{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:03:49Z","timestamp":1790802229407,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"US Government National Institutes of Health","doi-asserted-by":"publisher","award":["1T32HL166113-01"],"award-info":[{"award-number":["1T32HL166113-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jtcvs.2026.08.008","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:19:38Z","timestamp":1787584778000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severity and timing of elevated lactate correlates with mortality after cardiac surgery"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7260-0465","authenticated-orcid":false,"given":"T. Kurt","family":"Delay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricky","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kazaleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoyo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Wolverton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"China","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Bolling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorav","family":"Ailawadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.jtcvs.2026.08.008_bib1","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1056\/NEJMra1309483","article-title":"Lactic acidosis","volume":"371","author":"Kraut","year":"2014","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.jtcvs.2026.08.008_bib2","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1007\/s00134-014-3525-z","article-title":"Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine","volume":"40","author":"Cecconi","year":"2014","journal-title":"Intensive Care Med"},{"issue":"11","key":"10.1016\/j.jtcvs.2026.08.008_bib3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.jtcvs.2026.08.008_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.athoracsur.2011.07.086","article-title":"The Society of Thoracic Surgeons 30-day predicted risk of mortality score also predicts long-term survival","volume":"93","author":"Puskas","year":"2012","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.jtcvs.2026.08.008_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40273-014-0210-6","article-title":"A primer on marginal effects\u2014Part I: theory and formulae","volume":"33","author":"Onukwugha","year":"2015","journal-title":"Pharmacoeconomics"},{"issue":"2","key":"10.1016\/j.jtcvs.2026.08.008_bib6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s40273-014-0224-0","article-title":"A primer on marginal effects\u2014Part II: health services research applications","volume":"33","author":"Onukwugha","year":"2015","journal-title":"Pharmacoeconomics"},{"issue":"5","key":"10.1016\/j.jtcvs.2026.08.008_bib7","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1378\/chest.123.5.1361","article-title":"Frequency, risk factors, and outcome of hyperlactatemia after cardiac surgery","volume":"123","author":"Maillet","year":"2003","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.jtcvs.2026.08.008_bib8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.athoracsur.2012.07.020","article-title":"Lactate clearance time and concentration linked to morbidity and death in cardiac surgical patients","volume":"95","author":"Lindsay","year":"2013","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.jtcvs.2026.08.008_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00003246-199701000-00011","article-title":"Type B lactic acidosis following cardiopulmonary bypass","volume":"25","author":"Raper","year":"1997","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.jtcvs.2026.08.008_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1053\/j.jvca.2016.04.017","article-title":"Use of postoperative peak arterial lactate level to predict outcome after cardiac surgery","volume":"31","author":"Haanschoten","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jtcvs.2026.08.008_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.amsu.2021.103198","article-title":"Does severe hyperlactatemia during cardiopulmonary bypass predict a worse outcome?","volume":"73","author":"Seghrouchni","year":"2022","journal-title":"Ann Med Surg"},{"issue":"3","key":"10.1016\/j.jtcvs.2026.08.008_bib12","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jtcvs.2015.10.063","article-title":"Frequency and outcomes of severe hyperlactatemia after elective cardiac surgery","volume":"151","author":"Renew","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"10.1016\/j.jtcvs.2026.08.008_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1051\/ject\/201749007","article-title":"Hyperlactatemia and cardiac surgery","volume":"49","author":"Minton","year":"2017","journal-title":"J Extra Corpor Technol"},{"issue":"6","key":"10.1016\/j.jtcvs.2026.08.008_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/cc5113","article-title":"Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome","volume":"10","author":"Ranucci","year":"2006","journal-title":"Crit Care"},{"issue":"S15","key":"10.1016\/j.jtcvs.2026.08.008_bib15","doi-asserted-by":"crossref","first-page":"S1969","DOI":"10.21037\/jtd.2019.07.67","article-title":"Lactate guided resuscitation\u2014nothing is more dangerous than conscientious foolishness","volume":"11","author":"Marik","year":"2019","journal-title":"J Thorac Dis"},{"issue":"7","key":"10.1016\/j.jtcvs.2026.08.008_bib16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/jama.2019.0071","article-title":"Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: the ANDROMEDA-SHOCK randomized clinical trial","volume":"321","author":"Hern\u00e1ndez","year":"2019","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jtcvs.2026.08.008_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.chstcc.2025.100221","article-title":"Reflective biomarker or independent risk predictor?","volume":"4","author":"Rizaldi","year":"2025","journal-title":"CHEST Crit Care"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522326012262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522326012262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:20:58Z","timestamp":1790799658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522326012262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":17,"alternative-id":["S0022522326012262"],"URL":"https:\/\/doi.org\/10.1016\/j.jtcvs.2026.08.008","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Severity and timing of elevated lactate correlates with mortality after cardiac surgery","name":"articletitle","label":"Article Title"},{"value":"The Journal of Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtcvs.2026.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}