{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:37:03Z","timestamp":1791290223948,"version":"4.3.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFD0900400"],"award-info":[{"award-number":["2018YFD0900400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32030111"],"award-info":[{"award-number":["32030111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872585"],"award-info":[{"award-number":["31872585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jtemb.2021.126732","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T08:49:19Z","timestamp":1613378959000},"page":"126732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish"],"prefix":"10.1016","volume":"65","author":[{"given":"Kun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Hogstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Cheng","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Xiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-1609","authenticated-orcid":false,"given":"Zhi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2021.126732_bib0005","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/jn\/137.4.1101","article-title":"Zinc deficiency: a special challenge","volume":"137","author":"Hambidge","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2021.126732_bib0010","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1096\/fj.201800463","article-title":"Zinc reduces hepatic lipid deposition and activates lipophagy via Zn2+\/MTF-1\/PPAR\u03b1 and Ca2+\/CaMKK\u03b2\/AMPK pathways","volume":"32","author":"Wei","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.jtemb.2021.126732_bib0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1439-0396.2008.00888.x","article-title":"Bioavailability of co\u2010supplemented organic and inorganic zinc and selenium sources in a white fishmeal\u2010based rainbow trout Oncorhynchus mykiss) diet","volume":"94","author":"Rider","year":"2010","journal-title":"J. Anim. Physiol. An. N."},{"key":"10.1016\/j.jtemb.2021.126732_bib0020","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jtemb.2021.126732_bib0025","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase","volume":"334","author":"Zoncu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jtemb.2021.126732_bib0030","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nrm4024","article-title":"Autophagy at the crossroads of catabolism and anabolism","volume":"16","author":"Kaur","year":"2015","journal-title":"Nat. Rev. Mol. Cell Bio."},{"key":"10.1016\/j.jtemb.2021.126732_bib0035","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00018-019-03263-6","article-title":"Lipophagy mediated carbohydrate-induced changes of lipid metabolism via oxidative stress, endoplasmic reticulum ER) stress and ChREBP\/PPAR\u03b3 pathways","volume":"77","author":"Zhao","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jtemb.2021.126732_bib0040","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tcb.2010.12.006","article-title":"The three musketeers of autophagy: phosphorylation, ubiquitylation and acetylation","volume":"21","author":"McEwan","year":"2011","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jtemb.2021.126732_bib0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrm3249","article-title":"Canonical and non-canonical autophagy: variations on a common theme of self-eating","volume":"13","author":"Codogno","year":"2012","journal-title":"Nat. Rev. Mol. Cell Bio."},{"key":"10.1016\/j.jtemb.2021.126732_bib0050","doi-asserted-by":"crossref","first-page":"819","DOI":"10.4161\/auto.23908","article-title":"The emerging role of acetylation in the regulation of autophagy","volume":"9","author":"Banreti","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.jtemb.2021.126732_bib0055","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1111\/j.1460-9568.2006.05110.x","article-title":"Zinc neurotoxicity is dependent on intracellular NAD+ levels and the sirtuin pathway","volume":"24","author":"Cai","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jtemb.2021.126732_bib0060","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jinorgbio.2009.10.021","article-title":"Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1","volume":"104","author":"Chen","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jtemb.2021.126732_bib0065","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giy120","article-title":"Chromosomal-level assembly of yellow catfish genome using third-generation DNA sequencing and Hi-C analysis","volume":"7","author":"Gong","year":"2018","journal-title":"GigaScience"},{"key":"10.1016\/j.jtemb.2021.126732_bib0070","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.3390\/ijms21051615","article-title":"Nano-Zn increased Zn accumulation and triglyceride content by up-regulating lipogenesis in freshwater teleost, yellow catfish Pelteobagrus fulvidraco","volume":"21","author":"Ling","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jtemb.2021.126732_bib0075","doi-asserted-by":"crossref","first-page":"9206","DOI":"10.1021\/acs.est.8b02967","article-title":"Zn stimulates the phospholipids biosynthesis via the pathways of oxidative and endoplasmic reticulum stress in the intestine of freshwater teleost yellow catfish","volume":"52","author":"Wu","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jtemb.2021.126732_bib0080","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/jn\/nxaa125","article-title":"Dietary glucose increases glucose absorption and lipid deposition via SGLT1\/2 signaling and acetylated ChREBP in the intestine and isolated intestinal epithelial cells of yellow catfish","volume":"150","author":"Zhao","year":"2020","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2021.126732_bib0085","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jtemb.2021.126732_bib0090","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1101\/gr.124321.111","article-title":"Differential expression in RNA-seq: a matter of depth","volume":"21","author":"Tarazona","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.jtemb.2021.126732_bib0095","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1158\/0008-5472.CAN-04-3640","article-title":"Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase\/protein kinase B inhibitors","volume":"65","author":"Takeuchi","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.jtemb.2021.126732_bib0100","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbadis.2011.10.008","article-title":"Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis","volume":"1822","author":"Gomes","year":"2012","journal-title":"BBA-Mol. Basis. Dis."},{"key":"10.1016\/j.jtemb.2021.126732_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114420","article-title":"Waterborne Cu exposure increased lipid deposition and lipogenesis by affecting Wnt\/\u03b2-catenin pathway and the \u03b2-catenin acetylation levels of grass carp Ctenopharyngodon idella","volume":"263","author":"Xu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jtemb.2021.126732_bib0110","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.devcel.2008.08.012","article-title":"The role of autophagy in mammalian development: cell makeover rather than cell death","volume":"15","author":"Cecconi","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jtemb.2021.126732_bib0115","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1126\/science.1193497","article-title":"Autophagy and metabolism","volume":"330","author":"Rabinowitz","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jtemb.2021.126732_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.jtemb.2021.126732_bib0125","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm3757","article-title":"Making new contacts: the mTOR network in metabolism and signalling crosstalk","volume":"15","author":"Shimobayashi","year":"2014","journal-title":"Nat. Rev. Mol. Cell Bio."},{"key":"10.1016\/j.jtemb.2021.126732_bib0130","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1002\/hep.27667","article-title":"The small GTPase Rab7 as a central regulator of hepatocellular lipophagy","volume":"61","author":"Schroeder","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jtemb.2021.126732_bib0135","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/jcp.24399","article-title":"Sirtuins\u2019 modulation of autophagy","volume":"228","author":"Ng","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jtemb.2021.126732_bib0140","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12265-010-9200-z","article-title":"FoxO, autophagy, and cardiac remodeling","volume":"3","author":"Ferdous","year":"2010","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.jtemb.2021.126732_bib0145","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jtemb.2021.126732_bib0150","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.110.227371","article-title":"Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes","volume":"107","author":"Hariharan","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.jtemb.2021.126732_bib0155","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jtemb.2021.126732_bib0160","first-page":"329","article-title":"Molecular regulation of autophagy and its implications for metabolic diseases","volume":"17","author":"Ryter","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.jtemb.2021.126732_bib0165","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/jn\/nxz135","article-title":"Endoplasmic reticulum stress-mediated autophagy and apoptosis alleviate dietary fat-induced triglyceride accumulation in the intestine and in isolated intestinal epithelial cells of yellow catfish","volume":"149","author":"Ling","year":"2019","journal-title":"J. Nutr."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X21000225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X21000225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:49:18Z","timestamp":1777592958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X21000225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":33,"alternative-id":["S0946672X21000225"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2021.126732","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2021.126732","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126732"}}