{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:13:24Z","timestamp":1775135604630,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.jtemb.2009.06.006","type":"journal-article","created":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T05:51:28Z","timestamp":1249537888000},"page":"324-333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide on testicular damage induced by cadmium in mice"],"prefix":"10.1016","volume":"23","author":[{"given":"Ricardo","family":"Brand\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francielli Weber","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvane Souza","family":"Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Wayne","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2009.06.006_bib1","series-title":"Cadmium environmental health criteria","year":"1992"},{"key":"10.1016\/j.jtemb.2009.06.006_bib2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0278-6915(97)00063-X","article-title":"Art international literature survey of \u201cIARC Group I Carcinogens\u201d reported in mainstream cigarette smoke","volume":"35","author":"Smith","year":"1997","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib3","first-page":"179","article-title":"The nephropathy of chronic cadmium poisoning","volume":"vol. 80","author":"Piscator","year":"1986"},{"key":"10.1016\/j.jtemb.2009.06.006_bib4","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S0024-3205(03)00433-8","article-title":"Action of green tea catechin on bone metabolic disorder in chronic cadmium-poisoned rats","volume":"73","author":"Choi","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.jtemb.2009.06.006_bib5","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0024-3205(02)02379-2","article-title":"Effects of cadmium on E-cadherin and VE-cadherin in mouse lung","volume":"72","author":"Pearson","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.jtemb.2009.06.006_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrfmmm.2003.07.011","article-title":"Cadmium carcinogenesis","volume":"533","author":"Waalkes","year":"2003","journal-title":"Mutat Res"},{"key":"10.1016\/j.jtemb.2009.06.006_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/taap.1998.8559","article-title":"Heavy metals mercury, cadmium, and chromium inhibit the activity of the mammalian liver and kidney sulfate transporter sat-1","volume":"154","author":"Markovich","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib8","first-page":"312","article-title":"Effects of cadmium on rat sperm motility evaluated with computer assisted sperm analysis","volume":"14","author":"Xu","year":"2001","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.jtemb.2009.06.006_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.toxlet.2004.05.009","article-title":"Cadmium induced testicular damage and its response to administration of succimer and diphenyl diselenide in mice","volume":"152","author":"Santos","year":"2004","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jtemb.2009.06.006_bib10","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.fct.2005.05.015","article-title":"Efficacy of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and diphenyl diselenide on cadmium induced testicular damage in mice","volume":"43","author":"Santos","year":"2005","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib11","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.freeradbiomed.2004.03.010","article-title":"Cadmium inhibits the electron transfer chain and induces reactive oxygen species","volume":"36","author":"Wang","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jtemb.2009.06.006_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0300-483X(99)00067-0","article-title":"Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake","volume":"137","author":"Oteiza","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2009.06.006_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1615\/JEnvironPatholToxicolOncol.v20.i2.10","article-title":"Oxidative mechanisms in the toxicity of chromium and cadmium ions","volume":"20","author":"Stohs","year":"2001","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0890-6238(03)00100-X","article-title":"Cadmium-induced damage to primary cultures of rat Leydig cells","volume":"17","author":"Yang","year":"2003","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib15","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0890-6238(01)00184-8","article-title":"Effect of ethanol on cadmium-induced testicular toxicity in male rats","volume":"15","author":"Biswas","year":"2001","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0041-008X(91)90119-Y","article-title":"Effects of cadmium and other metal cations on other metal cations on in vitro Leydig cell testosterone production","volume":"108","author":"Laskey","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib17","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0278-6915(00)00077-6","article-title":"Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic\u2013pituitary\u2013testicular axis function in the rat","volume":"38","author":"Lafuente","year":"2000","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib18","doi-asserted-by":"crossref","first-page":"39428","DOI":"10.1074\/jbc.M305542200","article-title":"Cell death caused by selenium deficiency and protective effect of antioxidants","volume":"278","author":"Saito","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtemb.2009.06.006_bib19","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0899-9007(02)00916-4","article-title":"Free radicals, antioxidants and nutrition","volume":"18","author":"Fang","year":"2002","journal-title":"Nutrition"},{"key":"10.1016\/j.jtemb.2009.06.006_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1016-8478(23)13017-2","article-title":"Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species","volume":"17","author":"Gupta Sen","year":"2004","journal-title":"Mol Cell"},{"key":"10.1016\/j.jtemb.2009.06.006_bib21","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1021\/cr0406559","article-title":"Organoselenium and organotellurium compounds: toxicology and pharmacology","volume":"104","author":"Nogueira","year":"2004","journal-title":"Chem Rev"},{"key":"10.1016\/j.jtemb.2009.06.006_bib22","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1590\/S0100-879X2006005000171","article-title":"Pharmacology