{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:40:44Z","timestamp":1784641244010,"version":"3.55.0"},"reference-count":191,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400725"],"award-info":[{"award-number":["81400725"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jilin University Bethune Foundation","award":["2015201"],"award-info":[{"award-number":["2015201"]}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20160101030JC"],"award-info":[{"award-number":["20160101030JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jtemb.2017.12.005","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T08:15:15Z","timestamp":1513930515000},"page":"117-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes"],"prefix":"10.1016","volume":"46","author":[{"given":"Weixia","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonggao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jnutbio.2009.01.009","article-title":"Zinc and diabetes\u2013clinical links and molecular mechanisms","volume":"20","author":"Jansen","year":"2009","journal-title":"J. Nutr. Biochem."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0010","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/physrev.00035.2014","article-title":"The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism","volume":"95","author":"Kambe","year":"2015","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0015","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3892\/mmr.2014.2969","article-title":"Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review)","volume":"11","author":"Dong","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"7","key":"10.1016\/j.jtemb.2017.12.005_bib0020","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00775-014-1139-0","article-title":"Biological consequences of zinc deficiency in the pathomechanisms of selected diseases","volume":"19","author":"Jurowski","year":"2014","journal-title":"J. Biol. Inorg. Chem."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0025","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3945\/an.112.003210","article-title":"Discovery of human zinc deficiency: its impact on human health and disease","volume":"4","author":"Prasad","year":"2013","journal-title":"Adv. Nutr."},{"issue":"1\u20133","key":"10.1016\/j.jtemb.2017.12.005_bib0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12011-009-8504-9","article-title":"Zinc deficiency in chronic kidney disease: is there a relationship with adipose tissue and atherosclerosis?","volume":"135","author":"Lobo","year":"2010","journal-title":"Biol. Trace Elem. Res."},{"issue":"12","key":"10.1016\/j.jtemb.2017.12.005_bib0035","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/0026-0495(94)90016-7","article-title":"Hyperzincuria in individuals with insulin-dependent diabetes mellitus: concurrent zinc status and the effect of high-dose zinc supplementation","volume":"43","author":"Cunningham","year":"1994","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/j.jtemb.2017.12.005_bib0040","first-page":"720","article-title":"Hypozincemia in diabetes mellitus","volume":"42","author":"Garg","year":"1994","journal-title":"J. Assoc. Phys. India"},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11684-013-0251-9","article-title":"Zinc homeostasis in the metabolic syndrome and diabetes","volume":"7","author":"Miao","year":"2013","journal-title":"Front. Med."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40199-015-0127-4","article-title":"Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications","volume":"23","author":"Ranasinghe","year":"2015","journal-title":"Daru"},{"key":"10.1016\/j.jtemb.2017.12.005_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtemb.2017.03.006","article-title":"The beneficial effects of zinc on diabetes-induced kidney damage in murine rodent model of type 1 diabetes mellitus","volume":"42","author":"Yang","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12011-016-0868-z","article-title":"Serum trace elements and electrolytes are associated with fasting plasma glucose and HbA1c in postmenopausal women with type 2 diabetes mellitus","volume":"177","author":"Skalnaya","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0065","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10534-017-9996-y","article-title":"Zinc's role in the glycemic control of patients with type 2 diabetes: a systematic review","volume":"30","author":"de Carvalho","year":"2017","journal-title":"Biometals"},{"key":"10.1016\/j.jtemb.2017.12.005_bib0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2147\/DMSO.S48260","article-title":"Akt\/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes","volume":"7","author":"Mackenzie","year":"2014","journal-title":"Diabetes Metab. Syndr. Obes."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0075","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1582-4934.2005.tb00337.x","article-title":"The activation of Akt\/PKB signaling pathway and cell survival","volume":"9","author":"Song","year":"2005","journal-title":"J. Cell. Mol. Med."},{"issue":"8","key":"10.1016\/j.jtemb.2017.12.005_bib0080","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.cellsig.2013.03.025","article-title":"Cell survival and metastasis regulation by Akt signaling in colorectal cancer","volume":"25","author":"Agarwal","year":"2013","journal-title":"Cell Signal."},{"issue":"30","key":"10.1016\/j.jtemb.2017.12.005_bib0085","doi-asserted-by":"crossref","first-page":"28258","DOI":"10.1074\/jbc.M303318200","article-title":"Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells","volume":"278","author":"Wu","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0090","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2006.08.016","article-title":"Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions","volume":"454","author":"Walter","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0095","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/jn\/131.5.1414","article-title":"Zinc has an insulin-like effect on glucose transport mediated by phosphoinositol-3-kinase and Akt in 3T3-L1 fibroblasts and adipocytes","volume":"131","author":"Tang","year":"2001","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0100","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00775-009-0612-7","article-title":"Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1\/2 and PKB phosphorylation","volume":"15","author":"Pandey","year":"2010","journal-title":"J. Biol. Inorg. Chem."},{"issue":"10","key":"10.1016\/j.jtemb.2017.12.005_bib0105","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.imbio.2016.08.011","article-title":"Epigenetic mechanisms of macrophage activation in type 2 diabetes","volume":"222","author":"Ahmed","year":"2017","journal-title":"Immunobiology"},{"issue":"11","key":"10.1016\/j.jtemb.2017.12.005_bib0110","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/CIRCRESAHA.116.306819","article-title":"Epigenetic changes in diabetes and cardiovascular risk","volume":"118","author":"Keating","year":"2016","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11892-016-0723-9","article-title":"Epigenetic mechanisms in diabetic kidney disease","volume":"16","author":"Thomas","year":"2016","journal-title":"Curr. Diabetes Rep."