{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:33:47Z","timestamp":1780342427306,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["YJSKYCX2019-18HYD"],"award-info":[{"award-number":["YJSKYCX2019-18HYD"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773367"],"award-info":[{"award-number":["81773367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jtemb.2022.126953","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T11:28:54Z","timestamp":1645010934000},"page":"126953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Effects of carnosic acid on arsenic-induced liver injury in mice: A comparative transcriptomics analysis"],"prefix":"10.1016","volume":"71","author":[{"given":"Baiming","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jtemb.2022.126953_bib1","doi-asserted-by":"crossref","first-page":"e634","DOI":"10.1097\/JOM.0000000000001485","article-title":"Arsenic exposure, assessment, toxicity, diagnosis, and management: guidance for occupational and environmental physicians","volume":"60","author":"Baker","year":"2018","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.jtemb.2022.126953_bib2","doi-asserted-by":"crossref","first-page":"44424","DOI":"10.1038\/srep44424","article-title":"Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL\/6J and 129\u00d71\/SvJ mice","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.jtemb.2022.126953_bib3","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/wer.1166","article-title":"Occurrence and distribution of organic and inorganic pollutants in groundwater","volume":"91","author":"Kurwadkar","year":"2019","journal-title":"Water Environ. Res."},{"key":"10.1016\/j.jtemb.2022.126953_bib4","unstructured":"Agency for Toxic Substances Disease Registry (ATSDR), Toxicological profile for arsenic, Atlanta, GA, U.S. Division of Toxicology and Human Health Sciences. \u3008https:\/\/www.atsdr.cdc.gov\/toxprofiles\/Arsenic_addendum.pdf. February 2016\u3009."},{"issue":"1","key":"10.1016\/j.jtemb.2022.126953_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4274(02)00084-X","article-title":"Arsenic toxicity and potential mechanisms of action","volume":"133","author":"Hughes","year":"2002","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.jtemb.2022.126953_bib6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1289\/ehp.00108393","article-title":"Groundwater arsenic contamination in Bangladesh and West Bengal, India","volume":"108","author":"Chowdhury","year":"2000","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.jtemb.2022.126953_bib7","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00204-012-0904-5","article-title":"Metabolism of arsenic and its toxicological relevance","volume":"87","author":"Watanabe","year":"2013","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.jtemb.2022.126953_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.taap.2004.08.025","article-title":"Effect of chronic intake of arsenic-contaminated water on liver","volume":"206","author":"Mazumder","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.jtemb.2022.126953_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/01926230490261348","article-title":"Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver","volume":"32","author":"Cui","year":"2004","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.jtemb.2022.126953_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/toxsci\/56.1.18","article-title":"Biliary and urinary excretion of inorganic arsenic: monomethylarsonous acid as a major biliary metabolite in rats","volume":"56","author":"Gregus","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jtemb.2022.126953_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tox.2015.02.008","article-title":"Mechanisms of action for arsenic in cardiovascular toxicity and implications for risk assessment","volume":"331","author":"Sidhu","year":"2015","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.jtemb.2022.126953_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jat.1649","article-title":"Arsenic: toxicity, oxidative stress and human disease","volume":"31","author":"Jomova","year":"2011","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.jtemb.2022.126953_bib13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/BF01201767","article-title":"Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. III. Stability of phenolic diterpenes of rosemary extracts under thermal stress as required for technological processes","volume":"195","author":"Schwarz","year":"1992","journal-title":"Z. Lebensm. Unters. Forsch."},{"issue":"5","key":"10.1016\/j.jtemb.2022.126953_bib14","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1097\/CCM.0000000000000246","article-title":"Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia\/reperfusion injury","volume":"42","author":"Yan","year":"2014","journal-title":"Crit. Car. Med."},{"issue":"1","key":"10.1016\/j.jtemb.2022.126953_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4196\/kjpp.2016.20.1.15","article-title":"Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice","volume":"20","author":"Guo","year":"2016","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.jtemb.2022.126953_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1421438","article-title":"Carnosic acid, a natural diterpene, attenuates arsenic-induced hepatotoxicity via reducing oxidative stress, MAPK activation, and apoptotic cell death pathway","volume":"2018","author":"Das","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jtemb.2022.126953_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2012.11.001","article-title":"Carnosic acid attenuates lipopolysaccharide-induced liver injury in rats via fortifying cellular antioxidant defense system","volume":"53","author":"Xiang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2022.126953_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple hypothesis testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"key":"10.1016\/j.jtemb.2022.126953_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12967-015-0430-3","article-title":"Ameliorative effect of water spinach, Ipomea aquatica (Convolvulaceae), against experimentally induced arsenic toxicity","volume":"13","author":"Dua","year":"2015","journal-title":"J. Transl. Med."