in the molecular landscape of cancer","volume":"38","author":"Heath","year":"2018","journal-title":"Anticancer Res"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321005833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321005833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T17:15:42Z","timestamp":1758388542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522321005833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0022522321005833"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.02.099","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perioperative outcomes of pulmonary resection after neoadjuvant pembrolizumab in patients with non\u2013small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.02.099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}