{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:43:27Z","timestamp":1783367007957,"version":"3.54.6"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370241"],"award-info":[{"award-number":["82370241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jtcvs.2025.10.006","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:13:32Z","timestamp":1760145212000},"page":"886-895.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrin \u03b1V emerges as a potential therapeutic target with cautionary implications in thoracic aortic aneurysm and dissection"],"prefix":"10.1016","volume":"171","author":[{"given":"Sheng-an","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanzeng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanglong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixie","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.jtcvs.2025.10.006_bib1","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American heart association\/american college of cardiology joint committee on clinical practice guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.10.006_bib2","article-title":"Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection","volume":"239","author":"Elmarasi","year":"2024","journal-title":"J Cel Physiol"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.10.006_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pcad.2013.05.004","article-title":"Biomarkers in TAA\u2014The holy grail","volume":"56","author":"van Bogerijen","year":"2013","journal-title":"Prog Cardiovasc Dis"},{"issue":"12","key":"10.1016\/j.jtcvs.2025.10.006_bib4","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1001\/jamainternmed.2020.4199","article-title":"Association of fluoroquinolones with the risk of aortic aneurysm or aortic dissection","volume":"180","author":"Gopalakrishnan","year":"2020","journal-title":"JAMA Intern Med"},{"issue":"2","key":"10.1016\/j.jtcvs.2025.10.006_bib5","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.161729","article-title":"Ciprofloxacin exacerbates dysfunction of smooth muscle cells in a microphysiological model of thoracic aortic aneurysm","volume":"8","author":"Xiang","year":"2023","journal-title":"JCI insight"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.10.006_bib6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCRESAHA.118.312436","article-title":"Genetics of thoracic and abdominal aortic diseases","volume":"124","author":"Pinard","year":"2019","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.10.006_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41392-023-01456-x","article-title":"SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence","volume":"8","author":"Ding","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"7","key":"10.1016\/j.jtcvs.2025.10.006_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/CIRCULATIONAHA.122.063029","article-title":"Bestrophin3 deficiency in vascular smooth muscle cells activates MEKK2\/3-MAPK signaling to trigger spontaneous aortic dissection","volume":"148","author":"Zhang","year":"2023","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.10.006_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/eurheartj\/ehad534","article-title":"The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture","volume":"45","author":"Luo","year":"2024","journal-title":"Eur Heart J"},{"issue":"9","key":"10.1016\/j.jtcvs.2025.10.006_bib10","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCULATIONAHA.121.056640","article-title":"Legumain is an endogenous modulator of integrin \u03b1v\u03b23 triggering vascular degeneration, dissection, and rupture","volume":"145","author":"Pan","year":"2022","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.10.006_bib11","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jacasi.2025.01.005","article-title":"The CGAS-STING1 pathway as a mediator of innate immune response in cardiovascular disease","volume":"5","author":"Rouhi","year":"2025","journal-title":"JACC Asia"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.10.006_bib12","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3390\/cells11040646","article-title":"Role of integrins in modulating smooth muscle cell plasticity and vascular remodeling: from expression to therapeutic implications","volume":"11","author":"Jain","year":"2022","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.jtcvs.2025.10.006_bib13","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.ajpath.2015.05.013","article-title":"\u03b1v\u03b23 Integrins mediate flow-induced NF-\u03baB activation, proinflammatory gene expression, and early atherogenic inflammation","volume":"185","author":"Chen","year":"2015","journal-title":"Am J Pathol"},{"issue":"24","key":"10.1016\/j.jtcvs.2025.10.006_bib14","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1136\/heartjnl-2019-315103","article-title":"In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis","volume":"105","author":"Jenkins","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.jtcvs.2025.10.006_bib15","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3389\/fimmu.2019.01253","article-title":"Signal integration of IFN-I and IFN-II with TLR4 involves sequential recruitment of STAT1-complexes and NF\u03baB to enhance pro-inflammatory transcription","volume":"10","author":"Piaszyk-Borychowska","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.10.006_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.atherosclerosis.2014.02.029","article-title":"Modulation of vascular smooth muscle cell phenotype by STAT-1 and STAT-3","volume":"234","author":"Kirchmer","year":"2014","journal-title":"Atherosclerosis"},{"issue":"16","key":"10.1016\/j.jtcvs.2025.10.006_bib17","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1200\/JCO.2009.26.6650","article-title":"Phase I\/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma","volume":"28","author":"Stupp","year":"2010","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.10.006_bib18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11060-011-0650-1","article-title":"Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery","volume":"106","author":"Gilbert","year":"2012","journal-title":"J Neuro-oncol"},{"key":"10.1016\/j.jtcvs.2025.10.006_bib19","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1161\/ATVBAHA.123.319120","article-title":"FN (Fibronectin)-integrin alpha5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome","volume":"43","author":"Chen","year":"2023","journal-title":"Arterioscl Thromb Vasc Biol"},{"issue":"14","key":"10.1016\/j.jtcvs.2025.10.006_bib20","doi-asserted-by":"crossref","DOI":"10.1172\/JCI183558","article-title":"Integrin-mediated mTOR signaling drives TGF-beta overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice","volume":"135","author":"Gao","year":"2025","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.10.006_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1546","article-title":"Inhibition of TGF\u03b21 activation prevents radiation-induced lung fibrosis","volume":"14","author":"Yi","year":"2024","journal-title":"Clin Transl Med"},{"issue":"2","key":"10.1016\/j.jtcvs.2025.10.006_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41389-020-0190-7","article-title":"FARP1 boosts CDC42 activity from integrin \u03b1v\u03b25 signaling and correlates with poor prognosis of advanced gastric cancer","volume":"9","author":"Hirano","year":"2020","journal-title":"Oncogenesis"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.10.006_bib23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1021\/jm990446u","article-title":"Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic","volume":"43","author":"Miller","year":"2000","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.10.006_bib24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s40001-024-01808-5","article-title":"Multi-omics and immunogenomics analysis revealed PFKFB3 as a targetable hallmark and mediates sunitinib resistance in papillary renal cell carcinoma: in silico study with laboratory verification","volume":"29","author":"Lu","year":"2024","journal-title":"Eur J Med Res"},{"issue":"6","key":"10.1016\/j.jtcvs.2025.10.006_bib25","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1161\/ATVBAHA.121.315983","article-title":"Authentication of in situ measurements for thoracic aortic aneurysms in mice","volume":"41","author":"Ohno-Urabe","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522325008694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522325008694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:45:29Z","timestamp":1774968329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522325008694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0022522325008694"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2025.10.006","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrin \u03b1V emerges as a potential therapeutic target with cautionary implications in thoracic aortic aneurysm and dissection","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2025.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}