{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:17:16Z","timestamp":1793215036398,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL133667"],"award-info":[{"award-number":["R01HL133667"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL135145"],"award-info":[{"award-number":["R01HL135145"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL140325"],"award-info":[{"award-number":["R01HL140325"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14SDG20380081"],"award-info":[{"award-number":["14SDG20380081"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17POST33661278"],"award-info":[{"award-number":["17POST33661278"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19PRE34380625"],"award-info":[{"award-number":["19PRE34380625"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jtcvs.2021.11.024","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T20:02:04Z","timestamp":1637006524000},"page":"e333-e347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of early versus late onset mitral regurgitation on left ventricular remodeling in ischemic cardiomyopathy in an animal model"],"prefix":"10.1016","volume":"164","author":[{"given":"Takanori","family":"Kono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Onohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Amedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Corporan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muralidhar","family":"Padala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtcvs.2021.11.024_bib1","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib2","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrcardio.2015.161","article-title":"Mitral valve disease\u2013morphology and mechanisms","volume":"12","author":"Levine","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib4","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jacc.2015.02.009","article-title":"Secondary mitral regurgitation in heart failure: pathophysiology, prognosis, and therapeutic considerations","volume":"65","author":"Asgar","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib5","doi-asserted-by":"crossref","unstructured":"Mohananey D, Aljadah M, Smith AAH, Haines JF, Patel S, Villablanca P et al. The 2020 ACC\/AHA guidelines for management of patients with valvular heart disease: highlights and perioperative implications. J Cardiothorac Vasc Anesth. Published online April 17, 2021. https:\/\/doi.org\/10.1053\/j.jvca.2021.04.013","DOI":"10.1053\/j.jvca.2021.04.013"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib6","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/j.jtcvs.2019.06.109","article-title":"Mitral regurgitation worsens cardiac remodeling in ischemic cardiomyopathy in an experimental model","volume":"160","author":"Onohara","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib7","article-title":"An image guided transapical mitral valve leaflet puncture model of controlled volume overload from mitral regurgitation in the rat","volume":"19","author":"Corporan","year":"2020","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jtcvs.2020.08.119","article-title":"Hemodynamic and transcriptomic studies suggest early left ventricular dysfunction in a preclinical model of severe mitral regurgitation","volume":"161","author":"Corporan","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib9","doi-asserted-by":"crossref","first-page":"I241","DOI":"10.1161\/hc37t1.094522","article-title":"Initial effects of the left ventricular repair by plication may not last long in a rat ischemic cardiomyopathy model","volume":"104","author":"Nishina","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib10","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1067\/mtc.2001.112462","article-title":"Left ventricular aneurysm repair in rats: structural, functional, and molecular consequences","volume":"121","author":"Sakaguchi","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ejphar.2007.02.052","article-title":"Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats","volume":"564","author":"Agelaki","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12265-018-9861-6","article-title":"Amiodarone treatment in the early phase of acute myocardial infarction protects against ventricular fibrillation in a porcine model","volume":"12","author":"Sattler","year":"2019","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib13","doi-asserted-by":"crossref","first-page":"e0183323","DOI":"10.1371\/journal.pone.0183323","article-title":"Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats","volume":"12","author":"Kainuma","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib14","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1161\/01.CIR.103.13.1759","article-title":"Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment","volume":"103","author":"Grigioni","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib15","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/ERP-16-0019","article-title":"Timing surgery in mitral regurgitation: defining risk and optimising intervention using stress echocardiography","volume":"3","author":"Liu","year":"2016","journal-title":"Echo Res Pract"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcmg.2018.11.006","article-title":"Proportionate and disproportionate functional mitral regurgitation: a new conceptual framework that reconciles the results of the MITRA-FR and COAPT trials","volume":"12","author":"Grayburn","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib17","doi-asserted-by":"crossref","first-page":"S248","DOI":"10.1161\/CIRCULATIONAHA.112.000124","article-title":"Late repair of ischemic mitral regurgitation does not prevent left ventricular remodeling: importance of timing for beneficial repair","volume":"128","author":"Beaudoin","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib18","doi-asserted-by":"crossref","first-page":"I288","DOI":"10.1161\/CIRCULATIONAHA.106.681114","article-title":"Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study","volume":"116","author":"Beeri","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib19","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1152\/japplphysiol.00691.2011","article-title":"Temporal pattern of left ventricular structural and functional remodeling following reversal of volume overload heart failure","volume":"111","author":"Hutchinson","year":"2011","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib20","doi-asserted-by":"crossref","first-page":"e007163","DOI":"10.1161\/JAHA.117.007163","article-title":"Predictors of mortality in patients with severe ischemic cardiomyopathy undergoing surgical mitral valve intervention","volume":"6","author":"Kusunose","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib21","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.jcmg.2019.11.008","article-title":"Prognostic impact of ischemic mitral regurgitation severity and myocardial infarct quantification by cardiovascular magnetic resonance","volume":"13","author":"Cavalcante","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib22","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/ejcts\/ezw139","article-title":"Long-term results of mitral repair in patients with severe left ventricular dysfunction and secondary mitral regurgitation: does the technique matter?","volume":"50","author":"De Bonis","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib23","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s11748-018-1000-4","article-title":"Mid-term results of mitral valve repair for ischemic mitral regurgitation adjusted according to the degree of remodeling progression","volume":"66","author":"Furukawa","year":"2018","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib24","doi-asserted-by":"crossref","first-page":"S582","DOI":"10.21037\/jtd.2017.05.56","article-title":"Mitral valve repair and subvalvular intervention for secondary mitral regurgitation: a systematic review and meta-analysis of randomized controlled and propensity matched studies","volume":"9","author":"Mihos","year":"2017","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jtcvs.2017.03.039","article-title":"Mitral valve surgery and coronary artery bypass grafting for moderate-to-severe ischemic mitral regurgitation: meta-analysis of clinical and echocardiographic outcomes","volume":"154","author":"Virk","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1590\/S0102-67202012000100011","article-title":"Rat's age versus human's age: what is the relationship?","volume":"25","author":"Andreollo","year":"2012","journal-title":"Arq Bras Cir Dig"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.76.1.44","article-title":"Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction","volume":"76","author":"White","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib28","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1161\/CIRCULATIONAHA.104.508093","article-title":"Changes in ventricular size and function in patients treated with valsartan, captopril, or both after myocardial infarction","volume":"111","author":"Solomon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib29","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.jacc.2003.12.053","article-title":"Severity of left ventricular remodeling defines outcomes and response to therapy in heart failure: Valsartan Heart Failure Trial (Val-HeFT) echocardiographic data","volume":"43","author":"Wong","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib30","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ejcts.2004.12.031","article-title":"Preoperative left ventricular dimensions predict reverse remodeling following restrictive mitral annuloplasty in ischemic mitral regurgitation","volume":"27","author":"Braun","year":"2005","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2021.11.024_bib31","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.athoracsur.2012.05.005","article-title":"Postoperative recurrence of mitral regurgitation after annuloplasty for functional mitral regurgitation","volume":"94","author":"Lee","year":"2012","journal-title":"Ann Thorac Surg"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321016275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522321016275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T17:23:43Z","timestamp":1758389023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522321016275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0022522321016275"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.11.024","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of early versus late onset mitral regurgitation on left ventricular remodeling in ischemic cardiomyopathy in an animal model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2021.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}