{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:18:52Z","timestamp":1790662732292,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Children\u2019s Medical Safety Research Institute","award":["CMSRI"],"award-info":[{"award-number":["CMSRI"]}]},{"name":"not-for-profit research foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jtemb.2017.11.012","type":"journal-article","created":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T22:46:44Z","timestamp":1511736404000},"page":"76-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"special_numbering":"C","title":["Aluminium in brain tissue in autism"],"prefix":"10.1016","volume":"46","author":[{"given":"Matthew","family":"Mold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorcas","family":"Umar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Exley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2017.11.012_bib0005","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/nn.4353","article-title":"Genome-wide prediction and functional characterisation of the genetic basis of autism spectrum disorder","volume":"19","author":"Krishnan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.envint.2015.12.021","article-title":"Environmental factors in the development of autism spectrum disorders","volume":"88","author":"Sealey","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2015.06.005","article-title":"Microglia in the pathogenesis of autism spectrum disorders","volume":"100","author":"Koyama","year":"2015","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuroscience.2016.03.013","article-title":"The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder","volume":"324","author":"Li","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.jtemb.2017.11.012_bib0025","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/jnen\/nlx056","article-title":"Biology of microglia in the developing brain","volume":"76","author":"Kaur","year":"2017","journal-title":"J. Neuropathol Exp. Neurol."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0030","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00401-017-1736-4","article-title":"Autism spectrum disorder: neuropathology and animal models","volume":"134","author":"Varghese","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0035","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/srep01199","article-title":"Estimation of autistic children by metallomics analysis","volume":"3","author":"Yasuda","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0040","first-page":"545674","article-title":"Assessment of hair aluminium, lead and mercury in a sample of autistic Egyptian children: environmental risk factors of heavy metals in autism","author":"Mohamed","year":"2015","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0045","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3390\/ijerph13111095","article-title":"Role of metabolic genes in blood aluminium concentrations of Jamaican children with and without autism spectrum disorder","volume":"13","author":"Rahbar","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jtemb.2017.11.012_bib0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12011-016-0878-x","article-title":"Analysis of hair trace elements in children with autism spectrum disorders and communication disorders","volume":"177","author":"Skalny","year":"2017","journal-title":"Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0055","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.jinorgbio.2011.08.008","article-title":"Do aluminium vaccine adjuvants contribute to the rising prevalence of autism?","volume":"105","author":"Tomljenovic","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jinorgbio.2013.07.022","article-title":"Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes","volume":"128","author":"Shaw","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0065","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1039\/C1MT00139F","article-title":"Aluminium, iron and copper in human brain tissues donated to the medical research council\u2019s cognitive function and ageing study","volume":"4","author":"House","year":"2012","journal-title":"Metallomics"},{"key":"10.1016\/j.jtemb.2017.11.012_bib0070","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1038\/srep06287","article-title":"Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line","volume":"4","author":"Mold","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0075","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3233\/JAD-160648","article-title":"The identification of aluminium in human brain tissue using lumogallion and fluorescence microscopy","volume":"54","author":"Mirza","year":"2016","journal-title":"J. Alzh. Dis."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0080","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/jnnp.2005.086553","article-title":"Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall UK","volume":"77","author":"Exley","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jtemb.2017.11.012_bib0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00706-010-0417-y","article-title":"Aluminium in the human brain","volume":"142","author":"Exley","year":"2011","journal-title":"Monatsh. Chem."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1752-1947-8-41","article-title":"Elevated brain aluminium and early onset Alzheimer\u2019s disease in an individual occupationally exposed to aluminium: a case report","volume":"8","author":"Exley","year":"2014","journal-title":"J. Med. Case Rep."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0095","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jtemb.2016.12.001","article-title":"Aluminium in brain tissue in familial Alzheimer\u2019s disease","volume":"40","author":"Mirza","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0100","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.immuni.2013.02.012","article-title":"Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus","author":"Shechter","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jtemb.2017.11.012_bib0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.morpho.2015.12.003","article-title":"The toxicity of aluminium in humans","volume":"100","author":"Exley","year":"2016","journal-title":"Morphologie"},{"key":"10.1016\/j.jtemb.2017.11.012_bib0110","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.jtemb.2017.11.012_bib0115","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nrn.2017.110","article-title":"Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders","volume":"18","author":"Neniskyte","year":"2017","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X17308763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X17308763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T19:38:18Z","timestamp":1535225898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X17308763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":23,"alternative-id":["S0946672X17308763"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2017.11.012","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aluminium in brain tissue in autism","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2017.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}