{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:08:10Z","timestamp":1792789690298,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/25207-0"],"award-info":[{"award-number":["2018\/25207-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.115406\/2015"],"award-info":[{"award-number":["88887.115406\/2015"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["401170\/2016-0"],"award-info":[{"award-number":["401170\/2016-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["CTM2017-84763-C3-3-R"],"award-info":[{"award-number":["CTM2017-84763-C3-3-R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jtemb.2020.126613","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T11:48:52Z","timestamp":1594986532000},"page":"126613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["In vitro bioaccessibility of metals from tape tea \u2013 A low-cost emerging drug"],"prefix":"10.1016","volume":"62","author":[{"given":"Aline Martins de","family":"Andrade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-3952","authenticated-orcid":false,"given":"Rodrigo Moretto","family":"Galazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio Zezzi","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2020.126613_bib0005","series-title":"World Drug Report (United Nations publication, Sales No. E.18.XI.9)","year":"2018"},{"key":"10.1016\/j.jtemb.2020.126613_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/PAF.0b013e31827ab5f3","article-title":"Complicated suicide versus autoeroticism: a case involving multiple drugs and a porta-potty","volume":"34","author":"Dickerson","year":"2013","journal-title":"Am. J. Forensic Med. Pathol."},{"key":"10.1016\/j.jtemb.2020.126613_bib0015","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1039\/c4np00010b","article-title":"Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs","volume":"31","author":"Appendino","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jtemb.2020.126613_bib0020","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3949\/ccjm.79a.11147","article-title":"Synthetic legal intoxicating drugs: the emerging \u2018incense\u2019 and \u2018bath salt\u2019 phenomenon","volume":"79","author":"Jerry","year":"2012","journal-title":"Cleve. Clin. J. Med."},{"issue":"4","key":"10.1016\/j.jtemb.2020.126613_bib0025","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00213-013-3188-4","article-title":"Spicing things up: synthetic cannabinoids","volume":"228","author":"Spaderna","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jtemb.2020.126613_bib0030","first-page":"1800","article-title":"Evaluating the \u201cTape Tea\u201d myth as low cost abuse drug through mass spectrometry","volume":"27","author":"Lehmann","year":"2016","journal-title":"J. Braz. Chem. Soc."},{"issue":"9","key":"10.1016\/j.jtemb.2020.126613_bib0035","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.trac.2006.03.010","article-title":"In-vitro testing for assessing oral bioaccessibility of trace metals in soil and food samples","volume":"25","author":"Intawongse","year":"2006","journal-title":"Trends Analyt. Chem."},{"issue":"3","key":"10.1016\/j.jtemb.2020.126613_bib0040","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2125.2012.04425.x","article-title":"Bioavailability of bioactive food compounds: a challenging journey to bioefficacy","volume":"75","author":"Rein","year":"2012","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jtemb.2020.126613_bib0045","series-title":"BARGE Bioaccessibility Research Group of Europe","year":"2019"},{"key":"10.1016\/j.jtemb.2020.126613_bib0050","series-title":"Requirements for Specific Standardized Beverages. Electronic Codes of Federal Regulations","year":"2019"},{"key":"10.1016\/j.jtemb.2020.126613_bib0055","series-title":"Food and Drug Administration - Food Labeling: Revision of the Nutrition and Supplement Acts Labels. Rules and Regulations","first-page":"81","year":"2016"},{"issue":"13","key":"10.1016\/j.jtemb.2020.126613_bib0060","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1080\/10408398.2017.1315362","article-title":"Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?","volume":"58","author":"Bohn","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jtemb.2020.126613_bib0065","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3390\/ijerph15061293","article-title":"Deriving a drinking water guideline for a non-carcinogenic contaminant: the case of manganese","volume":"15","author":"Valcke","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.jtemb.2020.126613_bib0070","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4067\/S0716-97602006000100006","article-title":"Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination","volume":"39","author":"Roth","year":"2006","journal-title":"Biol. Res."},{"key":"10.1016\/j.jtemb.2020.126613_bib0075","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jfca.2018.02.006","article-title":"Contribution of tea (Camellia sinensis L.) to recommended daily intake of Mg, Mn, and Fe: an in vitro bioaccessibility assessment","volume":"69","author":"Erdemir","year":"2018","journal-title":"J. Food Anal."