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0120","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ajpath.2011.04.006","article-title":"Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism","volume":"179","author":"Zhao","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"1\u20133","key":"10.1016\/j.jtemb.2017.12.005_bib0125","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12011-013-9816-3","article-title":"Role of zinc in the regulation of autophagy during ethanol exposure in human hepatoma cells","volume":"156","author":"Liuzzi","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/07315724.1998.10718735","article-title":"Zinc, insulin and diabetes","volume":"17","author":"Chausmer","year":"1998","journal-title":"J. Am. Coll. Nutr."},{"issue":"8","key":"10.1016\/j.jtemb.2017.12.005_bib0135","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2337\/diacare.19.8.873","article-title":"Evidence of a relationship between childhood-onset type I diabetes and low groundwater concentration of zinc","volume":"19","author":"Haglund","year":"1996","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0140","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1080\/07315724.2010.10719900","article-title":"Type 1 diabetes mellitus and components in drinking water and diet: a population-based, case-control study in Prince Edward Island, Canada","volume":"29","author":"Benson","year":"2010","journal-title":"J. Am. Coll. Nutr."},{"issue":"3 Pt 1","key":"10.1016\/j.jtemb.2017.12.005_bib0145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1399-5448.2010.00678.x","article-title":"Low zinc in drinking water is associated with the risk of type 1 diabetes in children","volume":"12","author":"Samuelsson","year":"2011","journal-title":"Pediatr. Diabetes"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0150","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12011-016-0835-8","article-title":"The effect of zinc supplementation on insulin resistance in obese subjects: a systematic review","volume":"176","author":"Cruz","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0155","doi-asserted-by":"crossref","first-page":"167503","DOI":"10.1155\/2015\/167503","article-title":"Zinc transporters and zinc signaling: new insights into their role in type 2 diabetes","volume":"2015","author":"Myers","year":"2015","journal-title":"Int. J. Endocrinol."},{"issue":"9","key":"10.1016\/j.jtemb.2017.12.005_bib0160","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3945\/jn.109.119677","article-title":"Maternal zinc deficiency in rats affects growth and glucose metabolism in the offspring by inducing insulin resistance postnatally","volume":"140","author":"Jou","year":"2010","journal-title":"J. Nutr."},{"issue":"7","key":"10.1016\/j.jtemb.2017.12.005_bib0165","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3945\/jn.113.175158","article-title":"Zinc deficiency augments leptin production and exacerbates macrophage infiltration into adipose tissue in mice fed a high-fat diet","volume":"143","author":"Liu","year":"2013","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0170","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1530\/EJE-15-0681","article-title":"Characterization of zinc transporter 8 (ZnT8) antibodies in autoimmune diabetic patients from Argentinian population using monomeric, homodimeric, and heterodimeric ZnT8 antigen variants","volume":"174","author":"Faccinetti","year":"2016","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0175","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1210\/jc.2009-1733","article-title":"Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes","volume":"95","author":"Kawasaki","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0180","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2016.05.022","article-title":"Zinc and diabetes","volume":"611","author":"Chabosseau","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1210\/me.2015-1227","article-title":"Molecular genetic regulation of Slc30a8\/ZnT8 reveals a positive association with glucose tolerance","volume":"30","author":"Mitchell","year":"2016","journal-title":"Mol. Endocrinol."},{"issue":"10","key":"10.1016\/j.jtemb.2017.12.005_bib0190","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1172\/JCI68807","article-title":"The diabetes-susceptible gene SLC30A8\/ZnT8 regulates hepatic insulin clearance","volume":"123","author":"Tamaki","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030580","article-title":"Zinc prevents the development of diabetic cardiomyopathy in db\/db mice","volume":"18","author":"Wang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0200","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.toxlet.2015.01.010","article-title":"Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: important role of metallothionein","volume":"233","author":"Liang","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.freeradbiomed.2013.11.015","article-title":"Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt, but not Akt2","volume":"68","author":"Sun","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.jtemb.2017.12.005_bib0210","doi-asserted-by":"crossref","first-page":"e49257","DOI":"10.1371\/journal.pone.0049257","article-title":"Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0215","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2217\/nnm.12.205","article-title":"Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats","volume":"9","author":"Umrani","year":"2014","journal-title":"Nanomedicine (Lond.)"},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0220","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/153537020122600107","article-title":"Dietary zinc supplementation attenuates hyperglycemia in db\/db mice","volume":"226","author":"Simon","year":"2001","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0225","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1900\/RDS.2008.5.102","article-title":"Effect of zinc supplementation on microalbuminuria in patients with type 2 diabetes: a double blind, randomized, placebo-controlled, cross-over trial","volume":"5","author":"Parham","year":"2008","journal-title":"Rev. Diabetic Stud."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0230","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4103\/0976-9668.117002","article-title":"Effect of high-dose zinc supplementation with oral hypoglycemic agents on glycemic control and inflammation in type-2 diabetic nephropathy patients","volume":"4","author":"Khan","year":"2013","journal-title":"J. Nat. Sci. Biol. Med."},{"issue":"11","key":"10.1016\/j.jtemb.2017.12.005_bib0235","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jnutbio.2011.09.008","article-title":"Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc","volume":"23","author":"Jansen","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0240","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1900\/RDS.2009.6.64","article-title":"Effect of zinc supplementation on serum homocysteine in type 2 diabetic patients with microalbuminuria","volume":"6","author":"Heidarian","year":"2009","journal-title":"Rev. Diabetic Stud."