{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:12:42Z","timestamp":1788300762671,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"\"Ensuring excellence in RDI activity within USAMVBT\""}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jtemb.2019.06.013","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T23:40:09Z","timestamp":1561592409000},"page":"136-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Homeostatic changes of some trace elements in geriatric rats in the condition of oxidative stress induced by aluminum and the beneficial role of resveratrol"],"prefix":"10.1016","volume":"55","author":[{"given":"Florin","family":"Muselin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno","family":"G\u00e2rban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeo T.","family":"Cristina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru O.","family":"Doma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Dumitrescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru B.","family":"Vi\u021b\u0103laru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan","family":"B\u0103n\u0103\u021bean-Dunea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2019.06.013_bib0005","first-page":"147","article-title":"Magnesium and trace elements in the elderly: intake, status, and recommendations","volume":"6","author":"Vaquero","year":"2002","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0010","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/physrev.1998.78.2.547","article-title":"The free radical theory of aging matures","volume":"78","author":"Beckman","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0015","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0020","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.jtemb.2010.10.002","article-title":"Trace elements and ageing, a genomic perspective using selenium as an example","volume":"25S","author":"M\u00e9plan","year":"2011","journal-title":"J. Trace Elem. Res. Med. Biol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0025","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1177\/0748233715578035","article-title":"Effects of aluminium chloride on the serum protein, bilirubin and hepatic trace elements in chickens","volume":"32","author":"Wang","year":"2016","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0030","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3906\/sag-1501-101","article-title":"The consequences of aluminium intake on reproductive function in male rats: a three-generation study","volume":"46","author":"Muselin","year":"2016","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4149\/BLL_2017_053","article-title":"Anti-oxidative effect of resveratrol on aluminium induced toxicity in rat cerebral tissue","volume":"118","author":"Zakaria","year":"2017","journal-title":"Bratisl. Med. J."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4314\/tjpr.v13i2.2","article-title":"Protective effects of aqueous extract of Sempervivum tectorum L (Crassulaceae) on aluminium-induced oxidative stress in rat blood","volume":"13","author":"Muselin","year":"2014","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0045","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s11095-010-0055-4","article-title":"Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer","volume":"27","author":"Hadi","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0050","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s12011-016-0861-6","article-title":"Resveratrol attenuates cooper and zinc homeostasis and ameliorates oxidative stress in type 2 diabetic rats","volume":"177","author":"Asadi","year":"2017","journal-title":"Boil. Trace. Elem. Res."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0055","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1042\/bj3301173","article-title":"Structural dependence of flavonoid interaction with Cu2+ ions: implications for their antioxidant properties","volume":"330","author":"Brown","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0060","doi-asserted-by":"crossref","first-page":"C632","DOI":"10.1152\/ajpcell.00139.2009","article-title":"Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells","volume":"297","author":"Zhang","year":"2009","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0065","series-title":"Directive 2010\/63\/EU of the European Parliament and of the Council of 22, September 2010 on the Protection of Animals Used for Scientific Purposes","year":"2018"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0070","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0075","first-page":"10","article-title":"Peculiarities of the resveratrol action on some biochemical and hematological parameters preliminary data","author":"G\u00e2rban","year":"2014","journal-title":"The 20th Int. Symp. on Analytical and Environmental Problems"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.physbeh.2014.10.010","article-title":"Resveratrol exerts anti-in\ufb02ammatory and neuroprotective effects to prevent memory de\ufb01cits in rats exposed to chronic unpredictable mild stress","volume":"138","author":"Yazir","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0085","series-title":"SOP. 26 Euthanasia in Mice and Rats","author":"Peirce","year":"2006"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12858-018-0097-5","article-title":"Simple spectrophotometric assay for measuring catalase activity in biological tissues","volume":"19","author":"Hadwan","year":"2018","journal-title":"BMC Biochem."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0095","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1134\/S2079978017010010","article-title":"Determination of proteins in blood. Part 1: determination of total protein and albumin","volume":"7","author":"Buzanovskii","year":"2017","journal-title":"Ref. J. Chem."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tox.2004.02.014","article-title":"Aluminium-induced changes in hemato-biochemical parameters, lipid peroxidation and enzyme activities of male rabbits: protective role of ascorbic acid","volume":"199","author":"Yousef","year":"2004","journal-title":"Toxicol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0105","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1385\/BTER:79:1:67","article-title":"Effects of oral aluminium on essential trace elements metabolism during pregnancy","volume":"79","author":"Belles","year":"2001","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0110","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1289\/ehp.02110s5699","article-title":"Brain uptake, retention, and efflux of aluminum and manganese","volume":"110","author":"Yokel","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0115","first-page":"813","article-title":"The toxicology of aluminum in the brain: a review","volume":"21","author":"Yokel","year":"2000","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0120","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1042\/bj2560861","article-title":"Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation","volume":"256","author":"Gutteridge","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0125","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5414\/TEX01472","article-title":"Short-term