},{"issue":"7","key":"10.1016\/j.jtemb.2020.126613_bib0080","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1351\/pac200779071153","article-title":"Glossary of terms used in toxicology - 2nd Ed. \u2013 IUPAC recommendations","volume":"79","author":"Duffus","year":"2007","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.jtemb.2020.126613_bib0085","series-title":"Incorporating the First Addendum","article-title":"Guidelines for drinking-water quality","year":"2017"},{"key":"10.1016\/j.jtemb.2020.126613_bib0090","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/003655101753267964","article-title":"Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium","volume":"61","author":"Clyne","year":"2001","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.jtemb.2020.126613_bib0095","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0002-9343(72)90136-2","article-title":"Cobalt-beer cardiomyopathy a clinical and pathologic study of twenty-eight cases","volume":"53","author":"Alexander","year":"1972","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jtemb.2020.126613_bib0100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.taap.2019.03.003","article-title":"Comparison of the neurotoxicity associated with cobalt nanoparticles and cobalt chloride in Wistar rats","volume":"369","author":"Zheng","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jtemb.2020.126613_bib0105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.scitotenv.2012.06.009","article-title":"Cobalt metabolism and toxicology\u2014a brief update","volume":"432","author":"Simonsen","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jtemb.2020.126613_bib0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10633-014-9469-3","article-title":"The effect of cobalt on the human eye","volume":"130","author":"Lim","year":"2015","journal-title":"Doc. Ophtalmol."},{"key":"10.1016\/j.jtemb.2020.126613_bib0115","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1007\/s10653-016-9875-4","article-title":"Oral bioaccessibility of inorganic contaminants in waste dusts generated by laterite Ni ore smelting","volume":"40","author":"Ettler","year":"2018","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.jtemb.2020.126613_bib0120","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fct.2013.10.033","article-title":"Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax\/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers","volume":"63","author":"Wu","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2020.126613_bib0125","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.fct.2013.01.053","article-title":"DNA damage and oxidative stress in human B lymphoblastoid cells after combined exposure to hexavalent chromium and nickel compounds","volume":"55","author":"Lou","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2020.126613_bib0130","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00216-012-6611-5","article-title":"Ni speciation in tea infusions by monolithic chromatography\u2014ICP-MS and Q-TOF-MS","volume":"405","author":"Scancar","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jtemb.2020.126613_bib0135","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.fct.2009.03.018","article-title":"Protective role of vitamin E on nickel and\/or chromium induced oxidative stress in the mouse ovary","volume":"47","author":"Rao","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2020.126613_bib0140","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12011-019-01828-x","article-title":"Simplified method of multi-elemental analysis of dialyzable fraction of tea infusions by FAAS and ICP OES","volume":"195","author":"Szymczycha-Madeja","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2020.126613_bib0145","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s12011-017-1084-1","article-title":"Assessment of the bioaccessibility of trace elements in cat\u2019s claw teas by in vitro simulated gastrointestinal digestion using FAAS","volume":"182","author":"Pereira Junior","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jtemb.2020.126613_bib0150","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1039\/C8FO02368A","article-title":"Establishing the impact of food matrix effects on the bioaccessibility of nutraceuticals and pesticides using a standardized food model","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X20301784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X20301784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:14:39Z","timestamp":1760555679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X20301784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":30,"alternative-id":["S0946672X20301784"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2020.126613","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro bioaccessibility of metals from tape tea \u2013 A low-cost emerging drug","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2020.126613","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126613"}}