{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:31:28Z","timestamp":1774974688690,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jtcvs.2025.11.010","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:32:40Z","timestamp":1763656360000},"page":"836-848.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatial metrics of lymph node metastasis refine prognostic stratification of T1-T2 esophageal squamous cell carcinoma"],"prefix":"10.1016","volume":"171","author":[{"given":"Chuanquan","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maohui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jtcvs.2025.11.010_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.11.010_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2188\/jea.JE20120162","article-title":"Epidemiology of esophageal cancer in Japan and China","volume":"23","author":"Lin","year":"2013","journal-title":"J Epidemiol"},{"issue":"10110","key":"10.1016\/j.jtcvs.2025.11.010_bib3","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(17)31462-9","article-title":"Oesophageal cancer","volume":"390","author":"Lagergren","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jtcvs.2025.11.010_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/SLA.0b013e31815aaadf","article-title":"The number of metastatic lymph nodes and the ratio between metastatic and examined lymph nodes are independent prognostic factors in esophageal cancer regardless of neoadjuvant chemoradiation or lymphadenectomy extent","volume":"247","author":"Mariette","year":"2008","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.11.010_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13019-023-02350-x","article-title":"The prognostic value of 11(th) Japanese classification and 8(th) AJCC staging systems in Chinese patients with esophageal squamous cell carcinoma","volume":"18","author":"Zhang","year":"2023","journal-title":"J Cardiothorac Surg"},{"issue":"12","key":"10.1016\/j.jtcvs.2025.11.010_bib6","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1007\/s00268-015-3190-6","article-title":"Prognostic impact of distribution of lymph node metastases in stage III colon cancer","volume":"39","author":"Nagasaki","year":"2015","journal-title":"World J Surg"},{"issue":"6","key":"10.1016\/j.jtcvs.2025.11.010_bib7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1055\/s-0030-1249944","article-title":"Prognostic evaluation of nodal staging based on the new IASLC lymph node map for lung cancer","volume":"58","author":"Takamochi","year":"2010","journal-title":"Thorac Cardiovasc Surg"},{"issue":"22","key":"10.1016\/j.jtcvs.2025.11.010_bib8","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1056\/NEJMoa1112088","article-title":"Preoperative chemoradiotherapy for esophageal or junctional cancer","volume":"366","author":"Van Hagen","year":"2012","journal-title":"N Engl J Med"},{"issue":"21","key":"10.1016\/j.jtcvs.2025.11.010_bib9","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","article-title":"X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization","volume":"10","author":"Camp","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"9","key":"10.1016\/j.jtcvs.2025.11.010_bib10","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1001\/jamaoncol.2022.2810","article-title":"Association of intratumoral microbiota with prognosis in patients with nasopharyngeal carcinoma from 2 hospitals in China","volume":"8","author":"Qiao","year":"2022","journal-title":"JAMA Oncol"},{"issue":"12","key":"10.1016\/j.jtcvs.2025.11.010_bib11","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1097\/JS9.0000000000000723","article-title":"The number of metastatic lymph nodes is more predictive of prognosis than location-based N stage for nonsmall cell lung cancer: a retrospective cohort study","volume":"109","author":"Xu","year":"2023","journal-title":"Int J Surg"},{"issue":"5","key":"10.1016\/j.jtcvs.2025.11.010_bib12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1001\/jamasurg.2023.8015","article-title":"Pathomics signature for prognosis and chemotherapy benefits in stage III colon cancer","volume":"159","author":"Jiang","year":"2024","journal-title":"JAMA Surg"},{"issue":"3","key":"10.1016\/j.jtcvs.2025.11.010_bib13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejcts.2009.03.056","article-title":"The pattern and prevalence of lymphatic spread in thoracic oesophageal squamous cell carcinoma","volume":"36","author":"Chen","year":"2009","journal-title":"Eur J Cardiothorac Surg"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.11.010_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1442-2050.2010.01086.x","article-title":"Pattern of lymph node metastases of esophageal squamous cell carcinoma based on the anatomical lymphatic drainage system","volume":"24","author":"Tachimori","year":"2011","journal-title":"Dis