{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:21:47Z","timestamp":1764904907653,"version":"3.44.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM103730"],"award-info":[{"award-number":["T32GM103730"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jtcvs.2021.08.061","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T10:53:26Z","timestamp":1631616806000},"page":"141-152.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mitral regurgitation severity at left ventricular assist device implantation is associated with distinct myocardial transcriptomic signatures"],"prefix":"10.1016","volume":"166","author":[{"given":"Neal M.","family":"Duggal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ienglam","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith D.","family":"Aaronson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis D.","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo Y.-K.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan W.","family":"Haft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven F.","family":"Bolling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Abou El Ela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Janda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorav","family":"Ailawadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Nordsletten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2021.08.061_bib1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.healun.2020.03.003","article-title":"Impact of left ventricular assist device implantation on mitral regurgitation: an analysis from the MOMENTUM 3 trial","volume":"39","author":"Kanwar","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jtcvs.2019.03.089","article-title":"Right ventricular function and residual mitral regurgitation after left ventricular assist device implantation determines the incidence of right heart failure","volume":"159","author":"Tang","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib3","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/MAT.0b013e31826e4267","article-title":"Left ventricular reverse remodeling with a continuous-flow left ventricular assist device measured by left ventricular end-diastolic dimensions and severity of mitral regurgitation","volume":"58","author":"Morgan","year":"2012","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/MAT.0b013e31829ff57d","article-title":"Mitral regurgitation and axial flow left ventricular assist device: a computer simulation study","volume":"59","author":"Jelenc","year":"2013","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib5","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.healun.2014.11.023","article-title":"Uncorrected pre-operative mitral valve regurgitation is not associated with adverse outcomes after continuous-flow left ventricular assist device implantation","volume":"34","author":"Stulak","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/CRD.0000000000000269","article-title":"Functional mitral regurgitation in heart failure","volume":"27","author":"Shah","year":"2019","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib7","doi-asserted-by":"crossref","first-page":"e003157","DOI":"10.1161\/CIRCHEARTFAILURE.116.003157","article-title":"Myocardial recovery in patients receiving contemporary left ventricular assist devices: results from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)","volume":"9","author":"Topkara","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib8","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/ehf2.12629","article-title":"Outcomes of patients after successful left ventricular assist device explantation: a EUROMACS study","volume":"7","author":"Antonides","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib9","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jacc.2007.12.014","article-title":"Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure","volume":"51","author":"Kawase","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/clc.22900","article-title":"Specific biomarkers of myocardial inflammation and remodeling processes as predictors of mortality in high-risk patients undergoing percutaneous mitral valve repair (MitraClip)","volume":"41","author":"D\u00f6rr","year":"2018","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijcard.2016.10.038","article-title":"Inflammation versus mechanical stretch biomarkers over time in acutely decompensated heart failure with reduced ejection fraction","volume":"226","author":"Boulogne","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib12","first-page":"244","article-title":"Continuous-flow left ventricular assist devices and valvular heart disease: a comprehensive review","volume":"36","author":"Noly","year":"2020","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.healun.2013.06.025","article-title":"Outcome of unplanned right ventricular assist device support for severe right heart failure after implantable left ventricular assist device insertion","volume":"33","author":"Takeda","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib14","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.healun.2015.05.005","article-title":"Validation of clinical scores for right ventricular failure prediction after implantation of continuous-flow left ventricular assist devices","volume":"34","author":"Kalogeropoulos","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.healun.2017.09.016","article-title":"Concomitant mitral valve procedures in patients undergoing implantation of continuous-flow left ventricular assist devices: an INTERMACS database analysis","volume":"37","author":"Robertson","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jchf.2016.09.014","article-title":"Significance of residual mitral regurgitation after continuous flow left ventricular assist device implantation","volume":"5","author":"Kassis","year":"2017","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib17","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/aor.12831","article-title":"Impact of residual mitral regurgitation on right ventricular systolic function after left ventricular assist device implantation","volume":"41","author":"Ertugay","year":"2017","journal-title":"Artif Organs"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/MAT.0b013e31829be026","article-title":"Mitral