{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:24:36Z","timestamp":1768451076641,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Trace Elements in Medicine and Biology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jtemb.2022.127019","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T13:23:00Z","timestamp":1654867380000},"page":"127019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["(MeOPhSe)2, a synthetic organic selenium compound, inhibits virulence factors of Candida krusei: Adherence to cervical epithelial cells and biofilm formation"],"prefix":"10.1016","volume":"73","author":[{"given":"Victor Mendes","family":"de Siqueira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Graziele Marques","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliene Cristina da Silva","family":"Passos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Batista Teixeira","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Alberto-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maricilia Silva","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jtemb.2022.127019_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.00094","article-title":"Mechanisms of pathogenic Candida species to evade the host complement attack","volume":"10","author":"Singh","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jtemb.2022.127019_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antibiotics9060312","article-title":"Candidiasis and mechanisms of antifungal resistance","volume":"9","author":"Bhattacharya","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.jtemb.2022.127019_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-micro-091014-104330","article-title":"Candida albicans biofilms and human disease","volume":"69","author":"Nobile","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jtemb.2022.127019_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jtemb.2022.127019_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1469-0691.12539","article-title":"Global trends in the distribution of Candida species causing candidemia","volume":"20","author":"Guinea","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jtemb.2022.127019_bib6","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1128\/AAC.02615-13","article-title":"Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole","volume":"58","author":"Espinel-Ingroff","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jtemb.2022.127019_bib7","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1128\/AAC.42.10.2645","article-title":"Mechanism of fluconazole resistance in Candida krusei","volume":"42","author":"Orozco","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jtemb.2022.127019_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1099\/00222615-41-5-295","article-title":"Candida krusei: Biology, epidemiology, pathogenicity and clinical manifestations of an emerging pathogen","volume":"41","author":"Samaranayake","year":"1994","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jtemb.2022.127019_bib9","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.2147\/IDR.S247944","article-title":"Current aspects in the biology, pathogeny, and treatment of Candida krusei, a neglected fungal pathogen","volume":"13","author":"G\u00f3mez-Gaviria","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.jtemb.2022.127019_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.riam.2013.09.014","article-title":"Highlights in pathogenic fungal biofilms","volume":"31","author":"Sardi","year":"2014","journal-title":"Rev. Iberoam. De. Micol."},{"key":"10.1016\/j.jtemb.2022.127019_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s12941-015-0083-3","article-title":"Antifungal activity of amphotericin B and voriconazole against the biofilms and biofilm-dispersed cells of Candida albicans employing a newly developed in vitro pharmacokinetic model","volume":"14","author":"El-Azizi","year":"2015","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.jtemb.2022.127019_bib12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1439-0507.2011.02076.x","article-title":"Antifungal susceptibility of Candida albicans in biofilms","volume":"55","author":"Tobudic","year":"2012","journal-title":"Mycoses"},{"key":"10.1016\/j.jtemb.2022.127019_bib13","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.msec.2019.02.036","article-title":"Sodium alginate in oil-poloxamer organogels for intravaginal drug delivery: influence on structural parameters, drug release mechanisms, cytotoxicity and in vitro antifungal activity","volume":"99","author":"Querobino","year":"2019","journal-title":"Mater. Sci. Eng. C."},{"key":"10.1016\/j.jtemb.2022.127019_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mib.2018.02.005","article-title":"Antifungal drug resistance: evolution, mechanisms and impact","volume":"45","author":"Revie","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.jtemb.2022.127019_bib15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/EC.4.4.633-638.2005","article-title":"Candida biofilms: an update","volume":"4","author":"Ramage","year":"2005","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jtemb.2022.127019_bib16","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.archoralbio.2011.03.007","article-title":"New antimicrobial therapies used against fungi present in subgingival sites - a brief review","volume":"56","author":"Sardi","year":"2011","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jtemb.2022.127019_bib17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/08927014.2017.1295304","article-title":"In vitro inhibitory effects of farnesol and interactions between farnesol and antifungals against biofilms of Candida albicans resistant strains","volume":"33","author":"Xia","year":"2017","journal-title":"Biofouling"},{"key":"10.1016\/j.jtemb.2022.127019_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/viru.22913","article-title":"Candida albicans pathogenicity mechanisms","volume":"4","author":"Mayer","year":"2013","journal-title":"Virulence"},{"key":"10.1016\/j.jtemb.2022.127019_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw018","article-title":"Pathogenesis of Candida albicans biofilm","volume":"74","author":"Tsui","year":"2016","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.jtemb.2022.127019_bib20","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3109\/10408410903241436","article-title":"Our current understanding of fungal biofilms fungal biofilms gordon Ramage et al","volume":"35","author":"Ramage","year":"2009","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.jtemb.2022.127019_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/13693780500107554","article-title":"Candida biofilm: a well-designed protected environment","volume":"43","author":"Mukherjee","year":"2005","journal-title":"Med. Mycol."},{"key":"10.1016\/j.jtemb.2022.127019_bib22","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1601-0825.2007.01424.x","article-title":"Biofilm lifestyle of Candida: a mini review","volume":"14","author":"Seneviratne","year":"2008","journal-title":"Oral. Dis."