{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:21:26Z","timestamp":1778088086207,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803179"],"award-info":[{"award-number":["81803179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803178"],"award-info":[{"award-number":["81803178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M613153"],"award-info":[{"award-number":["2017M613153"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017M623197"],"award-info":[{"award-number":["2017M623197"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2016YFE0119100"],"award-info":[{"award-number":["2016YFE0119100"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["xjj2018149"],"award-info":[{"award-number":["xjj2018149"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["xjj2018147"],"award-info":[{"award-number":["xjj2018147"]}]},{"name":"Shaanxi Natural Science Basic Research Project - General Project (Youth)","award":["2018JQ8025"],"award-info":[{"award-number":["2018JQ8025"]}]},{"name":"Shaanxi Natural Science Basic Research Project - General Project (Youth)","award":["2018JQ8012"],"award-info":[{"award-number":["2018JQ8012"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jtemb.2019.04.002","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T09:38:00Z","timestamp":1555493880000},"page":"79-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Hair multi-bioelement profile of Kashin-Beck disease in the endemic regions of China"],"prefix":"10.1016","volume":"54","author":[{"given":"Xi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2019.04.002_bib0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.yexcr.2017.10.012","article-title":"Chondrocytes damage induced by T-2 toxin via Wnt\/beta-catenin signaling pathway is involved in the pathogenesis of an endemic osteochondropathy, Kashin-Beck disease","author":"Wang","year":"2017","journal-title":"Experimental cell research 361(1)"},{"issue":"7","key":"10.1016\/j.jtemb.2019.04.002_bib0010","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.joca.2014.05.012","article-title":"Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease","volume":"22","author":"Luo","year":"2014","journal-title":"Osteoarthritis and cartilage"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0015","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jtemb.2018.01.012","article-title":"Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease","volume":"50","author":"Ning","year":"2018","journal-title":"J Trace Elem Med Biol"},{"issue":"1-3","key":"10.1016\/j.jtemb.2019.04.002_bib0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12011-013-9651-6","article-title":"Effects of dietary factors on selenium levels of children to prevent Kashin-Beck disease during a high-prevalence period in an endemic area: a cohort study","volume":"153","author":"Ning","year":"2013","journal-title":"Biological trace element research"},{"issue":"5","key":"10.1016\/j.jtemb.2019.04.002_bib0025","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/ajcn\/47.5.889","article-title":"Long-term marginal zinc deprivation in rhesus monkeys. IV. Effects on skeletal growth and mineralization","volume":"47","author":"Leek","year":"1988","journal-title":"The American journal of clinical nutrition"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0030","first-page":"127","volume":"16","author":"Ochi","year":"2012","journal-title":"the Japanese Society for Dialysis Therapy"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122142","article-title":"Trace elements in scalp hair samples from patients with relapsing-remitting multiple sclerosis","author":"Tamburo","year":"2015","journal-title":"PloS one 10(4)"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijcard.2015.02.005","article-title":"Cortisol levels in scalp hair of patients with structural heart disease","volume":"184","author":"Younge","year":"2015","journal-title":"International journal of cardiology"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0045","series-title":"Activation analysis of hair as an indicator of contamination of man by environmental trace element pollutants","author":"YS","year":"1978"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0584-8547(95)01425-X","article-title":"Determination of metals in biofluids and tissues: sample preparation methods foratomic spectroscopic techniques","volume":"51","author":"KS","year":"1996","journal-title":"Spectrochim Acta Part B"},{"issue":"3","key":"10.1016\/j.jtemb.2019.04.002_bib0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/archinternmed.2009.495","article-title":"Acute selenium toxicity associated with a dietary supplement","volume":"170","author":"MacFarquhar","year":"2010","journal-title":"Archives of internal medicine"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0060","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00244-011-9689-4","article-title":"Freshwater fish-consumption relations with total hair mercury and selenium among women in eastern China","volume":"62","author":"Fang","year":"2012","journal-title":"Archives of environmental contamination and toxicology"},{"issue":"1-2","key":"10.1016\/j.jtemb.2019.04.002_bib0065","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jhazmat.2011.02.019","article-title":"Determination of mercury and selenium in herbal medicines and hair by using a nanometer TiO2-coated quartz tube atomizer and hydride generation atomic absorption spectrometry","volume":"189","author":"Li","year":"2011","journal-title":"Journal of hazardous materials"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0070","series-title":"Selenium in Food and Health","article-title":"United States of America","author":"Reilly","year":"2006"},{"issue":"3-4","key":"10.1016\/j.jtemb.2019.04.002_bib0075","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0753-3322(03)00035-0","article-title":"The antioxidant role of selenium and seleno-compounds","volume":"57","author":"Tapiero","year":"2003","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"11","key":"10.1016\/j.jtemb.2019.04.002_bib0080","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.joca.2014.07.023","article-title":"Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease","volume":"22","author":"Guo","year":"2014","journal-title":"Osteoarthritis and cartilage"},{"issue":"1","key":"10.1016\/j.jtemb.2019.04.002_bib0085","article-title":"Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach","volume":"7","author":"Hammad","year":"2018","journal-title":"Antioxidants (Basel)"},{"issue":"11","key":"10.1016\/j.jtemb.2019.04.002_bib0090","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.18632\/aging.101322","article-title":"Selenium preserves keratinocyte stemness and delays senescence by maintaining epidermal adhesion","volume":"9","author":"Jobeili","year":"2017","journal-title":"Aging"},{"issue":"11","key":"10.1016\/j.jtemb.2019.04.002_bib0095","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.joca.2013.08.002","article-title":"Oxidative stress and status of antioxidant enzymes in children with Kashin-Beck disease","volume":"21","author":"Wang","year":"2013","journal-title":"Osteoarthritis and cartilage"},{"issue":"11-12","key":"10.1016\/j.jtemb.2019.04.002_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2011.03.002","article-title":"Selenium, iodine, and the relation with Kashin-Beck disease","volume":"27","author":"Yao","year":"2011","journal-title":"Nutrition"},{"issue":"10","key":"10.1016\/j.jtemb.2019.04.002_bib0105","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.joca.2007.03.013","article-title":"Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats","volume":"15","author":"Ren","year":"2007","journal-title":"Osteoarthritis and cartilage"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.joca.2008.06.011","article-title":"Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis","volume":"17","author":"Zou","year":"2009","journal-title":"Osteoarthritis and cartilage"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1079\/PNS2002153","article-title":"The argument for increasing selenium intake","volume":"61","author":"Rayman","year":"2002","journal-title":"The Proceedings of the Nutrition Society"},{"issue":"7","key":"10.1016\/j.jtemb.2019.04.002_bib0120","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00775-011-0797-4","article-title":"Zinc homeostasis and signaling in health and diseases: Zinc signaling","volume":"16","author":"Fukada","year":"2011","journal-title":"Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0125","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s12011-017-0964-8","article-title":"Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium","volume":"179","author":"Wang","year":"2017","journal-title":"Biological trace element research"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0130","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12011-017-1054-7","article-title":"Serum and Hair Zinc Levels in Patients with Endemic Osteochondropathy in China: A Meta-analysis","volume":"181","author":"Wang","year":"2018","journal-title":"Biological trace element research"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0135","doi-asserted-by":"crossref","DOI":"10.3945\/ajcn.2008.26811C","article-title":"Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review","volume":"89","author":"Zimmermann","year":"2009","journal-title":"The American journal of clinical nutrition"},{"issue":"16","key":"10.1016\/j.jtemb.2019.04.002_bib0140","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM199810153391604","article-title":"Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status","volume":"339","author":"Moreno-Reyes","year":"1998","journal-title":"The New England journal of medicine"},{"issue":"4","key":"10.1016\/j.jtemb.2019.04.002_bib0145","first-page":"36","article-title":"Study on the Retations Between Kashin-Beck Disease and Iodine","volume":"14","author":"Jimin","year":"1999","journal-title":"Endemic Diseases Bulletin"},{"issue":"1","key":"10.1016\/j.jtemb.2019.04.002_bib0150","first-page":"19","article-title":"[A study on abnormal chondrocyte differentiation and abnormal expression of collagen types in articular cartilage from patients with Kaschin-Beck disease]","volume":"27","author":"Guo","year":"1998","journal-title":"Zhonghua bing li xue za zhi = Chinese journal of pathology"},{"issue":"1","key":"10.1016\/j.jtemb.2019.04.002_bib0155","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/bbrc.1997.6621","article-title":"Effect of boric acid solution on cartilage metabolism","volume":"234","author":"Benderdour","year":"1997","journal-title":"Biochemical and biophysical research communications"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0160","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jbmr.5650090206","article-title":"Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick","volume":"9","author":"Hunt","year":"1994","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research"},{"issue":"Suppl. 7","key":"10.1016\/j.jtemb.2019.04.002_bib0165","first-page":"83","article-title":"Essentiality of boron for healthy bones and joints","volume":"102","author":"Newnham","year":"1994","journal-title":"Environmental health perspectives"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0170","series-title":"The 3rd National Proceedings on Germanium in China","first-page":"19","article-title":"Biological effect of germanium mixture and the research on Germanium drugs","author":"Shugong","year":"1995"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0175","series-title":"The 3rd National Proceedings on Germanium in China","first-page":"61","article-title":"Experimental therapeutic effect of Germanium-132 on osteoporosis","author":"Hecheng","year":"1995"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0180","first-page":"65","article-title":"Assay of GSHpx, TBA, FFA in blood of children in Kashin-Beck disease","volume":"2","author":"Chun","year":"1983","journal-title":"Chinese Journal of Controlling Endemic Diseases"},{"key":"10.1016\/j.jtemb.2019.04.002_bib0185","first-page":"37","volume":"2","author":"Shufen","year":"1984"},{"issue":"2","key":"10.1016\/j.jtemb.2019.04.002_bib0190","first-page":"101","article-title":"The Study on Correlation Between the Chemical Elemental Content in the Hair of Children Suffered from Kashin-Beck disease","volume":"9","author":"Dunhu","year":"1990","journal-title":"Chinese Journal of Endemic Diseases"}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X1830470X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X1830470X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:07:56Z","timestamp":1760555276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X1830470X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":38,"alternative-id":["S0946672X1830470X"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2019.04.002","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hair multi-bioelement profile of Kashin-Beck disease in the endemic regions of China","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2019.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}