valve repair at the time of continuous-flow left ventricular assist device implantation confers meaningful decrement in pulmonary vascular resistance","volume":"59","author":"Taghavi","year":"2013","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.116.308030","article-title":"Chronic heart failure and inflammation: what do we really know?","volume":"119","author":"Dick","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib21","doi-asserted-by":"crossref","first-page":"20200098","DOI":"10.1098\/rsif.2020.0098","article-title":"Mitral valve leaflet response to ischaemic mitral regurgitation: from gene expression to tissue remodelling","volume":"17","author":"Howsmon","year":"2020","journal-title":"J R Soc Interface"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib22","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1001\/jamacardio.2020.1555","article-title":"Hybrid positron emission tomography\/magnetic resonance imaging in arrhythmic mitral valve prolapse","volume":"5","author":"Miller","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cpet.2018.12.009","article-title":"Potential role of PET in assessing ventricular arrhythmias","volume":"14","author":"Muser","year":"2019","journal-title":"PET Clin"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib24","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.hrthm.2015.08.014","article-title":"Incidence of abnormal positron emission tomography in patients with unexplained cardiomyopathy and ventricular arrhythmias: the potential role of occult inflammation in arrhythmogenesis","volume":"12","author":"Tung","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12265-016-9703-3","article-title":"CXCL10 is a circulating inflammatory marker in patients with advanced heart failure: a pilot study","volume":"9","author":"Altara","year":"2016","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4396368","article-title":"The CXCL10\/CXCR3 axis and cardiac inflammation: implications for immunotherapy to treat infectious and noninfectious diseases of the heart","volume":"2016","author":"Altara","year":"2016","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib27","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00065.2017","article-title":"Innate immune signaling and its role in metabolic and cardiovascular diseases","volume":"99","author":"Xu","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib28","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.molimm.2006.02.026","article-title":"Identification of IRF-8 and IRF-1 target genes in activated macrophages","volume":"44","author":"Dror","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib29","doi-asserted-by":"crossref","first-page":"e0171459","DOI":"10.1371\/journal.pone.0171459","article-title":"Correction: interferon regulatory factor 6 has a protective role in the host response to endotoxic shock","volume":"12","author":"Joly","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib30","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.118.039262","article-title":"S100a8\/a9 Signaling causes mitochondrial dysfunction and cardiomyocyte death in response to ischemic\/reperfusion injury","volume":"140","author":"Li","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2019.02.022","article-title":"Myeloperoxidase - a bridge linking inflammation and oxidative stress with cardiovascular disease","volume":"493","author":"Ndrepepa","year":"2019","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib32","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s12012-017-9441-z","article-title":"Necrostatin-1 protects against paraquat-induced cardiac contractile dysfunction via RIP1-RIP3-MLKL-dependent necroptosis pathway","volume":"18","author":"Zhang","year":"2018","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib33","doi-asserted-by":"crossref","first-page":"7782","DOI":"10.3390\/ijms21207782","article-title":"Programmed cell death in the left and right ventricle of the late phase of post-infarction heart failure","volume":"21","author":"Lichy","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib34","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S1053-2498(02)00557-0","article-title":"Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure","volume":"22","author":"Barton","year":"2003","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib35","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","article-title":"NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2119\/2006-00043.Molnar","article-title":"Activation of the poly(ADP-ribose) polymerase pathway in human heart failure","volume":"12","author":"Molnar","year":"2006","journal-title":"Mol Med"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12979-016-0080-1","article-title":"The inflammatory protein Pentraxin 3 in cardiovascular disease","volume":"13","author":"Fornai","year":"2016","journal-title":"Immun Ageing"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib38","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.healun.2013.06.004","article-title":"Pre-operative echocardiographic features associated with persistent mitral regurgitation after left ventricular assist device implantation","volume":"32","author":"Kitada","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib39","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002484","article-title":"Full expression of cardiomyopathy is partly dependent on B-cells: a pathway that involves cytokine activation, immunoglobulin deposition, and activation of apoptosis","volume":"5","author":"Cordero-Reyes","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.14797\/mdcj-9-1-15","article-title":"The role of B-cells in heart failure","volume":"9","author":"Cordero-Reyes","year":"2013","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib41","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fimmu.2019.00300","article-title":"Selectins and immune cells in acute myocardial infarction and post-infarction ventricular remodeling: pathophysiology and novel treatments","volume":"10","author":"Weil","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vph.2018.02.007","article-title":"Calcium sensing receptor expression and signalling in cardiovascular physiology and