{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:24:54Z","timestamp":1793895894614,"version":"4.8.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Seoul National University College of Medicine","id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Education Research Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jtemb.2020.126558","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T18:22:35Z","timestamp":1590344555000},"page":"126558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Exploring the role of copper and selenium in the maintenance of normal thyroid function among healthy Koreans"],"prefix":"10.1016","volume":"61","author":[{"given":"Min Joo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Chin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soie","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4-5","key":"10.1016\/j.jtemb.2020.126558_bib0005","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mam.2005.07.013","article-title":"Relevance, essentiality and toxicity of trace elements in human health","volume":"26","author":"Fraga","year":"2005","journal-title":"Mol. Aspects Med."},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0010","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3803\/EnM.2016.31.2.213","article-title":"Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease","volume":"31","author":"Wiersinga","year":"2016","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"6308","key":"10.1016\/j.jtemb.2020.126558_bib0015","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/349438a0","article-title":"Type I iodothyronine deiodinase is a selenocysteine-containing enzyme","volume":"349","author":"Berry","year":"1991","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jtemb.2020.126558_bib0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrendo.2011.174","article-title":"Selenium, selenoproteins and the thyroid gland: interactions in health and disease","volume":"8","author":"Schomburg","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jtemb.2020.126558_bib0025","article-title":"Trace element status and hypothyroidism: a systematic review and meta-analysis","author":"Talebi","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"issue":"11","key":"10.1016\/j.jtemb.2020.126558_bib0030","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1210\/jc.2015-2222","article-title":"Low population selenium status is associated with increased prevalence of thyroid disease","volume":"100","author":"Wu","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.jtemb.2020.126558_bib0035","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1089\/thy.2016.0256","article-title":"Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis","volume":"26","author":"Wichman","year":"2016","journal-title":"Thyroid"},{"issue":"1-3","key":"10.1016\/j.jtemb.2020.126558_bib0040","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12011-014-9992-9","article-title":"Thyroid function and serum copper, selenium, and zinc in general U.S. Population","volume":"159","author":"Jain","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0045","first-page":"79","article-title":"Potential influence of selenium, copper, zinc and cadmium on L-thyroxine substitution in patients with Hashimoto thyroiditis and hypothyroidism","volume":"125","author":"Rasic-Milutinovic","year":"2017","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"3","key":"10.1016\/j.jtemb.2020.126558_bib0050","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41574-019-0311-6","article-title":"Selenium in thyroid disorders \u2013 essential knowledge for clinicians","volume":"16","author":"Winther","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0055","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12011-015-0304-9","article-title":"The association between serum levels of selenium, copper, and magnesium with thyroid cancer: a meta-analysis","volume":"167","author":"Shen","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2020.126558_bib0060","first-page":"3029379","article-title":"Serum trace elements profile in Graves' disease patients with or without orbitopathy in northeast China","volume":"2018","author":"Liu","year":"2018","journal-title":"Biomed Res. Int."},{"issue":"3","key":"10.1016\/j.jtemb.2020.126558_bib0065","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12011-009-8478-7","article-title":"Interaction of copper with iron, iodine, and thyroid hormone status in goitrous patients","volume":"134","author":"Kazi","year":"2010","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0070","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jtemb.2009.11.003","article-title":"Trace elements status in multinodular goiter","volume":"24","author":"Giray","year":"2010","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0075","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF03350281","article-title":"Sonographic diagnosis and grading of Hashimoto\u2019s thyroiditis","volume":"14","author":"Sostre","year":"1991","journal-title":"J. Endocrinol. Invest."},{"issue":"14","key":"10.1016\/j.jtemb.2020.126558_bib0080","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000015055","article-title":"The association between thyroid echogenicity and thyroid function in pediatric and adolescent Hashimoto\u2019s thyroiditis","volume":"98","author":"Jeong","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"11","key":"10.1016\/j.jtemb.2020.126558_bib0085","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.6061\/clinics\/2012(11)05","article-title":"The role of the resistive index in Hashimoto\u2019s thyroiditis: a sonographic pilot study in children","volume":"67","author":"Sarikaya","year":"2012","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.jtemb.2020.126558_bib0090","series-title":"2015\u20132020 Dietary Guidelines for Americans","author":"he United States Department of Health and Human Services","year":"2015"},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0095","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuro.2010.12.006","article-title":"Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008","volume":"32","author":"Kim","year":"2011","journal-title":"Neurotoxicology"},{"issue":"7","key":"10.1016\/j.jtemb.2020.126558_bib0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph14070702","article-title":"Determination of trace metal levels in the general population of Korea","volume":"14","author":"Kim","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.jtemb.2020.126558_bib0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ophtha.2014.07.039","article-title":"Epidemiologic Survey Committee of Korean Ophthalmologic, five heavy metallic elements and age-related macular degeneration: Korean National Health and Nutrition Examination Survey, 2008-2011","volume":"122","author":"Park","year":"2015","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.jtemb.2020.126558_bib0110","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3945\/ajcn.111.023812","article-title":"Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements","volume":"95","author":"Duncan","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"issue":"7","key":"10.1016\/j.jtemb.2020.126558_bib0115","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8070931","article-title":"Micronutrient deficiencies in medical and surgical inpatients","volume":"8","author":"Berger","year":"2019","journal-title":"J. Clin. Med."