{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:49:15Z","timestamp":1790326155020,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jtcvs.2025.08.036","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:24:50Z","timestamp":1756945490000},"page":"540-550.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["One thousand cases of ex vivo lung perfusion for lung transplantation: A single-center experience"],"prefix":"10.1016","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-8094","authenticated-orcid":false,"given":"Shaf","family":"Keshavjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Sage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Borrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deween","family":"Piyasena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Wakeam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Donahoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"de Perrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharaniyaa","family":"Balachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasheed","family":"Ghany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aadil","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yasufuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Cypel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jtcvs.2025.08.036_bib1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.healun.2008.09.003","article-title":"Technique for prolonged normothermic ex vivo lung perfusion","volume":"27","author":"Cypel","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"15","key":"10.1016\/j.jtcvs.2025.08.036_bib2","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1056\/NEJMoa1014597","article-title":"Normothermic ex vivo lung perfusion in clinical lung transplantation","volume":"364","author":"Cypel","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib3","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1038\/s41467-023-40468-7","article-title":"A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization","volume":"14","author":"Sage","year":"2023","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.jtcvs.2025.08.036_bib4","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.healun.2017.07.021","article-title":"Report of the ISHLT working group on primary lung graft dysfunction, part I: definition and grading\u2014a 2016 consensus group statement of the International Society for Heart and Lung Transplantation","volume":"36","author":"Snell","year":"2017","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"10.1016\/j.jtcvs.2025.08.036_bib5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.healun.2022.10.016","article-title":"Determining the impact of ex-vivo lung perfusion on hospital costs for lung transplantation: a retrospective cohort study","volume":"42","author":"Peel","year":"2023","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/SLA.0000000000005887","article-title":"Evaluating the impact of ex vivo lung perfusion on organ transplantation: a retrospective cohort study","volume":"278","author":"Peel","year":"2023","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.jtcvs.2025.08.036_bib7","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1111\/ajt.15795","article-title":"Initial lung transplantation experience with uncontrolled donation after cardiac death in North America","volume":"20","author":"Healey","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2023.10690","article-title":"Lung transplantation from controlled and uncontrolled donation after circulatory death (DCD) donors with long ischemic times managed by simple normothermic ventilation and ex-vivo lung perfusion assessment","volume":"36","author":"Palleschi","year":"2023","journal-title":"Transpl Int"},{"issue":"20","key":"10.1016\/j.jtcvs.2025.08.036_bib9","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.3390\/jcm12206492","article-title":"Uncontrolled donation after circulatory death only lung program: an urgent opportunity","volume":"12","author":"Lazzeri","year":"2023","journal-title":"J Clin Med"},{"issue":"12","key":"10.1016\/j.jtcvs.2025.08.036_bib10","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1111\/aor.14820","article-title":"Extended ischemic times during ex vivo lung perfusion is not associated with increased mortality","volume":"48","author":"Gouchoe","year":"2024","journal-title":"Artif Organs"},{"issue":"2","key":"10.1016\/j.jtcvs.2025.08.036_bib11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.athoracsur.2020.08.042","article-title":"A retrospective review of declined lung donors: estimating the potential of ex vivo lung perfusion","volume":"112","author":"Okahara","year":"2021","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"10.1016\/j.jtcvs.2025.08.036_bib12","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1111\/ajt.16556","article-title":"Expanding donor availability in lung transplantation: a case report of 5000 miles traveled","volume":"21","author":"Fitch","year":"2021","journal-title":"Am J Transplant"},{"issue":"611","key":"10.1016\/j.jtcvs.2025.08.036_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf7601","article-title":"Static lung storage at 10\u00b0C maintains mitochondrial health and preserves donor organ function","volume":"13","author":"Ali","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104210","article-title":"Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy","volume":"83","author":"Ali","year":"2022","journal-title":"EBioMedicine"},{"issue":"Suppl 