{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:39:30Z","timestamp":1773290370777,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.jtemb.2009.01.001","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T10:51:56Z","timestamp":1235645516000},"page":"71-74","source":"Crossref","is-referenced-by-count":22,"title":["Selenium and thyroid hormone axis in critical ill states: An overview of conflicting view points"],"prefix":"10.1016","volume":"23","author":[{"given":"Roland","family":"G\u00e4rtner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2009.01.001_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1365-2265.1982.tb03173.x","article-title":"Relationship of altered thyroid hormone indices to survival in nonthyroidal illness","volume":"16","author":"Kaptein","year":"1982","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jtemb.2009.01.001_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/thy.1997.7.125","article-title":"Euthyroid sick syndrome: an overview","volume":"7","author":"McIver","year":"1997","journal-title":"Thyroid"},{"key":"10.1016\/j.jtemb.2009.01.001_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0009-8981(01)00744-6","article-title":"Alterations of serum selenium concentrations in the acute phase of pathological conditions","volume":"316","author":"Maehira","year":"2002","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jtemb.2009.01.001_bib4","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1083516","article-title":"Characterization of mammalian selenoproteomes","volume":"300","author":"Kryukov","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jtemb.2009.01.001_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2958.1991.tb00722.x","article-title":"Selenocysteine: the 21st amino acid","volume":"5","author":"B\u00f6ck","year":"1991","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jtemb.2009.01.001_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.nutr.27.061406.093716","article-title":"Metabolic regulation and function of glutathione peroxidase-1","volume":"27","author":"Lei","year":"2007","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jtemb.2009.01.001_bib7","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1515\/BC.2006.166","article-title":"Glutathione peroxidases and redox-regulated transcription factors","volume":"387","author":"Brigelius-Floh\u00e9","year":"2006","journal-title":"Biol Chem"},{"key":"10.1016\/j.jtemb.2009.01.001_bib8","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bbagen.2008.01.011","article-title":"Redox compartmentalization in eukaryotic cells","volume":"1780","author":"Go","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jtemb.2009.01.001_bib9","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1007\/s00134-003-2031-5","article-title":"Temporal changes in muscle glutathione in ICU patients","volume":"29","author":"Flaring","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jtemb.2009.01.001_bib10","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1096\/fj.00-0721fje","article-title":"Selenium deficiency increases the pathology of an influenza virus infection","volume":"15","author":"Beck","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.jtemb.2009.01.001_bib11","doi-asserted-by":"crossref","first-page":"17964","DOI":"10.1074\/jbc.M703075200","article-title":"The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages","volume":"282","author":"Vunta","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtemb.2009.01.001_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jtemb.2007.11.003","article-title":"New assay for the measurement of selenoprotein P as a sepsis biomarker from serum","volume":"22","author":"Hollenbach","year":"2008","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.jtemb.2009.01.001_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev.nutr.24.012003.132120","article-title":"Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis","volume":"25","author":"Burk","year":"2005","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jtemb.2009.01.001_bib14","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1097\/00003246-199809000-00021","article-title":"Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients","volume":"26","author":"Forceville","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtemb.2009.01.001_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/01.CCM.0000251124.83436.0E","article-title":"Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock","volume":"35","author":"Angstwurm","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jtemb.2009.01.001_bib16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00134-004-2522-z","article-title":"Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient","volume":"31","author":"Heyland","year":"2005","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jtemb.2009.01.001_bib17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/ACO.0b013e3282f49afe","article-title":"Critically elucidating the role of selenium","volume":"21","author":"Vincent","year":"2008","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.jtemb.2009.01.001_bib18","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1210\/er.2001-0034","article-title":"Selenium, the thyroid, and the endocrine system","volume":"26","author":"K\u00f6hrle","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jtemb.2009.01.001_bib19","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1210\/en.2005-1089","article-title":"Synthesis and metabolism of thyroid hormones is preferentially maintained in selenium-deficient transgenic mice","volume":"147","author":"Schomburg","year":"2006","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.jtemb.2009.01.001_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ecl.2007.04.007","article-title":"The nonthyroidal illness syndrome","volume":"36","author":"Adler","year":"2007","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.jtemb.2009.01.001_bib21","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1210\/er.2008-0019","article-title":"Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling","volume":"29","author":"Gereben","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jtemb.2009.01.001_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s001340000757","article-title":"Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial","volume":"27","author":"Berger","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jtemb.2009.01.001_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1530\/eje.0.1510047","article-title":"Selenium substitution has no direct effect on thyroid hormone metabolism in critically ill patients","volume":"151","author":"Angstwurm","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jtemb.2009.01.001_bib24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1172\/JCI7771","article-title":"potential role of activated NF-\u03baB in the pathogenesis of euthyroid sick syndrome","volume":"106","author":"Nagaya","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jtemb.2009.01.001_bib25","doi-asserted-by":"crossref","first-page":"38296","DOI":"10.1074\/jbc.M004866200","article-title":"Regulation of hepatocyte thyroxine 5\u2032-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome","volume":"275","author":"Yu","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtemb.2009.01.001_bib26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1365-2265.2007.03102.x","article-title":"Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock","volume":"68","author":"Rodriguez-Perez","year":"2008","journal-title":"Clin Endocrinol (Oxford)"},{"key":"10.1016\/j.jtemb.2009.01.001_bib27","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1210\/jc.2007-0510","article-title":"The type II iodothyronine deiodinase is up-regulated in skeletal muscle during prolonged critical illness","volume":"92","author":"Mebis","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jtemb.2009.01.001_bib28","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1210\/jc.2005-0535","article-title":"Serum 3,3\u2032,5\u2032-triiodothyronine (rT3) and 3,5,3\u2032-triiodothyronine\/rT3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activities","volume":"90","author":"Peeters","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jtemb.2009.01.001_bib29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1677\/joe.1.07056","article-title":"Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake","volume":"191","author":"Boelen","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jtemb.2009.01.001_bib30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2005.07.021","article-title":"Lechan RM Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels","volume":"1056","author":"Fekete","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.jtemb.2009.01.001_bib31","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1210\/en.2007-1697","article-title":"Induction of type 2 iodothyronine deiodinase in the mediobasal hypothalamus by bacterial lipopolysaccharide: role of corticosterone","volume":"149","author":"Sanchez","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.jtemb.2009.01.001_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1677\/joe.0.1460475","article-title":"The role of cytokines in the lipopolysaccharide-induced sick euthyroid syndrome in mice","volume":"146","author":"Boelen","year":"1995","journal-title":"J Endocrinol"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X09000029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X09000029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T08:46:08Z","timestamp":1558169168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X09000029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0946672X09000029"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2009.01.001","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}