},{"issue":"4-5","key":"10.1016\/j.jtemb.2020.126558_bib0120","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.mam.2005.07.015","article-title":"Copper, oxidative stress, and human health","volume":"26","author":"Uriu-Adams","year":"2005","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jtemb.2020.126558_bib0125","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jtemb.2015.07.002","article-title":"Trace elements profile is associated with insulin resistance syndrome and oxidative damage in thyroid disorders: manganese and selenium interest in Algerian participants with dysthyroidism","volume":"32","author":"Maouche","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"5","key":"10.1016\/j.jtemb.2020.126558_bib0130","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/thy.2016.0635","article-title":"Multiple nutritional factors and the risk of Hashimoto\u2019s thyroiditis","volume":"27","author":"Hu","year":"2017","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.jtemb.2020.126558_bib0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/BJ20111817","article-title":"Serum copper as a novel biomarker for resistance to thyroid hormone","volume":"443","author":"Mittag","year":"2012","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0140","first-page":"151","article-title":"Serum levels of calcium, selenium, magnesium, phosphorus, chromium, copper and iron--their relation to zinc in rats with induced hypothyroidism","volume":"52","author":"Baltaci","year":"2013","journal-title":"Acta Clin. Croat."},{"issue":"3","key":"10.1016\/j.jtemb.2020.126558_bib0145","first-page":"125","article-title":"l-Thyroxine-induced hyperthyroidism affects elements and zinc in rats","volume":"114","author":"Baltaci","year":"2013","journal-title":"Bratisl. Lek. Listy"},{"issue":"5","key":"10.1016\/j.jtemb.2020.126558_bib0150","first-page":"281","article-title":"The effect of thyroxine, the antithyroid drug propylthiouracil and thyroidectomy on mineral metabolism in rat tissues","volume":"20","author":"Al-Khayat","year":"1982","journal-title":"J. Clin. Chem. Clin. Biochem."},{"issue":"5","key":"10.1016\/j.jtemb.2020.126558_bib0155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.14712\/fb2007053050183","article-title":"Investigation of zinc and copper levels in methimazole-induced hypothyroidism: relation with the oxidant-antioxidant status","volume":"53","author":"Alturfan","year":"2007","journal-title":"Folia Biol. (Praha)"},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0160","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1385\/BTER:97:2:125","article-title":"Study of trace elements in blood of thyroid disorder subjects before and after 131I therapy","volume":"97","author":"Zhang","year":"2004","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jtemb.2020.126558_bib0165","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s12020-015-0761-0","article-title":"Increased thyroid cancer incidence in a basaltic volcanic area is associated with non-anthropogenic pollution and biocontamination","volume":"53","author":"Malandrino","year":"2016","journal-title":"Endocrine"},{"issue":"12","key":"10.1016\/j.jtemb.2020.126558_bib0170","first-page":"718","article-title":"Serum copper levels in benign and malignant thyroid diseases","volume":"113","author":"Kosova","year":"2012","journal-title":"Bratisl. Lek. Listy"},{"issue":"4","key":"10.1016\/j.jtemb.2020.126558_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152748","article-title":"Selenium status is positively associated with bone mineral density in healthy aging European men","volume":"11","author":"Beukhof","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jtemb.2020.126558_bib0180","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1139\/o90-089","article-title":"Interaction of sodium molybdate with the thyroid hormone receptor","volume":"68","author":"Faure","year":"1990","journal-title":"Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.jtemb.2020.126558_bib0185","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13046-017-0543-z","article-title":"Intake of boron, cadmium, and molybdenum enhances rat thyroid cell transformation","volume":"36","author":"Luca","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.jtemb.2020.126558_bib0190","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ijheh.2012.08.005","article-title":"Metals in blood and urine, and thyroid function among adults in the United States 2007-2008","volume":"216","author":"Yorita Christensen","year":"2013","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"7","key":"10.1016\/j.jtemb.2020.126558_bib0195","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.envres.2009.06.004","article-title":"Multiple metals predict prolactin and thyrotropin (TSH) levels in men","volume":"109","author":"Meeker","year":"2009","journal-title":"Environ. Res."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X20301231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X20301231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:15:14Z","timestamp":1760555714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X20301231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":39,"alternative-id":["S0946672X20301231"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2020.126558","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the role of copper and selenium in the maintenance of normal thyroid function among healthy Koreans","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2020.126558","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"126558"}}