},{"issue":"11","key":"10.1016\/j.jtemb.2022.126953_bib20","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0895-4356(93)90101-6","article-title":"Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries","volume":"46","author":"Danan","year":"1993","journal-title":"J. Clin. Epidemiol."},{"issue":"2","key":"10.1016\/j.jtemb.2022.126953_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0378-4274(98)00115-5","article-title":"Alteration in bilirubin excretion in individuals chronically exposed to arsenic in Mexico","volume":"99","author":"Hern\u00e1ndez-Zavala","year":"1998","journal-title":"Toxicol. Lett."},{"issue":"2","key":"10.1016\/j.jtemb.2022.126953_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00109-016-1477-1","article-title":"FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process","volume":"95","author":"Salminen","year":"2017","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.jtemb.2022.126953_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","article-title":"Understanding the physiology of FGF21","volume":"78","author":"Fisher","year":"2016","journal-title":"Annu. Rev. Physiol."},{"issue":"2","key":"10.1016\/j.jtemb.2022.126953_bib24","doi-asserted-by":"crossref","first-page":"R294","DOI":"10.1152\/ajpregu.00522.2016","article-title":"Arsenic exposure induces glucose intolerance and alters global energy metabolism","volume":"314","author":"Kirkley","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"4","key":"10.1016\/j.jtemb.2022.126953_bib25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1081\/CLT-100100949","article-title":"Hepatic damage caused by chronic arsenic toxicity in experimental animals","volume":"38","author":"Santra","year":"2000","journal-title":"J. Toxicol. Clin. Toxicol."},{"issue":"19","key":"10.1016\/j.jtemb.2022.126953_bib26","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1021\/acs.jafc.5b01246","article-title":"Carnosic acid as a major bioactive component in rosemary extract ameliorates high-fat-diet-induced obesity and metabolic syndrome in mice","volume":"63","author":"Zhao","year":"2015","journal-title":"J. Agric. Food Chem."},{"issue":"45","key":"10.1016\/j.jtemb.2022.126953_bib27","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1021\/bi500918m","article-title":"Structural and functional assessment of perilipin 2 lipid binding domain(s)","volume":"53","author":"Najt","year":"2014","journal-title":"Biochemistry"},{"issue":"10","key":"10.1016\/j.jtemb.2022.126953_bib28","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41419-018-1004-0","article-title":"Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway","volume":"9","author":"Qiu","year":"2018","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.jtemb.2022.126953_bib29","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbrc.2005.12.121","article-title":"Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet","volume":"340","author":"Motomura","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.jtemb.2022.126953_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097118","article-title":"Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice","volume":"9","author":"Carr","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jtemb.2022.126953_bib31","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4162\/nrp.2013.7.4.294","article-title":"Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice","volume":"7","author":"Park","year":"2013","journal-title":"Nutr. Res. Pract."},{"issue":"9","key":"10.1016\/j.jtemb.2022.126953_bib32","doi-asserted-by":"crossref","first-page":"97002","DOI":"10.1289\/EHP4415","article-title":"Lipid and cholesterol homeostasis after arsenic exposure and antibiotic treatment in mice: potential role of the microbiota","volume":"127","author":"Chi","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.jtemb.2022.126953_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112672","article-title":"Yinchenzhufu decoction protects against alpha-naphthylisothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses","volume":"254","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jtemb.2022.126953_bib34","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2174\/138920009790820138","article-title":"Expression, function and regulation of mouse cytochrome P450 enzymes: comparison with human P450 enzymes","volume":"10","author":"Hrycay","year":"2009","journal-title":"Curr. Drug Metab."},{"issue":"9","key":"10.1016\/j.jtemb.2022.126953_bib35","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1073\/pnas.0611724104","article-title":"Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation","volume":"104","author":"Miller","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.jtemb.2022.126953_bib36","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/mc.20446","article-title":"Disturbance of circadian gene expression in hepatocellular carcinoma","volume":"47","author":"Lin","year":"2008","journal-title":"Mol. Carcinog."},{"issue":"38","key":"10.1016\/j.jtemb.2022.126953_bib37","doi-asserted-by":"crossref","first-page":"64330","DOI":"10.18632\/oncotarget.19278","article-title":"miR-19b promotes breast cancer metastasis through targeting MYLIP and its related cell adhesion molecules","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.jtemb.2022.126953_bib38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3233\/CBM-201523","article-title":"Identification of MYLIP gene and miRNA-802 involved in the growth and metastasis of cervical cancer cells","volume":"30","author":"Ni","year":"2021","journal-title":"Cancer Biomark."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X22000335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X22000335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:16:31Z","timestamp":1760555791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X22000335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":38,"alternative-id":["S0946672X22000335"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2022.126953","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of carnosic acid on arsenic-induced liver injury in mice: A comparative transcriptomics analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2022.126953","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126953"}}