Esophagus"},{"issue":"3","key":"10.1016\/j.jtcvs.2025.11.010_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/JTO.0b013e31827e1f6d","article-title":"Explore the radiotherapeutic clinical target volume delineation for thoracic esophageal squamous cell carcinoma from the pattern of lymphatic metastases","volume":"8","author":"Cheng","year":"2013","journal-title":"J Thorac Oncol"},{"issue":"46","key":"10.1016\/j.jtcvs.2025.11.010_bib16","doi-asserted-by":"crossref","first-page":"76261","DOI":"10.18632\/oncotarget.12842","article-title":"A new classification of lymph node metastases according to the lymph node stations for predicting prognosis in surgical patients with esophageal squamous cell carcinoma","volume":"7","author":"Lin","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.11.010_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.suronc.2017.11.002","article-title":"The prevalence of lymph node metastasis for pathological T1 esophageal cancer: a retrospective study of 143 cases","volume":"27","author":"Duan","year":"2018","journal-title":"Surg Oncol"},{"issue":"6","key":"10.1016\/j.jtcvs.2025.11.010_bib18","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.3390\/cancers12061592","article-title":"Distribution of lymph node metastases in esophageal carcinoma patients undergoing upfront surgery: a systematic review","volume":"12","author":"Hagens","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.11.010_bib19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13019-020-01302-z","article-title":"Lymph node metastatic patterns and its clinical significance for thoracic superficial esophageal squamous cell carcinoma","volume":"15","author":"Wang","year":"2020","journal-title":"J Cardiothorac Surg"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.11.010_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chest.2016.10.010","article-title":"The eighth edition lung cancer stage classification","volume":"151","author":"Detterbeck","year":"2017","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.11.010_bib21","first-page":"290","article-title":"Breast cancer-major changes in the American Joint Committee on Cancer eighth edition cancer staging manual","volume":"67","author":"Giuliano","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1016\/j.jtcvs.2025.11.010_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jtcvs.2023.11.015","article-title":"Predicting outcomes in esophageal adenocarcinoma following neoadjuvant chemoradiation: interactions between tumor response and survival","volume":"168","author":"Solomon","year":"2024","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"8","key":"10.1016\/j.jtcvs.2025.11.010_bib23","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ejso.2016.05.025","article-title":"Nodal skip metastasis is associated with a relatively poor prognosis in thoracic esophageal squamous cell carcinoma","volume":"42","author":"Liu","year":"2016","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.11.010_bib24","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.athoracsur.2017.03.081","article-title":"Nodal skip metastasis in esophageal squamous cell carcinoma patients undergoing three-field lymphadenectomy","volume":"104","author":"Wang","year":"2017","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.11.010_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/01.sla.0000184211.75970.85","article-title":"Early esophageal cancer: pattern of lymphatic spread and prognostic factors for long-term survival after surgical resection","volume":"242","author":"Stein","year":"2005","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.jtcvs.2025.11.010_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/dote\/doad006","article-title":"Lymph node metastatic patterns and the development of multidisciplinary treatment for esophageal cancer","volume":"36","author":"Matsuda","year":"2023","journal-title":"Dis Esophagus"},{"issue":"2","key":"10.1016\/j.jtcvs.2025.11.010_bib27","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/cas.13891","article-title":"Proposed revision of N categories to the 8th edition of the AJCC-TNM staging system for non-surgical esophageal squamous cell cancer","volume":"110","author":"Hu","year":"2019","journal-title":"Cancer Sci"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522325009821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522325009821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:45:06Z","timestamp":1774968306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522325009821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0022522325009821"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2025.11.010","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial metrics of lymph node metastasis refine prognostic stratification of T1-T2 esophageal squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2025.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}