{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:33:30Z","timestamp":1785148410464,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jtcvs.2021.06.029","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T03:07:42Z","timestamp":1624676862000},"page":"e207-e226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Inhibition of mitochondrial reactive oxygen species improves coronary endothelial function after cardioplegic hypoxia\/reoxygenation"],"prefix":"10.1016","volume":"164","author":[{"given":"Yi","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth O.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W.","family":"Sellke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2021.06.029_bib1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.4103\/ija.IJA_379_17","article-title":"Basics of cardiopulmonary bypass","volume":"61","author":"Sarkar","year":"2017","journal-title":"Indian J Anaesthes"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib2","doi-asserted-by":"crossref","unstructured":"Tempe DK, Saigal D. Myocardial protection during cardiac surgery: An overview of cardioplegia: In: Sehgal R, Trikha A, eds. Yearbook of Anesthesiology-7. 2018;(Chapter 24):285-305.","DOI":"10.5005\/jp\/books\/14141_25"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fphar.2015.00296","article-title":"Strategies for pharmacological organoprotection during extracorporeal circulation targeting ischemia-reperfusion injury","volume":"6","author":"Salameh","year":"2015","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib4","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1097\/HCO.0000000000000340","article-title":"Microvascular dysfunction in patients with diabetes after cardioplegic arrest and cardiopulmonary bypass","volume":"31","author":"Feng","year":"2016","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib5","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.jtcvs.2018.05.090","article-title":"Enhanced coronary arteriolar contraction to vasopressin in patients with diabetes after cardiac surgery","volume":"156","author":"Sellke","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib6","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jtcvs.2009.05.032","article-title":"Altered coronary microvascular serotonin receptor expression after coronary artery bypass grafting with cardiopulmonary bypass","volume":"139","author":"Robich","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib7","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1161\/CIRCULATIONAHA.111.084590","article-title":"Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes","volume":"126","author":"Feng","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.surg.2008.03.032","article-title":"Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass","volume":"144","author":"Liu","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12012-018-9493-8","article-title":"Endothelial cells: from dysfunction mechanism to pharmacological effect in cardiovascular disease","volume":"19","author":"Haybar","year":"2019","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib10","first-page":"e04","article-title":"From oxidative stress to endothelial cell dysfunction","volume":"1","author":"Shahreza","year":"2016","journal-title":"J Prev Epidemiol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1253\/circj.CJ-08-1169","article-title":"Endothelial dysfunction","volume":"73","author":"Vanhoutte","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sj.bjp.0705425","article-title":"EDHF and endothelial potassium channels: IKCa and SKCa","volume":"140","author":"F\u00e9l\u00e9tou","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib13","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1124\/jpet.111.179242","article-title":"Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat","volume":"339","author":"Stankevi\u010dius","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib14","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1167\/iovs.08-3168","article-title":"Role of calcium-activated potassium channels with small conductance in bradykinin-induced vasodilation\u00a0of porcine retinal arterioles","volume":"50","author":"Dalsgaard","year":"2009","journal-title":"J Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib15","doi-asserted-by":"crossref","first-page":"e002062","DOI":"10.1161\/JAHA.115.002062","article-title":"Inactivation of endothelial small\/intermediate conductance of calcium; activated potassium channels contributes to coronary arteriolar dysfunction in diabetic patients","volume":"4","author":"Liu","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib16","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1161\/CIRCULATIONAHA.107.755827","article-title":"Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest","volume":"118","author":"Feng","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jtcvs.2010.04.005","article-title":"Use of intermediate\/small conductance calcium-activated potassium-channel activator for endothelial protection","volume":"141","author":"Yang","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib18","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jtcvs.2020.01.078","article-title":"Coronary endothelial dysfunction prevented by small-conductance calcium-activated potassium channel activator in mice and patients with diabetes","volume":"160","author":"Zhang","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2020.03.028","article-title":"Metabolic regulation of endothelial SK channels and human coronary microvascular function","volume":"312","author":"Liu","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib20","doi-asserted-by":"crossref","first-page":"25234","DOI":"10.3390\/ijms161025234","article-title":"Diabetic cardiovascular disease induced by oxidative stress","volume":"16","author":"Kayama","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCHEARTFAILURE.111.961565","article-title":"p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation","volume":"5","author":"Nakamura","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib22","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1139\/cjpp-2016-0142","article-title":"Dysfunction of endothelial progenitor cells in hyperlipidemic rats involves the increase of NADPH oxidase derived reactive oxygen species production","volume":"95","author":"Li","year":"2017","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.redox.2018.02.006","article-title":"Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: role of insufficient hydrogen