},{"key":"10.1016\/j.jtemb.2022.127019_bib23","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00204-021-03003-5","article-title":"Toxicology and pharmacology of synthetic organoselenium compounds: an update","volume":"95","author":"Nogueira","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jtemb.2022.127019_bib24","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1021\/cr0406559","article-title":"Organoselenium and organotellurium compounds: Toxicology and pharmacology","volume":"104","author":"Nogueira","year":"2004","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jtemb.2022.127019_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/j.1439-0507.2010.01994.x","article-title":"In vitro antifungal evaluation and structure-activity relationship of diphenyl diselenide and synthetic analogues","volume":"54","author":"Loreto","year":"2011","journal-title":"Mycoses"},{"key":"10.1016\/j.jtemb.2022.127019_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00924-20","article-title":"Screening repurposing libraries for identification of drugs with novel antifungal activity","volume":"64","author":"Wall","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jtemb.2022.127019_bib27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1439-0507.2010.01888.x","article-title":"Candida albicans growth and germ tube formation can be inhibited by simple diphenyl diselenides [(PhSe) 2, (MeOPhSe) 2, (p-Cl-PhSe) 2, (F 3CPhSe) 2] and diphenyl ditelluride","volume":"54","author":"Rosseti","year":"2011","journal-title":"Mycoses"},{"key":"10.1016\/j.jtemb.2022.127019_bib28","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.2174\/1381612825666181120155433","article-title":"The organochalcogen compound (MeOPhSe)2 inhibits both formation and the viability of the biofilm produced by candida albicans, at different stages of development","volume":"24","author":"de Amorim","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jtemb.2022.127019_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jtemb.2014.08.001","article-title":"Diphenyl diselenide (PhSe)2 inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability","volume":"29","author":"Rosseti","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.jtemb.2022.127019_bib30","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2174\/1570163811666140924121758","article-title":"Biofilm formation by Candida albicans is inhibited by 4,4-dichloro diphenyl diselenide (pCl-PhSe)2","volume":"11","author":"Rosseti","year":"2014","journal-title":"Curr. Drug Discov. Technol."},{"key":"10.1016\/j.jtemb.2022.127019_bib31","doi-asserted-by":"crossref","DOI":"10.1080\/08927014.2021.1897110","article-title":"PhSe)2 and (pCl-PhSe)2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti-biofilm activities","volume":"37","author":"da Silva","year":"2021","journal-title":"Biofouling"},{"key":"10.1016\/j.jtemb.2022.127019_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6882-12-6","article-title":"Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells","volume":"12","author":"Feldman","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.jtemb.2022.127019_bib33","article-title":"Biofilm of candida albicans: formation, regulation and resistance","author":"Pereira","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.jtemb.2022.127019_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.02173","article-title":"Azole antifungal resistance in Candida albicans and emerging non-albicans Candida species","volume":"7","author":"Whaley","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jtemb.2022.127019_bib35","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/AAC.02603-14","article-title":"In vivo and in vitro acquisition of resistance to voriconazole by Candida krusei","volume":"58","author":"Ricardo","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jtemb.2022.127019_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/1469-0691.12622","article-title":"Antifungal stewardship in invasive Candida infections","volume":"20","author":"Ruhnke","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jtemb.2022.127019_bib37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrmicro1340","article-title":"Long-term survival during stationary phase: evolution and the GASP phenotype","volume":"4","author":"Finkel","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jtemb.2022.127019_bib38","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00294-019-00938-2","article-title":"On the duration of the microbial lag phase","volume":"65","author":"Vermeersch","year":"2019","journal-title":"Curr. Genet."},{"key":"10.1016\/j.jtemb.2022.127019_bib39","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/mmy\/myy097","article-title":"Growth kinetics in Candida spp.: differences between species and potential impact on antifungal susceptibility testing as described by the EUCAST","volume":"57","author":"Bordallo-Cardona","year":"2019","journal-title":"Med. Mycol."},{"key":"10.1016\/j.jtemb.2022.127019_bib40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0076-6879(95)53038-X","article-title":"Adhesion and interaction of Candida albicans with mammalian tissues in vitro and in vivo","volume":"253","author":"Segal","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jtemb.2022.127019_bib41","doi-asserted-by":"crossref","unstructured":"M.J. Kennedy, Adhesion and association mechanisms of Candida albicans., Current Topics in Medical Mycology. 2 (1988) 73\u2013169. https:\/\/doi.org\/10.1007\/978\u20131-4612\u20133730-3_4.","DOI":"10.1007\/978-1-4612-3730-3_4"},{"key":"10.1016\/j.jtemb.2022.127019_bib42","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/BF01935532","article-title":"The effect of adhesion on survival and growth of microorganisms","volume":"46","author":"Bar-Or","year":"1990","journal-title":"Experientia"},{"key":"10.1016\/j.jtemb.2022.127019_bib43","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.72539","article-title":"Role of cytotoxicity experiments in pharmaceutical development","author":"B\u00e1cskay","year":"2018","journal-title":"Cytotoxicity"},{"key":"10.1016\/j.jtemb.2022.127019_bib44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fct.2019.04.038","article-title":"Microemulsions of essentials oils \u2013 Increase of solubility and antioxidant activity or cytotoxicity?","volume":"129","author":"Sieniawska","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jtemb.2022.127019_bib45","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF01201869","article-title":"Application of good laboratory practice (GLP) to culture collections of microbial and cell cultures","volume":"8","author":"Stevenson","year":"1992","journal-title":"World J. Microbiol. Biotechnol."}],"container-title":["Journal of Trace Elements in Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X22000992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0946672X22000992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:16:03Z","timestamp":1760555763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0946672X22000992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":45,"alternative-id":["S0946672X22000992"],"URL":"https:\/\/doi.org\/10.1016\/j.jtemb.2022.127019","relation":{},"ISSN":["0946-672X"],"issn-type":[{"value":"0946-672X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"(MeOPhSe)2, a synthetic organic selenium compound, inhibits virulence factors of Candida krusei: Adherence to cervical epithelial cells and biofilm formation","name":"articletitle","label":"Article Title"},{"value":"Journal of Trace Elements in Medicine and Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jtemb.2022.127019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127019"}}