{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:00:05Z","timestamp":1760576405727,"version":"build-2065373602"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jtemb.2021.126910","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T21:40:11Z","timestamp":1639604411000},"page":"126910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Comparison of X-ray absorption spectra from copper-loaded bovine and ovine livers"],"prefix":"10.1016","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6610-728X","authenticated-orcid":false,"given":"A.H.","family":"Clarkson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-2531","authenticated-orcid":false,"given":"N.R.","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2021.126910_bib0005","first-page":"1","article-title":"Short communication: survey of hepatic copper concentrations in Midwest dairy cows","author":"Strickland","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jtemb.2021.126910_bib0010","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1017\/S0021859614001026","article-title":"Intake of selected minerals on commercial dairy herds in central and northern England in comparison with requirements","volume":"153","author":"Sinclair","year":"2015","journal-title":"J. Agric. Sci."},{"key":"10.1016\/j.jtemb.2021.126910_bib0015","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/vr.h5977","article-title":"Taking action to reduce the risk of copper toxicity in cattle","volume":"177","author":"Grace","year":"2015","journal-title":"Vet. Rec."},{"key":"10.1016\/j.jtemb.2021.126910_bib0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/vr.103078","article-title":"Liver copper concentrations in cull cattle in the UK: Are cattle being copper loaded?","volume":"177","author":"Kendall","year":"2015","journal-title":"Vet. Rec."},{"key":"10.1016\/j.jtemb.2021.126910_bib0025","first-page":"60","article-title":"Copper is being overfed and can lead to fatalities","author":"Hunt","year":"2016","journal-title":"Dairy Farmer."},{"issue":"August","key":"10.1016\/j.jtemb.2021.126910_bib0030","first-page":"24","article-title":"Farmers warned about copper poisoning in sheep","author":"Price","year":"2016","journal-title":"Farmer\u2019s Wkly."},{"issue":"March","key":"10.1016\/j.jtemb.2021.126910_bib0035","first-page":"13","article-title":"Investigation finds dangerous levels of copper in feeds","author":"Price","year":"2017","journal-title":"Farmers Wkly."},{"issue":"November","key":"10.1016\/j.jtemb.2021.126910_bib0040","first-page":"6","article-title":"Dairy farmers could poison cows by feeding too much copper","author":"Alderton","year":"2015","journal-title":"Farmer\u2019s Wkly."},{"year":"2019","series-title":"Veterinary Investigation Surveillance Report (VIDA)","author":"AHPA","key":"10.1016\/j.jtemb.2021.126910_bib0045"},{"year":"2016","series-title":"Warning of the Risk of Chronic Copper Poisioning in Sheep","author":"AFBI","key":"10.1016\/j.jtemb.2021.126910_bib0050"},{"key":"10.1016\/j.jtemb.2021.126910_bib0055","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1017\/S0954422411000059","article-title":"Role of the rumen in copper and thiomolybdate absorption","volume":"24","author":"Gould","year":"2011","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.jtemb.2021.126910_bib0060","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/vr.100267","article-title":"Case study of copper poisoning in a British dairy herd","volume":"170","author":"Bidewell","year":"2012","journal-title":"Vet. Rec."},{"year":"1997","series-title":"Clinical Biochemistry of Domestic Animals","author":"Kaneko","key":"10.1016\/j.jtemb.2021.126910_bib0065"},{"key":"10.1016\/j.jtemb.2021.126910_bib0070","first-page":"429","article-title":"An ultrastructural and morphometric study of the liver of normal and copper-poisoned sheep","volume":"99","author":"Gooneratne","year":"1980","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jtemb.2021.126910_bib0075","first-page":"1","article-title":"Chronic copper poisoning in Sheep: liver injury","volume":"3","author":"Kumaratilake","year":"2014","journal-title":"J. Trace Elem. Anal."},{"key":"10.1016\/j.jtemb.2021.126910_bib0080","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.tvjl.2004.07.007","article-title":"Intracellular distribution of copper and zinc in the liver of copper-exposed cattle from northwest Spain","volume":"170","author":"L\u00f3pez-Alonso","year":"2005","journal-title":"Vet. J."},{"key":"10.1016\/j.jtemb.2021.126910_bib0085","first-page":"16","article-title":"Copper poisoning: an emerging disease in dairy cattle","author":"Bidewell","year":"2004","journal-title":"Vet. Lab. Agency."},{"year":"2010","series-title":"Mineral Nutrition of Livestock","author":"Suttle","key":"10.1016\/j.jtemb.2021.126910_bib0090"},{"key":"10.1016\/j.jtemb.2021.126910_bib0095","first-page":"77","article-title":"Effect of dietary molybdenum and sulphur on the copper status of hypercuprotic sheep after withdrawal of dietary copper","volume":"16","author":"Van Ryssen","year":"1986","journal-title":"S. Afr. J. Anim. Sci."},{"key":"10.1016\/j.jtemb.2021.126910_bib0100","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.tvjl.2004.01.019","article-title":"The role of metallothionein and zinc in hepatic copper accumulation in cattle","volume":"169","author":"L\u00f3pez-Alonso","year":"2005","journal-title":"Vet. J."