2","key":"10.1016\/j.jtcvs.2025.08.036_bib15","doi-asserted-by":"crossref","first-page":"S379","DOI":"10.1016\/j.ajt.2023.02.009","article-title":"OPTN\/SRTR 2021 Annual data report: lung","volume":"23","author":"Valapour","year":"2023","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib16","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.jtcvs.2012.08.009","article-title":"Experience with the first 50 ex vivo lung perfusions in clinical transplantation","volume":"144","author":"Yeung","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.jtcvs.2025.08.036_bib17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S2213-2600(18)30136-X","article-title":"Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study","volume":"6","author":"Warnecke","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib18","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/jamasurg.2019.4079","article-title":"Long-term outcomes of lung transplant with ex vivo lung perfusion","volume":"154","author":"Divithotawela","year":"2019","journal-title":"JAMA Surg"},{"issue":"11","key":"10.1016\/j.jtcvs.2025.08.036_bib19","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S2213-2600(19)30200-0","article-title":"Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial","volume":"7","author":"Loor","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.08.036_bib20","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/ejcts\/ezy354","article-title":"Lung transplantation after ex vivo lung perfusion in two Scandinavian centres","volume":"55","author":"Nilsson","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/frtra.2024.1324851","article-title":"Long-term outcomes of lung transplantation with ex vivo lung perfusion technique","volume":"3","author":"Buttar","year":"2024","journal-title":"Front Transplant"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib22","series-title":"Presented at: the Mechanical Support and Thoracic Transplantation Summit","article-title":"Initial 100 patient experience using a next-generation EVLP system","author":"Yamamoto","year":"2024"},{"issue":"632","key":"10.1016\/j.jtcvs.2025.08.036_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abm7190","article-title":"Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs","volume":"14","author":"Wang","year":"2022","journal-title":"Sci Transl Med"},{"issue":"4 Suppl","key":"10.1016\/j.jtcvs.2025.08.036_bib24","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.healun.2021.01.1773","article-title":"Developing universal ABO blood type donor lungs with ex vivo enzymatic treatment: a proof of concept feasibility study","volume":"40","author":"Wang","year":"2021","journal-title":"J Heart Lung Transplant"},{"issue":"11-12","key":"10.1016\/j.jtcvs.2025.08.036_bib25","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1089\/hum.2023.223","article-title":"CRISPR-Cas genome editing in ex vivo human lungs to rewire the translational path of genome-targeting therapeutics","volume":"35","author":"Mesaki","year":"2024","journal-title":"Hum Gene Ther"},{"issue":"10","key":"10.1016\/j.jtcvs.2025.08.036_bib26","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.healun.2023.06.001","article-title":"Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression","volume":"42","author":"Mesaki","year":"2023","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jtcvs.2025.08.036_bib27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41467-018-08261-z","article-title":"Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion","volume":"10","author":"Galasso","year":"2019","journal-title":"Nat Commun"},{"issue":"4 Suppl","key":"10.1016\/j.jtcvs.2025.08.036_bib28","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.healun.2019.01.117","article-title":"A clinical trial evaluating the effects of ultra-violet C treatment (UVC) during ex vivo lung perfusion (EVLP) as a method of inactivating hepatitis C infection in donor lungs","volume":"38","author":"Cypel","year":"2019","journal-title":"J Heart Lung Transplant"},{"issue":"12","key":"10.1016\/j.jtcvs.2025.08.036_bib29","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1111\/tri.13730","article-title":"Ex vivo perfusion in lung transplantation and removal of HCV: the next level","volume":"33","author":"Ribeiro","year":"2020","journal-title":"Transpl Int"},{"issue":"4 Suppl","key":"10.1016\/j.jtcvs.2025.08.036_bib30","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.healun.2021.01.1909","article-title":"Addition of dialysis to ex-vivo lung perfusion maintains homeostasis and stability of donor lungs: a proof of concept study","volume":"40","author":"Hough","year":"2021","journal-title":"J Heart Lung Transplant"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002252232500738X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002252232500738X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:15:54Z","timestamp":1780028154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002252232500738X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S002252232500738X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2025.08.036","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"One thousand cases of ex vivo lung perfusion for lung transplantation: A single-center experience","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2025.08.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}