{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:31:18Z","timestamp":1791977478115,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.jtemb.2012.03.017","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T16:48:57Z","timestamp":1336495737000},"page":"149-152","source":"Crossref","is-referenced-by-count":192,"title":["Osteoporosis and trace elements \u2013 An overview"],"prefix":"10.1016","volume":"26","author":[{"given":"Jan","family":"Aaseth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2012.03.017_bib0005","volume":"vol. 843","author":"WHO","year":"1994"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0010","series-title":"Third report on the world nutrition situation","doi-asserted-by":"crossref","DOI":"10.18356\/b9c08979-en","article-title":"Calcium, an emerging issue for developing countries","author":"United Nations Sub-Committee on Nutrition","year":"1997"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00003086-199602000-00009","article-title":"The epidemiology of osteoporosis","volume":"323","author":"Lau","year":"1996","journal-title":"Clin Orthoped Rel Res"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0020","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ymgme.2006.04.009","article-title":"Genetics of osteoporosis","volume":"88","author":"Huang","year":"2006","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0025","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00223-010-9361-4","article-title":"Analysis of three functional polymorphisms in relation to osteoporosis phenotypes: replication in a Spanish cohort","volume":"87","author":"Aguenda","year":"2010","journal-title":"Calcif tissue Int"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/BF03167724","article-title":"Exercise and osteoporosis 2001","volume":"170","author":"O\u2019Brien","year":"2001","journal-title":"Ir J Med Sci"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0040","doi-asserted-by":"crossref","first-page":"824","DOI":"10.7326\/0003-4819-108-6-824","article-title":"Weight-bearing exercise training and lumbar bone mineral content in postmenopausal women","volume":"108","author":"Dalsky","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0045","series-title":"Major and trace elements in human bone and teeth. Report NAHRES 39","author":"Iyengar","year":"1999"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0050","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00198-009-0860-y","article-title":"Bone mineral: update on chemical composition and structure","volume":"20","author":"Roy","year":"2009","journal-title":"Osteoporosis Int"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0055","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1007\/BF00297291","article-title":"Cross-cultural association between dietary animal protein and hip fracture: a hypothesis","volume":"50","author":"Abelow","year":"1992","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0060","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM199709043371009","article-title":"Diet and the prevention of osteoporostic fractures","volume":"337","author":"Prince","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0065","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1056\/NEJM199212033272305","article-title":"Vitamin D and calcium prevent hip fractures in elderly women","volume":"327","author":"Chapuy","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0070","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(07)61342-7","article-title":"Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis","volume":"370","author":"Tang","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0075","first-page":"350","article-title":"Management of osteoporosis; is there a role for vitamin K?","volume":"67","author":"Weber","year":"1997","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF03259899","article-title":"Recent developments in aluminum toxicology","volume":"4","author":"Monteagudo","year":"1989","journal-title":"Med Toxicol Adverse Drug Experience"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0085","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1096\/fasebj.1.5.3678698","article-title":"Effects of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women","volume":"1","author":"Nielsen","year":"1987","journal-title":"FASEP J"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0090","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0140-6736(98)09356-8","article-title":"Environmental exposure to cadmium, forearm density, and risk of fractures: prospective population study","volume":"353","author":"Staessen","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/(SICI)1520-670X(1996)9:3<87::AID-JTRA1>3.0.CO;2-E","article-title":"Copper supplementation and the maintenance of bone mineral density in middleaged women","volume":"9","author":"Eaton-Evans","year":"1996","journal-title":"J Trace Elem Exp Med"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/1043-2760(95)00111-T","article-title":"Anabolic effects of fluoride","volume":"6","author":"Pak","year":"1995","journal-title":"Trends Endocrin Metab"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0105","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1753-4887.1995.tb01505.x","article-title":"Magnesium supplementation and osteoporosis","volume":"53","author":"Sojka","year":"1995","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0110","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1080\/07315724.1993.10718327","article-title":"The role of trace minerals in osteoporosis","volume":"12","author":"Saltman","year":"1993","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.919117","article-title":"Cellular and molecular toxicity of lead in bone","volume":"91","author":"Pounds","year":"1991","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0120","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S8756-3282(01)00484-7","article-title":"Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis)","volume":"29","author":"Buehler","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0125","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1126\/science.7022654","article-title":"The