{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:57:15Z","timestamp":1769043435067,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460505"],"award-info":[{"award-number":["81460505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072320"],"award-info":[{"award-number":["81072320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30760210"],"award-info":[{"award-number":["30760210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.jtemb.2016.04.005","type":"journal-article","created":{"date-parts":[[2016,5,8]],"date-time":"2016-05-08T11:36:12Z","timestamp":1462707372000},"page":"84-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["The influence of manganese treatment on the distribution of metal elements in rats and the protection by sodium para-amino salicylic acid"],"prefix":"10.1016","volume":"36","author":[{"given":"Zong-Xiang","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Huan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ni","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Nan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Fa","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Dong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Ming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2016.04.005_bib0005","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ntt.2005.04.003","article-title":"Neurobehavioral evaluation of rhesus monkey infants fed cow\u2019s milk formula, soy formula, or soy formula with added manganese","volume":"27","author":"Golub","year":"2005","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0010","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/nbm.931","article-title":"Manganese toxicity upon overexposure","volume":"17","author":"Crossgrove","year":"2004","journal-title":"NMR Biomed."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuro.2015.04.002","article-title":"Ex vivo magnetic resonance imaging in South African manganese mine workers","volume":"49","author":"Criswell","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuro.2015.07.005","article-title":"Developmental exposure to manganese induces lasting motor and cognitive impairment in rats","volume":"50","author":"Peres","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0025","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/toxsci\/kfv047","article-title":"Pharmacokinetic evaluation of the equivalency of gavage, dietary, and drinking water exposure to manganese in F344 rats","volume":"145","author":"Foster","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/toxsci\/kfr033","article-title":"Manganese accumulation in the olfactory bulbs and other brain regions of asymptomatic welders","volume":"121","author":"Sen","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0035","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuro.2006.02.003","article-title":"Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure","volume":"27","author":"Li","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0040","first-page":"433","article-title":"Manganese mineral interactions in brain","volume":"20","author":"Lai","year":"1999","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0045","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neuro.2008.12.007","article-title":"Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats","volume":"30","author":"Zheng","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0050","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s12011-012-9377-x","article-title":"Effects of dietary manganese on Cu, Fe, Zn, Ca, Se, IL-1beta, and IL-2 changes of immune organs in cocks","volume":"148","author":"Liu","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0055","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuro.2005.09.003","article-title":"Follow-up of patients affected by manganese-induced Parkinsonism after treatment with CaNa2EDTA","volume":"27","author":"Herrero Hernandez","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0300-483X(75)90120-1","article-title":"Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study","volume":"5","author":"Tandon","year":"1975","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0065","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0006-8993(99)01558-9","article-title":"Alteration of iron homeostasis following chronic exposure to manganese in rats","volume":"833","author":"Zheng","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0070","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.jom.0000204114.01893.3e","article-title":"Effective treatment of manganese-induced occupational Parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study","volume":"48","author":"Jiang","year":"2006","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0075","first-page":"1054","article-title":"Study on serum level of four trace elements in HIV-infected persons","author":"Li","year":"2007","journal-title":"Chin J. Public Health"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1734-1140(12)70762-4","article-title":"Zinc deficiency induces behavioral alterations in the tail suspension test in mice: effect of antidepressants","volume":"64","author":"Mlyniec","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbr.2012.10.020","article-title":"The role of the GPR39 receptor in zinc deficient-animal model of depression","volume":"238","author":"Mlyniec","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0090","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1271\/bbb.120671","article-title":"Combined low calcium and lack magnesium is a risk factor for motor deficit in mice","volume":"77","author":"Taniguchi","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0095","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1684\/mrh.2009.0187","article-title":"Magnesium homeostasis and aging","volume":"22","author":"Barbagallo","year":"2009","journal-title":"Magnesium Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0100","first-page":"339","article-title":"Are age-related neurodegenerative diseases linked with various types of magnesium depletion?","volume":"10","author":"Durlach","year":"1997","journal-title":"Magnesium Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tox.2015.02.005","article-title":"Relationship between brain accumulation of manganese and aberration of hippocampal adult neurogenesis after oral exposure to manganese chloride in mice","volume":"331","author":"Kikuchihara","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0110","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/toxsci\/kfu249","article-title":"Elevated adult neurogenesis in brain subventricular zone following in vivo manganese exposure: roles of copper and DMT1","volume":"143","author":"Fu","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0115","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12011-013-9692-x","article-title":"Manganese-induced effects on cerebral trace element and nitric oxide of Hyline cocks","volume":"154","author":"Liu","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12011-012-9549-8","article-title":"Manganese-induced effects on testicular trace element levels and crucial hormonal parameters of Hyline cocks","volume":"151","author":"Liu","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0125","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuro.2014.03.007","article-title":"Vulnerability of welders to manganese exposure\u2014a neuroimaging study","volume":"45","author":"Long","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1385\/BTER:110:2:163","article-title":"Effects of acute manganese chloride exposure on lipid peroxidation and alteration of trace metals in rat brain","volume":"110","author":"Chen","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuro.2011.12.008","article-title":"Neurohepatic toxicity of subacute manganese chloride exposure and potential chemoprotective effects of lycopene","volume":"33","author":"Lebda","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2016.04.005_bib0140","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3748\/wjg.v8.i1.114","article-title":"Effect of manganese on heat stress protein synthesis of new-born rats","volume":"8","author":"Zhang","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.04.046","article-title":"Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro","volume":"1097","author":"Wang","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.jtemb.2016.04.005_bib0150","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11259-015-9626-5","article-title":"Effects of manganese deficiency on the microstructure of proximal tibia and OPG\/RANKL gene expression in chicks","volume":"39","author":"Liu","year":"2015","journal-title":"Vet. Res. Commun."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X16300591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X16300591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T15:27:22Z","timestamp":1600529242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X16300591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":30,"alternative-id":["S0946672X16300591"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2016.04.005","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of manganese treatment on the distribution of metal elements in rats and the protection by sodium para-amino salicylic acid","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2016.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}