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0245","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/BTER:112:2:109","article-title":"Effect of zinc supplementation on serum leptin levels and insulin resistance of obese women","volume":"112","author":"Marreiro","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0250","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.atherosclerosis.2011.07.097","article-title":"Oral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levels","volume":"219","author":"Seet","year":"2011","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0255","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10534-016-9911-y","article-title":"Zinc supplementation ameliorates glycoprotein components and oxidative stress changes in the lung of streptozotocin diabetic rats","volume":"9","author":"Sacan","year":"2016","journal-title":"Biometals"},{"key":"10.1016\/j.jtemb.2017.12.005_bib0260","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.yjmcc.2014.04.023","article-title":"Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent","volume":"74","author":"Sun","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0265","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/CIRCULATIONAHA.105.537894","article-title":"Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation","volume":"113","author":"Wang","year":"2006","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0270","doi-asserted-by":"crossref","first-page":"14","DOI":"10.17305\/bjbms.2015.63","article-title":"Effect and mechanisms of zinc supplementation in protecting against diabetic cardiomyopathy in a rat model of type 2 diabetes","volume":"15","author":"Lu","year":"2015","journal-title":"Bosn. J. Basic. Med. Sci."},{"issue":"1\u20132","key":"10.1016\/j.jtemb.2017.12.005_bib0275","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2010.11.001","article-title":"Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice","volume":"200","author":"Zhao","year":"2011","journal-title":"Toxicol. Lett."},{"issue":"8","key":"10.1016\/j.jtemb.2017.12.005_bib0280","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jnutbio.2011.05.011","article-title":"Zinc deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3","volume":"23","author":"Zhao","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0285","first-page":"62","article-title":"Diabetic neuropathy and zinc therapy","volume":"31","author":"Hayee","year":"2005","journal-title":"Bangladesh Med. Res. Counc. Bull."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0290","first-page":"303","article-title":"Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes to its glucoregulatory responses (review)","volume":"24","author":"Vardatsikos","year":"2009","journal-title":"Int. J. Mol. Med."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0295","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1172\/JCI10582","article-title":"Signaling pathways in insulin action: molecular targets of insulin resistance","volume":"106","author":"Pessin","year":"2000","journal-title":"J. Clin. Invest"},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0300","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4239\/wjd.v5.i3.244","article-title":"Defect of insulin signal in peripheral tissues: important role of ceramide","volume":"5","author":"Hage Hassan","year":"2014","journal-title":"World J. Diabetes"},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0305","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/bjh.13542","article-title":"The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells","volume":"172","author":"Hofbauer","year":"2016","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0310","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.vph.2015.03.003","article-title":"Akt isoforms in vascular disease","volume":"71","author":"Yu","year":"2015","journal-title":"Vasc. Pharmacol."},{"issue":"5675","key":"10.1016\/j.jtemb.2017.12.005_bib0315","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1126\/science.1096706","article-title":"A family with severe insulin resistance and diabetes due to a mutation in AKT2","volume":"304","author":"George","year":"2004","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0320","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuron.2012.03.010","article-title":"Somatic activation of AKT3 causes hemispheric developmental brain malformations","volume":"74","author":"Poduri","year":"2012","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0325","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00775-010-0716-0","article-title":"Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes","volume":"16","author":"Georgiades","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0330","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yexcr.2015.03.003","article-title":"Zinc promotes proliferation and activation of myogenic cells via the PI3K\/Akt and ERK signaling cascade","volume":"333","author":"Ohashi","year":"2015","journal-title":"Exp. Cell. Res."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0335","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jinorgbio.2006.12.015","article-title":"Insulinomimetic Zn complex (Zn(opt)2) enhances insulin signaling pathway in 3T3-L1 adipocytes","volume":"101","author":"Basuki","year":"2007","journal-title":"J. Inorg. Biochem."},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0340","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00775-008-0352-0","article-title":"Molecular mechanism of antidiabetic zinc-allixin complexes: regulations of glucose utilization and lipid metabolism","volume":"13","author":"Nakayama","year":"2008","journal-title":"J. Biol. Inorg. Chem."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0345","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12011-016-0661-z","article-title":"Zinc attenuates tubulointerstitial fibrosis in diabetic nephropathy via inhibition of HIF through PI-3K signaling","volume":"173","author":"Zhang","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0350","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/mabi.200800190","article-title":"A Zinc(II)\/poly(gamma-glutamic acid) complex as an oral therapeutic for the treatment of type-2 diabetic KKAy mice","volume":"9","author":"Karmaker","year":"2009","journal-title":"Macromol. Biosci."},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0355","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/jcmm.12239","article-title":"Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition","volume":"18","author":"Li","year":"2014","journal-title":"J. Cell. Mol. Med."