{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:16:14Z","timestamp":1775178974746,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL089315-11"],"award-info":[{"award-number":["R01HL089315-11"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18POST33990223"],"award-info":[{"award-number":["18POST33990223"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jtcvs.2021.08.013","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T23:37:58Z","timestamp":1629157078000},"page":"e389-e405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["A neonatal leporine model of age-dependent natural heart regeneration after myocardial infarction"],"prefix":"10.1016","volume":"164","author":[{"given":"Hanjay","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille E.","family":"Hironaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle M.","family":"Mullis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haley J.","family":"Lucian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Sook","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshara D.","family":"Thakore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Anilkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanjia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam W.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. Joseph","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2021.08.013_bib1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 Study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib2","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.CIR.0000036014.90197.FA","article-title":"Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications","volume":"106","author":"Bolognese","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jmbbm.2019.04.014","article-title":"Bioengineered analog of stromal cell-derived factor 1\u03b1 preserves the biaxial mechanical properties of native myocardium after infarction","volume":"96","author":"Wang","year":"2019","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.18632\/aging.101796","article-title":"Photosynthetic symbiotic therapy","volume":"11","author":"Wang","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib5","doi-asserted-by":"crossref","first-page":"674172","DOI":"10.3389\/fbioe.2021.674172","article-title":"The expanding armamentarium of innovative bioengineered strategies to augment cardiovascular repair and regeneration","volume":"9","author":"Elde","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib6","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.jtcvs.2019.11.140","article-title":"Neonatal heart regeneration: moving from phenomenology to regenerative medicine","volume":"159","author":"Sadek","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib8","doi-asserted-by":"crossref","first-page":"966","DOI":"10.18632\/aging.100526","article-title":"Complete cardiac regeneration in a mouse model of myocardial infarction","volume":"4","author":"Haubner","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib9","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.cell.2018.12.023","article-title":"A unique collateral artery development\u00a0program promotes neonatal heart regeneration","volume":"176","author":"Das","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib10","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1038\/s41598-020-63324-w","article-title":"Multiaxial lenticular stress-strain relationship of native myocardium is preserved by infarct-induced natural heart regeneration in neonatal mice","volume":"10","author":"Wang","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/cells9010229","article-title":"Natural heart regeneration in a neonatal rat myocardial infarction model","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib12","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1161\/CIRCULATIONAHA.118.034886","article-title":"Regenerative potential of neonatal porcine hearts","volume":"138","author":"Zhu","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib13","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","article-title":"Early regenerative capacity in the porcine heart","volume":"138","author":"Ye","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCRESAHA.115.307017","article-title":"Functional recovery of a human neonatal heart after severe myocardial infarction","volume":"118","author":"Haubner","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCRESAHA.119.315408","article-title":"Polyploidy in cardiomyocytes: roadblock to heart regeneration?","volume":"126","author":"Derks","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib16","first-page":"159","article-title":"Variability of cardiomyocyte DNA content, ploidy level and nuclear number in mammalian hearts","volume":"429","author":"Adler","year":"1996","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1525-1594.2002.06881.x","article-title":"Chronic heart failure model in rabbits based on the concept of the bifurcation\/trifurcation coronary artery branching pattern","volume":"26","author":"Lee","year":"2002","journal-title":"Artif Organs"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib18","doi-asserted-by":"crossref","first-page":"16012","DOI":"10.1038\/npjregenmed.2016.12","article-title":"Evolution, comparative biology and ontogeny of vertebrate heart regeneration","volume":"1","author":"Vivien","year":"2016","journal-title":"NPJ Regen Med"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00246-019-02163-7","article-title":"Postnatal cardiac development and regenerative potential in large mammals","volume":"40","author":"Velayutham","year":"2019","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib20","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/ng.3929","article-title":"Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration","volume":"49","author":"Patterson","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib21","doi-asserted-by":"crossref","first-page":"e53071","DOI":"10.7554\/eLife.53071","article-title":"Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling","volume":"9","author":"Shen","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-physiol-021119-034618","article-title":"Cardiomyocyte polyploidy and implications for heart regeneration","volume":"82","author":"Gan","year":"2020","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/CIRCULATIONAHA.118.033648","article-title":"Neonatal heart regeneration: comprehensive literature review","volume":"138","author":"Lam","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aao5553","article-title":"The local microenvironment limits the regenerative potential of the mouse neonatal heart","volume":"4","author":"Notari","year":"2018","journal-title":"Sci Adv"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1177\/2150135111413615","article-title":"Midterm outcome after surgical correction of anomalous left coronary artery from pulmonary artery","volume":"2","author":"Bakhtiary","year":"2011","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib26","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/CIRCULATIONAHA.119.044619","article-title":"Apical resection prolongs the cell cycle activity and promotes myocardial regeneration after left ventricular injury in neonatal pig","volume":"142","author":"Zhao","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib27","first-page":"53","article-title":"Regeneration of the myocardium of fetuses and newborn rabbits [in Russian]","volume":"39","author":"Malyshev","year":"1977","journal-title":"Arkh Patol"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib28","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1161\/CIRCULATIONAHA.117.030801","article-title":"Complement receptor c5ar1 plays an evolutionarily conserved role in successful cardiac regeneration","volume":"137","author":"Natarajan","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib29","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jtcvs.2017.08.127","article-title":"Angiogenesis precedes cardiomyocyte migration in regenerating mammalian hearts","volume":"155","author":"Ingason","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib30","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.aar2038","article-title":"Evidence for hormonal control of heart regenerative capacity during endothermy acquisition","volume":"364","author":"Hirose","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11886-020-01282-5","article-title":"Mechanisms of neonatal heart regeneration","volume":"22","author":"Cardoso","year":"2020","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib32","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s12265-017-9772-y","article-title":"SDF 1-alpha attenuates myocardial injury without altering the direct contribution of circulating cells","volume":"11","author":"Goldstone","year":"2018","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib33","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-019-1802-2","article-title":"An acute immune response underlies the benefit of cardiac stem cell therapy","volume":"577","author":"Vagnozzi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jtcvs.2021.08.013_bib34","doi-asserted-by":"crossref","first-page":"674180","DOI":"10.3389\/fcell.2021.674180","article-title":"Navigating the crossroads of cell therapy and natural heart regeneration","volume":"9","author":"Elde","year":"2021","journal-title":"Front Cell Dev Biol"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321012113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321012113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T17:20:22Z","timestamp":1758388822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522321012113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0022522321012113"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.08.013","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A neonatal leporine model of age-dependent natural heart regeneration after myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}