},{"key":"10.1016\/j.jtemb.2021.126910_bib0105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0378-4274(94)90071-X","article-title":"Species variation in hepatic metallothionein","volume":"74","author":"Henry","year":"1994","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jtemb.2021.126910_bib0110","first-page":"1","article-title":"Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge","volume":"21","author":"Clarkson","year":"2019","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.jtemb.2021.126910_bib0115","first-page":"1174","article-title":"Intracellular distribution of hepatic copper in normal and copper-loaded sheep","volume":"47","author":"Corbett","year":"1978","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl)."},{"key":"10.1016\/j.jtemb.2021.126910_bib0120","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/jn\/110.3.448","article-title":"Intracellular distribution of copper and zinc in sheep: effect of age and dietary levels of the metals","volume":"110","author":"Saylor","year":"1980","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2021.126910_bib0125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1079\/PNS19950017","article-title":"Copper and zinc metabolism in health and disease: speciation and interactions","volume":"54","author":"Bremner","year":"1995","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.jtemb.2021.126910_bib0130","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/jn\/110.3.460","article-title":"Copper- and zinc-binding proteins in sheep liver and intestine: effects of dietary levels of the metals","volume":"110","author":"Saylor","year":"1980","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2021.126910_bib0135","series-title":"9th Int. Sheep Vet. Congr.","first-page":"48","article-title":"The liver copper status of finished lambs in the UK","author":"Clarkson","year":"2017"},{"key":"10.1016\/j.jtemb.2021.126910_bib0140","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj2360585","article-title":"Structural study of the copper and zinc sites in metallothioneins by using extended X-ray-absorption fine structure","volume":"236","author":"Abrahams","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/j.jtemb.2021.126910_bib0145","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.foodchem.2014.05.018","article-title":"Speciation of copper in a range of food types by X-ray absorption spectroscopy","volume":"164","author":"Ceko","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.jtemb.2021.126910_bib0150","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1021\/bi801926e","article-title":"Tracing copper-thiomolybdate complexes in a prospective treatment for Wilson\u2019s disease","volume":"48","author":"Zhang","year":"2009","journal-title":"Biochemistry."},{"year":"2009","series-title":"Center for X-ray Optics and Advanced Light Source: X-ray Data","author":"Thompson","key":"10.1016\/j.jtemb.2021.126910_bib0155"},{"key":"10.1016\/j.jtemb.2021.126910_bib0160","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/ajcn\/88.3.826S","article-title":"Role of copper transporters in copper homeostasis","volume":"88","author":"Prohaska","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jtemb.2021.126910_bib0165","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/jn\/133.5.1579S","article-title":"Integrating trace element metabolism from the cell to the whole organism","volume":"133","author":"Thiele","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.jtemb.2021.126910_bib0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-5793(02)03253-2","article-title":"Effects of copper on the expression of metal transporters in human intestinal Caco-2 cells","volume":"527","author":"Tennant","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jtemb.2021.126910_bib0175","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S0029665199000646","article-title":"Considerations for determining \u201coptimal nutrition\u201d for copper, zinc, manganese and molybdenum","volume":"58","author":"Failla","year":"1999","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.jtemb.2021.126910_bib0180","series-title":"Cornell Nutr. Conf.","article-title":"Advancements in ruminant trace mineral nutrition","author":"Spears","year":"2013"},{"key":"10.1016\/j.jtemb.2021.126910_bib0185","doi-asserted-by":"crossref","first-page":"5556","DOI":"10.1039\/C4CC10366A","article-title":"The role of copper ions in pathophysiology and fluorescent sensors for the detection thereof","volume":"51","author":"Verwilst","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jtemb.2021.126910_bib0190","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0162-0134(01)00376-2","article-title":"Roles of metallothionein in copper homeostasis: responses to Cu-deficient diets in mice","volume":"88","author":"Suzuki","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jtemb.2021.126910_bib0195","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbamcr.2008.05.002","article-title":"\u201cPulling the plug\u201d on cellular copper: the role of mitochondria in copper export","volume":"1973","author":"Leary","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"year":"2010","series-title":"Introduction to X-ray Absorption Near Edge Spectroscopy (XANES)","author":"Sarangi","key":"10.1016\/j.jtemb.2021.126910_bib0200"},{"key":"10.1016\/j.jtemb.2021.126910_bib0205","doi-asserted-by":"crossref","first-page":"13144","DOI":"10.1021\/bi050925x","article-title":"X-ray absorption investigation of a unique protein domain able to bind both copper(I) and copper(II) at adjacent sites of the N-Terminus of Haemophilus ducreyi Cu,Zn superoxide dismutase","volume":"44","author":"D\u2019Angelo","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.jtemb.2021.126910_bib0210","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1039\/C5DT00634A","article-title":"Pharmacological activity of metal binding agents that alter copper bioavailability","volume":"44","author":"Helsel","year":"2015","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jtemb.2021.126910_bib0215","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1134\/S1061934815050093","article-title":"Synergistic effect of perchlorate ions and acetonitrile medium explored for extension in copper redoximetry","volume":"70","author":"Rizvi","year":"2015","journal-title":"J. Anal. Chem."