{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:34:45Z","timestamp":1784176485275,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jtcvs.2021.08.085","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T07:42:04Z","timestamp":1635147724000},"page":"e90-e99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Direct and indirect activation of the adenosine triphosphate\u2013sensitive potassium channel to induce spinal cord ischemic metabolic tolerance"],"prefix":"10.1016","volume":"165","author":[{"given":"Yuki","family":"Ikeno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian V.","family":"Ghincea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavriel F.","family":"Roda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Aftab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Weyant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Joseph C.","family":"Cleveland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Brett","family":"Reece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2021.08.085_bib1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jtcvs.2015.12.050","article-title":"Outcomes of 3309 thoracoabdominal aortic aneurysm repairs","volume":"151","author":"Coselli","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib2","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/ejcts\/ezv415","article-title":"Open thoracoabdominal aortic aneurysm repair in the modern era: results from a 20-year single-centre experience","volume":"49","author":"Murana","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib3","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jtcvs.2012.01.029","article-title":"Spinal cord protective strategies during descending and thoracoabdominal aortic aneurysm repair in the modern era: the role of intrathecal papaverine","volume":"143","author":"Lima","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"Suppl 2","key":"10.1016\/j.jtcvs.2021.08.085_bib4","doi-asserted-by":"crossref","first-page":"S475","DOI":"10.3233\/JAD-2010-100669","article-title":"Mitochondria: the missing link between preconditioning and neuroprotection","volume":"20","author":"Correia","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib5","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.addr.2008.03.020","article-title":"Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: mitochondrial targeted preconditioning","volume":"60","author":"Busija","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/aps.2012.138","article-title":"Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia","volume":"34","author":"Sun","year":"2013","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib7","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.jtcvs.2017.12.132","article-title":"Optimized induction of beta common receptor enhances the neuroprotective function of erythropoietin in spinal cord ischemic injury","volume":"155","author":"Yamanaka","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0003-4975(02)03716-5","article-title":"Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia","volume":"74","author":"Caparrelli","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib9","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2353\/ajpath.2006.050569","article-title":"The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord","volume":"168","author":"Roseborough","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib10","doi-asserted-by":"crossref","first-page":"18j","DOI":"10.1016\/0002-9149(89)90200-2","article-title":"Nicorandil as a hybrid between nitrates and potassium channel activators","volume":"63","author":"Taira","year":"1989","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib11","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2165\/11592300-000000000-00000","article-title":"Use of nicorandil in cardiovascular disease and its optimization","volume":"71","author":"Horinaka","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0006-8993(03)03383-3","article-title":"Nicorandil prevents oxidative stress-induced apoptosis in neurons by activating mitochondrial ATP-sensitive potassium channels","volume":"990","author":"Teshima","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00395-006-0612-5","article-title":"Nicorandil opens mitochondrial K(ATP) channels not only directly but also through a NO-PKG-dependent pathway","volume":"102","author":"Kuno","year":"2007","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.athoracsur.2020.08.038","article-title":"Reactive oxygen species mediate nicorandil-induced metabolic tolerance to spinal cord injury","volume":"112","author":"Ikeno","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jss.2010.12.025","article-title":"Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia","volume":"174","author":"Smith","year":"2012","journal-title":"J Surg Res"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib16","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/glia.23036","article-title":"Juvenile striatal white matter is resistant to ischemia-induced damage","volume":"64","author":"Ahrendsen","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/j.semtcvs.2019.02.025","article-title":"Spinal cord protection for thoracic aortic surgery: bench to bedside","volume":"31","author":"Ghincea","year":"2019","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib19","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2176\/nmc.ra.2017-0062","article-title":"Ischemic tolerance of the brain and spinal cord: a review","volume":"57","author":"Yunoki","year":"2017","journal-title":"Neurol Med Chir"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib20","doi-asserted-by":"crossref","first-page":"RA44","DOI":"10.12659\/MSM.881385","article-title":"Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury","volume":"17","author":"Weerateerangkul","year":"2011","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib21","doi-asserted-by":"crossref","first-page":"H468","DOI":"10.1152\/ajpheart.00360.2003","article-title":"Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection","volume":"286","author":"Oldenburg","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib22","doi-asserted-by":"crossref","first-page":"50949","DOI":"10.1074\/jbc.M308317200","article-title":"Reactions of PTIO and carboxy-PTIO with\u00b7 NO,\u00b7 NO2, and O2\u00b7\u2217","volume":"278","author":"Goldstein","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2015.04.053","article-title":"Clinical indicators of paraplegia underplay universal spinal cord neuronal injury from transient aortic occlusion","volume":"1618","author":"Bell","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.brainres.2004.04.032","article-title":"Loss of NeuN immunoreactivity after cerebral ischemia does not indicate neuronal cell loss: a cautionary note","volume":"1015","author":"Unal-Cevik","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib25","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.athoracsur.2018.09.031","article-title":"Pretreatment with diazoxide attenuates spinal cord ischemia-reperfusion injury through STAT3 pathway","volume":"107","author":"Yamanaka","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib26","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.athoracsur.2018.07.022","article-title":"Synergistic reduction of apoptosis with diazoxide and erythropoietin in spinal cord ischemic injury","volume":"106","author":"Yamanaka","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib27","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3389\/fnins.2018.00865","article-title":"Rapamycin enhances mitophagy and attenuates apoptosis after spinal ischemia-reperfusion injury","volume":"12","author":"Li","year":"2018","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00395-016-0588-8","article-title":"Ischemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery","volume":"111","author":"Hausenloy","year":"2016","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jtcvs.2021.08.085_bib29","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.3390\/ijms20205034","article-title":"Ischemia\/reperfusion injury revisited: an overview of the latest pharmacological strategies","volume":"20","author":"Soares","year":"2019","journal-title":"Int J Mol Sci"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321014070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321014070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:44:03Z","timestamp":1784133843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522321014070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0022522321014070"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.08.085","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct and indirect activation of the adenosine triphosphate\u2013sensitive potassium channel to induce spinal cord ischemic metabolic tolerance","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.08.085","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}