{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:42:53Z","timestamp":1791416573719,"version":"4.3.3"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503714"],"award-info":[{"award-number":["82503714"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2025KY731"],"award-info":[{"award-number":["2025KY731"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2025ZZBS14"],"award-info":[{"award-number":["2025ZZBS14"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQN26H160021"],"award-info":[{"award-number":["LQN26H160021"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LHDMY25H100001"],"award-info":[{"award-number":["LHDMY25H100001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1304500"],"award-info":[{"award-number":["2022YFA1304500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M763330"],"award-info":[{"award-number":["2024M763330"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jtcvs.2026.02.025","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:47:59Z","timestamp":1772207279000},"page":"1-10.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pathologic response and nodal status guide adjuvant immunotherapy in non\u2013small cell lung cancer after neoadjuvant chemoimmunotherapy: An eastern Asian cohort study"],"prefix":"10.1016","volume":"172","author":[{"given":"Yang","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cien","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanhong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taobo","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jtcvs.2026.02.025_bib1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1056\/NEJMoa2502931","article-title":"Overall survival with neoadjuvant nivolumab plus chemotherapy in lung cancer","volume":"393","author":"Forde","year":"2025","journal-title":"N Engl J Med"},{"issue":"10459","key":"10.1016\/j.jtcvs.2026.02.025_bib2","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(24)01756-2","article-title":"Neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab compared with neoadjuvant chemotherapy alone in patients with early-stage non-small-cell lung cancer (KEYNOTE-671): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"404","author":"Spicer","year":"2024","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.jtcvs.2026.02.025_bib3","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1056\/NEJMoa2304875","article-title":"Perioperative durvalumab for resectable non-small-cell lung cancer","volume":"389","author":"Heymach","year":"2023","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.jtcvs.2026.02.025_bib4","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1056\/NEJMoa2311926","article-title":"Perioperative nivolumab in resectable lung cancer","volume":"390","author":"Cascone","year":"2024","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jtcvs.2026.02.025_bib5","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.1285","article-title":"Neoadjuvant-adjuvant vs neoadjuvant-only PD-1 and PD-L1 inhibitors for patients with resectable NSCLC: an indirect meta-analysis","volume":"7","author":"Zhou","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jtcvs.2026.02.025_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jtcvs.2025.07.015","article-title":"Validation and refinement of the ninth edition ypN descriptor in patients with non-small cell lung cancer receiving neoadjuvant therapy","volume":"171","author":"Si","year":"2025","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.jtcvs.2026.02.025_bib7","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.cllc.2025.04.004","article-title":"Prognostic implications of lymph node status in non-small-cell lung cancer patients before and after neoadjuvant chemoimmunotherapy: a multicenter retrospective study","volume":"26","author":"Ma","year":"2025","journal-title":"Clin Lung Cancer"},{"issue":"3","key":"10.1016\/j.jtcvs.2026.02.025_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jtho.2024.09.1443","article-title":"Improved event-free survival after complete or major pathologic response in patients with resectable NSCLC treated with neoadjuvant chemoimmunotherapy regardless of adjuvant treatment: a systematic review and individual patient data meta-analysis","volume":"20","author":"Marinelli","year":"2025","journal-title":"J Thorac Oncol"},{"issue":"11","key":"10.1016\/j.jtcvs.2026.02.025_bib9","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/jnci\/djaf090","article-title":"Neoadjuvant vs perioperative chemo-immunotherapy according to pathological response in resectable non-small cell lung cancer: a reconstructed individual patient data meta-analysis","volume":"117","author":"Nuccio","year":"2025","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"10.1016\/j.jtcvs.2026.02.025_bib10","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jtho.2020.01.005","article-title":"IASLC multidisciplinary recommendations for pathologic assessment of lung cancer resection specimens after neoadjuvant therapy","volume":"15","author":"Travis","year":"2020","journal-title":"J Thorac Oncol"},{"issue":"4","key":"10.1016\/j.jtcvs.2026.02.025_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s10555-025-10289-9","article-title":"Lung cancer in non-smoking women (LCINSW): from risk factors to precision therapy","volume":"44","author":"Zhao","year":"2025","journal-title":"Cancer Metastasis Rev"},{"issue":"2","key":"10.1016\/j.jtcvs.2026.02.025_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/JTO.0000000000000033","article-title":"A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER)","volume":"9","author":"Shi","year":"2014","journal-title":"J Thorac Oncol"},{"issue":"17","key":"10.1016\/j.jtcvs.2026.02.025_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.70060","article-title":"Clinical strategies for