disease","volume":"107","author":"Schreckenberg","year":"2018","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/apha.12872","article-title":"Calcium-dependent Nedd4-2 upregulation mediates degradation of the cardiac sodium channel Nav1.5: implications for heart failure","volume":"221","author":"Luo","year":"2017","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib44","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ijcard.2016.06.253","article-title":"Characteristic adaptations of the extracellular matrix in dilated cardiomyopathy","volume":"220","author":"Louzao-Martinez","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib45","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1091\/mbc.11.7.2387","article-title":"Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases","volume":"11","author":"Yana","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-5793(01)02150-0","article-title":"Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25)","volume":"491","author":"English","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib47","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.ajpath.2012.02.018","article-title":"NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans","volume":"180","author":"Hahn","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib48","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1159\/000109148","article-title":"Involvement of NADPH oxidases in cardiac remodelling and heart failure","volume":"27","author":"Sirker","year":"2007","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/HYPERTENSIONAHA.120.15558","article-title":"Ca(2+)-Dependent NOX5 (NADPH oxidase 5) exaggerates cardiac hypertrophy through reactive oxygen species production","volume":"76","author":"Zhao","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib50","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1161\/CIRCULATIONAHA.115.016379","article-title":"Xanthine oxidase inhibitors in heart failure: where do we go from here?","volume":"131","author":"Tamariz","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib51","doi-asserted-by":"crossref","first-page":"e94249","DOI":"10.1172\/jci.insight.94249","article-title":"Pediatric dilated cardiomyopathy hearts display a unique gene expression profile","volume":"2","author":"Tatman","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib52","doi-asserted-by":"crossref","first-page":"109590","DOI":"10.1016\/j.biopha.2019.109590","article-title":"Clinical value of ARG1 in acute myocardial infarction patients: bioinformatics-based approach","volume":"121","author":"Zhang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib53","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/JOE-17-0031","article-title":"Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease","volume":"233","author":"Rodriguez-Calvo","year":"2017","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib54","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/MAT.0000000000001379","article-title":"Left ventricular assist device implantation in patients with preoperative severe mitral regurgitation","volume":"67","author":"Tang","year":"2021","journal-title":"ASAIO J"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib55","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ehf2.12919","article-title":"Persistent mitral regurgitation after left ventricular assist device: a clinical conundrum","volume":"8","author":"Cruz Rodriguez","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib56","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/j.athoracsur.2012.09.036","article-title":"Long-term use of ventricular assist device as a bridge to recovery in acute fulminant myocarditis","volume":"95","author":"George","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib57","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/eurjhf\/hfr174","article-title":"Ventricular assist device support as a bridge to heart transplantation in patients with giant cell myocarditis","volume":"14","author":"Murray","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib58","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/HYPERTENSIONAHA.107.100941","article-title":"Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response","volume":"51","author":"Fraccarollo","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib59","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00395-013-0384-7","article-title":"Anti-inflammatory and pro-angiogenic effects of beta blockers in a canine model of chronic ischemic cardiomyopathy: comparison between carvedilol and metoprolol","volume":"108","author":"Le","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib60","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/sj.jhh.1002101","article-title":"Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade","volume":"21","author":"Dandona","year":"2007","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib61","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.echo.2016.06.009","article-title":"Three-dimensional transthoracic echocardiography in the comprehensive evaluation of right and left heart chamber remodeling following percutaneous mitral valve repair","volume":"29","author":"Gripari","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jtcvs.2021.08.061_bib62","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.jtcvs.2018.12.071","article-title":"Mitral valve repair for severe mitral valve regurgitation during left ventricular assist device implantation","volume":"157","author":"Pawale","year":"2019","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321012629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321012629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T17:21:34Z","timestamp":1758388894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522321012629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0022522321012629"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.08.061","relation":{},"ISSN":["0022-5223"],"issn-type":[{"type":"print","value":"0022-5223"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitral regurgitation severity at left ventricular assist device implantation is associated with distinct myocardial transcriptomic signatures","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.08.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}