and toxicology of diphenyl diselenide in several biological models","volume":"40","author":"Rosa","year":"2007","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.jtemb.2009.06.006_bib23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.etap.2005.07.017","article-title":"Antisecretory and antiulcer effects of diphenyl diselenide","volume":"21","author":"Savegnago","year":"2006","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejphar.2006.10.003","article-title":"Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action","volume":"555","author":"Savegnago","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2005.01.002","article-title":"Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats","volume":"210","author":"Borges","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2009.06.006_bib26","series-title":"Selenium reagents and intermediates in organic synthesis","first-page":"25","article-title":"Selenoorganic functional groups","author":"Paulmier","year":"1986"},{"key":"10.1016\/j.jtemb.2009.06.006_bib27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jtemb.2009.06.006_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem"},{"key":"10.1016\/j.jtemb.2009.06.006_bib29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1034\/j.1600-0773.2001.d01-92.x","article-title":"Diphenyl diselenide and ascorbic changes deposition of selenium and ascorbic in liver and brain of mice","volume":"88","author":"Jacques-Silva","year":"2001","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cbi.2006.11.007","article-title":"Cadmium inhibits \u03b4-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents","volume":"165","author":"Luchese","year":"2007","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jtemb.2009.06.006_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000459097","article-title":"Delta-aminolevulinic acid dehydratase assay","volume":"28","author":"Sassa","year":"1982","journal-title":"Enzyme"},{"key":"10.1016\/j.jtemb.2009.06.006_bib33","first-page":"735","article-title":"Long-term treatment with 2,5-hexanedione has no effect on the specific activity of some brain and liver glycolytic enzymes of adult rats","volume":"24","author":"Pereira","year":"1991","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.jtemb.2009.06.006_bib34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jtemb.2009.06.006_bib35","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for cadmium, draft for public comment (update). Public Health Service, US Department of Health and Human Services, September 1997."},{"key":"10.1016\/j.jtemb.2009.06.006_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0300-483X(91)90030-5","article-title":"Studies on lipid peroxidation in rat tissues following administration of cadmium chloride","volume":"67","author":"Manca","year":"1991","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2009.06.006_bib37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.reprotox.2007.10.004","article-title":"Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium","volume":"25","author":"Acharya","year":"2008","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib38","series-title":"Cell and molecular biology of the testis","first-page":"166","article-title":"Regulation of spermatogenesis in the adult mammal: gonadotrophin and androgens","author":"Zirkin","year":"1993"},{"key":"10.1016\/j.jtemb.2009.06.006_bib39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02738619","article-title":"Role of cytokines in testicular function","volume":"10","author":"Hales","year":"1999","journal-title":"Endocrine"},{"key":"10.1016\/j.jtemb.2009.06.006_bib40","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/MCB.22.7.2294-2303.2002","article-title":"The ubiquitin ligase component siah1a is required for completion of meiosis I in male mice","volume":"22","author":"Dickins","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0378-4274(03)00265-0","article-title":"Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat","volume":"145","author":"Tandon","year":"2003","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jtemb.2009.06.006_bib42","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.1016\/S0021-9258(17)36891-6","article-title":"Glutathione\u2013ascorbic acid antioxidant system in animals","volume":"269","author":"Meister","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jtemb.2009.06.006_bib43","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1089\/152308601317203594","article-title":"GSH is required to recycle ascorbic acid in cultured liver cell lines","volume":"3","author":"Li","year":"2001","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jtemb.2009.06.006_bib44","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jat.1282","article-title":"Ebselen attenuates cadmium-induced testicular damage in mice","volume":"28","author":"Ardais","year":"2008","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.jtemb.2009.06.006_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0300-483X(03)00250-6","article-title":"Organochalcogens effects on aminolevulinate dehydratase activity from human erythrocytic cells in vitro","volume":"191","author":"Nogueira","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2009.06.006_bib46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1107\/S0907444999014894","article-title":"The porphobilinogen synthase family of metalloenzymes","volume":"56","author":"Jaffe","year":"2000","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.jtemb.2009.06.006_bib47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cbi.2007.09.005","article-title":"Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats","volume":"171","author":"Borges","year":"2008","journal-title":"Chem Biol Interact"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X09000881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X09000881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:06:18Z","timestamp":1760555178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X09000881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0946672X09000881"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2009.06.006","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide on testicular damage induced by cadmium in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2009.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}