},{"key":"10.1016\/j.jtemb.2021.126910_bib0220","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1039\/an9931801411","article-title":"Cathodic stripping voltammetry of glutathione in natural waters","volume":"118","author":"Le Gall","year":"1993","journal-title":"Analyst"},{"key":"10.1016\/j.jtemb.2021.126910_bib0225","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1009653002399","article-title":"Evidence for strong copper(I) complexation by organic ligands in seawater","volume":"4","author":"Leal","year":"1998","journal-title":"Aquat. Geochemistry."},{"key":"10.1016\/j.jtemb.2021.126910_bib0230","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0753-3322(03)00012-X","article-title":"Trace elements in human physiology and pathology","volume":"57","author":"Tapiero","year":"2003","journal-title":"Copper, Biomed. Pharmacother."},{"key":"10.1016\/j.jtemb.2021.126910_bib0235","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.bbamcr.2012.02.011","article-title":"Charting the travels of copper in eukaryotes from yeast to mammals","volume":"1823","author":"Nevitt","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jtemb.2021.126910_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jtemb.2021.126910_bib0245","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.febslet.2013.05.019","article-title":"Copper chaperones. The concept of conformational control in the metabolism of copper","volume":"587","author":"Palumaa","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jtemb.2021.126910_bib0250","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0162-0134(86)80062-9","article-title":"X-ray absorption studies of the copper-beta domain of rat liver metallothionein","volume":"27","author":"George","year":"1986","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jtemb.2021.126910_bib0255","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3390\/sym11040460","article-title":"Symmetry in recognition of supramolecular synthons\u2013Competition between hydrogen bonding and coordination bond in multinuclear CuII\u20134f complexes with Bicompartmental Schiff base ligand","volume":"11","author":"Miroslaw","year":"2019","journal-title":"Symmetry (Basel)."},{"key":"10.1016\/j.jtemb.2021.126910_bib0260","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/iub.1620","article-title":"Thiol-based copper handling by the copper chaperone Atox1","volume":"69","author":"Hatori","year":"2017","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jtemb.2021.126910_bib0265","doi-asserted-by":"crossref","first-page":"1091S","DOI":"10.1093\/ajcn\/67.5.1091S","article-title":"Mechanisms for protection against copper toxicity","volume":"67","author":"Dameron","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jtemb.2021.126910_bib0270","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0021-9975(89)90065-0","article-title":"Intravenously administered tetra-thiomolybdate and the removal of copper from the liver of copper-loaded sheep","volume":"101","author":"Kumaratilake","year":"1989","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.jtemb.2021.126910_bib0275","series-title":"Proc. 12th Int. Symp. Trace Elem. Metab. Man Anim.","first-page":"40","article-title":"The effect of an intra-venous infusion of thiomolybdate on copper status and ovarian function of sheep","author":"Kendall","year":"2005"},{"key":"10.1016\/j.jtemb.2021.126910_bib0280","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1021\/ja029054u","article-title":"Tetrathiomolybdate causes formation of hepatic copper- molybdenum clusters in an animal model of Wilson\u2019s disease","volume":"125","author":"George","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jtemb.2021.126910_bib0285","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1126\/science.1179907","article-title":"Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation","volume":"15","author":"Alvarez","year":"2010","journal-title":"Science (80-.)."},{"key":"10.1016\/j.jtemb.2021.126910_bib0290","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/etc.379","article-title":"Extraordinary stability of copper(I)-tetrathiomolybdate complexes: possible implications for aquatic ecosystems","volume":"30","author":"Helz","year":"2011","journal-title":"Environ. Toxicol. Chem."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X21002005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X21002005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:13:27Z","timestamp":1760555607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X21002005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":58,"alternative-id":["S0946672X21002005"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2021.126910","relation":{},"ISSN":["0946-672X"],"issn-type":[{"type":"print","value":"0946-672X"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of X-ray absorption spectra from copper-loaded bovine and ovine livers","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2021.126910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126910"}}