},{"issue":"26","key":"10.1016\/j.jtemb.2017.12.005_bib0360","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1021\/acs.jafc.5b01238","article-title":"Effects of D-pinitol on insulin resistance through the PI3K\/Akt signaling pathway in type 2 diabetes mellitus rats","volume":"63","author":"Gao","year":"2015","journal-title":"J. Agric. Food. Chem."},{"issue":"9","key":"10.1016\/j.jtemb.2017.12.005_bib0365","doi-asserted-by":"crossref","first-page":"22856","DOI":"10.3390\/ijms160922856","article-title":"The role of PTP1B O-GlcNAcylation in hepatic insulin resistance","volume":"16","author":"Zhao","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0370","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2337\/db08-1697","article-title":"Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling","volume":"58","author":"Wang","year":"2009","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.jtemb.2017.12.005_bib0375","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1042\/CS20150009","article-title":"Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K\/Akt pathway in type 2 diabetic mice and hepatocytes","volume":"129","author":"Liu","year":"2015","journal-title":"Clin. Sci. (Lond.)"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0380","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.metabol.2009.12.028","article-title":"Effects of adrenaline on whole-body glucose metabolism and insulin-mediated regulation of glycogen synthase and PKB phosphorylation in human skeletal muscle","volume":"60","author":"Jensen","year":"2011","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0385","doi-asserted-by":"crossref","first-page":"E1188","DOI":"10.1152\/ajpendo.00547.2004","article-title":"Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle","volume":"288","author":"Dokken","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.jtemb.2017.12.005_bib0390","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.freeradbiomed.2010.07.020","article-title":"Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: roles of Akt, mTOR, GSK3beta, and PTEN","volume":"49","author":"Zhang","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.jtemb.2017.12.005_bib0395","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.bbalip.2016.02.016","article-title":"Lipid metabolism and signaling in cardiac lipotoxicity","volume":"1861","author":"D'Souza","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.jtemb.2017.12.005_bib0400","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.bbalip.2016.01.019","article-title":"PPARbeta\/delta and lipid metabolism in the heart","volume":"1861","author":"Palomer","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.jtemb.2017.12.005_bib0405","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1248\/cpb.c12-00078","article-title":"Pharmacological and pharmacokinetic studies of anti-diabetic tropolonato-Zn(II) complexes with Zn(S(2)O(2)) coordination mode","volume":"60","author":"Murakami","year":"2012","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"8","key":"10.1016\/j.jtemb.2017.12.005_bib0410","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1248\/cpb.56.1181","article-title":"Insulinomimetic Zn(II) complexes as evaluated by both glucose-uptake activity and inhibition of free fatty acids release in isolated rat adipocytes","volume":"56","author":"Nishide","year":"2008","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0415","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12011-013-9704-x","article-title":"Development of new zinc dithiosemicarbazone complex for use as oral antidiabetic agent","volume":"154","author":"Kadowaki","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0420","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1017\/BJN20061951","article-title":"Zn-limited diet modifies the expression of the rate-regulatory enzymes involved in phosphatidylcholine and cholesterol synthesis","volume":"96","author":"Gomez","year":"2006","journal-title":"Br. J. Nutr."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0425","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.plipres.2005.12.002","article-title":"From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions","volume":"45","author":"Feige","year":"2006","journal-title":"Prog. Lipid Res."},{"issue":"9","key":"10.1016\/j.jtemb.2017.12.005_bib0430","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/ndt\/gfl212","article-title":"PPAR-alpha and \u2013 gamma agonists attenuate diabetic kidney disease in the apolipoprotein E knockout mouse","volume":"21","author":"Calkin","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"issue":"12","key":"10.1016\/j.jtemb.2017.12.005_bib0435","first-page":"3930","article-title":"Nuclear receptors PPARbeta\/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart","volume":"117","author":"Burkart","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0440","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/01.RES.0000207406.94146.c2","article-title":"Diabetic cardiomyopathy: the search for a unifying hypothesis","volume":"98","author":"Poornima","year":"2006","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0445","doi-asserted-by":"crossref","first-page":"E945","DOI":"10.1152\/ajpendo.90292.2008","article-title":"Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity","volume":"296","author":"Liang","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0450","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3389\/fphys.2015.00325","article-title":"Complex coordination of cell plasticity by a PGC-1alpha-controlled transcriptional network in skeletal muscle","volume":"6","author":"Kupr","year":"2015","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0455","doi-asserted-by":"crossref","first-page":"H185","DOI":"10.1152\/ajpheart.00081.2008","article-title":"The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis","volume":"295","author":"Lehman","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"Suppl. 1","key":"10.1016\/j.jtemb.2017.12.005_bib0460","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.freeradbiomed.2014.10.851","article-title":"Redox and zinc signalling pathways converging on protein tyrosine phosphatases","volume":"75","author":"Bellomo","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0465","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ccr.2016.07.002","article-title":"The metal face of protein tyrosine phosphatase 1B","volume":"327\u2013328","author":"Bellomo","year":"2016","journal-title":"Coord. Chem. Rev."},{"issue":"12","key":"10.1016\/j.jtemb.2017.12.005_bib0470","doi-asserted-by":"crossref","first-page":"9322","DOI":"10.1074\/jbc.C111.320796","article-title":"Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase beta activity","volume":"287","author":"Wilson","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0475","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00775-016-1364-9","article-title":"Bis(hinokitiolato)zinc complex ([Zn(hkt)]) activates Akt\/protein kinase B independent of insulin signal transduction","volume":"21","author":"Naito","year":"2016","journal-title":"J. Biol. Inorg. Chem."