sulfide","volume":"16","author":"Cheng","year":"2018","journal-title":"Redox Biol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib24","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/CIRCRESAHA.111.300233","article-title":"Mitochondria and endothelial function","volume":"112","author":"Kluge","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib25","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.freeradbiomed.2007.12.036","article-title":"A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria","volume":"44","author":"Trnka","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib26","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1089\/ars.2010.3713","article-title":"Lipopolysaccharide-induced mitochondrial DNA depletion","volume":"15","author":"Choumar","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib27","doi-asserted-by":"crossref","first-page":"F734","DOI":"10.1152\/ajprenal.00643.2013","article-title":"Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury","volume":"306","author":"Patil","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib28","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1016\/j.ajpath.2014.05.019","article-title":"Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis","volume":"184","author":"Wang","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.109.214601","article-title":"Therapeutic targeting of mitochondrial superoxide in hypertension","volume":"107","author":"Dikalova","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-374841-6.00001-3","article-title":"A practical guide to the preparation of Ca(2+) buffers","volume":"99","author":"Bers","year":"2010","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib31","first-page":"II395","article-title":"Coronary endothelial injury after cardiopulmonary bypass and ischemic cardioplegia is mediated by oxygen-derived free radicals","volume":"88","author":"Sellke","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib32","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0003-4975(10)64518-3","article-title":"The effects of cardiopulmonary bypass and cold cardioplegia on coronary flow velocity and the reactive hyperemic response in patients and dogs","volume":"45","author":"Hiratzka","year":"1988","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib33","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0022-5223(98)70059-5","article-title":"Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction","volume":"116","author":"Tofukuji","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib34","doi-asserted-by":"crossref","first-page":"4350965","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-mediated cellular signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib35","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib36","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species","volume":"44","author":"He","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib37","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0008-6363(00)00078-X","article-title":"Status of myocardial antioxidants in ischemia\u2013reperfusion injury","volume":"47","author":"Dhalla","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-017-3264-x","article-title":"Decreased coronary arteriolar response to KCa channel opener after cardioplegic arrest in diabetic patients","volume":"445","author":"Liu","year":"2018","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib39","doi-asserted-by":"crossref","first-page":"H886","DOI":"10.1152\/ajpheart.00216.2004","article-title":"Mathematical modeling of the nitric oxide\/cGMP pathway in the vascular smooth muscle cell","volume":"289","author":"Yang","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1085\/jgp.200709875","article-title":"Ca2+-activated K+ channels in murine endothelial cells: block by intracellular calcium and magnesium","volume":"131","author":"Ledoux","year":"2008","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/hr.2016.180","article-title":"The NOX2-derived reactive oxygen species damaged endothelial nitric oxide system via suppressed BKCa\/SKCa in preeclampsia","volume":"40","author":"Chen","year":"2017","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib42","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jtcvs.2020.01.078","article-title":"Coronary endothelial dysfunction prevented by small-conductance calcium-activated potassium channel activator in mice and patients with diabetes","volume":"160","author":"Zhang","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib43","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s004240050444","article-title":"Kinetic properties of DM-nitrophen and calcium indicators: rapid transient response to flash photolysis","volume":"434","author":"Escobar","year":"1997","journal-title":"Pflugers Arch"},{"issue":"Pt 3","key":"10.1016\/j.jtcvs.2021.06.029_bib44","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1113\/jphysiol.1995.sp020991","article-title":"Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes","volume":"488","author":"Trafford","year":"1995","journal-title":"J Physiol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-374841-6.00001-3","article-title":"A practical guide to the preparation of Ca(2+) buffers","volume":"99","author":"Bers","year":"2010","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002062","article-title":"Inactivation of endothelial small\/intermediate conductance of calcium activated potassium channels contributes to coronary arteriolar dysfunction in diabetic patients","volume":"4","author":"Liu","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jtcvs.2021.06.029_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2020.03.028","article-title":"Metabolic regulation of endothelial SK channels and human coronary microvascular function","volume":"312","author":"Liu","year":"2020","journal-title":"Int J Cardiol"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321009831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321009831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T17:19:03Z","timestamp":1758388743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522321009831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0022522321009831"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.06.029","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of mitochondrial reactive oxygen species improves coronary endothelial function after cardioplegic hypoxia\/reoxygenation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.06.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}