essential elements","volume":"213","author":"Mertz","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00000441-199701000-00005","article-title":"Sustained-release sodium fluoride in the management of established postmenopausal osteoporosis","volume":"3313","author":"Pak","year":"1997","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0135","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00198-007-0437-6","article-title":"Effects of treatment with fluoride on bone mineral density and fracture risk\u2014a metaanalysis","volume":"19","author":"Vestergaard","year":"2008","journal-title":"Osteoporosis Int"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s001980050132","article-title":"Therapy of established postmenopausal osteoporosis with monofluorophosphate plus calcium: dose-related effect on bone density and fracture rate","volume":"9","author":"Ringe","year":"1999","journal-title":"Osteoporosis Int"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0145","first-page":"274","article-title":"The microscopic morphology of fluoride induced bone","volume":"177","author":"Vegorita","year":"1983","journal-title":"Clin Orthop"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0150","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1210\/jc.81.1.269","article-title":"Calcium deficiency in fluoride-treated osteoporotic patients despite calcium supplementation","volume":"81","author":"Dure-Smith","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0155","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/8756-3282(93)90203-M","article-title":"Fluoride increases osteoblastic function and population after in vivo administration, but not after in vitro exposure","volume":"14","author":"Chavassieux","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0160","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jbmr.5650030504","article-title":"Fluoride content in human iliac bone: results in controls, patients with fluorosis, and osteoporotic patients treated with fluoride","volume":"3","author":"Boivin","year":"1988","journal-title":"Bone Miner Res"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0165","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/ard.56.6.357","article-title":"Is addition of fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis","volume":"56","author":"Lems","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0170","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1210\/jc.84.9.3013","article-title":"Monofluorophosphate combined with hormone replacement therapy induces a synergistic effect on bone mass by dissociating bone formation and resorption in postmenopausal women: a randomized study","volume":"84","author":"Alexandersen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl. 1","key":"10.1016\/j.jtemb.2012.03.017_bib0175","first-page":"5276","article-title":"Addition of bisphosphonate to fluoride therapy reduces adverse fluoride effects on bone quality and improves efficacy","volume":"14","author":"Schnitzler","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0180","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0185","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0140-6736(97)02342-8","article-title":"Randomized controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on estrogen for osteoporosis","volume":"350","author":"Lindsey","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0190","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF00570150","article-title":"Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone","volume":"62","author":"Matsumoto","year":"1988","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0195","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jbmr.5650080512","article-title":"An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats","volume":"8","author":"Marie","year":"1993","journal-title":"J Bone Miner Res"},{"issue":"Suppl. 1","key":"10.1016\/j.jtemb.2012.03.017_bib0200","first-page":"306","article-title":"The strontium salt S12911 inhibits the expression of carbonic anhydrase and the vitronectin receptor in chicken bone marrow cultures and bone resorption in mouse calvaria and isolated rat osteoclasts","volume":"7","author":"Su","year":"1992","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0205","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/8756-3282(90)90086-E","article-title":"Effects of low doses of strontium on bone quality and quantity in rats","volume":"11","author":"Grynpass","year":"1990","journal-title":"Bone"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0210","first-page":"5","article-title":"Effect of low doses of stable strontium on bone metabolism in rats","volume":"11","author":"Marie","year":"1985","journal-title":"Miner Electrol Metab"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0215","series-title":"Proceedings of Missour\u00eds 19th annual conference on trace substances","first-page":"193","article-title":"Histomorphometry of bone changes in human subjects following low dosage of stable strontium","author":"Marie","year":"1985"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0220","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2165\/11206440-000000000-00000","article-title":"Spotlight on strontium ranelate: in postmenopausal osteoporosis","volume":"27","author":"Deaks","year":"2010","journal-title":"Drugs Aging"},{"key":"10.1016\/j.jtemb.2012.03.017_bib0225","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0026-0495(86)90013-2","article-title":"Short-term effects of fluoride and strontium on bone formation and resorption in mouse","volume":"35","author":"Marie","year":"1986","journal-title":"Metabolism"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X12000727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X12000727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T09:01:36Z","timestamp":1594112496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X12000727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":45,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0946672X12000727"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2012.03.017","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}