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0480","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00775-007-0330-y","article-title":"Thionein\/metallothionein control Zn(II) availability and the activity of enzymes","volume":"13","author":"Krezel","year":"2008","journal-title":"J. Biol. Inorg. Chem."},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0485","doi-asserted-by":"crossref","first-page":"L883","DOI":"10.1152\/ajplung.00197.2005","article-title":"p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase\/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression","volume":"289","author":"Wu","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0490","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0092-8674(02)00966-2","article-title":"Ligand-induced, receptor-mediated dimerization and activation of EGF receptor","volume":"110","author":"Schlessinger","year":"2002","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0495","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010030","article-title":"EGFR signaling in liver diseases","volume":"17","author":"Komposch","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0500","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.taap.2005.11.011","article-title":"Inhibition of protein tyrosine phosphatase activity mediates epidermal growth factor receptor signaling in human airway epithelial cells exposed to Zn2+","volume":"214","author":"Tal","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0505","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1165\/rcmb.2003-0233OC","article-title":"Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation","volume":"30","author":"Wu","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0510","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0041-008X(03)00219-9","article-title":"Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor","volume":"191","author":"Samet","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0515","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1089\/ars.2008.2161","article-title":"The insulin-like growth factor family: molecular mechanisms, redox regulation, and clinical implications","volume":"11","author":"Vardatsikos","year":"2009","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0520","first-page":"975495","article-title":"Insulin-like growth factor and epidermal growth factor signaling in breast cancer cell growth: focus on endocrine resistant disease","volume":"2015","author":"Voudouri","year":"2015","journal-title":"Anal. Cell. Pathol. (Amst.)"},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0525","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ijc.11487","article-title":"The IGF-1 receptor in cancer biology","volume":"107","author":"Baserga","year":"2003","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0530","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0014-4827(03)00406-3","article-title":"Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin\/insulin-like growth factor-1 signaling","volume":"291","author":"Haase","year":"2003","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0535","doi-asserted-by":"crossref","first-page":"H569","DOI":"10.1152\/ajpheart.00293.2009","article-title":"Molecular mechanism underlying Akt activation in zinc-induced cardioprotection","volume":"297","author":"Lee","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1\u20133","key":"10.1016\/j.jtemb.2017.12.005_bib0540","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejphar.2013.05.020","article-title":"Zinc supplementation inhibits the increase in osteoclastogenesis and decrease in osteoblastogenesis in streptozotocin-induced diabetic rats","volume":"714","author":"Iitsuka","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0545","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1038\/ncomms8769","article-title":"PI3K\/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis","volume":"6","author":"Lee","year":"2015","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.jtemb.2017.12.005_bib0550","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1039\/c3mt00197k","article-title":"PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation","volume":"6","author":"Plum","year":"2014","journal-title":"Metallomics"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0555","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/art.24225","article-title":"Increased expression of the Akt\/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis","volume":"60","author":"Cravero","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0560","doi-asserted-by":"crossref","first-page":"E565","DOI":"10.1152\/ajpendo.00467.2009","article-title":"Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance","volume":"298","author":"Liu","year":"2010","journal-title":"Am J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0565","doi-asserted-by":"crossref","first-page":"F965","DOI":"10.1152\/ajprenal.00236.2010","article-title":"TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1","volume":"299","author":"Morse","year":"2010","journal-title":"Am. J. Physiol. Renal. Physiol."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0570","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.exger.2010.01.004","article-title":"Oxidative stress: biomarkers and novel therapeutic pathways","volume":"45","author":"Maiese","year":"2010","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0575","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.18295\/squmj.2016.16.02.002","article-title":"Mechanisms of diabetes-induced liver damage: the role of oxidative stress and inflammation","volume":"16","author":"Mohamed","year":"2016","journal-title":"Sultan Qaboos Univ. Med. J."},{"issue":"11","key":"10.1016\/j.jtemb.2017.12.005_bib0580","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1515\/cclm.2011.250","article-title":"Oxidative stress and diabetes mellitus","volume":"49","author":"Yang","year":"2011","journal-title":"Clin. Chem. Lab. Med."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0585","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/1479164113520332","article-title":"Resveratrol ameliorates diabetic vascular inflammation and macrophage infiltration in db\/db mice by inhibiting the NF-kappaB pathway","volume":"11","author":"Guo","year":"2014","journal-title":"Diabetes Vasc. Dis. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0590","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2008.10.007","article-title":"Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes","volume":"46","author":"He","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0595","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADpH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.jtemb.2017.12.005_bib0600","doi-asserted-by":"crossref","first-page":"E1483","DOI":"10.3390\/ijms17091483","article-title":"Mammalian metallothionein-2A and oxidative stress","volume":"17","author":"Ling","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0605","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/jcmm.13050","article-title":"Zinc rescues obesity-induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress-activated BCL10\/CARD9\/p38 MAPK pathway","volume":"21","author":"Wang","year":"2017","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0610","doi-asserted-by":"crossref","first-page":"F105","DOI":"10.1152\/ajprenal.00034.2013","article-title":"Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice","volume":"306","author":"Tachibana","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0615","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/cvr\/cvq265","article-title":"Oestrogen prevents cardiomyocyte apoptosis by suppressing p38alpha-mediated activation of p53 and by down-regulating p53 inhibition on p38beta","volume":"89","author":"Liu","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0620","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/tox.20532","article-title":"Involment of p53, Bax, and Bcl-2 pathway in microcystins-induced apoptosis in rat testis","volume":"26","author":"Li","year":"2011","journal-title":"Environ. Toxicol."},{"issue":"15","key":"10.1016\/j.jtemb.2017.12.005_bib0625","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1128\/MCB.24.15.6728-6741.2004","article-title":"In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation","volume":"24","author":"Erster","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0630","doi-asserted-by":"crossref","first-page":"e955995","DOI":"10.1080\/23723548.2014.955995","article-title":"Mitochondrial death functions of p53","volume":"1","author":"Marchenko","year":"2014","journal-title":"Mol. Cell. Oncol."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0635","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1530\/JME-15-0232","article-title":"Oxidative and endoplasmic reticulum stress in beta-cell dysfunction in diabetes","volume":"56","author":"Hasnain","year":"2016","journal-title":"J. Mol. Endocrinol."},{"issue":"8","key":"10.1016\/j.jtemb.2017.12.005_bib0640","doi-asserted-by":"crossref","first-page":"812","DOI":"10.2174\/1389203715666140930125426","article-title":"Endoplasmic reticulum stress, diabetes mellitus, and tissue injury","volume":"15","author":"Huang","year":"2014","journal-title":"Curr. Protein Pept. Sci."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0645","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0650","article-title":"Cardiac changes in apoptosis, inflammation, oxidative stress, and nitric oxide system induced by prenatal and postnatal zinc deficiency in male and female rats","author":"Juriol","year":"2016","journal-title":"Eur. J. Nutr."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0655","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3164\/jcbn.15-87","article-title":"Dietary zinc deficiency induces oxidative stress and promotes tumor necrosis factor-alpha- and interleukin-1beta-induced RANKL expression in rat bone","volume":"58","author":"Suzuki","year":"2016","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0660","doi-asserted-by":"crossref","first-page":"C47","DOI":"10.1152\/ajpcell.00208.2016","article-title":"NADpH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage","volume":"312","author":"Li","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0665","article-title":"Investigation of lipid peroxidation and antiapoptotic effects of zinc aganist liver damage in diabetic rats","author":"Tuncdemir","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"issue":"10","key":"10.1016\/j.jtemb.2017.12.005_bib0670","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1039\/C4MT00097H","article-title":"Zinc modulates aluminium-induced oxidative stress and cellular injury in rat brain","volume":"6","author":"Singla","year":"2014","journal-title":"Metallomics"},{"issue":"8","key":"10.1016\/j.jtemb.2017.12.005_bib0675","first-page":"1519","article-title":"Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats","volume":"35","author":"Mehta","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0680","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.taap.2009.06.009","article-title":"Nrf2 signaling and cell survival","volume":"244","author":"Niture","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0685","doi-asserted-by":"crossref","first-page":"e1153","DOI":"10.1038\/cddis.2014.118","article-title":"Essential role of pH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt\/GSK3beta\/Fyn kinase axis during oxidative hepatocellular toxicity","volume":"5","author":"Rizvi","year":"2014","journal-title":"Cell Death Dis."},{"issue":"22","key":"10.1016\/j.jtemb.2017.12.005_bib0690","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M611336200","article-title":"GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2","volume":"282","author":"Jain","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0695","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/mol.111.077149","article-title":"Fyn inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury","volume":"82","author":"Koo","year":"2012","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0700","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.exger.2007.11.005","article-title":"Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc","volume":"43","author":"Maret","year":"2008","journal-title":"Exp. Gerontol."},{"issue":"18","key":"10.1016\/j.jtemb.2017.12.005_bib0705","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1111\/j.1742-4658.2006.05428.x","article-title":"Aldehydes release zinc from proteins. A pathway from oxidative stress\/lipid peroxidation to cellular functions of zinc","volume":"273","author":"Hao","year":"2006","journal-title":"FEBS J."},{"issue":"44","key":"10.1016\/j.jtemb.2017.12.005_bib0710","doi-asserted-by":"crossref","first-page":"34803","DOI":"10.1074\/jbc.M007339200","article-title":"The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene","volume":"275","author":"Langmade","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0715","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061289","article-title":"Proteomic high affinity Zn2+ trafficking: where does metallothionein fit in?","volume":"18","author":"Petering","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1\u20133","key":"10.1016\/j.jtemb.2017.12.005_bib0720","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2011.09.177","article-title":"Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid beta-protein via the PI3K\/Akt\/Bad\/Bcl(XL)-regulated mitochondrial apoptotic pathway","volume":"672","author":"Zeng","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0725","doi-asserted-by":"crossref","first-page":"E794","DOI":"10.1152\/ajpendo.00791.2007","article-title":"Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K\/Akt, Bcl-2, and phospho-Bad signaling","volume":"294","author":"Dufour","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0730","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neulet.2011.05.003","article-title":"Nicotinamide attenuates the ischemic brain injury-induced decrease of Akt activation and Bad phosphorylation","volume":"498","author":"Koh","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0735","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/0970-1591.139570","article-title":"Molecular basis for the effects of zinc deficiency on spermatogenesis: an experimental study in the Sprague-dawley rat model","volume":"31","author":"Omu","year":"2015","journal-title":"Indian J. Urol."