effects of aluminum and selenium on redox status in mice brain and blood","volume":"34","author":"Staneviciene","year":"2017","journal-title":"Trace Elem. Electrolytes"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0130","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12011-013-9854-x","article-title":"Copper and resveratrol attenuates serum catalase, glutathione peroxidase, and element values in rats with DMBA-induced mammary carcinogenesis","volume":"156","author":"Skrajnowska","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0135","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1182\/blood.V84.1.325.325","article-title":"Importance of catalase in the disposal of hydrogen peroxide within human erythrocytes","volume":"84","author":"Gaetani","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0140","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.etap.2008.10.001","article-title":"Aluminum accumulation induced testicular oxidative stress and altered selenium metabolism in mice","volume":"27","author":"Guo","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0145","first-page":"118","article-title":"The two faces of reactive oxygen species","volume":"62","author":"Zab\u0142ocka","year":"2008","journal-title":"Post. Hig. Med. Dosw."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3923\/ijp.2011.12.21","article-title":"A systematic review on oxidant\/antioxidant imbalance in aluminium toxicity","volume":"7","author":"Mohammadir","year":"2011","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0155","first-page":"7","article-title":"Correlation of oxidative stress with serum trace element levels and antioxidant enzyme status in beta thalassemia major patients: a review of the literature","volume":"270923","author":"Shazia","year":"2012","journal-title":"Anemia"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0160","first-page":"239","article-title":"Selenium biochemistry and cancer: a review of the literature","volume":"9","author":"Patrick","year":"2004","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0165","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/ajcn\/85.1.173","article-title":"Glutathione, glutathione peroxidase, and selenium status in HIV-positive and HIV-negative adolescents and young adults","volume":"85","author":"Stephensen","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0170","doi-asserted-by":"crossref","first-page":"C367","DOI":"10.1152\/ajpcell.1994.266.2.C367","article-title":"Human kidney proximal tubules are the main source of plasma glutathione peroxidase","volume":"266","author":"Avissar","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0175","series-title":"Aging: Oxidative Stress and Dietary Antioxidants","first-page":"157","article-title":"Chapter 16. Magnesium, oxidative stress, and aging muscle","author":"Barbagallo","year":"2014"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0180","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1073\/pnas.0501559102","article-title":"Decline in skeletal muscle mitochondrial function with aging in humans","volume":"102","author":"Short","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0185","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/jn\/111.2.266","article-title":"Tissue iron, copper and zinc levels in offspring of iron-sufficient and iron deficient rats","volume":"111","author":"Sherman","year":"1987","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0190","first-page":"75","article-title":"Tissue levels of iron, copper, zinc and magnesium in iron deficient rats","volume":"14","author":"Oladiji","year":"2003","journal-title":"Biokemistri"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0195","first-page":"11","article-title":"Experimental evaluation of protective action of resveratrol against aluminium-induced toxicity in male rats","volume":"6","author":"Hammoud","year":"2019","journal-title":"Int. J. Adv. Res. Biol. Sci."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0200","doi-asserted-by":"crossref","first-page":"369","DOI":"10.15537\/smj.2016.4.13611","article-title":"Protective effect of resveratrol against aluminium chloride induced nephrotoxicity in rats","volume":"37","author":"Al Dera","year":"2016","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0205","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10571-007-9233-2","article-title":"Antioxidant enzymatic system in neuronal and glial cells enriched fractions of rat brain after aluminum exposure","volume":"27","author":"Khanna","year":"2007","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0210","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s11033-018-4408-0","article-title":"Post-exposure distribution of selenium and aluminum ions and their effects on superoxide dismutase activity in mouse brain","volume":"45","author":"Sadauskiene","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0215","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1039\/C4MT00097H","article-title":"Zinc modulates aluminium-induced oxidative stress and cellular injury in rat brain","volume":"6","author":"Singla","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.jtemb.2019.06.013_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-013-8417-7","article-title":"Zinc, a neuroprotective agent against aluminum-induced oxidative DNA injury","volume":"48","author":"Singla","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0225","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10571-013-0010-0","article-title":"Influence of zinc on the biokinetics of (65) Zn in brain and whole body and its bio-distribution in aluminium-intoxicated rats","volume":"34","author":"Singla","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0230","first-page":"133","article-title":"Age-related changes of some trace element contents in intact thyroid of males investigated by energy dispersive x-ray fluorescent analysis","volume":"1","author":"Zaichick","year":"2017","journal-title":"MOJ Gerontol. Ger."},{"key":"10.1016\/j.jtemb.2019.06.013_bib0235","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s12011-018-1247-8","article-title":"Accumulation patterns of sub-chronic aluminum toxicity model after gastrointestinal administration in rats","volume":"185","author":"Drobyshev","year":"2018","journal-title":"Biol. Trace Elem. Res."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X19302883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X19302883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:07:33Z","timestamp":1760555253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X19302883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":47,"alternative-id":["S0946672X19302883"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2019.06.013","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homeostatic changes of some trace elements in geriatric rats in the condition of oxidative stress induced by aluminum and the beneficial role of resveratrol","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2019.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}