lung cancer management: recommendations from the Bridging the Gaps Lung Cancer Consensus Conference 2024","volume":"131","author":"Florez","year":"2025","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.jtcvs.2026.02.025_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2023.102040","article-title":"Neoadjuvant nivolumab plus chemotherapy versus chemotherapy for resectable NSCLC: subpopulation analysis of Chinese patients in CheckMate 816","volume":"8","author":"Wang","year":"2023","journal-title":"ESMO Open"},{"key":"10.1016\/j.jtcvs.2026.02.025_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2025.108760","article-title":"Attrition with adjuvant, neoadjuvant, and perioperative immunotherapy-based treatment protocols in patients with resectable non-small-cell lung cancer. A meta-analysis of prospective trials","volume":"209","author":"Guerrera","year":"2025","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.jtcvs.2026.02.025_bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13045-025-01768-1","article-title":"PACIFIC-5: a phase III clinical trial of consolidation durvalumab in patients with unresectable stage III NSCLC and no progression after concurrent or sequential chemoradiotherapy","volume":"18","author":"Wu","year":"2025","journal-title":"J Hematol Oncol"},{"issue":"1","key":"10.1016\/j.jtcvs.2026.02.025_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1470-2045(21)00606-9","article-title":"Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial","volume":"23","author":"Le Pechoux","year":"2022","journal-title":"Lancet Oncol"},{"issue":"8","key":"10.1016\/j.jtcvs.2026.02.025_bib18","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jamaoncol.2021.1910","article-title":"Effect of postoperative radiotherapy for patients with pIIIA-N2 non-small cell lung cancer after complete resection and adjuvant chemotherapy: the phase 3 PORT-C randomized clinical trial","volume":"7","author":"Hui","year":"2021","journal-title":"JAMA Oncol"},{"issue":"5","key":"10.1016\/j.jtcvs.2026.02.025_bib19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S2213-2600(20)30391-X","article-title":"Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials","volume":"9","author":"Theelen","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jtcvs.2026.02.025_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2025.108758","article-title":"Efficacy and safety of consolidative thoracic radiotherapy for extensive-stage small-cell lung cancer in the era of immunotherapy: a real-world study","volume":"208","author":"Zhang","year":"2025","journal-title":"Lung Cancer"},{"issue":"10","key":"10.1016\/j.jtcvs.2026.02.025_bib21","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.annonc.2023.07.001","article-title":"Overall survival with adjuvant atezolizumab after chemotherapy in resected stage II-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase III trial","volume":"34","author":"Felip","year":"2023","journal-title":"Ann Oncol"},{"issue":"9","key":"10.1016\/j.jtcvs.2026.02.025_bib22","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1097\/JS9.0000000000000496","article-title":"Does major pathological response after neoadjuvant immunotherapy in resectable nonsmall-cell lung cancers predict prognosis? A systematic review and meta-analysis","volume":"109","author":"Chen","year":"2023","journal-title":"Int J Surg"},{"issue":"21","key":"10.1016\/j.jtcvs.2026.02.025_bib23","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1056\/NEJMoa2202170","article-title":"Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer","volume":"386","author":"Forde","year":"2022","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.jtcvs.2026.02.025_bib24","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S1470-2045(20)30453-8","article-title":"Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial","volume":"21","author":"Provencio","year":"2020","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jtcvs.2026.02.025_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8513747","article-title":"Different in situ immune patterns between primary tumor and lymph node in non-small-cell lung cancer: potential impact on neoadjuvant immunotherapy","volume":"2022","author":"Ye","year":"2022","journal-title":"J Immunol Res"},{"issue":"7","key":"10.1016\/j.jtcvs.2026.02.025_bib26","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/jnci\/djaf061","article-title":"Dynamic ctDNA informs whole-course postoperative precise management of NSCLC (LUNGCA study)","volume":"117","author":"Xia","year":"2025","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"10.1016\/j.jtcvs.2026.02.025_bib27","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.21037\/tlcr-2025-470","article-title":"Utility of ctDNA-molecular residual disease in predicting minimal residual disease in non-small cell lung cancer patients after radical resection","volume":"14","author":"Masago","year":"2025","journal-title":"Transl Lung Cancer Res"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522326001820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522326001820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:35:19Z","timestamp":1782812119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522326001820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0022522326001820"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2026.02.025","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathologic response and nodal status guide adjuvant immunotherapy in non\u2013small cell lung cancer after neoadjuvant chemoimmunotherapy: An eastern Asian cohort study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2026.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by The American Association for Thoracic Surgery","name":"copyright","label":"Copyright"}]}}