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0740","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the light: the growing complexity of p53","volume":"137","author":"Vousden","year":"2009","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0745","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrc2584","article-title":"p53 polymorphisms: cancer implications","volume":"9","author":"Whibley","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0750","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5483\/BMBRep.2014.47.3.261","article-title":"Structural insights into the transcription-independent apoptotic pathway of p53","volume":"47","author":"Chi","year":"2014","journal-title":"BMB Rep."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0755","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.placenta.2016.03.001","article-title":"Macrophage migration inhibitory factor induces phosphorylation of Mdm2 mediated by phosphatidylinositol 3-kinase\/Akt kinase: role of this pathway in decidual cell survival","volume":"41","author":"Costa","year":"2016","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0760","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.3892\/ijo.2016.3472","article-title":"Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt\/MDM2\/p53 pathway in cisplatin-resistant ovarian cancer A2780\/CP70 cells","volume":"48","author":"Tu","year":"2016","journal-title":"Int. J. Oncol."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0765","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12263-011-0248-4","article-title":"Zinc deficiency or excess within the physiological range increases genome instability and cytotoxicity, respectively, in human oral keratinocyte cells","volume":"7","author":"Sharif","year":"2012","journal-title":"Genes Nutr."},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0770","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.bbadis.2013.02.023","article-title":"Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt\/GSK3beta-dependent inhibition of apoptosis and ER stress","volume":"1832","author":"Dong","year":"2013","journal-title":"Biochim. Biophys. Acta."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0775","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3390\/nu8040227","article-title":"Insulin protects hepatic lipotoxicity by regulating ER stress through the PI3 K\/Akt\/p53 involved pathway independently of autophagy inhibition","volume":"8","author":"Ning","year":"2016","journal-title":"Nutrients"},{"issue":"41","key":"10.1016\/j.jtemb.2017.12.005_bib0780","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1038\/onc.2008.247","article-title":"The PTEN-PI3K pathway: of feedbacks and cross-talks","volume":"27","author":"Carracedo","year":"2008","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.jtemb.2017.12.005_bib0785","doi-asserted-by":"crossref","first-page":"e0141286","DOI":"10.1371\/journal.pone.0141286","article-title":"Quality control measures over 30 years in a multicenter clinical study: results from the diabetes control and complications trial\/epidemiology of diabetes interventions and complications (DCCT\/EDIC) study","volume":"10","author":"Lorenzi","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.jtemb.2017.12.005_bib0790","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2215\/CJN.02870316","article-title":"Albuminuria changes and cardiovascular and renal outcomes in type 1 diabetes: the DCCT\/EDIC study","volume":"11","author":"de Boer","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"11","key":"10.1016\/j.jtemb.2017.12.005_bib0795","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/dme.13126","article-title":"Glycaemic control and risk of incident urinary incontinence in women with Type 1 diabetes: results from the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications (DCCT\/EDIC) study","volume":"33","author":"Lenherr","year":"2016","journal-title":"Diabetic Med."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0800","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1755-8794-3-33","article-title":"Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus","volume":"3","author":"Bell","year":"2010","journal-title":"BMC Med. Genomics"},{"issue":"5","key":"10.1016\/j.jtemb.2017.12.005_bib0805","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nm.2135","article-title":"Methylation determines fibroblast activation and fibrogenesis in the kidney","volume":"16","author":"Bechtel","year":"2010","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.jtemb.2017.12.005_bib0810","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/nm.3363","article-title":"Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes","volume":"19","author":"Hasegawa","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0815","doi-asserted-by":"crossref","first-page":"654148","DOI":"10.1155\/2014\/654148","article-title":"Histone lysine methylation in diabetic nephropathy","volume":"2014","author":"Sun","year":"2014","journal-title":"J. Diabetes Res."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0820","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/JOE-16-0322","article-title":"Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC","volume":"232","author":"Dong","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0825","doi-asserted-by":"crossref","first-page":"3853242","DOI":"10.1155\/2016\/3853242","article-title":"Involvement of histone lysine methylation in p21 gene expression in rat kidney in vivo and rat mesangial cells In vitro under diabetic conditions","volume":"2016","author":"Li","year":"2016","journal-title":"J. Diabetes Res."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0830","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1681\/ASN.2013121274","article-title":"MicroRNA-21 in glomerular injury","volume":"26","author":"Lai","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0835","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1074\/jbc.M116.753822","article-title":"Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1","volume":"292","author":"Lee","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0840","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.gene.2015.07.015","article-title":"Dysregulated miR-103 and miR-143 expression in peripheral blood mononuclear cells from induced prediabetes and type 2 diabetes rats","volume":"572","author":"Vatandoost","year":"2015","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0845","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ki.2014.111","article-title":"Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy","volume":"86","author":"Wang","year":"2014","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0850","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/me.2015-1176","article-title":"A20 inhibits beta-cell apoptosis by multiple mechanisms and predicts residual beta-cell function in type 1 diabetes","volume":"30","author":"Fukaya","year":"2016","journal-title":"Mol. Endocrinol."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0855","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.diabres.2014.09.014","article-title":"Decreased A20 mRNA and protein expression in peripheral blood mononuclear cells in patients with type 2 diabetes and latent autoimmune diabetes in adults","volume":"106","author":"Cheng","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0860","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jnutbio.2014.10.005","article-title":"Maternal high-zinc diet attenuates intestinal inflammation by reducing DNA methylation and elevating H3K9 acetylation in the A20 promoter of offspring chicks","volume":"26","author":"Li","year":"2015","journal-title":"J. Nutr. Biochem."},{"issue":"1\u20133","key":"10.1016\/j.jtemb.2017.12.005_bib0865","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12011-012-9508-4","article-title":"Zinc supplementation attenuates metallothionein and oxidative stress changes in kidney of streptozotocin-induced diabetic rats","volume":"150","author":"Ozcelik","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0870","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbagrm.2010.10.004","article-title":"The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter","volume":"1809","author":"Okumura","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.jtemb.2017.12.005_bib0875","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1007\/s11033-010-0615-z","article-title":"Biological role of microRNA-103 based on expression profile and target genes analysis in pigs","volume":"38","author":"Li","year":"2011","journal-title":"Mol. Biol. Rep."},{"issue":"7353","key":"10.1016\/j.jtemb.2017.12.005_bib0880","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nature10112","article-title":"MicroRNAs 103 and 107 regulate insulin sensitivity","volume":"474","author":"Trajkovski","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0885","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/ncb2211","article-title":"Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism","volume":"13","author":"Jordan","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0890","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.biopha.2016.09.068","article-title":"Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in Type-2 diabetes","volume":"84","author":"El-Gharbawy","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.jtemb.2017.12.005_bib0895","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1172\/JCI69866","article-title":"Human IAPP-induced pancreatic beta cell toxicity and its regulation by autophagy","volume":"124","author":"Shigihara","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.jtemb.2017.12.005_bib0900","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/MCO.0000000000000068","article-title":"Molecular regulation of autophagy and its implications for metabolic diseases","volume":"17","author":"Ryter","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"8","key":"10.1016\/j.jtemb.2017.12.005_bib0905","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1080\/15548627.2016.1184799","article-title":"Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis","volume":"12","author":"Lee","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.jtemb.2017.12.005_bib0910","doi-asserted-by":"crossref","first-page":"17637","DOI":"10.1038\/srep17637","article-title":"Podocyte injury in diabetic nephropathy: implications of angiotensin II-dependent activation of TRPC channels","volume":"5","author":"Ilatovskaya","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jtemb.2017.12.005_bib0915","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2337\/db15-0473","article-title":"Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy","volume":"65","author":"Tagawa","year":"2016","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jtemb.2017.12.005_bib0920","doi-asserted-by":"crossref","first-page":"F156","DOI":"10.1152\/ajprenal.00409.2012","article-title":"Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus","volume":"304","author":"Vallon","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"11","key":"10.1016\/j.jtemb.2017.12.005_bib0925","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1681\/ASN.2012111080","article-title":"Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions","volume":"24","author":"Yamahara","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.jtemb.2017.12.005_bib0930","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10565-013-9261-2","article-title":"Dopamine- and zinc-induced autophagosome formation facilitates PC12 cell survival","volume":"29","author":"Hung","year":"2013","journal-title":"Cell Biol. Toxicol."},{"issue":"12","key":"10.1016\/j.jtemb.2017.12.005_bib0935","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1016\/j.neurobiolaging.2015.09.006","article-title":"The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP\/mutant presenilin-1-transfected Chinese hamster ovary cells","volume":"36","author":"Seo","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"18","key":"10.1016\/j.jtemb.2017.12.005_bib0940","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1089\/ars.2013.5391","article-title":"p62\/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model","volume":"21","author":"Haga","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0945","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ejphar.2016.09.013","article-title":"Intracellular zinc status influences cisplatin-induced endothelial permeability through modulation of PKCalpha, NF-kappaB and ICAM-1 expression","volume":"791","author":"Bodiga","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jtemb.2017.12.005_bib0950","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnut.2014.00014","article-title":"Zinc is an antioxidant and anti-inflammatory agent: its role in human health","volume":"1","author":"Prasad","year":"2014","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.jtemb.2017.12.005_bib0955","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-3-30","article-title":"Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes","volume":"3","author":"Lee","year":"2010","journal-title":"Mol. Brain"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X17306600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X17306600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T01:39:10Z","timestamp":1660181950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X17306600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":191,"alternative-id":["S0946672X17306600"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2017.12.005","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2017.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}